%0 Journal Article %T Association of Matrix Metalloproteinase1-1607 1G>2G Polymorphism and Lung Cancer Risk: An Update by Meta-Analysis %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Ma, Yue %A Yang, Xi %A Xie, Yu-Ping %A Yi, Cheng %A Zhao, Fen %A Huang, Ying %D 2019 %\ 06/01/2019 %V 20 %N 6 %P 1841-1847 %! Association of Matrix Metalloproteinase1-1607 1G>2G Polymorphism and Lung Cancer Risk: An Update by Meta-Analysis %K matrix metalloproteinase1 (MMP1) %K Lung cancer %K Polymorphism %K Meta-analysis %R 10.31557/APJCP.2019.20.6.1841 %X Objective: The association between matrix metalloproteinase1 (MMP1)-1607 1G>2G polymorphism and lung cancerrisk is still inconclusive and inconsistent. We conducted a meta-analysis to estimate the potential relationship betweenMMP1-1607 1G>2G polymorphism and lung cancer risk. Methods: The comprehensive searches of the PubMed, Webof Science, Medline, CBM, CNKI, Weipu, and Wanfang databases, published up to Nov 10, 2018. Statistical analyseswere performed with Review Manager 5.3 software. Results: A total of 14 relevant studies containing 6068 cases and5860 controls were included in the study. The results indicated that MMP1-1607 1G>2G polymorphism was significantlyassociated with increased lung cancer risk under four models: 2G vs. 1G model (pooled OR = 1.19, 95% CI = 1.05-1.34,P < 0.0001); 2G/2G vs. 1G/1G (pooled OR = 1.34, 95% CI = 1.09-1.64, P = 0.003); 2G/2G vs. 1G/1G+1G/2G (pooledOR = 1.26, 95% CI = 1.06-1.49, P < 0.0001); 2G/2G+1G/2G vs. 1G/1G (pooled OR = 1.21, 95% CI = 1.05-1.40, P= 0.01). Subgroup analyses showed that there was a higher increase in smoking status under three models: 2G/2Gvs. 1G/1G (pooled OR = 2.07, 95% CI = 1.14-3.77, P = 0.02); 2G/2G vs. 1G/1G+1G/2G (pooled OR = 1.71, 95% CI= 1.17-2.52, P = 0.006); 2G/2G+1G/2G vs. 1G/1G (pooled OR = 2.03, 95% CI = 1.14-3.62, P = 0.02). In addition,subgroup analyses by ethnicity further identified the significant association in Asians. Non-smoking population andethnicity among Caucasian had no relationship with lung cancer susceptibility in four models. Conclusion: Our studysuggested that MMP1-1607 1G>2G polymorphism was a risk factor for developing lung cancer risk. %U https://journal.waocp.org/article_88611_19f6acf39f11df2f5f9daa68a76e1a0c.pdf