%0 Journal Article %T Association of Dietary Intake Ratio of n-3/n-6 Polyunsaturated Fatty Acids with Breast Cancer Risk in Western and Asian Countries: A Meta-Analysis %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Nindrea, Ricvan Dana %A Aryandono, Teguh %A Lazuardi, Lutfan %A Dwiprahasto, Iwan %D 2019 %\ 05/01/2019 %V 20 %N 5 %P 1321-1327 %! Association of Dietary Intake Ratio of n-3/n-6 Polyunsaturated Fatty Acids with Breast Cancer Risk in Western and Asian Countries: A Meta-Analysis %K breast cancer %K Omega-3 %K omega-6 %K Polyunsaturated fatty acids %R 10.31557/APJCP.2019.20.5.1321 %X Objective: This systematic review and meta-analysis were performed to determine association of dietary intake ratioof n-3/n-6 polyunsaturated fatty acids with breast cancer risk in Western and Asian countries. Methods: The authorsconducted a meta-analysis of published research articles on association of dietary intake ratio of n-3/n-6 polyunsaturatedfatty acids (PUFAs) with breast cancer risk in Western and Asian countries published between January 2000 and February2019 in online article databases of PubMed, ProQuest and EBSCO. Pooled risk ratios (RR) were calculated usingfixed and random-effect models. Publication bias was visually evaluated by performing funnel plots and statisticallyassessed by Egger’s and Begg’s tests. Data were processed by using Stata version 14.2 (Stata Corporation). Results:This study reviewed 913 articles. There were 13 studies included in systematic review continued by meta-analysisof relevant data with total number of samples: 275,264 patients. The results showed dietary intake ratio of n-3/n-6PUFAs with breast cancer risk in Western and Asian countries (RR = 0.99; 95% CI: 0.92-1.07). Dietary intake ratioof n-3/n-6 PUFAs with breast cancer risk in Western countries reached (RR = 0.98; 95% CI: 0.91-1.06) and there wasany significant publication bias for studies included. Dietary intake ratio of n-3/n-6 PUFAs with breast cancer risk inAsian countries reached (RR = 1.18; 95% CI: 0.94-1.47) and there was not any significant publication bias for studiesincluded. Conclusion: This analysis confirmed association of dietary intake ratio of n-3/n-6 PUFAs with breast cancerrisk in Western and Asian countries. Higher dietary intake ratio is associated with lower risk of breast cancer in Asiancountries rather than Western countries. This study suggests increasing dietary intake ratio n-3/n-6 PUFAs will providebenefit for breast cancer prevention. %U https://journal.waocp.org/article_87371_2cb374daf7fa840e4fed13bf55376676.pdf