West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Applied Artificial Intelligence for Tobacco Cessation in the Era of COVID-19: A Perspective
2551
2552
EN
Mrinal
Shete
0000-0003-1304-9658
D Y Patil Dental School, Lohegaon , Pune, India.
shete.mrinal@gmail.com
Anagha
Shete
0000-0003-4070-1963
D Y Patil Dental School, Lohegaon , Pune, India.
dranaghashete@yahoo.com
10.31557/APJCP.2022.23.8.2551
COVID-19 has affected many health services including Tobacco cessation measures. To continue with the strategies used for the de-addiction of tobacco, we need to adapt to the changing times. The use of Artificial Intelligence will help dental health care professionals to reach a larger population, effectively implement measures for tobacco cessation, and meticulous follow-up of patients.
Artificial intelligence,Tobacco cessation,quitline
https://journal.waocp.org/article_90251.html
https://journal.waocp.org/article_90251_599b1100b41478c6a7bcb511d1fc72f7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Serum Lactate Dehydrogenase Enzyme as a Tumor Marker in Potentially Malignant Disorders: A Systematic Review and Meta–Analysis
2553
2559
EN
Wagisha
Barbi
All India Institute of Medical Sciences Patna Bihar, India.
wagishabarbie@gmail.com
Bharathi M
Purohit
0000000342731699
Division of Public Health Dentistry, Centre for Dental Education and Research, National Centre of Excellence for Implementation of National Oral Health Programme, All India Institute of Medical Sciences, New Delhi, India.
bharathipurohit@gmail.com
10.31557/APJCP.2022.23.8.2553
Background: Oral cancer is often preceded by Potentially Malignant Disorders (PMDs) and important role of biochemical markers for early diagnosis has been well documented; however, there is limited evidence of Serum lactate dehydrogenase (SLDH) as an effective biochemical marker in diagnosis of PMDs. The present meta-analysis was conducted to assess if serum LDH can be a used as standard biomarker for PMDs and consequently aid in diagnosis of oral cancer. Methods: A comprehensive search was conducted in Medline, Scopus, Web of Science, EBSCO host, Cochrane databases and Google Scholar for studies evaluating estimation of SLDH in PMDs. Search strategy included all types of studies evaluating level of SLDH in patients with PMDs. PRISMA guidelines were followed for the meta-analysis. Fixed-effects model was used to assess the mean differences in SLDH levels between healthy controls and PMDs. Results: A total number of nine studies were included in meta-analysis after screening for inclusion and exclusion criteria. Potentially malignant disorder was significantly associated with increased serum LDH level compared to healthy controls (pooled SMD: 1.83 (95% CI, 1.52, 2.15) (P < 0.00001; Subgroup analysis of OSMF (Oral Submucous Fibrosis) studies showed significant association with increased serum LDH level compared to healthy controls (pooled SMD: 2.57 (95% CI, 2.16, 2.98; P < 0.00001). Sensitivity analysis for the five studies reflected a significant reduction in I2 values to 24 % (P=0.26). Funnel plots were derived for any evidence of publication bias among the studies. Conclusion: Meta-analysis suggests that SLDH is increased in potentially malignant disorders compared to healthy controls. The results of this metanalysis should encourage use of SLDH as a biomarker in diagnosis of PMDs.
Potentially malignant disorders (PMDs),oral cancer,lactate dehydrogenase enzyme,precancerous lesion
https://journal.waocp.org/article_90222.html
https://journal.waocp.org/article_90222_ac074c5ed57849c9ee54ed6193f259ec.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Comparing Early-Stage Breast Cancer Patients with Sentinel Lymph Node Metastasis with and without Completion Axillary Lymph Node Dissection: A Systematic Review and Meta-Analysis
2561
2571
EN
Naeimeh
Heiranizadeh
Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
hrdcsadri@yahoo.com
Mohammad
Rafiei shahamabadi
Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
mrafie2007@gmail.com
Hamid Reza
Dehghan
Research
Center for Health Technology Assessment and Medical Informatics, School of Public Health, Shahid Sadoughi University
of Medical Sciences, Yazd, Iran.
hamidreza.dehghan@gmail.com
Jamal
Jafari-Nedooshan
Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
jamalnedooshan@yahoo.com
Saeid
Kargar
Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
saeedkargar@yahoo.com
Mohammad
Zare
Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
mohammadzare85@yahoo.com
Abdolhamid
Amooei
Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
ab.amooee@yahoo.com
Seyed Mostafa
Shiryazdi
Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
smshiryazdi@gmail.com
Mohammad Ali
Broomand
Department of Radiation Oncology, Shahid Sadoughi University of Medical Sciences and
Health Services, Yazd, Iran.
mohammadalibroomand@gmail.com
Mohammad Taghi
Moravej
Research
Center for Health Technology Assessment and Medical Informatics, School of Public Health, Shahid Sadoughi University
of Medical Sciences, Yazd, Iran.
mohammadmoravej.mm@gmail.com
Zahra
Sadri
Clinical Research Development Center of Shahid Sadoughi University of Medical Sciences, Yazd.
