West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Induction of Apoptotic Death and Cell Cycle Arrest in HeLa Cells by Extracellular Factors of Breast Cancer Cells
3307
3316
EN
Devashree
Jahagirdar
Cancer and Translational Research Lab, Dr D.Y. Patil Biotechnology and Bioinformatics Institute, Dr D.Y. Patil Vidyapeeth, India.
devashreejahagirdar@gmail.com
Charusheela R
Gore
Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.
shantugore@gmail.com
Himadri
Patel
Cancer and Translational Research Lab, Dr D.Y. Patil Biotechnology and Bioinformatics Institute, Dr D.Y. Patil Vidyapeeth, India.
patelhimadri2@gmail.com
Kunjal
Maria
Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.
mariakunjal@gmail.com
Ishita
Tnadon
Cancer and Translational Research Lab, Dr D.Y. Patil Biotechnology and Bioinformatics Institute, Dr D.Y. Patil Vidyapeeth, India.
tandoanishita11@gmail.com
Nilesh K
Sharma
0000-0002-8774-3020
Cancer and Translational Research Lab, Dr D.Y. Patil Biotechnology and Bioinformatics Institute, Dr D.Y. Patil Vidyapeeth, India.
nilesh.sharma@dpu.edu.in
10.31557/APJCP.2018.19.12.3307
Background: There are evidences on the role of extracellular factors in cellular communication between cancer<br />cells and non-cancerous cells to support tumor progression and a phenomenon of cancer cachexia. However, evidences<br />are scarce to show the effects of extracellular factors from one carcinoma microenvironment upon growth and survival<br />of another carcinoma. Methodology: To address the above issue, we have selected excised breast carcinoma tissue<br />samples and in vitro grown MCF-7 sources of extracellular factors and tested their effects to evaluate growth and<br />proliferation inhibitory potential against a cervical carcinoma cell line HeLa. Results: Data from the in vitro experiments<br />like Trypan blue dye exclusion, MTT assay, cell cycle assay and annexin V/PI staining lead us to suggest that the<br />extracellular factors collected from the culture medium of in vitro grown MCF-7 and excised breast carcinoma tissue<br />play an apoptosis inducing and cell cycle arrest role in HeLa. In these in vitro experiments, we detected the presence of<br />up to 40-50% apoptotic cell death in HeLa cells and increase in G2-M cell cycle phase from 11%-25% due to treatment<br />with extracellular factors from human breast carcinoma cells. Discussion and Conclusion: These observations are<br />novel and suggest that extracellular factors from breast carcinoma play an apoptosis inducing and growth inhibitory<br />role upon on HeLa cells. This study can also support the concept of cancer cachexia and a possible hypothesis for rare<br />chance of synchronous two or more primary tumor in a single patient.
heterogeneity,growth,Death,Neoplasms,microenvironment
https://journal.waocp.org/article_80036.html
https://journal.waocp.org/article_80036_c79138282757caf0db97da13b57bcce9.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Prevalence of BCR-ABL T315I Mutation in Malaysian Patients with Imatinib-Resistant Chronic Myeloid Leukemia
3317
3320
EN
Yuslina
Mat Yusoff
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
yuslina@imr.gov.my
Zahidah
Abu Seman
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
zahidah@imr.gov.my
Norodiyah
Othman
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
norodiyah@imr.gov.my
Nor Rizan
Kamaluddin
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
norizan@imr.gov.my
Ezalia
Esa
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
ezalia@imr.gov.my
Nor Amalina
Zulkiply
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
noramalinazulkiply@gmail.com
Julia
Abdullah
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
leeya987@yahoo.com
Zubaidah
Zakaria
Haematology Unit, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Wilayah Persekutuan Kuala Lumpur,
Malaysia.
zubaidah@imr.gov.my
10.31557/APJCP.2018.19.12.3317
Objective: Chronic Myeloid Leukemia (CML) is caused by a reciprocal translocation between chromosomes 9<br />and 22, t(9;22) (q34;q11) which encodes for the BCR-ABL fusion protein. Discovery of Imatinib Mesylate (IM) as<br />first line therapy has brought tremendous improvement in the management of CML. However, emergence of point<br />mutations within the BCR-ABL gene particularly T315I mutation, affects a common BCR-ABL kinase contact residue<br />which impairs drug binding thus contribute to treatment resistance. This study aims to investigate the BCR-ABL T315I<br />mutation in Malaysian patients with CML. Methods: A total of 285 patients diagnosed with CML were included in this<br />study. Mutation detection was performed using qualitative real-time PCR (qPCR). Results: Fifteen out of 285 samples<br />(5.26%) were positive for T315I mutations after amplification with real-time PCR assay. From the total number of<br />positive samples, six patients were in accelerated phase (AP), four in chronic phase (CP) and five in blast crisis (BC).<br />Conclusion: Mutation testing is recommended for choosing various tyrosine kinase inhibitors (TKIs) to optimize<br />outcomes for both cases of treatment failure or suboptimal response to imatinib. Therefore, detection of T315I mutation<br />in CML patients are clinically useful in the selection of appropriate treatment strategies to prevent disease progression.
Chronic myeloid leukemia,BCR/ABL gene,T315I mutation,tyrosine kinase inhibitor
https://journal.waocp.org/article_80040.html
https://journal.waocp.org/article_80040_002f76a33f14d1cd9e6d81d751beccb8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Simulation Models in Gastric Cancer Screening: A Systematic Review
3321
3334
EN
Ayako
Matsuda
0000-0002-2036-5360
Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
amatsuda@med.teikyo-u.ac.jp
Kumiko
Saika
Division of Screening Assessment and Management, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
ksaika@ncc.go.jp
Rina
Tanaka
Department of Medical Informatics, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
r-tana@hirosaki-u.ac.jp
Yuri
Ito
Department of Cancer Epidemiology, Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
itou-yu2@mc.pref.osaka.jp
Keisuke
Fukui
Department of Cancer Epidemiology, Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
fukui-ke@mc.pref.osaka.jp
Ken-Ichi
Kamo
Department of Plastic and Reconstructive Surgery, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan.
kamo@sapmed.ac.jp
10.31557/APJCP.2018.19.12.3321
Background: Together with such high-quality approaches as randomized controlled trials and large-scale cohort<br />studies, simulation models are often employed to evaluate the effect of cancer screening methods and decide on<br />their appropriateness. This study aimed to evaluate all effects of gastric cancer screening that have been assessed<br />using simulation models, including cost-effectiveness, mortality reduction, and early-stage detection. Methods: We<br />performed a systematic review using PubMed and Web of Science. We evaluated the effect of screening related to<br />cost, such as incremental cost-effectiveness and incremental cost-effectiveness ratios; we also separately assessed<br />effects other than cost, such as quality-adjusted life-years, number of deaths prevented, life-years saved, relative risk<br />of mortality from gastric cancer, life expectancy, and incidence reduction. The methods targeted for evaluation were<br />Helicobacter pylori testing or endoscopy. Results: We identified 19 studies dealing with simulation models in gastric<br />cancer screenings: 14 examined H. pylori screening and 7 focused on endoscopy. Among those studies, two assessed<br />both H. pylori and endoscopy screening. Most of the studies adopted a Markov model, and all the studies evaluated<br />cost-effectiveness. Of the 14 H. pylori screening studies, 13 demonstrated cost-effectiveness and 11 also showed good<br />results other than cost-effectiveness, such as extension of life-years and increase in early-stage detection. In three of the<br />five endoscopy studies, the target population was patients; all five studies obtained good results for cost-effectiveness<br />and four observed good results other than for cost-effectiveness. Conclusions: In this study, we showed that the H.<br />pylori screening test was cost-effective in terms of simulation model investigations. However, the H. pylori screening<br />test should not ordinarily be recommended since there is insufficient evidence that it reduces gastric cancer mortality.<br />In Japan, simulation modeling should be employed to plan for cancer control, and the appropriate use of simulation<br />models should be examined for future use.
Simulation Model,Gastric cancer,Screening,Systematic review
https://journal.waocp.org/article_77046.html
https://journal.waocp.org/article_77046_16e6f0bc29f5539dcfee492984d4ed65.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
An Effective Two Way Classification of Breast Cancer Images: A Detailed Review
3335
3339
EN
Sinthia
P
0000-0001-8040-6710
Department of EIE, Saveetha Engineering College, Chennai, India.
sinthiapanneerselvam@gmail.com
Malathi
M
Department of EIE, Saveetha Engineering College, Chennai, India.
malathi_friends2000@yahoo.co.in
10.31557/APJCP.2018.19.12.3335
Cancer, a disease of cells, causes cell growth which differs from normal cell growth ratio, this cell growth spreads<br />in the human body and kills the body cells. Breast cancer, it’s a highly heterogeneous disease and western women<br />commonly witness this. Mammography, a pre-screening X-ray based check is used to diagnose woman’s breast cancer.<br />This basic test mode helps in identifying breast cancer at early stage and this early stage detection would support in<br />recovering more number of women from this serious disease. Medical centres deputed highly skilled radiologists and<br />they were given the responsibility of analysing this mammography results but still human errors are inevitable. An error<br />frequency ratio is high when radiologists exhausted in their analysis task and leads variations in either observations<br />ie., internal or external observation. Also, quality of the image plays vital role in Mammographic sensitivity and leads<br />to variation. Several automation processes were tried in streamlining and standardising diagnosis analysis process and<br />quality of breast cancer images were improved. This paper inducts a two way mode algorithm for grouping of breast<br />cancer images to 1. benign (tumour growing, but not dangerous) and 2. malignant (cannot be controlled, it causes death)<br />classes. Two-way mode data mining algorithms are used due to thinly dispersed distribution of abnormal mammograms.<br />First type algorithm is k-means algorithm, which regroups the given data elements into clusters (ie., prioritized by the<br />users). Second type algorithm is Support Vector Machine (SVM), which is used to identify the most suitable function<br />which differentiates the members based on the training data.
Mammogram,breast cancer,k-means,SVM
https://journal.waocp.org/article_77412.html
https://journal.waocp.org/article_77412_8fbcb6fede4e15e68460e2291f7e2ef8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Overview on Epigenetic Re-programming: A Potential Therapeutic Intervention in Triple Negative Breast Cancers
3341
3351
EN
Ezanee Azlina
Mohamad Hanif
0000-0002-7386-7727
UKM Medical Molecular Biology Institute (UMBI), University Kebangsaan Malaysia Medical Centre, Jalan Yaccob Latiff, Bandar
Tun Razak, Cheras, Kuala Lumpur, Malaysia.
ezanee.azlina.mohamad.hanif@ppukm.ukm.edu.my
Shamsul Azhar
Shah
UKM Medical Molecular Biology Institute (UMBI), University Kebangsaan Malaysia Medical Centre, Jalan Yaccob Latiff, Bandar
Tun Razak, Cheras, Kuala Lumpur, Malaysia.
drsham@ppukm.ukm.edu.my
10.31557/APJCP.2018.19.12.3341
Breast cancer treatments leads to variable responses. Hormonal therapy is beneficial to receptor positive breast cancer<br />subtypes and display better clinical outcome than triple negative breast cancers (TNBCs) with FEC (5-Fluorouracil,<br />Epirubicin and Cyclophosphamide) the mainstay chemotherapy regiment. Owning to their negative expressions of<br />estrogen (ER), progesterone (PR) and HER2 receptors, disease recurrence and metastasis befalls some patients indicating<br />resistance to FEC. Involvement of epigenetic silencing through DNA methylation, histone methylation, acetylation and<br />sumoylation may be the key player in FEC chemoresistance. Epigenetic and molecular profiling successfully classified<br />breast cancer subtypes, indicating potential driver mechanisms to the progression of TNBCs but functional mechanisms<br />behind chemoresistance of these molecular markers are not well defined. Several epigenetic inhibitors and drugs have<br />been used in the management of cancers but these attempts are mainly beneficial in hematopoietic cancers and not<br />specifically favourable in solid tumours. Hypothetically, upon administration of epigenetic drugs, recovery of tumour<br />suppressor genes is expected. However, high tendency of switching on global metastatic genes is predicted. Polycomb<br />repressive complex (PRC) such as EZH2, SETD1A, DNMT, is known to have repressive effects in gene regulation and<br />shown to inhibit cell proliferation and invasion in breast cancers. Individual epigenetic regulators may be an option<br />to improve chemo-drug delivery in cancers. This review discussed on molecular signatures of various breast cancer<br />subtypes and on-going attempts in understanding underlying molecular mechanisms of epigenetic regulators as well<br />as providing insights on possible ways to utilize epigenetic enzymes/inhibitors with responses to chemotherapeutic<br />drugs to re-program cellular and biological outcome in TNBCs.
triple negative breast cancers,TNBCs,epigenetic modifiers,FEC,Relapse
https://journal.waocp.org/article_80052.html
https://journal.waocp.org/article_80052_4f475799e37b2b67d0a0caafbf0c2317.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis
3353
3359
EN
Mansour
Moghimi
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
moghimim1350@gmail.com
Hossein
Ahrar
Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
ahrar.hossein43@gmail.com
Mojgan
Karimi-Zarchi
Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
mk.zarchi55@gmail.com
Kazem
Aghili
Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
kaz.aghili@gmail.com
Marjansadat
Salari
Department of Biology, Ashkezar Branch, Islamic Azad University, Yazd, Iran.
sm.latifi65@gmail.com
Masoud
Zare-Shehneh
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
masoud.zareshehneh@gmail.com
Hossein
Neamatzadeh
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
neamatzadehh@gmail.com
10.31557/APJCP.2018.19.12.3353
Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to<br />be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we<br />performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies<br />assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies<br />with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the<br />rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,<br />95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C<br />vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=<br />1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies<br />was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism<br />with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests<br />that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but<br />not by ethnicity.
