%0 Journal Article %T Gleason Pattern 5 is a Possible Pathologic Predictor for Biochemical Recurrence after Laparoscopic Radical Prostatectomy %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Ikeda, Masaomi %A Amano, Noriyuki %A Sakata, Yusuke %A Honda, Tomotsugu %A Tachibana, Takashi %A Hirano, Shuhei %A Yamashita, Hideyuki %A Ishii, Junichiro %A Irie, Akira %D 2019 %\ 03/01/2019 %V 20 %N 3 %P 783-788 %! Gleason Pattern 5 is a Possible Pathologic Predictor for Biochemical Recurrence after Laparoscopic Radical Prostatectomy %K Gleason pattern 5 %K Biochemical recurrence %K Prostate Cancer %K laparoscopic radical prostatectomy %K surgical margin %R 10.31557/APJCP.2019.20.3.783 %X Objective: Several prognostic factors for biochemical recurrence after radical prostatectomy have been reported,including initial prostate-specific antigen level, Gleason score, positive surgical margin, and seminal vesicle invasion.Here we investigate whether Gleason pattern 5 is a predictor for biochemical recurrence. Methods: This retrospectivestudy included 168 patients who underwent laparoscopic radical prostatectomy from 2006 to 2015. The relationshipbetween biochemical recurrence after laparoscopic radical prostatectomy and the presence of Gleason pattern 5, evenas a tertiary pattern, was investigated. Biochemical recurrence was defined when the prostate-specific antigen levelrose to >0.2 ng/ml after having decreased to recurrence-free survival was estimated by the Kaplan-Meier method. Multivariate analysis was performed using aCox proportional hazards regression model. Results: The median age was 66 years, median initial prostate-specificantigen level was 6.9 ng/ml, and median follow-up period was 47.3 months. Biochemical recurrence was recognizedin 27 patients (16.1%) after laparoscopic radical prostatectomy, and 5-year biochemical recurrence-free survival was78.6%. Gleason pattern 5 was noted in 5 patients as the primary pattern, in 10 as the secondary pattern, and in 5 as thetertiary pattern. According to multivariate analysis, presence of Gleason pattern 5 (HR = 4.75, p=0.001) and positivesurgical margin (HR = 4.66, p=0.001) were independent predictive factors for biochemical recurrence-free survival.Conclusion: Gleason pattern 5 appears to be an important predictive factor for biochemical recurrence after laparoscopicradical prostatectomy. %U https://journal.waocp.org/article_82768_6e9d658319b247d49d7bc05bf4467c5b.pdf