zsadri33@yahoo.com
10.31557/APJCP.2022.23.8.2561
Background: Currently, the standard method for staging and treatment of axillary lymph nodes for early-stage breast cancer is sentinel lymph node biopsy (SLNB), while axillary lymph node dissection (ALND) is used in cases with palpable axillary lymph nodes or positive SLNB cases. The aim of this review was to compare overall survival (OS), disease-free survival (DFS), and axillary recurrence in early-stage breast cancer patients underwent SLNB or SLNB and completion ALND. Methods: The databases of PubMed, Scopus, and Cochrane Library were searched using the key words of “breast cancer”, “axillary lymph node dissection”, and “sentinel lymph node dissection”. In addition, other sources were searched for ongoing studies (i.e., clinicaltrials.gov). The clinical trials were evaluated based on the Jadad quality criteria, and cohort studies were evaluated according to the STROBE criteria. At the end of the search, the articles were screened independently by two reviewers to check their eligibility to be included in the study. Afterwards, the data were extracted independently by two researchers. Results: After searching the databases, 169 papers were retrieved. However, after removing the duplicates and studying the titles and abstracts of these papers, only ten ones underwent further investigation. After reading full-text of each article, four studies were finalized. Following a manual search, 27 papers were entered into the study for the final evaluation, 11 of which were included in the meta-analysis based on the inclusion and exclusion criteria. The findings showed no significant differences in OS, DFS, and axillary recurrence in early-stage breast cancer patients underwent SLNB or SLNB and completion ALND. Conclusion: The findings did not confirm that ALND improved OS, DFS, and axillary recurrence in patients who were clinically node-negative and positive SLNB.
early-stage breast cancer,axillary lymph node dissection,sentinel lymph node biopsy,survival
https://journal.waocp.org/article_90254.html
https://journal.waocp.org/article_90254_cea4c51495e56ab655c5d1ed2841d913.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
β-Eudesmol Inhibits the Migration of Cholangiocarcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via PI3K/AKT and p38MAPK Modulation
2573
2581
EN
Bishwanath
Acharya
Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Pathum Thani 12120,
Thailand.
bacharya777@gmail.com
Wanna
Chajaroenkul
Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Pathum Thani 12120,
Thailand.
wn_ap39@hotmail.com
Kesara
Na-Bangchang
0000-0001-6389-0897
Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Pathum Thani 12120,
Thailand.
kesaratmu@yahoo.com
10.31557/APJCP.2022.23.8.2573
Background: Cholangiocarcinoma (CCA) is a highly aggressive tumor with a greater risk of distant metastasis. A drug that prevents CCA development and spread is urgently needed. In this research, we investigated the effect of β-eudesmol on the migration and invasion and epithelial-mesenchymal transformation (EMT) of the CCA cell line. Materials and Methods: MTT and transwell assays were used to investigate the antiproliferative activity, as well as activity on cell migration and cell invasion. Real-time PCR and western blot analysis were used to investigate the expression of EMT marker genes and proteins. Results: β-eudesmol was shown to exhibit potent antiproliferative activity (IC50 92.25-185.67 µM) and to significantly reduce CCA cell migration and invasion (27.3-62.7%). At both mRNA and protein levels, it significantly up-regulated the expression of epithelial marker E-cadherin (3-3.4-fold), while down-regulated the expression of mesenchymal markers-vimentin (0.6-0.8-fold) and snail-1 (0.4-0.6-fold). Furthermore, β-eudesmol inhibited PI3K and AKT phosphorylation (0.5-0.8-fold), while activating p38MAPK activity (1.2-3.6-fold). Conclusion: Altogether, the anti-metastatic activity of β-eudesmol might be due to its suppressive effect on EMT via modulating the PI3K/AKT and p38MAPK signaling cascades.
β -eudesmol,cholangiocarcinoma,EMT,migration and invasion,PI3K/Akt
https://journal.waocp.org/article_90237.html
https://journal.waocp.org/article_90237_f95cc0112392c5dac480ea94bad83de5.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Spatial Distribution of Head and Neck Cancer in Chiang Mai, Thailand
2583
2590
EN
Walaithip
Bunyatisai
0000-0002-6675-2948
Data Science Research Center, Department of Statistics, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
walaithip.bun@gmail.com
Somvilai
Chakrabandhu
0000-0002-9860-2098
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
somjee@hotmail.com
Patumrat
Sripan
0000-0002-8337-9524
Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai,
Thailand.
pspatumrat3@gmail.com
Apinut
Rankantha
0000-0001-8826-5158
Department of Statistics, Faculty
of Science, Chiang Mai University, Chiang Mai, Thailand.
apinutdook@gmail.com
Sukon
Prasitwattanaseree
0000-0002-1987-773X
Department of Statistics, Faculty
of Science, Chiang Mai University, Chiang Mai, Thailand.
sprasitwattanaseree@gmail.com
Imjai
Chitapanarux
0000-0002-8552-0149
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
imjai@hotmail.com
10.31557/APJCP.2022.23.8.2583
Background: The incidence of Head and neck (HN) cancers in Thailand is rising and survival rates not improving. Variations of its incidence among geographical areas may due to various contributing factors. Methods: We focused on data from 25 districts within Chiang Mai province, Thailand. The temporal change was described separately into two periods, 2007-2012 and 2013-2018. The OpenBUGS and the Quantum Geographic Information System were utilized to determine the geographical patterns in the incidence of HN cancer and focus on oropharynx. Results: The number of new cases of HN cancer was 1,186, of which 835 cases (70%) were male. Among those patients 548 diagnosed in 2007-2012 and 638 diagnose in 2013-2018. High risk patterns of both overall HN and oropharyngeal cancer incidences were found in the central and southern areas of the province in 2007-2013. However, the geographical patterns of the incidence of oropharyngeal cancer showed the changed pattern, with high RR in central and northern areas in more recent period. Over two periods, the RR of the cancers incidence decrease. The RR of oropharyngeal increased in Fang district and it remained high in Mueang district. Conclusion: This study have highlighted specific areas with a high risk of head and neck cancer and oropharyngeal cancer incidences in Chiang Mai province, along with the spatial inequalities in their distributions, with cluster formation. These results may be helpful in guiding any strategy put in place to respond to the high risk incidence of the cancers in specific areas.