breast cancer,Interleukin-10,Polymorphism,Meta-analysis
https://journal.waocp.org/article_77417.html
https://journal.waocp.org/article_77417_52a43dd5a140e41f1052c6e419b48ddf.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions
3361
3366
EN
Mouna
Jendoubi-Ferchichi
0000-0003-3258-6889
Viral and Molecular Tumor Diagnostics Unit, Laboratory Services, Habib Thameur Hospital, Tunis, Tunisia.
mounaferchichi@hotmail.fr
Latifa
Satouri
Viral and Molecular Tumor Diagnostics Unit, Laboratory Services, Habib Thameur Hospital, Tunis, Tunisia.
latifasatouri@hotmail.fr
Fatma
Ghoul
Viral and Molecular Tumor Diagnostics Unit, Laboratory Services, Habib Thameur Hospital, Tunis, Tunisia.
fatmaghoul80@gmail.com
Monia
Malek-Mellouli
Department of Gynecology and Obstetrics, La Rabta Maternity and Neonatology Center, Tunis, Tunisia.
melloulimonia@yahoo.fr
Abdel Moneem
Derbal
Laboratory of Pathological Anatomy, Kheireddine Pacha Avenue, Tunis, Tunisia.
derbal.abdelmonem@topnet.tn
Mohamed Kamel
Makni
Laboratory of Pathological Anatomy, Kheireddine Pacha Avenue, Tunis, Tunisia.
mknimedkamel@topnet.tn
Hedi
Reziga
Department of Gynecology and Obstetrics, La Rabta Maternity and Neonatology Center, Tunis, Tunisia.
hedireziga@rns.tn
Ali
Baba
Gynecology and Obstetrics office, 25 Habib Bourguiba Avenue, Tunis, Tunisia.
dralibaba@live.fr
Mohamed
Zili
Viral and Molecular Tumor Diagnostics Unit, Laboratory Services, Habib Thameur Hospital, Tunis, Tunisia.
mohamed.zili@rns.tn
Michel
Segondy
Pathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, EFS, CHU Montpellier, Montpellier, France.
m-segondy@chu-montpellier.fr
Ridha
Khelifa
Viral and Molecular Tumor Diagnostics Unit, Laboratory Services, Habib Thameur Hospital, Tunis, Tunisia.
khelifa.ridha@rns.com
10.31557/APJCP.2018.19.12.3361
Background: High-risk human papillomavirus (HPV) types are the main etiological factors for cervical cancer.<br />HPV16 and HPV18 are generally the most common forms associated with development of high-grade cervical lesions.<br />This study was undertaken to identify intratypic variants of HPV16 and HPV18 among women with cervical lesions<br />in Tunisia. Materials and Methods: DNA was extracted from cervical samples collected from 49 women. using a<br />PureLinkTM Genomic DNA mini Kit (Invitrogen). E6 and L1 open reading frames (ORF) were amplified by PCR<br />and viral DNA amplicons were subjected to automated sequencing using Big Dye Terminators technology (Applied<br />Biosystems). The obtained sequences were analyzed using an appropriate software program to allow phylogenetic<br />trees to be generated. Results: HPV16 and HPV18 were detected in 15 and 5 cases, respectively. HPV16 E6 sequences<br />clustered with the European German lineage (A2) whereas one isolate diverged differently in the L1 region and<br />clustered with the African sub-lineage (B1). HPV 18 E6 sequences clustered with the European sub-lineage (A1)<br />but L1 sequences clustered as a new clade which diverged from A1-A5. Conclusions: Our results suggest that the<br />distribution of HPV16 and HPV18 sequences in women with cervical lesions in Tunisia is mainly related to European<br />epidemiological conditions and point to the presence of recombinant HPV forms.
HPV16,HPV18,Phylogeny,Tunisia
https://journal.waocp.org/article_77047.html
https://journal.waocp.org/article_77047_1f98a903308d4ca5c9ac60068ecfd6c7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Factors Influencing Knowledge and Practice Regarding Cervical Cancer and Pap smear Testing among Omani Women
3367
3374
EN
Nasar
Alwahaibi
Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
nasar@squ.edu.om
Waad
Alsalami
Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
promisesalami94@gmail.com
Nasra
Alramadhani
Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
u1014@squ.edu.om
Atheer
Alzaabi
Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman.
atheeralzab@gmail.com
10.31557/APJCP.2018.19.12.3367
Background: Knowledge of cervical cancer and performance of Pap smear testing are influenced by several<br />sociodemographic factors. This study aimed to describe the effect of relevant variables on knowledge and compliance<br />with guidelines in Oman. Methods: In this cross-sectional survey, participants were divided into three groups: patients<br />who attended Outpatient Gynecology Department, female medical staff and university graduate students. Results: There<br />were 204 outpatients, 133 staff, and 157 students. Adequate knowledge among was seen in 38.7%, 35.3%, and 7.6%,<br />respectively. Knowledge of cervical cancer and Pap smear was significantly lower among outpatients with secondary<br />education, while those with high level of income were more likely to have adequate cancer knowledge. Uptake of Pap<br />smear was significantly greater among outpatients aged ≥ 30 years, with high income and a positive history of cancer.<br />Conclusion: Culturally tailored interventions that focus on improving cancer risk knowledge are needed to maximize<br />screening uptake for cervical cancer.
Cervical cancer,Pap smear,Knowledge,performance,sociodemographic factors
https://journal.waocp.org/article_77403.html
https://journal.waocp.org/article_77403_04b76b58653f09f4ea1684089a9fe4b8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Combining the Prostate Cancer Risk Index (PRIX) with the Presence of Secondary Circulating Prostate Cells to Predict the Risk of Biochemical Failure after Radical Prostatectomy for Prostate Cancer
3375
3381
EN
Nigel P
Murray
0000-0001-8154-8550
CTC Unit, Faculty of Medicine, University Finis Terrae, Chile.
nigelpetermurray@gmail.com
Socrates
Aedo
0000-0001-5567-3374
CTC Unit, Faculty of Medicine, University Finis Terrae, Chile.
socrates.aedo@gmail.com
Cynthia
Fuentealba
0000-000304100-6997
Urology Service, Hospital de Carabineros de Chile, Santiago, Chile.
cynthia_fuentealba_s@yahoo.es
Eduardo
Reyes
0000-0001-8430-3030
Faculty
of Medicine University Diego Portales Santiago, Chile.
ereyessan@gmail.com
Omar
Jacob
Urology Service, Hospital de Carabineros de Chile, Santiago, Chile.
mimilizama@gmail.com
10.31557/APJCP.2018.19.12.3375
Introduction: The use of pre- and post-surgery variables has been used to create nomograms in order to identify<br />patients at high risk of treatment failure. The PRIX nomogram is one such device; we compare the PRIX nomogram<br />with the presence of secondary circulating prostate cells to predict those men who will undergo treatment failure.<br />Methods and Patients: Men who underwent radical prostatectomy for prostate cancer entered the study. The PRIX<br />score was calculated from the total serum PSA pre-surgery, the biopsy Gleason score and clinical stage. Circulating<br />prostate cells were detected from venous blood one month after surgery, using differential gel centrifugation and standard<br />immunocytochemistry with anti-PSA. A test was considered positive when 1 CPC/blood sample was detected. Patients<br />were followed up for five years and biochemical failure was defined as a serum PSA >0.2ng/ml. Kaplan-Meier and<br />Cox proportional models were used to calculate survival curves. Results: 321 men participated, of whom 131 (40.8%)<br />underwent biochemical failure within 5 years. A higher PRIX score was associated with increased failure risk, as was<br />the presence of CPCs. The predictive power of CPCs was significantly higher than the PRIX score. Combining the<br />two methods, for equal PRIX scores, scores but CPC positive had a worse biochemical failure free survival than men<br />with high PRIX scores but CPC negative. For men with PRIX scores of ≥4 the use of CPC detection did not aid in the<br />clinical decision making process. For those with PRIX scores of 0 and 1, CPC detection identified men with a high risk<br />of treatment failure. Conclusions: The combined PRIX/CPC score improved the predictive values of men at high risk<br />of biochemical failure. Both are simple systems that could be incorporated in a general hospital. Further multicenter<br />studies are warranted to confirm these results.
Prostate Cancer,PRIX score,circulating prostate cells,biochemical failure
https://journal.waocp.org/article_80094.html
https://journal.waocp.org/article_80094_a40d2d4a5890fa6e59ef5bded70d6ec1.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
CD200 Expression in Diagnostic and Prognostic Assessment of Mature B Cell Lymphophoproliferative Neoplasms
3383
3392
EN
Neveen Bahaa
El Din Fouad
Clinical Pathology Department, Faulty of Medicine, Cairo University, Egypt.
nbfpiano@yahoo.com
Noha Yehia
Ibrahim
0000-0003-3291-0036
Clinical Oncology Department (NEMROCK), Cairo University, Egypt.
dr.noha11@hotmail.com
Rania Salah
Abdel Aziz
Clinical Pathology
Department, National Cancer Institute (NCI), Cairo University, Egypt.
rania_smansy@yahoo.com
Sarah Khalid
Ibrahim
Clinical Pathology
Department, National Cancer Institute (NCI), Cairo University, Egypt.
sarahibrahim_2020@yahoo.com
10.31557/APJCP.2018.19.12.3383
Background: Multiparameter flow cytometry is a useful tool for diagnostic evaluation of mature B-cell neoplasms<br />(MBN). Recently, it has been shown that assessment of CD200 expression may improve the distinction between<br />chronic lymphocytic leukemia (CLL; CD200 positive) and mantle cell lymphoma (MCL; CD200 negative), but any<br />potential as a prognostic marker for CLL remains to be established. Materials and methods: This cross sectional<br />study was conducted on sixty-seven patients newly diagnosed as having mature B-cell lymphoproliferative disorders<br />Levels of CD 200 in lymphoma cells were assessed. Results: CD200 was consistently expressed in CLL and hairy<br />cell leukemia B cells, but not in MCL cells. Heterogeneous expression was noted in other CD5 positive Non-Hodgkin<br />lymphomas. High CD200 expression (≥50%) was associated with a higher CD5, 19 and CD23 expression, older<br />age, higher TLC and absolute lymphocyte count, hepatomegaly, splenomegaly and a higher Rai stage. There were<br />no significant correlations between CD200 expression and response to treatment. Conclusion: CD200 could be of high<br />value in distinguishing CLL, MCL, and atypical CLL. CD200 expression can also be of prognostic and therapeutic<br />value in CLL cases.
CD200,Mature B-cell neoplasms,Flowcytometry,CLL
https://journal.waocp.org/article_77404.html
https://journal.waocp.org/article_77404_5f3dea8c8f9e1e7e7776e6a8296f94bb.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Cytotoxic and Antiproliferative Activity of Polyisoprenoids in Seventeen Mangroves Species Against WiDr Colon Cancer Cells
3393
3400
EN
Dini P
Sari
Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.
permatasaridini21@yahoo.com
Mohammad
Basyuni
0000-0003-1120-8571
Department of Forestry, Faculty of Forestry, Universitas Sumatera Utara, Jl. Tri Dharma Ujung No. 1 Medan, North Sumatra, 20155, Indonesia.
m.basyuni@usu.ac.id
Poppy AZ
Hasibuan
Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.
poppyanjelisa94@gmail.com
Sumardi
Sumardi
Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, Indonesia.
mardisaad@gmail.com
Arif
Nuryawan
Department of Forestry, Faculty of Forestry, Universitas Sumatera Utara, Jl. Tri Dharma Ujung No. 1 Medan, North Sumatra, 20155, Indonesia.
arif.nury@gmail.com
Ridha
Wati
Department of Forestry, Faculty of Forestry, Universitas Sumatera Utara, Jl. Tri Dharma Ujung No. 1 Medan, North Sumatra, 20155, Indonesia.
ridhawati62@gmail.com
10.31557/APJCP.2018.19.12.3393
Background: Secondary metabolites from the group of isoprenoid compounds are widely distributed in mangrove<br />plants. Polyisoprenoids (dolichol and polyprenol) are known to have benefits as anticancer agents. The present study<br />was conducted to determine the cytotoxic potential of polyisoprenoids in leaves from seventeen selected mangrove<br />species against colon cancer (WiDr) cells. Methods: Cytotoxic activity was evaluated by MTT assay in vitro using<br />WiDr human colon cancer cells and 3T3 fibroblasts from Swiss albino mouse embryo tissue as controls. Mechanisms<br />of action were approached by assessing apoptosis and the cell cycle using flow cytometry and fluorescence microscopy<br />with annexin V-FITC, as well as expression of Bcl-2 and cyclin D1 by immunocytochemistry. Results: Polyisoprenoids<br />from N. fruticans leaves demonstrated the highest anticancer activity, with an IC50 of 180.2 μg/mL, as compared to<br />397.7 μg/mL against 3T3 normal cells. Significant decrease in the expression of Bcl-2 and cyclin D1 was also noted,<br />facilitating apoptosis and arrest of the cell cycle in the G0-G1 phase in WiDr cells. The present study showed for the<br />first time that polyisoprenoids from N. fruticans exhibit concrete anticancer activity in vitro, decreasing cell proliferation<br />and inducing apoptosis in colon cancer cells. Conclusions: Polyisoprenoids isolated from N. fruticans leaves may have<br />promise as a source of anticancer agents.
