%0 Journal Article %T Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Mohamed, Amal Ahmed %A Omar, Heba %A Ghaffar, Mohamed F Abdel %A Marie, Mohamad Saeed %A Ramadan, Mohamed Ezz El Arab %A Talima, Soha M %A Daly, Mostufa EL %A Mahmoud, Seham %D 2019 %\ 01/01/2019 %V 20 %N 1 %P 139-143 %! Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma %K Pancreatic %K adenocarcinoma %K Polymorphism %K Adiponectin %R 10.31557/APJCP.2019.20.1.139 %X Introduction: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. Thereis a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer.The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism andthe risk of pancreatic cancer. Methods: Prospective case-control study included 77 patients (29 women and 48 men)with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participantswere genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C>A, rs266729C>G andrs2241766G>T) by PCR. Clinical, biochemical, and radiological data analyzed. Results: We demonstrated a significantassociation between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreaticadenocarcinoma (p<0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphismhave a lower frequency of lymph node involvement (p 0.05). Smoking and older age were independent predictors ofpancreatic adenocarcinoma. Conclusion: We provided evidence that variants in adiponectin gene might influence thedevelopment and progression of pancreatic cancer. %U https://journal.waocp.org/article_81678_58e832780eaf454cc583b90d6c098327.pdf