Head and neck cancers,Besag-York-Mollié,Chiang Mai,spatial analysis,Thailand
https://journal.waocp.org/article_90253.html
https://journal.waocp.org/article_90253_f773b35ef5726bb3e1a55ee0515b059e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra
2591
2597
EN
Kailas
D
Datkhile
0000-0001-9222-8579
Department of Molecular Biology & Genetics, Krishna Institute of Medical Sciences, “Deemed to be University”, Taluka-Karad,
Dist- Satara, Pin-415 539, (Maharashtra) India.
hodgeneticslab@kimskarad.in
Pratik
P
Durgawale
Department of Molecular Biology & Genetics, Krishna Institute of Medical Sciences, “Deemed to be University”, Taluka-Karad,
Dist- Satara, Pin-415 539, (Maharashtra) India.
pratikpdurgawale@gmail.com
Rashmi
A
Gudur
Department of Oncology Krishna Institute of Medical Sciences “Deemed to be
University” Taluka-Karad, Dist- Satara, Pin-415 539, Maharashtra, India.
rashmiagudur@gmail.com
Anand
K
Gudur
Department of Oncology Krishna Institute of Medical Sciences “Deemed to be
University” Taluka-Karad, Dist- Satara, Pin-415 539, Maharashtra, India.
anandgudur@gmail.com
Satish
R
Patil
Department of Molecular Biology & Genetics, Krishna Institute of Medical Sciences, “Deemed to be University”, Taluka-Karad,
Dist- Satara, Pin-415 539, (Maharashtra) India.
kddatkhile@gmail.com
10.31557/APJCP.2022.23.8.2591
Background: In last few years several studies all over the world discovered the genetic polymorphisms in different cytochrome P450 genes associated with risk of various cancers, but contradictory outcomes were evidenced in case of cervical cancer risk. In this case-control study we aimed to see whether the polymorphism of CYP2D6 or CYP2E1 genes may or may not be associated with cervical cancer risk in women of rural Maharashtra. Methods: In this case-control study, the association of CYP2D6 and CYP2E1 gene polymorphism with cervical cancer risk was studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The study was conducted with 350 clinically confirmed cervical cancer patients and 350 healthy women in a population of South-Western Maharashtra. The Odds ratio (OR) with 95% confidence interval and p-value were evaluated, where p ≤0.005 was considered as statistically significant. Results: After the analysis of SNP (rs389209) of CYP2D6 and SNPs (rs2031920, rs6413432, rs6413420) of CYP2E1, we noticed that variant allele A of CYP2E1*6 showed significant increase in cervical cancer cases (OR=4.81; 95% CI: 1.57- 14.77; p=0.005). The genotypic distribution of heterozygote G/A genotype of CYP2D6*4 showed negative association with cervical cancer development when age of cancer occurrence (OR=0.41; 95% CI: 0.27- 0.61; p<0.0001) and tobacco history (OR=0.35; 95% CI: 0.20- 0.59; p=0.0001) was considered. Conclusion: The findings from this study supported that rs6413432 SNP of CYP2E1*6 increased cervical cancer risk in the studied rural women population.
Cervical cancer,CYP2D6,CYP2E1,Genetic polymorphism,PCR-RFLP
https://journal.waocp.org/article_90238.html
https://journal.waocp.org/article_90238_bd23d182a604236cbe6c86b692389cb5.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Cytology, High-Risk Human Papillomavirus Testing and Serum CA19-9 in a Large Cohort of Patients with Invasive Cervical Adenocarcinomas: Correlation with a New Pathogenetic Classification
2599
2605
EN
Haiyan
Shi
Department of Surgical Pathology and Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Zhejiang
Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, School of
Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
shihy1991@zju.edu.cn
Yu
Ma
Department of Surgical Pathology and Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Zhejiang
Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, School of
Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
5308007@zju.edu.cn
Ying
Shao
Department of Surgical Pathology and Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Zhejiang
Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, School of
Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
shaoying0559@zju.edu.cn
Yan
Zhang
Department of Surgical Pathology and Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Zhejiang
Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, School of
Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
zhangyan88@zju.edu.cn
Bingjian
Lu
Department of Surgical Pathology and Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Zhejiang
Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, School of
Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
lbj@zju.edu.cn
10.31557/APJCP.2022.23.8.2599
Aims: This study aims to investigate the screening value of cytology, high-risk human papillomavirus (hrHPV) testing and serum CA19-9 in cervical adenocarcinomas. Materials and Methods: We employed HPV RNA in situ hybridization and immunohistochemistry to reclassify 209 cervical adenocarcinomas according to the International Endocervical Adenocarcinoma Criteria and Classification (IECC). We analyzed the diagnostic value of cytology, hrHPV testing and serum CA19-9 in these tumors and their detection variance among IECC histotypes. Results: We found that the sensitivity of cytology or hrHPV test alone was 74.1% (129/174) or 72% (131/182), respectively. Non-HPV related adenocarcinoma showed a lower detection rate of cytology (60%, 27/45 vs. 79.1%, 102/129, p=0.017) or hrHPV testing (9.8%, 4/41 vs. 90.1%, 127/141, p<0.0001), compared to HPV-related adenocarcinomas. The cytology and hrHPV co-testing significantly demonstrated a higher sensitivity (151/165, 91.5%) than single test alone (p<0.001). Nevertheless, the sensitivity of co-testing was substantially lower for gastric-type adenocarcinoma (GAC) (74.1%, 20/27) than that for non-GAC (94.9%, 131/138) (p=0.001). Serum CA19-9 (>40 U/mL) identified 44.1% (15/34) GACs including 75% (6/8) that were missed by co-testing, much higher than for non-GACs (10.7%, 19/177; p<0.001). The combination of cytology, hrHPV test and serum CA19-9 enhanced the detection rate of GACs (92.9%, 26/28). Conclusion: We conclude that cytology and hrHPV co-testing is not very effective for non-HPV related adenocarcinoma, particularly for GAC. As such, additional serum CA19-9 should be given in women with potential cancer risks.