Antiproliferative,Apoptosis,Dolichol,Nypa fruticans,mangrove
https://journal.waocp.org/article_77405.html
https://journal.waocp.org/article_77405_9476ed6720f8a0a9f12ed3fcc8e9e1df.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Utilization of Colorectal Cancer Screening among Saudi Elderly Population: A Study from the Saudi National Survey for Elderly Health
3401
3407
EN
Abdullah
Khoja
Department of Public Health and Family Medicine, College of Medicine, Al Imam Mohammad ibn Saud Islamic University (IMSIU), Riyadh, Kingdom of Saudi Arabia.
atkhoja@imamu.edu.sa
Mohammad
Aljawadi
0000-0002-5114-1343
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
maljawadi@ksu.edu.sa
Sulaiman A
Al-Shammari
Department of Family and Community Medicine, College of
Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
sulaiman@ksu.edu.sa
Nader N
Bokhari
Emergency Medicine, Security Forces Hospital, Health Ministers’ Council for the Gulf Cooperation Council States Riyadh, Saudi Arabia.
nabokhari@sfh.med.sa
Abdulrahman A
Aldarwish
College of Medicine, Al Imam Mohammad ibn Saud Islamic University
(IMSIU), Riyadh, Kingdom of Saudi Arabia.
abadarwish@sm.imamu.edu.sa
Waleed K
Mardini
College of Medicine, Al Imam Mohammad ibn Saud Islamic University
(IMSIU), Riyadh, Kingdom of Saudi Arabia.
wkmardini@sm.imamu.edu.sa
Tawfik A
Khoja
Former Director General, Executive Board,
Health Ministers’ Council for the Gulf Cooperation Council States Riyadh, Saudi Arabia.
khojatawfik@gmail.com
10.31557/APJCP.2018.19.12.3401
Objective: The goal of this study was to measure colorectal cancer screening (CRCS) utilization in Saudi Arabia ’s<br />elderly population and to assess the factors associated with CRCS. Methods: The Saudi National Survey for Elderly<br />Health was used to examine CRCS utilization. It is a nationally representative population-based cross-sectional survey<br />that was conducted between 2006-2007. Utilization of CRCS was defined as any colonoscopy during the last five years or<br />fecal occult blood test (FOBT) during the twelve months before the interview. Multivariable logistic regression was used<br />to assess patients’ demographics, co-morbidities, number of visits to primary health clinics, and hospital availability<br />and accessibility impact on CRCS. Results: The prevalence of CRCS utilization among Saudi elderly population was<br />5.64%. The fecal occult blood test was done in 4.4% of subjects while scope use was performed in 0.55%. In addition,<br />0.69% of patients have gone through both FOBT and scope use. Having blood in stools (OR=2.80; 95%CI: 1.3-6.00),<br />Self-drivers (OR= 2.52) private driver (OR=2.1; 95%CI: 1.15-3.7) having 4 or more visits to primary care centers 1.81<br />(95%CI: 1.14-2.86) were positively associated with CRCS utilization. On the other hand, being single was negatively<br />associated with CRCS utilization. Conclusion: In this nationally representative sample CRCS prevalence was very<br />low. According to our findings and in the context of the burden of colorectal cancer on the population, we recommend<br />developing national evidence-based policies and programs that take in consideration easiness of transportation and the<br />availability of primary care centers near to Saudi elderly population.
Saudi Arabia,Colon cancer,older adults
https://journal.waocp.org/article_80099.html
https://journal.waocp.org/article_80099_8e8d8735738463e373391fba6b20f63b.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Relationship between Health Literacy and Adherence to Recommendations to Undergo Cancer Screening and Health-Related Behaviors among Insured Women in Japan
3409
3413
EN
Eiko
Goto
Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo, Japan.
gotoue-tky@umin.ac.jp
Hirono
Ishikawa
Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo, Japan.
hirono-tky@umin.ac.jp
Tsuyoshi
Okuhara
Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo, Japan.
okuhara-ctr@umin.ac.jp
Takahiro
Kiuchi
Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo, Japan.
tak-kiuchi@umin.org
10.31557/APJCP.2018.19.12.3409
Background: Health literacy serves as a major barrier to effective preventive health behaviors, such as cancer<br />screening, and this relationship has not been studied among insured women in Japan. We examined the relationship<br />between health literacy and adherence to recommendations to undergo cancer screening, and health-related behaviors,<br />among Japanese women who were insured by a health insurance society. Methods: We conducted a cross-sectional<br />observation study of 670 insured Japanese women. For this, we used a self-administered questionnaire to assess<br />environments, self-rated health status, cancer screening behavior, health-related behaviors (dietary behavior, exercise<br />frequency, alcohol consumption and smoking behavior), and health literacy. Results: Among the participants, 206<br />completed the questionnaire (response rate, 30.7%). Fifty-seven had undergone breast and/or cervical cancer screening.<br />The mean health literacy score was 3.44 (standard deviation = 0.68). In logistic regression models adjusted for age,<br />self-rated economic status, and having a primary care physician, there was no statistically significant relationship between<br />health literacy and adherence to recommendations to undergo cancer screening, and health-related behaviors. However,<br />age and having a primary care physician were significantly associated with cancer screening and health-related behaviors.<br />Health literacy was not found significantly associated with effective preventive health behaviors. Conclusions: The<br />present study found no statistically significant relationship between health literacy and adherence to recommendations<br />to undergo cancer screening and health-related behaviors. Rather, cancer screening and health-related behaviors were<br />found related to medical support from physicians and those their own age. Further study is needed for exploring these<br />associations among insured women in Japan.
Health literacy,cancer screening,Health-related behavior,Japanese women
https://journal.waocp.org/article_80030.html
https://journal.waocp.org/article_80030_cf95427c31138cc9855a3390ad6844df.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population
3415
3425
EN
Rajani
Kumawat
Department of Biochemistry, AIIMS, New Delhi, India.
dr.rajanikumawat@gmail.com
Srinivas
gowda
0000-0002-9600-6161
Department of Biochemistry, AIIMS, New Delhi, India.
messagesrinih@gmail.com
Ekta
Debnath
Department of Biochemistry, Lady Harding Medical College, New Delhi, India.
debnathekta@yahoo.in
Safoora
Rashid
Department of Gastroenterology and Nutrition Medicine, AIIMS, New Delhi, India.
safoo.rashid@gmail.com
Ram
Niwas
Department of Pulmonary Medicine, AIIMS, Jodhpur, India.
drrniwas@gmail.com
Yakhlesh
Gupta
Department of Biochemistry, AIIMS, New Delhi, India.
gyakhlesh@gmail.com
Ashish Datta
Upadaya
Department of Biostatistics, AIIMS, India.
aduaiims@rediffmail.com
Ashish
Suri
Department of Neurosurgery, AIIMS, New Delhi, India.
surineuro@gmail.com
P Sarat
Chandra
Department of Neurosurgery, AIIMS, New Delhi, India.
saratpchandra@gmail.com
Deepak K
Gupta
Department of Neurosurgery, AIIMS, New Delhi, India.
drdeepakgupta@gmail.com
Ramakrishnan
Lakshmy
Department of Cardiac Biochemistry, AIIMS, New Delhi, India.
lakshmy_ram@yahoo.com
Chitra
Sarkar
Department of Pathology, AIIMS, New Delhi, India.
sarkar.chitra@gmail.com
Subrata
sinha
Department of Biochemistry, AIIMS, New Delhi, India.
sub_sinha@hotmail.com
Kunzang
Chosdol
Department of Biochemistry, AIIMS, New Delhi, India.
kcaiimsbiochem@gmail.com
10.31557/APJCP.2018.19.12.3415
Background: The association of primary brain tumors with Single Nucleotide polymorphisms (SNPs) in genes of<br />folate metabolising enzymes have been reported to vary among different ethnic population. Here, we have studied the<br />association of SNPs of folate metabolizing genes with the primary brain tumors (glioma and meningioma) in North Indian<br />population. Methods: SNPs of genes coding for folate metabolizing enzymes was carried out in 288 study population<br />from North India [Glioma (n=108), Meningioma (n=76) and healthy-control (n=104)]. The allele-specific polymerase<br />chain reaction (ARMS-PCR) was used to analyse the SNP A1298C of the MTHFR (Methylenetetrahydrofolate-reductase)<br />and the SNP A66G of the methionine synthase reductase (MTRR) genes. The PCR-RLFP (Restriction Fragment Length<br />Polymorphism) was used to analyse the SNP C677T of the Methylene tetrahydrofolate-reductase and the SNP A2756G<br />of the methionine-synthase (MTR) genes. Serum homocysteine, vitamin B12 and folate levels were evaluated in controls/<br />patients serum using Chemiluminescence immunoassay and the levels were correlated with SNPs genotype. Results:<br />The CC genotype of MTHFR A1298C was observed to have reduced risk of having meningioma than AA genotype<br />(odd ratio=0.62, 95%CI 0.32-0.97, p=0.03). Similarly, the AG genotype of MTRR A66G showed reduced risk of<br />glioma than AA genotype (odd ratio=0.56, 95%CI 0.32-0.97, p=0.039). Furthermore, in patients with AA genotype of<br />MTR A2756G and CT genotype of MTHFR C677T showed higher serum homocysteine level than GG genotype (8.6<br />μmol/L, p=0.048) and CC genotype (11.2μmol/L, p=0.039) respectively. Conclusion: Our findings provide an insight<br />into the risk association of SNPs in MTHFR A1298C and MTRR A66G genes with glioma/meningioma patients.<br />Further studies are needed to evaluate their clinical implications.
SNP,Glioma,Indian,homocysteine,Folate
https://journal.waocp.org/article_80090.html
https://journal.waocp.org/article_80090_55c9c9da313f1fd58cb87fd3aeaf1ce0.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Melittin Induced G1 Cell Cycle Arrest and Apoptosis in Chago-K1 Human Bronchogenic Carcinoma Cells and Inhibited the Differentiation of THP-1 Cells into Tumour- Associated Macrophages
3427
3434
EN
Chartsiam
Tipgomut
Department of Biology, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok, Thailand.
synchro.nize.130@gmail.com
Arin
Wongprommoon
Homerton College, University of Cambridge, Hills Road, Cambridge CB2 8PH,
UK.
bht9216@gmail.com
Emi
Takeo
Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan.
emi_takeo@bio.eng.osaka-u.ac.jp
Teeranai
Ittiudomrak
Program in Biotechnology, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok, Thailand.
teeranai.itt@hotmail.com
Songchan
Puthong
Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, 254, Phayathai Road, Bangkok, Thailand.
songchan.p@chula.ac.th
Chanpen
Chanchao
Department of Biology, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok, Thailand.
chanpen.c@chula.ac.th
10.31557/APJCP.2018.19.12.3427
Background: Bronchogenic carcinoma (lung cancer) is one of the leading causes of death. Although many<br />compounds isolated from natural products have been used to treat it, drug resistance is a serious problem, and alternative<br />anti-cancer drugs are required. Here, melittin from Apis mellifera venom was used, and its effects on bronchogenic<br />carcinoma cell proliferation and tumour-associated macrophage differentiation were evaluated. Methods: The half<br />maximal inhibitory concentration (IC50) of melittin was measured by MTT. Cell death was observed by annexin V<br />and propidium iodide (PI) co-staining followed by flow cytometry. Cell cycle arrest was revealed by PI staining and<br />flow cytometry. To investigate the tumour microenvironment, differentiation of circulating monocytes (THP-1) into<br />tumour-associated macrophages (TAMs) was assayed by sandwich-ELISA and interleukin (IL)-10 levels were determined.<br />Cell proliferation and migration was observed by flat plate colony formation. Secretion of vascular endothelial growth<br />factor (VEGF) was detected by ELISA. The change in expression levels of CatS, Bcl-2, and MADD was measured by<br />quantitative RT-PCR. Results: Melittin was significantly more cytotoxic (p < 0.01) to human bronchogenic carcinoma<br />cells (ChaGo-K1) than to the control human lung fibroblasts (Wi-38) cells. At 2.5 μM, melittin caused ChaGo-K1<br />cells to undergo apoptosis and cell cycle arrest at the G1 phase. The IL-10 levels showed that melittin significantly<br />inhibited the differentiation of THP-1 cells into TAMs (p < 0.05) and reduced the number of colonies formed in the<br />treated ChaGo-K1 cells compared to the untreated cells. However, melittin did not affect angiogenesis in ChaGo-K1<br />cells. Unlike MADD, Bcl-2 was up-regulated significantly (p < 0.05) in melittin-treated ChaGo-K1 cells. Conclusion:<br />Melittin can be used as an alternative agent for lung cancer treatment because of its cytotoxicity against ChaGo-K1<br />cells and the inhibition of differentiation of THP-1 cells into TAMs.
