%0 Journal Article %T Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Selected Malaysian Population: A Case- Control Study %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Goud, E V Soma Sekhar %A Malleedi, Shanthi %A Ramanathan, Anand %A Wong, Gou Rean %A Hwei Ern, Beatrix Tan %A Yean, Goh Yin %A Ann, Ho Hui %A Syan, Tan Yuen %A Zain, Rosnah %D 2019 %\ 03/01/2019 %V 20 %N 3 %P 935-941 %! Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Selected Malaysian Population: A Case- Control Study %K Genotype %K Interleukin-10 %K oral cancer %K oral squamous cell carcinoma %K Polymorphism %R 10.31557/APJCP.2019.20.3.935 %X Background: Interleukin-10 (IL10) genotypes have been closely correlated to the susceptibility for oral squamous cellcarcinoma. More than half of oral cancers in the world occur in Asia with estimated 168,850 new cases were diagnosedin this geographical region alone. Considering the rising numbers of oral cancer cases in Malaysia, association of IL10A1082G gene polymorphism was correlated. Methodology: 41 oral squamous cell carcinoma (OSCC) cases and 48healthy controls of comparable age, gender, and with habits like smoking, alcohol consumption and betel quid chewingwere selected. In this case-control study, samples were collected from the Oral Cancer Research and CoordinatingCentre (OCRCC), Faculty of Dentistry, University of Malaya, Malaysia. Genotyping conditions were evaluated bypolymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The PCR products were subjectedto digestion by MnlI enzyme (NEB, UK) to screen for the IL10 A-1082G. Digested DNA products were analyzed byelectrophoresis on 4% (w/v) agarose gel, stained with ethidium bromide and imaged under UV illumination. Chi-squaretest and Fisher’s Exact test were used in statistical analysis. Results: AG genotypes were present in 81.3% and 86.0% ofhealthy control and OSCC cases respectively (OR=0.468, 95% CI=0.133-1.653). No significant association was foundbetween IL10 A1082G polymorphism with risk habits, clinico-pathological parameters and 5-years overall survival.The findings also show no significant correlation between the IL10 genotype and features of OSCC within the casegroup as measured by tumor size, lymph node involvement, stage, invasive front, grading, depth, pattern of invasion.Conclusion: This study suggests that functional polymorphism AG of IL10 A1082G may have no influence with OSCCsusceptibility. However, further investigation with larger sample sizes can be conducted to provide additional evidenceto support the lack of association of IL10 A1082G polymorphism in oral cancer. %U https://journal.waocp.org/article_83331_f8661b2997943b044966208d830b9ff0.pdf