cervical adenocarcinoma,gastric-type,Cytology,high-risk human papillomavirus (hrHPV) testing,CA19-9
https://journal.waocp.org/article_90223.html
https://journal.waocp.org/article_90223_61e930673e73e94feb654d093c838d4f.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Prognostic Role of Oncogenic and Tumor-Suppressing miRNA Types in Egyptian Uterine Cancer Patients
2607
2615
EN
Elsayed
I
Salim
0000-0002-0327-5355
Department of Zoology, Research Lab. for Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta 31527,
Egypt.
elsayed.salim@science.tanta.edu.eg
Doha
M
Beltagy
0000-0003-2689-2695
Department of Chemistry, Biochemistry Division, Faculty of Science, Damanhour University, Damanhour 22516, Egypt.
dohabeltagy@sci.dmu.edu.eg
Nehal
M
Elmashad
0000-0002-7570-5748
Department of Clinical Oncology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
nehal.elmashad@med.tanta.edu.eg
Mohamed
A
Abodonia
Department of Zoology, Research Lab. for Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta 31527,
Egypt.
mohamed_abodonia@yahoo.com
10.31557/APJCP.2022.23.8.2607
Objective: Uterine or endometrial cancer affects many women postmenopausal and may reach an advanced stage before signs and symptoms can be noticed. Micro RNAs (miRNAs), non-coding RNAs, play key roles in gene expression regulation and are linked to cancer. This study aimed to elucidate whether some specific types of miRNAs (miRNA133-a, miRNA-21, miRNA-205) can act as prognostic or diagnostic biomarkers for endometrial carcinoma (ER) in Egyptian patients. Methods: Blood samples from 36 patients suffering from endometrial carcinoma and 15 healthy volunteers were tested for expression levels of miRNA 133a-2, 21 and 205. Results: The expression levels of miRNA133a-2, miRNA-21, and miRNA-205 were significantly elevated in ER patients when compared with the control group, the highest levels were noticed in miRNA133a-2. The CA125 levels were significantly higher in all patients as compared with healthy subjects. Conclusion: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients. The studied miRNA species warrant validation for prospective targeting inhibitory protocols in EC.
endometrial carcinoma,miR133a-2,miR-21,MiR-205,Egyptian patients
https://journal.waocp.org/article_90224.html
https://journal.waocp.org/article_90224_cc49bd6377ab538b51ed062326b227d1.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Association of the Manganese Superoxide Dismutase (Mn-SOD) Gene C47T Polymorphism with Lung Cancer: A Case-Control Study
2617
2621
EN
Wisam
H
Hoidy
Department of Chemistry, College of education, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.
wisam.hoidy@qu.edu.iq
Shaimaa
M
Esaa
Department of Chemistry, College of education, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.
shaimaa.essa@qu.edu.iq
Mohammed
Hamza
Al-Saadi
Department of Internal Medicine, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.
mohammed_1982@gmail.com
10.31557/APJCP.2022.23.8.2617
Objective: The objective of this study was to determine the association between manganese superoxide dismutase (Mn-SOD) gene C47 T polymorphism and the risk of malignant lung cancer in Iraqi smokers. Methods: Blood samples were obtained from 260 lung cancer patients (88 females and 172 males) and 295 healthy individuals (91 females and 204 males). DNA was extracted from blood samples and the SOD2 gene was amplified using specific primers. The nucleotide sequences of the SOD2 gene were analyzed by using BLAST server at National Center for Biotechnology Information (NCBI) and the Raptorx app. Results: TT, CT, and CC genotypes concentrations were 48.1%, 33.2%, and 18.7%, respectively, in the control group. The concentrations of TT, CT, and CC genotypes were 43.5%, 31.5%, and 25%, respectively, in the case group. There were no statistical differences between cases and controls in terms of genotype frequency of SOD2C47T polymorphism. We observed that SOD2C47T polymorphism CT genotype did not increase the risk of lung cancer development compared to those with TT genotype (OR= 0.951, 95% CI = 0.648-1.396; P = 0.798). In addition, it was observed that CC genotype did not increase the risk of lung cancer development in comparison with TT genotype ( OR=0.673, 95% Cl=0.435-1.041: P=0.075).Conclusion: These results indicated that there was no association between SOD2C47T polymorphism and the risk of lung cancer development in Iraqi smokers.