Apoptosis,bronchogenic carcinoma,melittin,tumor-associated macrophage,cathepsin S
https://journal.waocp.org/article_77406.html
https://journal.waocp.org/article_77406_47ba9fcd1fa1734bb148764f50eb9529.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Platelet-to-Lymphocyte Ratio and Large Tumor Size Predict Microvascular Invasion after Resection for Hepatocellular Carcinoma
3435
3441
EN
Narongsak
Rungsakulkij
0000000335225800
Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
narongsak.run@mahidol.ac.th
Somkit
Mingphruedh
0000-0002-1404-1968
Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
somkit.m@gmail.com
Wikran
Suragul
0000-0002-9933-9279
Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
wikran.srg@gmail.com
Pongsatorn
Tangtawee
0000-0001-9598-5479
Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
pongsatornmd@gmail.com
Paramin
Muangkaew
0000-0002-2470-8164
Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
ra064@hotmail.com
Suraida
Aeesoa
0000-0002-4137-3861
Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
suraida.aee@mahidol.ac.th
10.31557/APJCP.2018.19.12.3435
Background: Recurrence after curative resection of hepatocellular carcinoma (HCC) is associated with early death<br />and poor prognosis. Microvascular invasion (mVI) is strongly associated with disease recurrence. Although many studies<br />have examined the relationship between various serum inflammatory indices and post-treatment prognosis, little is<br />known about preoperative predictors of microvascular invasion in HCC. Methods: Patients who underwent curative<br />hepatic resection for HCC at our institute from January 2006 to December 2016 were retrospectively reviewed. The<br />associations between mVI and various potential risk factors, including tumor size, hepatitis B and C virus infection,<br />Child–Pugh scores, platelet-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio, were analyzed. Optimal cut-off<br />values were determined using receiver operating characteristic curves. Results: A total of 330 HCC patients were<br />enrolled in this study, of whom 74 (22.4%) had tumors with mVI. After univariate analysis, two parameters were<br />significantly associated with mVI after hepatic resection: platelet-to-lymphocyte ratio ≥102 (odds ratio [OR] 2.385,<br />p = 0.001) and tumor size ≥5 cm (OR 4.29, p < 0.001). Both variables remained significant risk factors for mVI after<br />multivariate analysis: platelet-to-lymphocyte ratio ≥102 (OR 1.831, p = 0.034) and tumor size ≥5 cm (OR 3.791,<br />p < 0.001). Conclusions: Large tumor size (≥5 cm) and high platelet-to-lymphocyte ratio (≥102) are independent<br />predictive factors for mVI in HCC.
Hepatocellular carcinoma,risk factors,platelet-to-lymphocyte,Prognosis,microvascular
https://journal.waocp.org/article_77407.html
https://journal.waocp.org/article_77407_a1d216a87e1d2759d7f7178ec991af0a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Effect of Consultation on Adherence to Clinical Breast Examination and Mammography in Iranian Women: A Randomized Control Trial
3443
3449
EN
Ameneh
Mirmohammadirad
Chronic Diseases (Home Care) Research Center, Department of Mother and Child Health, Hamadan
University of Medical Sciences, Hamadan, Iran.
mirmohammadirad.a@gmail.com
Parisa
Parsa
0000-0002-2834-2470
Chronic Diseases (Home Care) Research Center, Department of Mother and Child Health, Hamadan
University of Medical Sciences, Hamadan, Iran.
pparsa2003@yahoo.com
Batul
Khodakarami
0000-0002-2503-1239
Department of Midwifery, Hamadan
University of Medical Sciences, Hamadan, Iran.
zahrabatul2006@yahoo.com
Ghodratalah
Roshnaei
Modeling of
Non-Communicable Diseases Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Hamadan
University of Medical Sciences, Hamadan, Iran.
gh.roshanaei@umsha.ac.ir
10.31557/APJCP.2018.19.12.3443
Background: Early diagnosis of breast cancer is directly related to success in treatment. The aim of this study was<br />to determine the effect of consultation based on the health belief model on performance of clinical breast examination<br />(CBE) and mammography in women. Methods: This research was a clinical trial study. Eligible women aged> 40<br />years attending to Hamadan health care centers in 2016 were randomly assigned to experimental and control groups<br />(n = 75 in each group). The experimental group received 4 weekly sessions of breast cancer screening consulting based<br />on Health Belief Model (HBM). Knowledge on breast cancer, HBM constructs, and practices were compared between<br />two groups before, one and three months after intervention. Results: Before the intervention, no significant differences<br />were observed in knowledge, HBM constructs and practice between experimental and control groups. While one and<br />three months post intervention significant differences were detected between two groups on HBM constructs (except<br />susceptibility and severity) and knowledge (p <0.05). Conclusions: The results showed the consultation promoted<br />breast cancer screening in women.
breast cancer,Screening,consultation,Health Belief Model,Iran
https://journal.waocp.org/article_76645.html
https://journal.waocp.org/article_76645_b218bebd1065cf5895d4725f796bccb7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer
3451
3455
EN
Abdulkuddous
Heydari-Mehrabadi
Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
haydary1365@yahoo.com
Dor Mohammad
Kordi-Tamandani
0000-0002-4358-4785
Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
dor_kordi@science.usb.ac.ir
Tayebeh
Baranzehi
0000-0001-5352-0171
Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
kiana8588@gmail.com
Simin
Hemati
Department of Radiation Oncology, Isfahan University of
Medical Science, Isfahan, Iran.
esmatrigi@gmail.com
10.31557/APJCP.2018.19.12.3451
Abstract: Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces,<br />such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at<br />a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression<br />patterns of ASIC1 and IL-6 genes and the IL-6rs-174 and ASIC1rs 75624685 polymorphisms in the pathogenesis of<br />gastric cancer. Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of the<br />ASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls.<br />We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. Results:<br />Our results showed a significant association between expression of ASIC1 and elevated risk of gastric cancer (p<0.001).
Gastric cancer,Polymorphism,Expression,IL-6,ASIC1
https://journal.waocp.org/article_77409.html
https://journal.waocp.org/article_77409_d61c81d9b0116c7b432ba8b983b06032.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Psychometric Properties of the Persian Version of the Sibling Cancer Needs Instrument (SCNI)
3457
3462
EN
Zeynab
Masoudifar
School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
z.masoodi1392@gmail.com
Leila
Khanali Mojen
0000-0002-5394-7818
School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
leilakhanali@yahoo.com
Maryam
Rassouli
School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
rassouli.m@gmail.com
Maliheh
Nasiri
0000-0003-1496-7442
School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
malihenasiri@gmail.com
Pandora
Patterson
Can Teen, The Australian Organisation for Young People
Living with Cancer, Sydney, Australia.
pandora.patterson@canteen.org.au
Fiona
Mc Donald
Can Teen, The Australian Organisation for Young People
Living with Cancer, Sydney, Australia.
fiona.mcdonald@canteen.org.au
Peyman
Eshghi
Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children’s
Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
peshghi64@gmail.com
10.31557/APJCP.2018.19.12.3457
The sibling cancer needs instrument (SCNI) is the first developed specifically for assessing psychosocial unmet<br />needs of adolescents having a sibling with cancer. The aim of this study is to evaluate the psychometric properties of its<br />Persian version. Methods: For this methodological study, the SCNI was translated into Persian using back-translation<br />and revised according to the comments of the developer of the instrument. Then face validity, content validity, construct<br />validity, internal consistency and the stability of the Persian version of the instrument were measure, by examining<br />a population of 180 adolescents having a sibling with cancer in six hospitals in Tehran, Iran. The data were analyzed<br />using SPSS version 16 and EQS version 6.1. Results: Confirmatory factor analysis approved the construct validity of<br />the instrument and its seven domains. Cronbach’s alpha was measured as 0.97 for the total instrument and 0.80- 0.92<br />for its seven domains. In order to evaluate ttest-retest reliability, the intra-class correlation coefficient (ICC) was also<br />calculated (0.94). Conclusions: The Persian version of SCNI has acceptable psychometric properties. It can be used<br />for measuring the unmet psychosocial needs in adolescents who have a sibling with cancer in the Persian-speaking<br />population.
Psychometrics,cancer,Adolescent,sibling,needs assessment
https://journal.waocp.org/article_80076.html
https://journal.waocp.org/article_80076_3eb9c09efabd360ee6291adaaa9fc292.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Expression of PAX-5 in B Cell Hodgkin and Non Hodgkin Lymphoma
3463
3466
EN
Muhammad Rahil
Khan
Department of Pathology, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Pakistan.
muhammad.rahil@hotmail.com
Arsalan
Ahmad
Department of Pathology, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Pakistan.
Naila
Kayani
Department of Pathology, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Pakistan.
Khurram
Minhas
Department of Pathology, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Pakistan.
10.31557/APJCP.2018.19.12.3463
Background: B-cell malignancies including Precursor B-cell lymphoblastic lymphoma/leukemia and Hodgkin<br />Lymphoma show a wide spectrum of B-cell differentiation from early stage B-cell precursors to mature B-cells ending in<br />terminal differentiation to plasma cells. Pan-B-cell antigens routinely used for the diagnosis of B-cell lymphoma, include<br />CD19, CD20, CD22 and CD79a.PAX-5 protein, also known as B-cell-specific activation protein is a B-cell-specific<br />transcription factor; essential for commitment and functional maintenance used in the diagnosis of B cell Hodgkin<br />and non-Hodgkin lymphoma. PAX-5 show nuclear positivity in B cell lymphomas and moderate (dim) positivity in<br />Hodgkinlymphoma Reed Sternberg cells make this marker ideal for diagnosing B cell malignances. Objective: To<br />determine the expression of PAX-5 in B cell Hodgkin and non-Hodgkin Lymphoma in order to improve the diagnosis<br />of B-cell lymphomas. Methods: In this Prospective study, all the cases of B cell lymphoma diagnosed at The Aga<br />Khan University Hospital, Karachi from July 2010 to July 2011were included. A panel of Immunohistochemical stain<br />was performed in all cases along with additional PAX- 5 stain with appropriate controls. Results: Total 125 cases were<br />included. Hodgkin Lymphoma (Mixed cellularity) was the commonest B-cell lymphoma subtype, 32 (25%) cases.<br />Other common subtypes included Hodgkin lymphoma (Nodular sclerosis subtype), diffuse large B-cell lymphoma<br />and B lymphoblastic lymphoma. Conclusion: This study demonstrates that PAX-5 is the most sensitive and reliable<br />immuhohistochemicalmarker in the diagnosis of B cell Hodgkin and non-Hodgkin lymphoma.
KEYWORDS: PAX-5,Hodgkin lymphoma,Non Hodgkin Lymphoma
https://journal.waocp.org/article_80032.html
https://journal.waocp.org/article_80032_885801f5e5aa2368cb30ccc577a37dde.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Probably Benign Solid Breast Lesions on Ultrasound: Need for Biopsy Reassessed
3467
3471
EN
Kulsoom
Fatima
0000-0002-0635-8471
Department of Radiology, Aga Khan University, Karachi, Pakistan.
kulsoom.fatima@aku.edu
Imrana
Masroor
0000-0002-6126-9965
Department of Radiology, Aga Khan University, Karachi, Pakistan.
imrana.masroor@aku.edu
Samina
Khanani
Department of Radiology, Aga Khan University, Karachi, Pakistan.
samina.khanani@aku.edu
10.31557/APJCP.2018.19.12.3467
Objective: To determine the negative predictive value of ultrasound for breast masses with probably benign<br />morphology, and to assess whether follow-up may be an acceptable alternative to biopsy. Methods: After Institutional<br />Review Board approval, all solid breast masses categorized as probably benign (American College of Radiology Breast<br />Imaging Reporting and Data System [BI-RADS] 3) on ultrasound from January 2014 to December 2015, and having<br />either tissue diagnosis or imaging stability for 24 months, or downgrading to BIRADS 2 during imaging surveillance<br />were included. Result: A total of 157 lesions in 40 patients constituted the study population. The mean patient age was<br />31.3 years (range, 20-56 years). Seventeen of these 157 lesions underwent tissue diagnosis with no invasive breast cancer.<br />Out of the remaining 140 lesions, 115 were stable on imaging for 24 months or more. The rest 25 were deemed benign<br />because of decrease in size on follow up (n=1), non-recommendation of further imaging by the second radiologist on<br />follow up ultrasound (n= 13) or presence of benign tissue diagnosis in the largest lesion (n=11). Conclusion: Ultrasound<br />has 100% negative predictive value for breast lesions with probably benign morphology, whether palpable or not.<br />Follow up is an appropriate option to immediate biopsy of such lesions keeping in mind that noncompliance with<br />surveillance may be a potential problem.
Keywords: BI-RADS,probably benign,biopsy,Ultrasound
https://journal.waocp.org/article_77410.html
https://journal.waocp.org/article_77410_bf0e1505a770294ca29a31e067ba2092.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Molecular Targeting of Notch Signaling Pathway by DAPT in Human Ovarian Cancer: Possible Anti Metastatic Effects
3473
3477
EN
Maryam
Akbarzadeh
Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
marya.akbarzadeh@gmail.com
Maryam
Majidinia
Solid Tumor Research Center, Urmia University of Medical Science, Urmia, Iran.
majidinia.1359@gmail.com
Sedigheh
Fekri Aval
0000-0002-6749-0679
Department of Medical Biotechnology, Faculty
of Advanced Medical Sciences, Tabriz
University of Medical Sciences, Tabriz, Iran.
fekrise@tbzmed.ac.ir
Soltanali
Mahbub
Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
soltanalimahbub@gmail.com
Nosratollah
Zarghami
Department of Medical Biotechnology, Faculty
of Advanced Medical Sciences, Tabriz
University of Medical Sciences, Tabriz, Iran.
zarghami@tbzmed.ac.ir
10.31557/APJCP.2018.19.12.3473
Background: Ovarian cancer is one of the most important gynecological malignancies, causing significant mortality.<br />Recently, there has been extensive attention to the involvement of signaling cascades in its initiation/progression. In this<br />study, we focused on the possible role of Notch signal transduction in proliferation and metalloproteinase 2 and 9 function<br />in human ovarian cancer OVCAR-3 cells. Methods: MTT proliferation assays were used to evaluate effects of a DAPT<br />inhibitor on cell proliferation. For measurement of Hes-1 mRNA levels, quantitative reverse transcription polymerase<br />chain reaction (qRT-PCR) was applied following 48 h incubation with the inhibitor. In addition, metalloproteinase<br />(MMPs) activity was assessed by zymography. Results: Inhibition of Notch signaling resulted in a significant reduction<br />in OVCAR-3 cell proliferation. Additionally, DAPT treatment of cells significantly decreased Hes-1 mRNA levels<br />(p < 0.05) as well as activity of MMP-2 and -9 (p < 0.05). Conclusion: Our results suggested that suppression of Notch<br />signaling by a specific inhibitor can effectively decrease proliferation and the potential for metastasis of OVCAR-3 cells<br />via a reduction in the activity of metalloproteinases 2 and 9. Thus, pharmacological targeting of the Notch signaling<br />pathway could be a promising future treatment for ovarian cancer.
