%0 Journal Article %T The Association of PNPLA3, COX-2 and DHCR7 Polymorphisms with Advanced Liver Fibrosis in Patients with HCV Mono-Infection and HCV/HIV Co-Infection %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Kiatbumrung, Rattanaporn %A Chuaypen, Natthaya %A Payungporn, Sunchai %A Avihingsanon, Anchalee %A Tangkijvanich, Pisit %D 2018 %\ 08/01/2018 %V 19 %N 8 %P 2191-2197 %! The Association of PNPLA3, COX-2 and DHCR7 Polymorphisms with Advanced Liver Fibrosis in Patients with HCV Mono-Infection and HCV/HIV Co-Infection %K polymorphisms %K HCV %K HIV %K fibrosis %K cirrhosis %R 10.22034/APJCP.2018.19.8.2191 %X There is increasing evidence that host genetic variations may influence the natural history of chronic hepatitis C virus(HCV) infection. The aim of this study was to determine the association between single nucleotide polymorphisms (SNPs)of PNPLA3 (rs738409), COX-2 (rs689465) and DHCR7 (rs12785878) and advanced liver fibrosis in Thai patients. Atotal of 220 patients with HCV mono-infection, 200 patients with HCV/HIV co-infection and 200 healthy controls wereenrolled. The SNPs were detected by allelic discrimination using real-time PCR with TaqMan probes. Liver stiffnessmeasurement (LSM) was assessed by transient elastography. Our results showed that the distribution of the studiedSNPs were not significantly different between the HCV mono- and co-infected groups. The frequencies AG and GGgenotypes of rs689465 and GG genotype of rs12785878 were less commonly found in the HCV mono- and co-infectedgroups compare with healthy controls (P<0.01). Among patients with HCV infection, older age, HIV co-infection,GG genotype of rs738409 and GG genotype of rs689465 were independently associated with advanced liver fibrosis(LSM≥9.5 kPa) in multivariate analysis. Moreover, the percentage of patients with advanced liver fibrosis increasedsignificantly along with the accumulated numbers of these risk genotypes. In conclusion, PNPLA3 (rs738409) andCOX-2 (rs689465) polymorphisms were associated with advanced liver fibrosis in patients with HCV mono- andco-infection, suggesting that these variants might play an important role in progressive liver fibrosis in these patients. %U https://journal.waocp.org/article_66509_bfbb3bba770959718741d079735e55ba.pdf