%0 Journal Article %T CD133 Role in Oral Carcinogenesis %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Luna, Ealber Carvalho Macedo %A Bezerra, Thâmara Manoela Marinho %A Barros Silva, Paulo Goberlânio de %A Cavalcante, Roberta Barroso %A Costa, Fábio Wildson Gurgel %A Alves, Ana Paula Negreiros Nunes %A Chaves, Filipe Nobre %A Pereira, Karuza Maria Alves %D 2020 %\ 09/01/2020 %V 21 %N 9 %P 2501-2506 %! CD133 Role in Oral Carcinogenesis %K premalignant lesions %K oral squamous cells carcinoma %K oral carcinogenesis %K CD133 %K stem cells %R 10.31557/APJCP.2020.21.9.2501 %X Objective: to investigate CD133 immunoexpression, cancer stem cells marker, in oral epithelial dysplasias (OEDs) and oral squamous cells carcinomas (OSCCs) and understandits possible involvement in the malignant transformation process of these lesions and to better elucidate their biological behavior. Material and methods: Tissue samples of 15 cases of OSCCs and 15 OEDs were subjected to CD133 antibody immunohistochemistry reactions. The analysis used quantitative parameters (number of immunostained cells regardless of immunostaining sublocations). Results: All samples of OSCCs and OEDs showed positive immunostaining, with no significant difference between these groups (p = 0.283). We did not observe statistical difference between the degree of dysplasia and the amount of CD133+ cells (p = 0.899). CD133 immunoexpression showed no association with the OEDs and OSCCs sites. It was observed that nuclear and cytoplasmic immunostaining was more evident with the progression of the malignant process. Conclusion: It is suggested that the CD133 cellular localization together with the histopathological criteria of OEDs classification can contribute to provide more concrete indications about the oral carcinogenesis process. %U https://journal.waocp.org/article_89248_cf93a790b4ac1aa97e55bbd402b8161a.pdf