Notch signaling pathway,Metalloproteinases,Ovarian Cancer
https://journal.waocp.org/article_77411.html
https://journal.waocp.org/article_77411_084e1b8c027dd7fa5f7a3ed82a6ace46.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Induction of Apoptosis by an Extract of Persian Gulf Marine Mollusc, Turbo Coronatus through the Production of Reactive Oxygen Species in Mouse Melanoma Cells
3479
3488
EN
Fatemeh
Zangeneh
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran.
fazanganeh@gmail.com
Amir
Vazirizadeh
The Marine Biology and Fishery Science Department, Persian Gulf Institute, Persian Gulf University, Bushehr, Iran.
vaziriamir@yahoo.com
Mohammad Reza
Mirshamsi
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran.
mohammad.mirshamsi@gmail.com
Amir
Fakhri
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran.
amirfakhri@yahoo.com
Mehrdad
Faizi
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran.
faizi64@yahoo.com
Jalal
Pourahmad
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran.
j.pourahmadjaktaji@utoronto.ca
10.31557/APJCP.2018.19.12.3479
Objective: A variety of approaches such as surgery, chemotherapy, radiotherapy, hormonal therapy and<br />immunotherapy are used to treat melanomas, but unfortunately in most case, the response is very weak and often side<br />effects are serious. This study concerns selective toxicity of an extract of Turbo coronatus on cells and mitochondria from<br />a syngeneic mouse model of melanoma. Methods: Cells and mitochondria isolated from extra tumoral and melanoma<br />tissues were exposed toa T. coronatus crude extract and fractions obtained by gel-filtration chromatography and assayed<br />for mitochondrial and cellular parameters. Result: Crude extract (375, 750 and 1,500 μg/ml) and fraction 1; F1; (275,<br />550 and 1100 μg/ml) of T. coronatus extract induced a significant (p<0.05) increase of the reactive oxygen species<br />(ROS) level, swelling of mitochondria, collapse of mitochondrial membrane potential (MMP), release of cytochrome<br />c and caspase-3 activation only in the mitochondria and cells obtained from melanoma but not extra tumoral tissues. In<br />addition, the F1 fraction decreased the percentage of viable cells and induced apoptosis in melanoma cells. Conclusion:<br />For the first time we could demonstrate that the F1 fraction of a T. coronatus extract, selectively induces ROS mediated<br />cytotoxicity by directly targeting mitochondria in melanoma tissues and it may be a suitable candidate for novel drug<br />treatment of malignant melanomas.
Melanoma,Turbo coronatus,mitochondria,Apoptosis,Gel filtration
https://journal.waocp.org/article_77049.html
https://journal.waocp.org/article_77049_9856713c5344fb70bb1e28d813edf823.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
5-Year Survival Rates and Prognostic Factors in Patients with Synchronus and Metachronus Breast Cancer from 2010 to 2015
3489
3493
EN
Arash
Sarveazad
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
arashsarveazad@gmail.com
Asrin
Babahajian
Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
babahajian3@yahoo.com
Jebreil
shamsadin
Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical science, Bandar Abbas, Iran.
shams.jebreil@gmail.com
Mansour
Bahardoust
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
mansourbahari93@gmail.com
10.31557/APJCP.2018.19.12.3489
Introduction: Currently breast (BC) cancer is a serious medical problem in all countries of the world. Survival<br />depends on many factors. The present study focused on 5-year survival and its related factors in patients with BC in<br />Iran. Material and methods. The present analytical retrospective study was performed (from March 2010 until March<br />2015) on patients with BC followed for at least 6 months. The main variables assessed were tumor size, grade of lymph<br />node involvement, metastasis, stage, history, human epidermal growth factor receptor expression, and tumor origin.<br />Analysis of survival was accomplished using the Kaplan- Meier method. Results: Some 351 (80.2%) of the total of<br />438 individuals had unilateral and 87(19.8%) had bilateral cancer, 28 (35.6%) of the latter being synchronous and<br />56(64.4%) metachronous. Mean duration of follow-up was 47.44±28.19 months, during which 61 (17.3%) patients<br />with unilateral and 18 with bilateral cancer eventually died. The 5-year survival rate in patients with unilateral BC was<br />significantly higher than those with bilateral BC (Log-rank Test chi2= 3.11, p=0.032). In addition, with metachronous<br />cases, the survival rate was 64.2% in comparison with 51.6% for synchronous BCs. Survival rate was significantly<br />(p value =0.038) higher with metachronous than with synchronous cancers (Log-rank Test chi2=3.54, p=0.038). The<br />highest survival rate was reported for BCs originating from lobule tissue and the lowest rate examples of interstitial<br />tissue origin (Log-rank Test chi2=11.54, p=0.0001). Patients with earl stage lesions (M1) survived longer than with<br />other stages (Log-rank Test chi2= 9.55, p=0.001). Conclusion: In this study, most women with BC had a positive<br />family history and were married. The 5-year survival rate was lower with advanced stages of cancer. According to our<br />findings, survival rates might improve if patients undergo screening and diagnosis is made at an early stage of the disease.
breast cancer,survival,Metastasis,clinical stage,Iran
https://journal.waocp.org/article_79153.html
https://journal.waocp.org/article_79153_8d01a770aed3be4954e47f90a1ad3be8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Outcomes and Complications of Simultaneous Laparoscopic Cystectomy and Laparoscopic Nephroureterectomy with Umbilical Reduced Port Surgery
3495
3500
EN
Yutaro
Tanaka
Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
yuyu_tanaka@hotmail.com
Takehiko
Okamura
0000-0003-0954-3995
Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
hiko2546@kosei.anjo.aichi.jp
Ryosuke
Chaya
Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
brutus.you.are.fool.r.c@gmail.com
Takashi
Nagai
0000-0002-9635-4553
Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
tkshng73@gmail.com
Daichi
Kobayashi
Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
daichikoba1979@yahoo.co.jp
Takahiro
Kobayashi
Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
kobayachinko@yahoo.co.jp
Hidetoshi
Akita
Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
fqpfb961@gmail.com
Takahiro
Yasui
Department of Nephro-Urology, Nagoya City
University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Japan.
yasui@med.nagoya-cu.ac.jp
10.31557/APJCP.2018.19.12.3495
Objective: In recent years, although reduced port surgeries (RPS) have been reported for many urological diseases,<br />there have been no reports regarding simultaneous laparoscopic cystectomy and unilateral or bilateral nephroureterectomy<br />with umbilical RPS. Therefore, the aim of this study was to evaluate outcomes and complications of simultaneous<br />laparoscopic cystectomy and unilateral or bilateral nephroureterectomy with umbilical RPS. Methods: We performed<br />a preliminary case series of 4 patients with synchronous upper urinary tract (UUT) tumor and invasive bladder cancer<br />who underwent simultaneous laparoscopic cystectomy and unilateral or bilateral nephroureterectomy with umbilical RPS<br />between 2014 and 2017 at our hospital. Demographic data, pathologic features, the surgical technique, and outcomes<br />were retrospectively analyzed. Result: All 4 patients were men whose median age was 79 years (range 65-85 years) and<br />median body mass index was 24.2 kg/m2 (range 21.5-27.3 kg/m2). The laparoscopic approach was technically successful<br />in all 4 patients without the need for open conversion. The median total operative time was 434 minutes (range 372-481<br />minutes). The median estimated blood loss was 773 ml (range 153-923 ml), median interval to resuming oral intake<br />was 2 days (range 1-7 days), and median hospital stay was 16 days (range 13-20 days). Conclusion: The reduced port<br />approach is technically feasible in terms of many outcome measures, with significant cosmetic advantages. This method<br />can be performed safely and recommended as a viable option for patients with concomitant UUT and bladder cancer.
Cystectomy,nephroureterectomy,Umbilical approach,reduced port surgery
https://journal.waocp.org/article_80042.html
https://journal.waocp.org/article_80042_7395d99f6b4be489d3524ec757aa0b28.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer Cells
3501
3509
EN
Roopesh
Krishnankutty
0000-0002-1496-6135
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
rkrishnankutty@hamad.qa
Ahmad
Iskandarani
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
aiskandarani@hamad.qa
Lubna
Therachiyil
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
ltherachiyil@hamad.qa
Shahab
Uddin
0000-0003-1886-6710
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
skhan34@hamad.qa
Fouad
Azizi
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
fazizi@hamad.qa
Michael
Kulinski
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
mkulinski@hamad.qa
Ajaz Ahmad
Bhat
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
ajaz.bhatt@gmail.com
Ramzi M
Mohammad
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar.
mohammad@karmanos.org
10.31557/APJCP.2018.19.12.3501
Background/ Objective: Camel milk is traditionally known for its human health benefits and believed to be a remedy<br />for various human ailments including cancer. The study was aimed to evaluate the inhibitory effects of commercially<br />available camel milk on cancer cells and its underlying mechanism(s). Materials and Methods: Two cell lines:<br />colorectal cancer HCT 116 and breast cancer MCF-7 were cultured with different doses of camel milk. The effects of<br />camel milk on cell death were determined by MTT assay, viability by trypan blue exclusion assay and migration by in<br />vitro scratch assay. The mechanism was elucidated by western blotting and confocal microscopy was used to confirm<br />autophagy. Results: Camel milk significantly reduced proliferation, viability as well as migration of both the cells.<br />The accumulation of LC3-II protein along with reduction in expression of p62 and Atg 5-12, the autophagy proteins<br />implied induction of autophagy. The (GFP)-LC3 puncta detected by confocal microscopy confirmed the autophagosome<br />formation in response to camel milk treatment. Conclusion: Camel milk exerted antiproliferative effects on human<br />colorectal HCT 116 and breast MCF-7 cancer cells by inducing autophagy.
colorectal cancer,breast cancer,Camel Milk,Autophagy
https://journal.waocp.org/article_80077.html
https://journal.waocp.org/article_80077_7e3e1b16ebe93b4c57f3778071e5a2d6.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran
3511
3515
EN
Parisa
Kangari
Department of Biology, higher education institute of Rab – Rashid, Tabriz, Iran.
Tahereh
Zarnoosheh Farahany
Department of Biology, School of Advanced Technologies in Medicine, Islamic Azad University Medical Branch of Tehran, Tehran, Iran.
Ali
Golchin
0000-0001-8661-5046
Department of Tissue Engineering and Applied Cell Sciences, Student Research Committee, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
agolchin.vet10@yahoo.com
Somayeh
Ebadollahzadeh
Department of Tissue engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Arash
Salmaninejad
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Soltan Ali
Mahboob
Department of Tissue engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza
Nourazarian
Department of biochemistry and clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
10.31557/APJCP.2018.19.12.3511
Background: Breast cancer is caused by breast tissue malignant cells and it has become one of the main medical concerns with a socio-economic significance especially for women. Among the multiple factors involved in the initiation, progression, and invasion of breast cancer, oxidative stress plays an important role. Antioxidant status, lipid peroxidation, and oxidative stress in newly diagnosed breast cancer patients were determined to find a defined pattern of oxidative stress in these patients. Methods: The malondialdehyde (MDA) levels (as an indicator of lipid peroxidation), glutathione peroxidase (GPX), and superoxide dismutase (SOD) activities of newly diagnosed breast cancer patients (n=38) and controls (n=38) were assessed using blood samples. Results: MDA level and SOD activity were significantly higher in the breast cancer patients compared to the healthy subjects group (p
breast cancer,Lipid peroxidation,oxidative stress,Superoxide dismutase,Glutathione peroxidase
https://journal.waocp.org/article_76652.html
https://journal.waocp.org/article_76652_3b36f65cb54ee471edf87cb63754c0f7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
An Automatic Bone Disorder Classification Using Hybrid Texture Feature Extraction with Bone Mineral Density
3517
3523
EN
Ramkumar
S
0000-0001-5762-1455
Department of EIE, Annamalai University, India.
sram0829@gmail.com
Malathi
R
Department of EIE, Annamalai University, India.
10.31557/APJCP.2018.19.12.3517
A novel approach has been proposed to classify bone disorders for classifying the radiographic bone image as<br />normal, Osteopenia and Osteoporosis. The proposed system consists of three major stages to predict the accurate bone<br />disorder classification. In the first stage, image preprocessing is performed where bilateral filtering is applied to remove<br />noise and to enhance the image quality. Then, the image is fed to Otsu based segmentation approach for segmenting<br />the abnormal area of the bone image. In the second stage, Discrete Wavelet Transform (DWT) is used to the segmented<br />image. Once the image gets segmented then, the Gray-Level Co-occurrence Matrix (GLCM) method is applied to extract<br />the features in terms of statistical texture-based. Further the image which is applied to Principle Component Analysis<br />(PCA) to reduce size of the feature vector. Besides, Bone Mineral Density (BMD) feature namely calcium volume is<br />estimated from abnormal region in the segmented bone image and it is concatenated with the extracted texture features<br />to obtain the final feature vectors. In the final stage, the Multi-class Support Vector Machine (MSVM) takes feature<br />vectors as a inputto classify bone disorders. The simulation result demonstrates that the proposed system achieved the<br />accuracy of 95.1% and sensitivity of 96.15%.