Sod2,Lung cancer,Polymorphism
https://journal.waocp.org/article_90229.html
https://journal.waocp.org/article_90229_8d786c1d179af2a863e250e25cde0656.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Synergistic Cytotoxic and Antimigratory Effect of Brazilein and Doxorubicin on HER2-Overexpressing Cells
2623
2632
EN
Sri
Handayani
0000-0001-5677-779X
Research Center for Food Technology and Processing, National Research and Innovation Agency (BRIN), JL. Jogja - Wonosari, km 31.5, Yogyakarta, Indonesia
srih016@lipi.go.id
Ratna
Asmah
Susidarti
0000-0002-0973-441X
Cancer Chemoprevention
Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
ratna_asmah@ugm.ac.id
Rohmad
Yudi
Utomo
0000-0003-4803-9417
Cancer Chemoprevention
Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
rohmad.yudi.utomo@mail.ugm.ac.id
Edy
Meiyanto
0000-0002-0886-6322
Cancer Chemoprevention
Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
edy_meiyanto@ugm.ac.id
Riris Istighfari
Istighfari
Jenie
0000-0002-0230-6260
Cancer Chemoprevention
Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
riris_jenie@ugm.ac.id
10.31557/APJCP.2022.23.8.2623
Objective: The present research aims to report cytotoxic and antimigratory activities of the oxidized form of brazilin, i.e., brazilein, and the effects of the combination of brazilein-doxorubicin on MCF-7/HER2 cells. Methods: The MTT assay was conducted to test the cytotoxic activity, while flow cytometry with PI and PI-annexin V staining were respectively performed for cell cycle and apoptosis analyses. Migration and invasion analyses were assessed via Boyden chamber assay, while HER2, Rac1, p120, MMP2, and MMP9 protein levels were determined by immunoblotting and gelatin zymography. Molecular docking of ligands with HER2, Src, PI3Kα, PI3KΔ, and PI3Kγ proteins was evaluated using MOE 2010. Results: The MTT assay showed that the IC50 value of brazilein against MCF-7/HER2 cells was 51 ± 2.1 µM. Moreover, brazilein and its combination with doxorubicin-induced G2/M accumulation and apoptosis. Combination of brazilein-doxorubicin inhibited cell migration and tended to decrease HER2, Rac1, p120, MMP2, and MMP9 protein expression levels. Based on our molecular docking study, the docking score of brazilein with PI3Kγ is comparable to that of the native ligand. Conclusion: Taken together, a combination of brazilein-doxorubicin exhibited synergistic cytotoxic and antimigratory effects on MCF-7/HER2 cells.<br />
Combination therapy,Caesalpinia sappan L,matrix metalloproteinase,PI3K,Molecular docking
https://journal.waocp.org/article_90230.html
https://journal.waocp.org/article_90230_b13178eac62d69fffeaaa4434b21c2c2.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Effective Method for Nurses Education: Gaming versus Lecturing
2633
2642
EN
Izzeldeen
Almashayek
Pediatric Ward, King Hussein Cancer Center, Amman, The Hashimate kingdom of Jordan.
ezzeddini@yahoo.com
Hisham
Al-Khateeb
Pediatric Ward, King Hussein Cancer Center, Amman, The Hashimate kingdom of Jordan.
Mustafa
Bader
Pediatric Ward, King Hussein Cancer Center, Amman, The Hashimate kingdom of Jordan.
10.31557/APJCP.2022.23.8.2633
Introduction: There were many educational methods used in teaching nursing students and nursing staff, such as traditional lecturing and game-based learning; there was no consensus in the literature on the best teaching method. The study aimed to investigate the effectiveness of game-based learning versus traditional lecturing on the knowledge acquisition of newly employed nurses. Materials and Methods: Pretest and posttest quasi-experimental was used to conduct this study in an oncology center located in Amman, Jordan. 156 newly employed nurses participated in the study, 70 in the lecture group, and 86 in the game group, nurses from both groups were assigned to each learning group according to their employment time during orientation period (first month of employment). For lecture group, new employed nurses were assigned in two different times. For the game group, new employed nurses were assigned in four different times. We use an instrument composed of fifteen questions measuring nurse’s knowledge acquisition regarding pressure injury, this instrument was used as pretest and posttest for both learning groups. Results: There was a significant difference between pretest and posttest scores in the lecture group (P= < 0.001), and there was a significant mean difference between pretest and posttest scores in the game group (P= < 0.001), which indicates that both educational methods had a positive impact on nurse’s knowledge. However, there was a significant mean difference between the posttest scores between game group and lecture group to the favor of the lecture group (mean=8.17, 9.00 respectively, P =0.003). Discussion: The current study showed that lecture was more effective than the game in knowledge acquisition. More studies with a larger sample are needed to evaluate the game’s effectiveness as an educational method versus lecture.
Teaching strategies,Education,Nurses,game,traditional lecturing
https://journal.waocp.org/article_90247.html
https://journal.waocp.org/article_90247_378c6a53930a8876f4fc26d26d43ece4.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Ovarian Cancer-Self Assessment: An Innovation for Early Detection and Risk Assessment of Ovarian Cancer
2643
2647
EN
Siti
Salima
0000-0002-8616-086X
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.
s.salima@unpad.ac.id
Anita
Rachmawati
0000-0003-3365-7167
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.
anita.rachmawati@unpad.ac.id
Ali
Budi
Harsono
0000-0001-6342-321X
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.
ali.budi@unpad.ac.id
Febia
Erfiandi
0000-0002-4836-5899
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.
febiaerfiandi@gmail.com
Hilman
Fauzi
0000-0003-1685-9533
Biomedical
Engineering, Faculty of Electrical Engineering, Telkom University, Bandung, Indonesia.
