%0 Journal Article %T MicroRNA-215 as a Diagnostic Marker in Egyptian Patients with Hepatocellular Carcinoma %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A El Mahdy, Hussein Ahmed %A Abdelhamid, Ismail Abdelshafy %A Amen, Ahmed Ibrahim %A Abdelsameea, Eman %A Hassouna, Mona M %D 2019 %\ 09/01/2019 %V 20 %N 9 %P 2723-2731 %! MicroRNA-215 as a Diagnostic Marker in Egyptian Patients with Hepatocellular Carcinoma %K hepatocellular carcinoma (HCC) %K chronic hepatitis C virus (chronic HCV) %K MicroRNA-215 (miR-215) %R 10.31557/APJCP.2019.20.9.2723 %X Background: MicroRNAs are mentioned as a small non-coding RNAs groups and aberrant miRNA expression wasfound in hepatocellular carcinoma (HCC) patients. Aim: To evaluate role of plasma MicroRNA-215 as a diagnostictool in HCC patients. Methods: A prospective study included 195 subjects: healthy controls (group I), cirrhotic patients(group II), and patients with HCC (group III). Clinical examination, radiological and laboratory investigations whichincluded quantification of miR-215 by Real-time qPCR were done for all cases. Results: Spearman’s rank correlationrevealed that in HCC group, there was a negative correlation between MiRNA-215 and serum AFP levels and focal sizelesion (cm) (rs = -0.72, - 0.94 respectively, p<0.001). Receiver operating characteristics analysis for discriminationbetween cirrhosis and HCC groups regarding microRNA-215 displayed 78.3% sensitivity, 88.0% specificity at cutoffvalue of ≤ 1.90. Area under the curve (AUC) was 0.87 (p< 0.001). As regards AFP, it had a sensitivity of 81.7%, aspecificity of 66.7 at cutoff value of ≥ 11.50 (ng/mL). Conclusions: Plasma level of miR-215 may be a promisingbiomarker in HCC diagnosis. Moreover, if miR-215 combined with AFP, it can be used as a diagnostic biomarker, forearly detection of HCC. %U https://journal.waocp.org/article_88719_f1db4ac5c86ee471326d39c93e25a7e5.pdf