%0 Journal Article %T Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Al Zoubi, Mazhar Salim %A Al Khateeb, Wesam %A El-Oqlah, Musab %A Migdady, Mu’ath %A Abu Al-Arja, Manl Issam %A Bzour, Muna %A El-Oqlah, Ahmad %A Almubarak, Samah %A Al-Qudah, Mahmoud A %A Al-Batayneh, Khalid %A Mkhael, Michella %A Elokda, Ahmed %A Ansari, Prawej %A Hannan, JMA %A Nasef, Mohamed M %A Tambuwala, Murtaza M %A Bakshi, Hamid A %D 2022 %\ 01/01/2022 %V 23 %N 1 %P 161-169 %! Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats %K benign prostatic hyperplasia %K anti-inflammation %K Anti-proliferation %K Anti-angiogenesis %K M. peregrina %R 10.31557/APJCP.2022.23.1.161 %X Aim: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Methods: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. Results: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. Conclusion: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity. %U https://journal.waocp.org/article_89948_ddd5493bdbd95c834d5a5ce4d4fd4d91.pdf