hilmanfauzitsp@telkomuniversity.ac.id
Heti
Prasekti
0000-0002-2592-2082
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.
hprasekti@gmail.com
Rena
Nurita
0000-0002-6004-3497
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.
renanurita@gmail.com
10.31557/APJCP.2022.23.8.2643
Objective: The modality to detect ovarian cancer at an early stage is very limited. Early diagnosis determines the prognosis. This study aimed to develop a risk assessment tool for early detection of ovarian cancer using artificial intelligence. To accomplish this, the presence of ten signs and symptoms reported by patients with ovarian cancer was assessed. Methods: This study was carried out as a cohort study of patients diagnosed with suspected ovarian tumors undergoing cytoreduction operation at Hasan Sadikin Hospital, Bandung, from December 2019 to September 2020. Compared to ovarian cancer self-assessment through questionnaire, postoperative histopathology in patients with suspected ovarian tumors. The questionnaire proceeded by artificial intelligence is grouped into risk and no risk. Statistical analyses were done using Chi-Square and Exact Fisher Test. Result: In total, 115 patients included in this study. The differences were statistically significant in terms of the six variables (abdominal bloating, nausea/vomiting, decreased of appetite, fullness, menstrual disturbance, and weight loss) ovarian cancer self-assessment compared to postoperative histopathology with a tendency towards benign ovarian tumors (p<0.05), while there was no statistically significant difference in the four variables (abdominal enlargement, abdominal pain, urinating disturbance, and defecation disturbance) (p>0.05). According to the artificial intelligence grouping, fifty-five patients were at risk, and sixty patients were not at risk. The Fifty-five risk patients were related with postoperative histopathology diagnosis (with RR 0.682 and CI 95% 0.519-0.895). Conclusion: Risk assessments based on ovarian cancer self-assessment unfortunately were not comparable to postoperative histopathology as a single predictor. Ten variables in ovarian cancer artificial intelligence self-assessment for early detection needs improvement in adding another variable like tumor marker and ultrasonography assessment.
Keywords: artificial intelligence,Malignancy,Ovarian Cancer,Screening,self-assessment
https://journal.waocp.org/article_90245.html
https://journal.waocp.org/article_90245_4364e60cdc08d6a2138cb1d7c31090b4.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
The Relationship between Circulating Irisin and Oxidative Stress in Gastric and Colorectal Cancer Patients
2649
2654
EN
Ahmed
Abd
Tumer
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
tootbar91@yahoo.com
Farah
A.
Rashid
0000-0001-7211-6158
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
far@sc.nahrainuniv.edu.iq
10.31557/APJCP.2022.23.8.2649
Objective: Gastric and colorectal cancers are two obesity-related cancers. Irisin is a dipo-myokine with an important role in the body’s energy homeostasis. Oxidative Stress has a crucial role in tumorigenesis. Therefore, this study aims to investigate the association of circulating irisin with oxidative stress in gastric and colorectal cancer patients. Methods: A case-control study involving 62 gastric and colorectal cancers and 22 healthy individuals was carried out. Serum irisin and Total Antioxidant Capacity were measured by sandwich enzyme-linked immunosorbed assay (ELIZA) kits. Total Oxidative Stress (TOS) was measured using colorimetric methods and oxidative stress index (OSI) was also calculated. Results: Serum irisin decreased significantly (p<0.0001) in gastric and colorectal cancer cases compared to healthy individuals. The TOS and OSI levels increased significantly (p<0.0001) in gastric and colorectal cancer cases compared to healthy individuals. No significant correlation was found in terms of irisin, TOS, TAC, and OSI in gastric and colorectal cancer cases and control groups. Conclusion: Circulating irisin decreases and oxidative stress increases in gastric and colorectal cancers. There is no correlation between irisin and oxidative stress. The mechanism by which irisin is associated with oxidative stress is still not clear.
colorectal cancer,Gastric cancer,irisin,oxidative stress
https://journal.waocp.org/article_90239.html
https://journal.waocp.org/article_90239_0eef0a6448535d01edd6125be6bac420.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Genomic Pattern of GSTM1 and T1 Gene Null polymorphism of Head and Neck Cancer Patients in Eastern India
2655
2659
EN
Richa
Surit
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences Sheikhpura, Patna, Bihar, India.
richasurit@gmail.com
Santosh
Kumar
0000-0002-3270-0488
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences Sheikhpura, Patna, Bihar, India.
santoshjik6@gmail.com
Dinesh
Kumar
Sinha
0000-0002-4454-8989
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences Sheikhpura, Patna, Bihar, India.
drdineshkumarsinha@gmail.com
Ravi
Shekhar
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences Sheikhpura, Patna, Bihar, India.
ravishekhar1974@yahoo.com
10.31557/APJCP.2022.23.8.2655
Objective: Homozygous deletion i.e., null polymorphism of the Glutathione S transferases genes hinders detoxification reactions by altering the sensitization of glutathione s transferases enzymes. Hence, we analysed the association between the GSTM1 and GSTT1 gene polymorphisms and head and neck cancer (HNC). Methods: The study consists of 238 healthy controls and 160 diagnosed cases of HNC, who attended the Regional Cancer Centre, Indira Gandhi Institute of Medical Sciences (a tertiary care hospital). DNA was extracted from whole blood of patients and control using Qiagen DNA extraction kit. GSTM1 and GSTT1 gene polymorphisms were examined using PCR and agarose gel electrophoresis. Results: GSTM0 null polymorphism was 26.25% and 15.13% in cases and control respectively. GSTT0 null polymorphism was observed in 18.13% cases and 8.82% in control groups. The GSTM0 null polymorphism was present significantly in case group as compared to control group (OR = 1.997, p = 0.006). There was also significant association of GSTT0 null polymorphism with case group as compared to control group (OR = 2.288, p = 0.006). The combined genotypes were also analysed. GSTM0T1 genotype (n = 27) was found to be most common among HNC group followed next by GSTM0T0 double deletion (n =15). Conclusion: The result indicated that there was strong association of GSTM0 and GSTT0 null polymorphism in those patients. The combined genotypes i.e., GSTM0T1 and GSTM0T0 null polymorphism also showed significant association in HNC patients.
