%0 Journal Article %T CD133 Act as an Essential Marker in Ovarian Carcinogenesis %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Ikram, Dzul %A Masadah, Rina %A Nelwan, Berti J %A Zainuddin, Andi Alfian %A Ghaznawie, Mahmud %A Wahid, Syarifuddin %D 2021 %\ 11/01/2021 %V 22 %N 11 %P 3525-3531 %! CD133 Act as an Essential Marker in Ovarian Carcinogenesis %K CD133 %K Cancer stem cells %K carcinogenesis %K Ovarian Cancer %R 10.31557/APJCP.2021.22.11.3525 %X Objective: To analyze the role of cancer stem cells (CSC) in ovarian carcinogenesis through the identification of CD133 expression in the normal ovary (NO), serous cystadenoma (SC), borderline serous tumour (BST), low-grade serous carcinoma (LGSC), and high-grade serous carcinoma (HGSC). Materials and methods: A total of 48 tissue samples contain 5 NO, 10 SC, 5 BST, 8 LGSC, and 20 HGSC were stained with anti-CD133 antibody by immunohistochemical protocol. The difference in the H-score of CD133 expression between groups and their relationship to age, histomorphology, and localization was analyzed. Results: CD133 expression varied among tumor groups, with clinicopathologic parameters showing diverse associations (age p = 0.773; histomorphology p = 0.001; and localization p = 0.026). The comparison of CD133 H-scores differed significantly between each group (p = 0.0031), in which precursor and malignant lesions possessed more robust CD133 expression. Conclusion: The presence of CD133 cellular expression and localization in different types of serous ovarian tumours suggests that these markers are involved in ovarian tumorigenesis. %U https://journal.waocp.org/article_89843_d44526c176fcf2e58d165f1dedddde75.pdf