%0 Journal Article %T Evaluating the Incidence Rate of an Accelerated Short Course High Dose Rate Intravaginal Brachytherapy Complications in Patients with Endometrial Cancer %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Amouzegar Hashemi, Farnaz %A Vesgari Kiasari, Zakieh %A Kalaghchi, Bita %A Aghili, Mahdi %A Gholami, Soraya %A Mansouri, Sepideh %A Moalej, Sepand %A Maddah Safaei, Afsaneh %D 2019 %\ 07/01/2019 %V 20 %N 7 %P 2039-2043 %! Evaluating the Incidence Rate of an Accelerated Short Course High Dose Rate Intravaginal Brachytherapy Complications in Patients with Endometrial Cancer %K Accelerated short course high dose rate brachytherapy %K Complications %K Endometrial cancer %K organ at risk %R 10.31557/APJCP.2019.20.7.2039 %X Background: Brachytherapy in treatment of endometrial cancer patients is growing and therefore, evaluation ofmore feasible schedule has become of great importance. The purpose of current study was to evaluate the complicationsof accelerated short course high dose rate intravaginal brachytherapy (HDR IVB), a new brachytherapy approachwhich is a more feasible treatment option in developing countries. Method: From 2017 to 2018, 54 patients diagnosedwith endometrial cancer and FIGO stages IA to IIB who underwent total abdominal hysterectomy with a bilateralsalpingo-oophorectomy were enrolled in present study. They were treated with a total dose of 25 Gy in 5 fractionswhich was prescribed daily. A dose of 5 Gy was prescribed at a depth of 0.5 cm in the upper third and middle thirdof vagina. Adverse effects related to organs at risk consist of bladder, vagina and rectum were documented based onthe Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0). Results: The accelerated short courseHDR IVB was well tolerated and no grade 3 or higher toxicities was reported for patients during the follow up period.There were no chronic rectal toxicities and only one patient showed chronic urinary toxicities. However, the incidencerate of vaginal toxicities at the end of 4-month and 8-month follow up periods was higher than acute toxicities andsignificantly lower in elderly group compared to younger group. Conclusion: Overall, the accelerated HDR IVB wassafe and was well tolerated in endometrial cancer patients and the incidence rate of undue complications were equal,if not less, in elderly patients compared to the younger ones. %U https://journal.waocp.org/article_88629_155a01012b13623c45f56d359c598ff2.pdf