Glutathione-s-transferase M1 gene,Glutathione-s-transferase T1 gene,null polymorphism,head and neck cancer
https://journal.waocp.org/article_90231.html
https://journal.waocp.org/article_90231_16a26ace088495f080a2c2dbcbaa13bc.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Addition of Gallic Acid Overcomes Resistance to Cisplatin in Ovarian Cancer Cell Lines
2661
2669
EN
Najwa
Al Balushi
Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box 35, PC 123, AlKhoud, Muscat, Oman.
n.km@windowslive.com
Syed
Imran
Hassan
0000-0003-1839-184X
Department of Chemistry, College of Science, Sultan Qaboos University, P. O. Box 36, PC 123, AlKhoud, Muscat,
Oman.
s.hasan@squ.edu.om
Nada
Abdullah
Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box 35, PC 123, AlKhoud, Muscat, Oman.
nadaabdulla111@gmail.com
Buthaina
Al Dhahli
Department of Allied Health Sciences, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box 35, PC 123, AlKhoud, Muscat, Oman.
baldhahli@squ.edu.om
Shadia
Al Bahlani
Department of Allied Health Sciences, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box 35, PC 123, AlKhoud, Muscat, Oman.
bahlani@squ.edu.om
Ikhlas
Ahmed
Department of Pharmacology and Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box 35, PC 123, AlKhoud, Muscat, Oman.
ianewlook@gmail.com
Benjamin
K
Tsang
0000-0003-1213-3946
Departments of Obstetrics & Gynecology, Cellular & Molecular Medicine and the Interdisciplinary School of Health Sciences, and the Centre for Infection, Immunity and Inflammation, University of Ottawa; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1N 6N5, Canada.
btsang@ohri.ca
Sergey
Dobretsov
0000-0002-1769-6388
Department of Marine Science & Fisheries, College of Agricultural & Marine Sciences, Sultan Qaboos University, P. O. Box 34, PC 123, AlKhoud, Muscat, Oman.
sergey@squ.edu.om
Yahya
Tamimi
Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box 35, PC 123, AlKhoud, Muscat, Oman.
yahyatam@squ.edu.om
Ikram A
Burney
Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box 35, PC 123, AlKhoud, Muscat, Oman.
ikramburney@hotmail.com
10.31557/APJCP.2022.23.8.2661
Objective: Ovarian cancer is one of the leading causes of cancer-related mortality in women, and is often associated with drug resistance. Therefore, finding effective drugs, including naturally derived compounds, is urgently needed. Herein, we aimed to test the anti-cancer potential of gallic acid monohydrate (GA) and its congeners on cisplatin-sensitive (A2780S), and resistant (A2780CP) ovarian cancer and normal ovarian (HOSE6-3) cell lines. Methods: Cytotoxicity was assessed by AlamarBlue and CCK08 assays by exposing cells to different concentrations of cisplatin (0-21µg/mL), GA and its congeners (0-100µg/mL), and a combination of GA and cisplatin. Apoptosis was estimated by Hoechst stain and monitoring the relative RNA expression of the apoptotic effector caspase-3 using qRT-PCR. Results: GA decreased cell viability in a concentration-dependent manner in all cell lines, with an IC50 of 19.39µg/mL (A2780S), 35.59 µg/mL (A2780CP), and 49.32µg/mL (HOSE6-3). GA displayed higher cytotoxicity than its congeners. An apoptotic rate estimation of approximately 20% and 30% was obtained in A2780S and A2780CP. While the cytotoxicity observed with cisplatin and GA was comparable, combining the two enhanced the cytotoxicity significantly, especially in the A2780CP cell line (p<0.05). Conclusion: These data suggest that GA may help overcome the resistance. Hence, the cytotoxic effects of GA, especially on chemo-resistant ovarian cancer cells merit further investigation.<br />
Ovarian Cancer,Gallic acid,Cisplatin,Cytotoxicity,Chemo-resistance
https://journal.waocp.org/article_90248.html
https://journal.waocp.org/article_90248_f16eb118cc43f608aac911b54cd13041.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
In Vitro Study on Effect of Zinc Oxide Nanoparticles on the Biological Activities of Croton tiglium L. Seeds Extracts
2671
2686
EN
Wael Mahmoud
Aboulthana
http://orcid.org/0000-0002-4848-0731
Biochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt.
wmkamel83@hotmail.com
Nagwa
Ibrahim
Omar
Biochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt.
nagwam2012@gmail.com
Amal
Mohamed
El-Feky
0000-0002-4805-3254
Pharmacognosy Department, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt.
ammelfeky@hotmail.com
Enas
Ahmed
Hasan
Egyptian Organization for Biological Products & Vaccines (Vacsera), Giza, Egypt.
enas_ahmed515@yahoo.com
Noha
El-Sayed
Ibrahim
0000-0002-7176-4687
Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt.
