%0 Journal Article %T Study of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Akhter, Khaleda %A Enamur Rashid, Mohammed %D 2019 %\ 02/01/2019 %V 20 %N 2 %P 503-508 %! Study of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma %K cancer %K Chemotherapy %K Dihydropyrimidine Dehydrogenase %K Prognosis %K thymidylate synthase %R 10.31557/APJCP.2019.20.2.503 %X Background: The study aims to analyze Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase(DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma (OSCC). Methods: 50 oral squamous cellcarcinoma samples were taken from non-treated cancer patients at Hiroshima University Dental Hospital. The patientswere investigated for TS, that included 36 males and 14 females. Additionally, 31 patients were evaluated for DPDthat included 22 males and 9 females. Results: The samples had also undergone clinical and pathological evaluation,immunohistochemical staining, evaluation of immune-staining, enzymatic expression, and statistical analyses. Meanage of the population was 62.1 years. Conclusion: Over-expression of TS contributes significantly to the resistance of5-FU treatment; while inhibition of intra-tumoral DPD increases the sensitivity level. TS levels are not only predictiveof 5-FU response, but also prognostic in clinical value of non-treated cancer patients. %U https://journal.waocp.org/article_82410_3759db361bcc5fb5fc610cb5c8588a2b.pdf