%0 Journal Article %T Antiproliferative Effects of Curcumin Different Types of Breast Cancer %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Guneydas, Goksu %A Topcul, Mehmet R %D 2022 %\ 03/01/2022 %V 23 %N 3 %P 911-917 %! Antiproliferative Effects of Curcumin Different Types of Breast Cancer %K curcumin %K breast cancer %K Cell kinetics %K xCelligence %R 10.31557/APJCP.2022.23.3.911 %X Objective: Breast cancer is one of the most frequently diagnosed malignancy among women. Turmeric is isolated from Curcuma longa. Curcumin is main curcuminoid of the turmeric which is a member of Zingiberaceae. In this current study antiproliferative effects of curcumin were investigated in luminal A breast cancer cell line MCF-7 and triple negative breast cancer cell line MDA-MB-231. Methods: For this purpose cell viability, cell index values by xCELLigence Real-Time Cell Analysis DP instrument, mitotic index and apoptotic index analysis were used. Results: Cell viability and cell index values showed that 75 µM concentration of curcumin was IC50 concentration. When IC50 concentration was applied to both cell lines, a significant decrease was observed in the mitotic index values, while a significant increase was observed in the apoptotic index values (p<0.05). Conclusion: Curcumin, which has antiproliferative effects on breast cancer cells, is thought to be effective in cancer treatment. %U https://journal.waocp.org/article_90024_34a6cc208b3344583fbb67b180560f18.pdf