%0 Journal Article %T Simulation Models in Gastric Cancer Screening: A Systematic Review %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Matsuda, Ayako %A Saika, Kumiko %A Tanaka, Rina %A Ito, Yuri %A Fukui, Keisuke %A Kamo, Ken-Ichi %D 2018 %\ 12/01/2018 %V 19 %N 12 %P 3321-3334 %! Simulation Models in Gastric Cancer Screening: A Systematic Review %K Simulation Model %K Gastric cancer %K Screening %K Systematic review %R 10.31557/APJCP.2018.19.12.3321 %X Background: Together with such high-quality approaches as randomized controlled trials and large-scale cohortstudies, simulation models are often employed to evaluate the effect of cancer screening methods and decide ontheir appropriateness. This study aimed to evaluate all effects of gastric cancer screening that have been assessedusing simulation models, including cost-effectiveness, mortality reduction, and early-stage detection. Methods: Weperformed a systematic review using PubMed and Web of Science. We evaluated the effect of screening related tocost, such as incremental cost-effectiveness and incremental cost-effectiveness ratios; we also separately assessedeffects other than cost, such as quality-adjusted life-years, number of deaths prevented, life-years saved, relative riskof mortality from gastric cancer, life expectancy, and incidence reduction. The methods targeted for evaluation wereHelicobacter pylori testing or endoscopy. Results: We identified 19 studies dealing with simulation models in gastriccancer screenings: 14 examined H. pylori screening and 7 focused on endoscopy. Among those studies, two assessedboth H. pylori and endoscopy screening. Most of the studies adopted a Markov model, and all the studies evaluatedcost-effectiveness. Of the 14 H. pylori screening studies, 13 demonstrated cost-effectiveness and 11 also showed goodresults other than cost-effectiveness, such as extension of life-years and increase in early-stage detection. In three of thefive endoscopy studies, the target population was patients; all five studies obtained good results for cost-effectivenessand four observed good results other than for cost-effectiveness. Conclusions: In this study, we showed that the H.pylori screening test was cost-effective in terms of simulation model investigations. However, the H. pylori screeningtest should not ordinarily be recommended since there is insufficient evidence that it reduces gastric cancer mortality.In Japan, simulation modeling should be employed to plan for cancer control, and the appropriate use of simulationmodels should be examined for future use. %U https://journal.waocp.org/article_77046_16e6f0bc29f5539dcfee492984d4ed65.pdf