%0 Journal Article %T A Comparative Study of Two Chemo-radiation Regimens for the Cancer of Larynx %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Singh, Sharad %A Prasad, S N %A Korde, Mangesh %A Kumar, Sunny %A Elhence, Aditya %A Shakya, Vaibhav %D 2018 %\ 11/01/2018 %V 19 %N 11 %P 3265-3270 %! A Comparative Study of Two Chemo-radiation Regimens for the Cancer of Larynx %K Photon radiation %K EBRT %K Chemo-Radiation Regimens %K chemoradiotherapy %R 10.31557/APJCP.2018.19.11.3265 %X The region of head and neck is critical for respiration, nutrition, and speech. The management of laryngeal tumourscan stimulate mutilations and cosmetic deformities and worsen the life. A “non-operative approach” is preferred forpatients to whom radiation following surgery, possibly, will direct severe functional destruction predominantly inadvanced stage patients having a bulk of carcinoma larynx. The case material for the study was selected from thecross-section of patients registered at the J. K. Cancer Institute, Kanpur. Histologically squamous cell carcinoma 64patients were registered and equally and randomly placed into Arm I and Arm II. “Arm I” patients and “Arm II” wascomprised of randomly selected 64 patients, having histopathologically proven squamous cell carcinoma of the larynx.All patients (32 patients) belonging to “Arm I” received concurrent chemoradiotherapy of Inj. Cisplatin 100 mg/m2for three-weekly underwent EBRT with 60 Co/LINAC and photon radiation of 70 Gy in 35 fractions for 7 weeks(2 parallel opposed fields). All the patients (32 patients) belongs to “Arm II” received chemo boost as Inj. Cisplatin 6mg/m2 on last 15 fractions of treatment underwent EBRT with 60 Co/ LINAC photon radiation of 70 Gy in 35 fractionsfor 7 weeks. Radiotherapy was delivered in supine position by parallel opposing fields including the primary tumour,disease extension, and neck nodes. The study concluded that the loco-regional responses are analogous in Arm I andArm 2, however Arm II had additional treatment allied toxicities and resulting from numerous of treatment breaks. %U https://journal.waocp.org/article_76490_b7a20f5d91eb9c71c3fb23e2ec0f8be6.pdf