Osteoporosis,osteopenia,DWT (Discrete Wavelet Transform),GLCM (Gray-Level Co-occurrence Matrix),MSVM (Multi-class Support Vector Machine)
https://journal.waocp.org/article_80141.html
https://journal.waocp.org/article_80141_185c6fdd4f26ad59dfce22d96e29736a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
The Role of Diuretics in Treatment of Aromatase Inhibitors Induced Musculoskeletal Symptoms in Women with Non Metastatic Breast Cancer
3525
3531
EN
Alshimaa Mahmoud
Alhanafy
0000-0002-5452-5967
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Menoufia University, Shebin El kom, Egypt.
alshimaa_alhanafy@yahoo.com
Alaa
Labeeb
Department of Rheumatology, Physical Medicine and Rehabilitation, Faculty of Medicine - Menoufia University, Shebin El Kom, Egypt.
Ashraf
Khalil
Department of Clinical Chemistry, National Liver Institute, Menoufia University, Shebin El kom, Egypt.
10.31557/APJCP.2018.19.12.3525
Background: Around 50% of women receiving Aromatase Inhibitors (AIs) develop musculoskeletal symptoms<br />which may become severe causing interruption of treatment. Patients with AI-induced arthralgia had higher rates of<br />joint effusions and fluid in the tendons, so use of diuretics may be helpful. Methods: This prospective phase II study<br />was conducted in department of clinical oncology and nuclear medicine, Menoufia University Hospital, Egypt, between<br />Jan. to Dec. 2015. Fifty Women with stage I,II and III breast cancer receiving AIs as adjuvant hormonal treatment<br />complaining of AIs related musculoskeletal symptoms received Lasilactone® 50 mg tablet; (an oral combination of<br />Frusemide 20mg/Spironolactone 50 mg), every other day for 4 weeks. Patients were assessed by modified Western<br />Ontario and McMaster Universities osteoarthritis (WOMAC) index for lower limb and the quick Disabilities of the<br />Arm, Shoulder and Hand Score (DASH) scoring system for upper limbs, Arabic versions, at baseline and after 4 weeks<br />of treatment. Results: The mean WOMAC pain score improved significantly (6.0 v 10; P < 0.001), the mean WOMAC<br />stiffness score improved (2.3 v 3.9; P = 0.002), the mean WOMAC functional score improved (8.7 v 15; P < 0.001),<br />the total WOMAC score improved (17 v 29; P < 0.001), also a significant difference was noticed for the quick DASH<br />score; total score (16 v 25; P = 0.02) After use of diuretics for 4 weeks of treatment compared with baseline scores.<br />Conclusions: The use of diuretics effectively reduces AI related musculoskeletal symptoms with good tolerance
Diuretics,Aromatase inhibitors,Musculoskeletal Symptoms
https://journal.waocp.org/article_80108.html
https://journal.waocp.org/article_80108_0775eba40490716d95e2cc187834c372.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
A Pharmacological Strategy Using Stemofoline for more Efficacious Chemotherapeutic Treatments Against Human Multidrug Resistant Leukemic Cells
3533
3543
EN
Sonthaya
Umsumarng
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
s.umsumarng@gmail.com
Sariya
Mapoung
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
srmapoung@gmail.com
Supachai
Yodkeeree
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
yodkeelee@hotmail.com
Stephen G
Pyne
School of Chemistry, University of Wollongong, Wollongong, New South
Wales, Australia.
spyne@uow.edu.au
Pornngarm
Limtrakul Dejkriengkraikul
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
pornngarm.d@cmu.ac.th
10.31557/APJCP.2018.19.12.3533
Our previous study reported that stemofoline (STF) exhibited a synergistic effect with chemotherapeutic drugs in<br />human multidrug-resistant (MDR) leukemic cells (K526/Adr) by inhibiting the function of P-glycoprotein, which is a<br />membrane transporter that is overexpressed in several types of MDR cancers. This study further investigated the effects of<br />a combination treatment of STF and doxorubicin (DOX) in vitro and in vivo. The combination treatment of 50 mg/kg of<br />STF strongly enhanced the anti-tumor activity of DOX in SCID-beige mice bearing K562/Adr xenografts without<br />additional toxicity when compared to the single treatment groups. Additionally, an examination of the proliferation<br />markers (Ki67) and the apoptotic marker (TUNEL) in tumor tissues in each group revealed that the combination<br />therapy significantly reduced Ki67 positive cells and increased apoptotic cells. From the in vitro experiments we also<br />found that this combination treatment dramatically induced G1 and G2M arrest in K562/Adr when compared to a single<br />treatment of DOX. STF treatment alone did not show any cytotoxic effect to the cells. These results suggest that the<br />accumulation of DOX enhanced by STF was sufficient to induce cell cycle arrest in K562/Adr. These findings support<br />our previous in vitro data and indicate the possibility of developing STF as an adjuvant therapy in cancer treatments.
Chemotherapy,Leukemia,p-glycoprotein,Xenograft model,Stemofoline
https://journal.waocp.org/article_77413.html
https://journal.waocp.org/article_77413_1516b7cea93e1b5d03105b56943066f3.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Rate and Predictive Factors for Sustained Complete Response after Selective Transarterial Chemoembolization (TACE) in Patients with Hepatocellular Carcinoma
3545
3550
EN
Kittipitch
Bannangkoon
Department of Radiology, Faculty of Medicine, Prince of Songkla University, 15
Kanchanavanit Road, Hat Yai, Songkhla, Thailand.
drkittipitch@gmail.com
Keerati
Hongsakul
Department of Radiology, Faculty of Medicine, Prince of Songkla University, 15
Kanchanavanit Road, Hat Yai, Songkhla, Thailand.
hkeerati@medicine.psu.ac.th
Teeravut
Tubtawee
Department of Radiology, Faculty of Medicine, Prince of Songkla University, 15
Kanchanavanit Road, Hat Yai, Songkhla, Thailand.
ttubtawee@gmail.com
Edward
Mc Neil
0000-0002-9492-1040
Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, 15
Kanchanavanit Road, Hat Yai, Songkhla, Thailand.
edward.m@psu.ac.th
Hutcha
Sriplung
Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, 15
Kanchanavanit Road, Hat Yai, Songkhla, Thailand.
hutcha.s@gmail.com
Virasakdi
Chongsuwiwatvong
Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, 15
Kanchanavanit Road, Hat Yai, Songkhla, Thailand.
cvirasak@gmail.com
10.31557/APJCP.2018.19.12.3545
Background: To determine the effectiveness and performance of selective conventional transarterial<br />chemoembolization (TACE) and analyze the potential predictive factors of sustained complete response (CR) for<br />patients with hepatocellular carcinoma (HCC). Materials and Methods: Total of 52 patients with HCC (33 males,<br />19 females; mean age 64.0 ± 9.6 years) who underwent 81 sessions of selective TACE between November 2015 and<br />March 2017 at Songklanagarind hospital were reviewed. The Kaplan-Meier method was used to describe CR rates at<br />various time points. Univariate and multivariate logistic regression models were performed to determine the predictive<br />factors for sustained CR at six months. Results: The CR rates after selective TACE at 1, 4, 6, 9 and 12 months were<br />87%, 81%, 62%, 40% and 31%, respectively. Univariate and multivariate analyses demonstrated that alpha fetoprotein<br />level <100ng/ml, a tumor size in summation ≤ 30 mm, ≤ 2 sessions of selective TACE and unilobar involvement had a<br />significantly higher odds of sustaining complete response at six months (p =0.018, 0.031, 0.032, and 0.044, respectively).<br />Conclusions: Selective TACE has a good therapeutic results and can sustained complete response in selected HCC<br />patients. Serum AFP≤ 100 ng/ml, a few sessions of selective TACE, tumor size in summation ≤ 30 mm and unilobar<br />involvement were favorable predictive factors for sustained complete response of HCC patients.
complete response,predictive factors,selective TACE,Hepatocellular carcinoma
https://journal.waocp.org/article_80053.html
https://journal.waocp.org/article_80053_d9ddc98f53c39fc9a71cd3fb3f059da8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Malignancy in Systemic Lupus Erythematosus (SLE) Patients
3551
3555
EN
Rizna Abdul
Cader
0000-0001-7331-2572
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala
Lumpur, Malaysia.
rizna_c@hotmail.com
Amy Khoo
Mei Yee
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala
Lumpur, Malaysia.
amykhoo0101@gmail.com
Azrul
Yassin
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala
Lumpur, Malaysia.
azrulreesha@gmail.com
Ismail
Ahmad
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala
Lumpur, Malaysia.
m_dsparekusa2004@yahoo.com
Siti Nurfatin
Haron
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala
Lumpur, Malaysia.
fateen_krusty@yahoo.com
10.31557/APJCP.2018.19.12.3551
Background: Malignancies are among the leading causes of death in Systemic Lupus Erythematosus (SLE)<br />patients with studies reporting a higher prevalence of malignancy in SLE patients compared to the general population.<br />We wanted to determine the frequency of cancer in a cohort of SLE patients and identify its associated risk factors.<br />Methods: Cross-sectional study involving SLE patients attending the nephrology outpatient clinic, Universiti<br />Kebangsaan Malaysia Medical Centre between January and June 2014. Results: We recruited 228 patients (207 female,<br />21 male), aged 40.48 ± 12.86 years with mean SLE duration of 11.65 ± 6.46 years. Majority (87%) had lupus nephritis<br />and were in remission with a median SLEDAI score 2 (0, 14). Majority (89%) were on corticosteroid with either a<br />steroid sparing agent like mycophenolate mofetil (15.4%), azathioprine (36.8%) or ciclosporin (15.4%). One hundred<br />and sixty (70.2%) patients were either receiving or had received intravenous cyclophosphamide with median dose<br />of 5,173.6 ± 3,242.4 mg. Seven female patients were diagnosed with cancer during the course of their SLE with 56<br />(34-78) years being median age at malignancy and SLE duration of 4 (0-12) years. Majority (5/7) had lupus nephritis<br />and all patients a median dose of prednisolone 10 (2.5, 10) mg with 10 (4-24) years of steroids. Two patients had a<br />family history of cancer with majority developing cancer after the diagnosis of SLE. Two patients received intravenous<br />cyclophosphamide prior to the development of cancer for their SLE compared to overall cohort of 160. Three patients<br />had colorectal cancer, 2 had cervical cancer, 1 had breast cancer, and one patient had germ cell tumour and one thyroid<br />cancer. All patients had their cancer successful treated with no signs of recurrence. Conclusion: We found a lower<br />occurrence of cancer in our SLE patients as compared with the reported literature.
cancer,Cyclophosphamide,lupus nephritis,Malignancy,Systemic lupus erythematosus
https://journal.waocp.org/article_80050.html
https://journal.waocp.org/article_80050_ec99670a2f0f0f20bb04025ed019be8a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Prognostic Value of BCL2 in Women Patients with Invasive Breast Cancer
3557
3564
EN
E-Z
Ayadi
Procédés de criblage moléculaire et cellulaire, Centre of Biotechnology of Sfax B.P K.3038 Sfax, Tunisia.
ayadiemna90@gmail.com
B
Cherif
Procédés de criblage moléculaire et cellulaire, Centre of Biotechnology of Sfax B.P K.3038 Sfax, Tunisia.
boutheina.cherif.cbs@gmail.com
Y
Ben Hamed
Patholab Private Cytopathology Laboratory Dar elhkim route touristique 4190 homtessouk, Djerba,Tunisia.
youssef.benhamed@yahoo.fr
N
Ben Yahia
Laboratoire d’anatomie et de cytologie pathologique, EPS Farhat Hached Hospital, Sousse,Tunisia.
nejib.benyahia@gmail.com
M
Mokni
Patholab Private Cytopathology Laboratory A. Ibn Khaldoun Sfax, Tunisia.
moncefmokni@gmail.com
A
Rebai
Procédés de criblage moléculaire et cellulaire, Centre of Biotechnology of Sfax B.P K.3038 Sfax, Tunisia.
ahmed.rebai@gmail.com
H
Ayadi
Procédés de criblage moléculaire et cellulaire, Centre of Biotechnology of Sfax B.P K.3038 Sfax, Tunisia.
ayadi.hammadi@gmail.com
R
Jlidi
Patholab Private CytoPathology Laboratory R. du Caire, Cité Jardin Sfax,Tunisia.
rachid.jlidi@gmail.com
10.31557/APJCP.2018.19.12.3557
Background: Breast cancers are heterogeneous, making it essential to recognize several biomarkers for cancer<br />outcome predictions especially in young women where the classical prediction parameters are not suitable. The goal<br />from this study is to evaluate the impact of B cell lymphoma 2 (BCL2), P53 and Ki-67 proteins expression on survival<br />in young women patients with invasive ductal carcinoma. Patients and methods: Samples and clinical data from 238<br />patients were collected between 2003 and 2017. They were selected according to 2 criteria: age ≤40 years old and most of<br />them are affected by an Invasive Ductal Carcinoma. We evaluated BCL2, P53 and ki-67 expression by immunochemistry<br />test, and then we assessed correlations of these biomarkers expression with patient’s clinicopathological characteristics<br />and survival. Results: Triple negative breast cancer group showed a high frequency among our cohort but we emphasize<br />an almost equitable distribution among all molecular groups. Contrary to other studies which reported that luminal A<br />was correlated with better prognosis, our analysis demonstrated that luminal A is correlated with the Scarff, Bloom<br />and Richardson (SBR) grading 2 or SBR grading 3. To better investigate the prognosis, we analyze three biomarkers<br />known by their impact on physiopathology behavior on breast cancer BCL2, ki-67and P53. BCL2 is the more relevant<br />one, it was correlated with molecular subtypes (p=0.0012) and SBR grading (p=0.0016). BCL2 seems to be the good<br />prognostic biomarker related to survival (p=0.004) with a protective role among patients when endocrine therapy<br />is not provided and Lymph Node (LN) involvement is positive (p=0.021, p=0.000 respectively). Conclusions: The<br />classical prognostic parameters based mainly on the molecular classification in breast cancer seem insufficient in the<br />case of young women. BCL2 protein expression analysis provides a better prognostic value. BCL2 should be clinically<br />associated in current practice when young women specimens are diagnosticated.
breast cancer,BCL2,Young Women,Prognosis
https://journal.waocp.org/article_77418.html
https://journal.waocp.org/article_77418_5f2774f69a886ad44570240df86d0ae7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Helicobacter pylori Infection and Related Gastrointestinal Diseases in Southeast Asian Countries: An Expert Opinion Survey
3565
3569
EN
Duc Trong
Quach
0000-0003-0141-921X
Department of Internal Medicine, University of Medicine and Pharmacy at Hochiminh City, Hochiminh, Vietnam.
drquachtd@gmail.com
Ratha-korn
Vilaichone
0000-0003-4298-9331
Division of Gastroenterology, Department of Medicine, Thammasat University Hospital, Pathumthani, Thailand.
vilaichone@hotmail.co.th
Khien Van
Vu
Department of Gastrointestinal Endosccopy, 108 Central Military Hospital, Hanoi, Vietnam.
khienvuvan@hotmail.com
Yoshio
Yamaoka
Department of Medicine, Gastroenterology Section, Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Texas, USA.
yyamaoka@bcm.edu
Kentaro
Sugano
Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University, Japan.
sugano@jichi.ac.jp
Varocha
Mahachai
National Gastric Cancer and Gastrointestinal diseases Research Center, Pathumthani Thailand.
varocha.m@gmail.com
10.31557/APJCP.2018.19.12.3565
Background: Helicobacter pylori (H. pylori) infection is currently considered as an infectious disease irrespective of<br />symptoms and stage of disease. This study aimed to survey the impact of H. pylori infection and the current management<br />approaches in Southeast Asian countries. Materials and methods: This is a survey among 26 experts from 9 Southeast<br />Asian countries (Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand and Vietnam),<br />who attended a meeting to develop the ASEAN consensus on H. pylori management in November 2015. Results: The<br />prevalence of H. pylori varied significantly from 20% to 69% among countries, highest in Myanmar and lowest in<br />Malaysia. The rate of H. pylori infection in patients with gastritis, peptic ulcer disease and gastric cancer (GC) also<br />varied significantly, not only among countries but also among regions within the same country. The most common<br />method for H. pylori diagnosis before treatment was rapid urease test, followed by urea breath test. In multi-ethnic<br />countries, some ethnic groups including Chinese, Batak and Minahasanese were considered as having higher risk of<br />GC. There have been no national screening programs for GC in all countries, and a majority of patients with GC were<br />diagnosed in advanced stages with very poor 5-year survival. Conclusions: The prevalence of H. pylori infection and<br />its infection rates in related gastrointestinal diseases were significantly different among Southeast Asian countries. The<br />prognosis of patients with GC in the region was very poor. The result of this survey is a platform for future international<br />and regional research collaboration.
Helicobacter pylori,Gastritis,peptic ulcer disease,Gastric cancer,Southeast Asia
https://journal.waocp.org/article_80143.html
https://journal.waocp.org/article_80143_9595c87bc0bd96f8afb13e60703b2e0d.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Automatic Approach for Cervical Cancer Detection and Segmentation Using Neural Network Classifier
3571
3580
EN
Elayaraja
P
0000-0003-3579-2098
Department of Ece, Kongunadu College of Engineering and Technology, Trichy, Tamilnadu, India.
sunandmun@gmail.com
Suganthi
M
Head of Ece, Mahendra College of
Engineering, Salem, India.
msuganthib@gmail.com
10.31557/APJCP.2018.19.12.3571
Cervical cancer leads to major death disease in women around the world every year. This cancer can be cured if it<br />is initially screened and giving timely treatment to the patients. This paper proposes a novel methodology for screening<br />the cervical cancer using cervigram images. Oriented Local Histogram Technique (OLHT) is applied on the cervical<br />image to enhance the edges and then Dual Tree Complex Wavelet Transform (DT-CWT) is applied on it to obtain<br />multi resolution image. Then, features as wavelet, Grey Level Co-occurrence Matrix (GLCM), moment invariant<br />and Local Binary Pattern (LBP) features are extracted from this transformed multi resolution cervical image. These<br />extracted features are trained and also tested by feed forward back propagation neural network to classify the given<br />cervical image into normal and abnormal. The morphological operations are applied on the abnormal cervical image<br />to detect and segment the cancer region. The performance of the proposed cervical cancer detection system is analyzed<br />in the terms of sensitivity, specificity, accuracy, positive predictive value, negative predictive value, Likelihood Ratio<br />positive, Likelihood ratio negative, precision, false positive rate and false negative rate. The performance measures for<br />the cervical cancer detection system achieves 97.42% of sensitivity, 99.36% of specificity, 98.29% of accuracy, PPV<br />of 97.28%, NPV of 92.17%, LRP of 141.71, LRN of 0.0936, 97.38 % precision, 96.72% FPR and 91.36% NPR. From<br />the simulation results, the proposed methodology outperforms the conventional methodologies for cervical cancer<br />detection and segmentation process.
Cervical cancer,Cervigram,Features,Gabor transforms,Neural Networks
https://journal.waocp.org/article_77414.html
https://journal.waocp.org/article_77414_8a2a6c34820acf3c43c34be2995b2052.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Topoisomerase II α Gene alteration in Triple Negative Breast Cancer and Its Predictive Role for Anthracycline-Based Chemotherapy (Egyptian NCI Patients)
3581
3589
EN
Mahitab Ibrahim
Eltohamy
Department of Pathology, National Cancer Institute, Cairo University, Egypt.
mahitabaltohami@yahoo.com
Omnia Mohammed
Badawy
Department of Pathology, National Cancer Institute, Cairo University, Egypt.
omniabadawy75@hotmail.com
Naglaa
El kinaai
Department of Pathology, National Cancer Institute, Cairo University, and Children’s Cancer Hospital Egypt, Cairo, Egypt.
naglaa_elkinaai@yahoo.com
Iman
Loay
Department of Pathology, National Cancer Institute, Cairo University, Egypt.
imanloay@gmail.com
Hanan Ramadan
Nassar
Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt.
nhanan_67@yahoo.com
Rasha Mahmoud
Allam
Department of Biostatistics and Cancer Epidemiology, National Cancer Institute, Cairo University, Egypt.
allam.rasha@yahoo.com
Mona Ali
Sakr
Department of Pathology, National Cancer Institute, Cairo University, Egypt.
m.sakr14263@gmail.com
10.31557/APJCP.2018.19.12.3581
Objective: Triple negative breast cancer is an aggressive variant of breast cancer; it forms about 15% of breast<br />cancer cases. It lacks the responsiveness to hormonal and targeted therapies. Anthracyclines remain the treatment option<br />for these patients. Anthracyclines are cardiotoxic, so predicting sensitivity of response by biological predictors may<br />have a role in selecting suitable candidates for these drugs. Material and methods: This study included 50 TNBC<br />cases, from National Cancer Institute, Cairo University(NCI-CU), Egypt, who underwent surgery and received adjuvant<br />chemotherapy. Archived blocks were obtained and immunostaining for Ki-67 LI and Fluorescent In situ Hybridization<br />(FISH) technique to assess TOP2A gene copy number and chromosome 17CEP status were done. Analysis of association<br />between TOP2A alterations and CEP17 polysomy as well as Ki-67 LI with other clinicopathological parameters was<br />done. Associations between the biological markers and event free survival (EFS) and overall survival (OS), were also<br />performed. Results: TOP2A alteration was seen in 9/50 cases (5 amplified and 4 deleted). CEP17 Polysomy was detected<br />in 14% of cases. Most of patients (80%) showed Ki-67 LI ≥20%. There was a significant association between TOP2A<br />gene and CEP17 status. Outcome was better with abnormal TOP2A gene status and CEP17 polysomy, radiotherapy<br />and combined anthracyclines and taxanes in the adjuvant setting, however P-values were not significant. Conclusion:<br />TOP2A gene alterations and CEP17 polysomy may have prognostic and predictive role in TNBC treated with adjuvant<br />Anthracyclines.
TOP2A,CEP17 polysomy,anthracyclines,TNBC
https://journal.waocp.org/article_77419.html
https://journal.waocp.org/article_77419_437dcb24dc74faf79a05a38746a4f955.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Features of Microcalcifications on Screening Mammography in Young Women
3591
3596
EN
Atsushi
Fushimi
0000-0003-1328-8835
Department of Surgery, Sakuragaoka Hospital, Shizuoka, Japan.
fushimi@jikei.ac.jp
Naoko
Fukushima
Department of Surgery, Sakuragaoka Hospital, Shizuoka, Japan.
naoko9037@gmail.com
Toshimasa
Suzuki
Department of Surgery, Sakuragaoka Hospital, Shizuoka, Japan.
suzutoshi42@yahoo.co.jp
Rei
Kudo
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
reisan42@gmail.com
Hiroshi
Takeyama
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
takeyama@jikei.ac.jp
10.31557/APJCP.2018.19.12.3591
Background: There is no decrease in the number of breast cancer deaths if screening mammography is performed<br />in women aged hereditary breast cancer. Therefore, more accurate screening mammography for young women is needed. Objective: To<br />evaluate the features of screening mammographic findings, particularly microcalcifications, in women aged to increase the positive predictive value of screening mammography in young women. Methods: We retrospectively<br />reviewed the data of consecutive women who underwent opportunistic and organized breast cancer screening at the<br />Sakuragaoka Hospital (Shizuoka, Japan) between April 2013 and March 2015. We compared the mammographic<br />findings and features of microcalcifications between women aged Results: The study included 3645 women. Of these 3645 women, 415 (11.4%) were aged were aged 40–49 years, and 2011 (55.2%) were aged 50–74 years. Women aged recalled for microcalcifications than those aged 50–74 years (Young women were more likely to be recalled for small round and segmental microcalcifications [(OR): 1.799 (95% CI: 0.751–2.846); 40–49 years, OR: 1.394 (95% CI: 0.714–2.074)] and less likely to be recalled for<br />small round and grouped microcalcifications [(95% CI: 0.496–1.428)] compared with women aged 50–74 years. Conclusions: On screening mammography, women<br />aged microcalcifications. False-positive results may be reduced by reflecting the characteristics of microcalcification findings<br />among young women without breast cancer in the future.
mammography,breast cancer,Young Women,microcalcifications,Screening
https://journal.waocp.org/article_77420.html
https://journal.waocp.org/article_77420_b6f349a2b86d9a9787563704a4c6e963.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Factors Affecting Survival in Neuroendocrine Tumors: A 15-Year Single Center Experience
3597
3603
EN
Abdullah
Sakin
0000-0003-2538-8569
Department of Medical Oncology, Yuzuncu Yil University Medical School, 65090, Van, Turkey.
drsakin@hotmail.com
Makbule
Tambas
Department of Radiation Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul, Turkey.
makbule_tambas@hotmail.com
Saban
Secmeler
Department of Medical Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul,
Turkey.
drsabansecmeler@hotmail.com
Orcun
Can
Department of Medical Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul,
Turkey.
orcuncan2004@yahoo.com
Serdar
Arici
0000-0003-2018-6554
Department of Medical Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul,
Turkey.
serdararici@hotmail.com
Nurgul
Yasar
0000-0002-3231-1749
Department of Medical Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul,
Turkey.
yasarnurgul@yahoo.com
Caglayan
Geredeli
0000-0002-3982-7465
Department of Medical Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul,
Turkey.
caglayange@hotmail.com
Cumhur
Demir
0000-0001-7345-6197
Department of Medical Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul,
Turkey.
cdemir@dr.com
Sener
Cihan
0000-0002-3960-4982
Department of Medical Oncology, University of Health Sciences, Okmeydani Training and Research Hospital, 34384, Istanbul,
Turkey.
sener70@yahoo.com
10.31557/APJCP.2018.19.12.3597
Background: Neuroendocrine tumors are a heterogeneous group of tumors that can originate from all of the<br />neuroendocrine cells in the body, mostly from the gastrointestinal tract. In addition to early diagnosis, streaming<br />patients into appropriate prognostic groups is an important component of treatment. In this study, we examined the<br />factors that affect survival in patients we followed in our center between 2000-2016. Methods: The demographic data,<br />clinical and pathological features of patients were obtained from their medical files. TNM staging and tumor grading<br />were performed according to AJCC and WHO 2010 classification. SPSS 15.0 for Windows programme was used for<br />statistical analysis. Results: 85 patients (32 male, 53 female) were included into the study. The median age of the patients<br />was 55,7 (27-83) years. Eighty percent of the tumors were of gastroenteropancreatic system, most commonly stomach<br />(27.1%) origin. Nineteen patients (22.4%) died during follow-up. In univariate analysis; age (p<0,001), stage (p=0.002),<br />primary tumor localization (p=0.005), grade (p<0.001), Ki-67 value (p<0.001), number of metastases (p=0.001) and<br />type of surgery (p<0.001) were found to be factors affecting survival. Age (p=0.024) and Ki67 (p <0.001) were the<br />independent prognostic factors for survival in multivariate analysis. For the cut-off value of 6%, Ki-67 had a sensitivity<br />of 83.3% and specifity of 71.4% for survival determination. Conclusion: Ki-67 ratio and age were the most important<br />factors affecting survival in neuroendocrine tumors in our study. Ki-67 ratio has a high sensitivity and specificity for<br />predicting survival, a cut-off value of 6% may be used to predict survival.
age,Grade,Ki-67,Neuroendocrine tumor,survival
https://journal.waocp.org/article_77050.html
https://journal.waocp.org/article_77050_9287fce9b0419545df74b53707df05e0.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Rhinacanthin-C Extracted from Rhinacanthus nasutus (L.) Inhibits Cholangiocarcinoma Cell Migration and Invasion by Decreasing MMP-2, uPA, FAK and MAPK Pathways
3605
3613
EN
Parichart
Boueroy
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
joomjim_mc@hotmail.com
Sunitta
Saensa‑Ard
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
nunit_94@hotmail.com
Pongpun
Siripong
Natural Products Research Section,
Research Division, National Cancer Institute; Bangkok, Thailand.
pongpun8@yahoo.com
Sakawrat
Kanthawong
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
sakawrat@kku.ac.th
Chariya
Hahnvajanawong
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
hchari@kku.ac.th
10.31557/APJCP.2018.19.12.3605
Cholangiocarcinoma is a malignant tumor with high metastatic and mortality rates. We investigated the effects<br />of rhinacanthin-C on cell proliferation, migration, invasion and the expression of proteins regulating cancer cell<br />invasion-regulated proteins in a cholangiocarcinoma (KKU-M156) cell line. Cytotoxicity of rhinacanthin-C was<br />determined by the SRB assay. Using wound-migration, chamber-migration and chamber-invasion assays, we assessed<br />the effects of rhinacanthin-C against KKU-M156 cells. The activities of matrix metalloproteinases 2 and 9 (MMP-2,<br />MMP-9) and urokinase-type plasminogen activator (uPA) were determined using gelatinase and uPA zymography<br />assays. The expression of invasion-regulated proteins was investigated using western-blot analysis. After treatment<br />with rhinacanthin-C, KKU-M156 cells exhibited antiproliferative effects in a dose-dependent manner with greater<br />efficacy than in Vero cells: IC50 values were 1.50 and 2.37 μM, respectively. Rhinacanthin-C significantly inhibited cell<br />migration and invasion of KKU-M156 cells in a dose-dependent manner. Consistent with this observation, treatment<br />with rhinacanthin-C was associated with a decrease in the expression levels of FAK, p-FAK, MMP-2, and a decrease in<br />the levels of p38-, JNK1/2- and ERK1/2-MAPK pathways as well as inhibiting NF-κB/p65 expression and translocation<br />of NF-κB/p65 to the nucleus. We have shown for the first time that the anti-metastatic effects of rhinacanthin-C on<br />KKU-M156 cells are mediated via inhibition of the expression of invasion-regulated proteins. Rhinacanthin-C may<br />deserve consideration as a potential agent for the treatment of cholangiocarcinoma.
Rhinacanthin-C,Invasion,migration,Metastasis
https://journal.waocp.org/article_80051.html
https://journal.waocp.org/article_80051_d02e21d71a9e0cc71c3d2102d9828579.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Diagnostic Accuracy of Axillary Ultrasonography Compared with Intra-operative Pathological Findings in Patients with Breast Cancer
3615
3621
EN
Alireza
Rezvani
0000-0002-1597-8787
Breast Cancer Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
rezvaniar@sums.ac.ir
Aryan
Zahergivar
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
aryan_zaher123@yahoo.com
Pooya
Iranpour
Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
iranpour@sums.ac.ir
Majid
Akrami
Breast Cancer Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
akramimd@yahoo.com
Sepehr
Kazemi
Breast Cancer Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
sepehr_kazemi1992@yahoo.com
10.31557/APJCP.2018.19.12.3615
Objective: Breast cancer is the most common cancer and leading cause of mortality in women worldwide. Diagnosis of<br />axillary lymph node involvement, frequently by axillary ultrasonography (AUS), is an important step in patients with<br />primary breast cancer, while the gold standard pathological examination is only applicable during surgery. Thus,<br />we aimed to evaluate the predictive value of AUS in detection of lymph node involvement. Methods: A total of 56<br />patients with primary breast cancer, who were candidate of mastectomy were included in this study. A single radiologist<br />performed pre-operative axillary sonography for all the patients and reported the results in a checklist. The results<br />were then compared with intra-operative pathological results of lymph node dissection to evaluate the sensitivity,<br />specificity, positive and negative predictive values of AUS in detection of the disease. Result: The results showed that<br />pre-operative AUS had a sensitivity of 63.3%, specificity of 84.6%, positive predictive value of 82.6%, and negative<br />predictive value of 66.6%. Correlation between axillary lymph node characteristics revealed that the absence of fatty<br />hilum, cortical thickness, and loss of ovality of the lymph nodes were the most specific factors in detection of lymph<br />nodes’ involvement. Conclusion: AUS has a low sensitivity and cannot determine the presence of micro-metastases<br />and suspicious lymph nodes accurately in early stages of the disease, and it seems that defining new parameters may<br />help for increasing the sensitivity and specificity of the axillary lymph node sonography. Apparently, pathological<br />examination remains the gold standard diagnostic method.
Breast Neoplasms,Ultrasonography,lymph nodes,Axilla
https://journal.waocp.org/article_80054.html
https://journal.waocp.org/article_80054_779f1a6bec1192aa354d1c4ff0fa93e9.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Lymph Node Ratio: Is It an Independent Prognostic Factor for Stage III Cutaneous Melanoma?
3623
3627
EN
Abolfazl
Salari
Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex,
Tehran University of Medical Sciences, Tehran, Iran.
abolfazl_salari_70@yahoo.com
Fatemeh
Nili
Department of Pathology, Imam Khomeini Hospital Complex,
Tehran University of Medical Sciences, Tehran, Iran.
f-nili@sina.tums.ac.ir
Amir Mohsen
Jalaeefar
Department Of Surgery, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University Of Medical Sciences, Tehran, Iran.
jalaeefar@gmail.com
Mohammad
Shirkhoda
Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex,
Tehran University of Medical Sciences, Tehran, Iran.
mshirkhoda@sina.tums.ac.ir
10.31557/APJCP.2018.19.12.3623
Objective: Lymph node ratio (LNR) is defined as the ratio of the number of metastatic lymph nodes to the dissected<br />lymph nodes. LNR is a prognostic factor for many tumor types. The present study aimed to evaluate the prognostic<br />value of LNR in melanoma. Methods: This retrospective cohort study was conducted on 123 patients with stage III<br />cutaneous melanoma. Multivariate Cox proportional hazards model was used to evaluate the correlations between LNR<br />and other clinicopathological factors associated with survival. The patients were divided into four groups in terms of<br />the LNR, including groups A (LNR≤0.18), B (0.18<LNR≤0.37), C (0.37<LNR≤0.625), and D (LNR>0.625). Results:<br />Initially, LNR was evaluated as a continuous quantity associated with survival. In the univariate analysis, a significant<br />correlation was observed between LNR, overall survival (OS), and disease free survival (DFS). Meanwhile, the only<br />association observed in the multivariate analysis was between LNR and OS. Increased LNR from group A to group D<br />reduced OS from 46 (±44.09) to 22.5 (±16.33) months (P=0.022). According to the multivariate analysis, prognostic<br />factors in OS were tumor thickness, American joint committee of cancer (AJCC) N stage, interferon administration,<br />and undergoing chemotherapy. Conclusion: According to the results, LNR could be used as an independent prognostic<br />factor for estimating the survival of patients with stage III cutaneous melanoma also designing an effective adjuvant<br />treatment protocol for these patients.
cutaneous melanoma,lymph node ratio,lymph node dissection
https://journal.waocp.org/article_77051.html
https://journal.waocp.org/article_77051_f1d89d53333d830e77930152ebb71521.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Risk Factors and Prognosis of Spontaneously Ruptured Hepatocellular Carcinoma in Thailand
3629
3634
EN
Jitrapa
Kerdsuknirun
Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Thammasat University Hospital, Pathumthani, Thailand.
jittu_tujit@yahoo.com
Virunpat
Vilaichone
Patumwan Demonstration
School, Srinakharinwirot University, Bangkok,Thailand.
virunpat.vil@gmail.com
Ratha-Korn
Vilaichone
0000-0003-4298-9331
Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Thammasat University Hospital, Pathumthani, Thailand.
vilaichone@hotmail.co.th
10.31557/APJCP.2018.19.12.3629
Objective: Hepatocellular carcinoma (HCC) is the fatal cancer worldwide. Spontaneously Rupture remains<br />important complication of HCC. The incidence of spontaneous HCC rupture was high in ASEAN but limited studies<br />were reported. The aim of this study was to evaluate predictors and overall survival of ruptured HCC in tertiary care<br />center in Thailand. Methods: We conducted a retrospective cohort study of HCC patients aged ≥15 years old during<br />January 2012-January 2016 and followed up through June 2016 at Thammasat University Hospital, Thailand. All<br />clinical information, laboratory and radiologic findings were collected from reviewing computer data base of medical<br />records. Results: 333 patients had completely retrievable information. Of which, 51patients (15.3%) had spontaneous<br />ruptured HCC. Clinical symptoms with abdominal discomfort and anemic symptoms were significantly higher in<br />ruptured than non-ruptured HCC groups. (76.47% vs.39.36%: p<0.001, 13.73vs.0.71%, p<0.001). Furthermore, size<br />of tumors, presences of metastasis and serum AFP>200 ng/mL were significantly higher in ruptured than non-ruptured<br />HCC groups (10.29cm. vs. 6.47cm. p<0.001, 17.65% vs. 8.16%, p=0.034, 60.78% vs. 36.88%, p=0.001, respectively).<br />In multivariate analysis, age, abdominal discomfort, anemic symptoms, Child-Pugh score>6 were independent risk<br />factors of HCC rupture (OR=0.96, 95%CI=0.93-0.99, p=0.02; OR=3.47, 95%CI=1.26-9.6, p=0.016; OR=54.51,<br />95%CI=7.09-418.89, p<0.001; OR=2.62, 95%CI=1.09-6.31, p=0.031, respectively). 1-year and 2-year survival rates<br />of ruptured HCC were 66.9% and 44.6% respectively. Conclusions: Age, abdominal discomfort, anemic symptoms<br />and Child-Pugh score>6 might be predictive factors of spontaneous ruptured HCC. Ruptures of HCC remained a fatal<br />disease with poor survival rate in Thailand. Appropriate treatment in early stage could be effective tool to improve the<br />treatment outcomes
Hepatocellular carcinoma,ruptured,Thailand
https://journal.waocp.org/article_77415.html
https://journal.waocp.org/article_77415_ee57f2e6297bb6c362cc09c7c3a6145a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
12
2018
12
01
Prevention of Malignant Transformation of Oral Leukoplakia and Oral Lichen Planus Using Laser: An Observational Study
3635
3641
EN
Karandeep Singh
Arora
0000-0003-1753-2305
Department of Oral Medicine and Radiology, M. M. College of Dental Sciences and Research, Mullana, Ambala, Haryana, India.
drkaranarora@yahoo.com
Rahul
Bansal
Department of Oral Medicine and Radiology, M. M. College of Dental Sciences and Research, Mullana, Ambala, Haryana, India.
rahul85bansal@gmail.com
Shreeyam
Mohapatra
2Department of Oral Medicine and Radiology, SCB Dental College and Hospital, Cuttack, Odisha, India.
shreeyam080@gmail.com
Akshay
Verma
Department of Oral Pathology and Microbiology, Rajasthan
Dental College and Hospital, Jaipur, Rajasthan, India.
dr.akashyavermaop@gmail.com
Sakshi
Sharma
Department of Public Health Dentistry, Bhojia Dental College and Hospital,
Bhud, Baddi, Himachal Pradesh, India.
sakshisharma639@gmail.com
Shubhangi
Pareek
Department of Oral Pathology and
Microbiology, Institute of Dental Sciences, Bhubneshwar, Odisha, India.
shubhi.pareek@gmail.com
10.31557/APJCP.2018.19.12.3635
Objectives: The present observational study was conducted with an aim to evaluate the efficacy of diode laser in<br />management of homogenous oral leukoplakia (OL) and reticular oral lichen planus (OLP), so that these potentially<br />malignant disorders can be limited and further malignant transformation can be prevented. Further the assessment<br />of associated postoperative complications after laser therapy was also carried out. Study Design: Present study was<br />carried out using diode laser 810nm on 60 subjects, of whom 30 subjects were of homogenous OL and 30 subjects<br />were of reticular OLP aged between 20 – 60 years, the diagnosis of which was histopathologically confirmed. Results:<br />Of the 60 subjects none complained of pain during and immediately after surgery with no bleeding at any stage of the<br />procedure. By the end of 3rd day post operative most subjects reported no pain and swelling and very few subjects had<br />negligible pain and swelling when evaluated. On subsequent follow-up of 1,2 and 4 week(s) none of the subject reported<br />of pain, swelling or bleeding and it was noted that all the areas treated with laser had healed without scarring with no<br />signs of recurrence. Fibrosis was seen in two male patients and one female patient treated for OL and OLP respectively.<br />Conclusion: Patient compliance and contentment without any postoperative complications were observed to be of high<br />degree in the present study. Thus diode laser can be considered as a best alternative to conventional surgical treatment<br />modality in managing OL and OLP and preventing its further transformation.
Diode laser,Oral leukoplakia,Oral lichen planus,potentially malignant lesions,Prevention
https://journal.waocp.org/article_80075.html
https://journal.waocp.org/article_80075_f2f7abd7cb326420e8e4a9c4b33f5172.pdf