nohaelsayed855@gmail.com
Ahmed
Mahmoud
Youssef
0000-0002-6501-6658
Packaging Materials Department, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt.
drahmadyoussef1977@gmail.com
10.31557/APJCP.2022.23.8.2671
Objective: Croton tiglium L. seeds were studied against colon cancer induced chemically in rats after incorporating silver nanoparticles (Ag-NPs) but the body has no the ability to discrete silver or silver ions. Therefore, the present study was designed to reveal the biological activities of different C. tiglium L. seeds extracts incorporated with zinc oxide nanoparticles (ZnO-NPs). Results: It was found that C. tiglium L. seeds provided with high contents of total protein (27.43 g/100g), carbohydrate (18.29 g/100 g) and lipid (46.31 g/100 g). The chromatographic techniques revealed that concentrations of the predominant compounds increased in all studied extracts (ethanolic, aqueous and petroleum ether) after incorporating ZnO-NPs. The in vitro biological activities showed that the aqueous extract possessed the highest antioxidant and scavenging activities. It exhibited the highest inhibitory effect on α-amylase (41.89%) and acetyl cholinesterase (AChE) (23.00%) in addition to its higher anti-arthritic activity. All the biological activities increased after incorporating ZnO-NPs. It showed the highest cytotoxic activity that increased after incorporating ZnO-NPs against human colon carcinoma (CACO-2) cells. Therefore, this extract was selected for undergoing further studies on CACO-2 cells. The aqueous extract incorporated with ZnO-NPs arrested growth of CACO-2 cells at G2/M and increased percentage of total apoptotic cells and necrosis. The median lethal dose (LD50) showed that the extracts incorporated with ZnO-NPs were safer than the native extracts. Conclusion: The study showed that the aqueous extract was the most active extract that consequently exhibited promising biological activities after incorporating ZnO-NPs.
Croton tiglium seeds,Zinc Oxide Nanoparticles,Green Nanotechnology,Biological activity,Toxicity
https://journal.waocp.org/article_90258.html
https://journal.waocp.org/article_90258_4aca6d57ad39cf076f2f83625485fa16.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Clinical Significance of MiR-130b and MiR-125b as Biomarkers in Hepatocellular Carcinoma
2687
2693
EN
Sherin Sobhy
El-Naidany
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine Menoufia University, Egypt.
sherinsobhy@ymail.com
Ebrahim
Zid
Department
of Organic chemistry, Faculty of Science, Menoufia University, Egypt.
ifzeid36@gmail.com
Fatma
M
Reda
Chemistry Department, Faculty of Science, Menoufia
University, Egypt.
fatmareda285@gmail.com
Ali
Nada
Hepatology Department, National Liver Institute, Menoufia University, Egypt.
alinada@yahoo.com
Eman
A M
Fouda
Department of Biochemistry,
Faculty of Science, Menoufia University, Egypt.
e_a_f1110@yahoo.com
10.31557/APJCP.2022.23.8.2687
Objective: This study aimed to assess the role of miR-130b and miR-125b expression in Hepatocellular Carcinoma (HCC) progression. Subjects and Methods: This study was carried out on 150 subjects classified into three groups: Group I, 50 healthy controls; Group II, 50 patients with liver cirrhosis; Group III, 50 patients with HCV related HCC. The controls were frequency matched based on age and sex with the other groups. All individuals were subjected to testing for liver function, alpha-fetoprotein (AFP), and viral markers. miR-130b and miR-125b were detected in plasma using a quantitative real-time RT-PCR. Results: miR-130b was significantly upregulated, whereas miR-125b was significantly downregulated in HCC patients compared with cirrhotic patients and healthy controls. There was a significant correlation between miR-130b and AFP and tumor size. Receiver operating curve (ROC) analyses suggested that plasma miR-130b had a significant diagnostic value for HCC with a sensitivity of 92% and a specificity of 77.5%. A sensitivity of 85.5% and a specificity of 82.5% was observed for miR-125b for HCC. Conclusion: Plasma miR-130b and miR-125b may play a role in disease progression and development of HCC and may act as potential biomarkers for the diagnosis of HCC.
Keywords: miR-130,miR-125b,Liver Cirrhosis,hepatocellular carcinoma (HCC)
https://journal.waocp.org/article_90255.html
https://journal.waocp.org/article_90255_b26149a24dcb54c346c2cafb7f2ca1f9.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Efficacy of Adjuvant Transarterial Chemoembolization Combined Antiviral Therapy for HBV-Related HCC with MVI after Hepatic Resection: A Multicenter Study
2695
2703
EN
Yupeng
Tang
Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350005, China.
typ0422@126.com
Jinyu
Zhang
Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350005, China.
drjinyu0310@163.com
Guixiang
Chen
Department of Operating theatre, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350005, China.
360906354@qq.com
Jinhua
Zeng
Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350005, China.
zengjinhua1207@hotmail.com
Jianxing
Zeng
Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350005, China.
zjx_20051@163.com
10.31557/APJCP.2022.23.8.2695
Background: Efficacy of transarterial chemoembolization (TACE) combined antiviral therapy (AVT) on long-term outcome in hepatitis B virus-related HCC with microvascular invasion (MVI) after hepatic resection is unclear. Methods: A multicenter retrospective study was conducted. All patients were divided into four groups according to postoperative adjuvant therapy (control group, AVT group, TACE group, and combined group). The overall survival (OS) and recurrence-free survival (RFS) were analyzed. Results: A total of 1090 patients were enrolled in this study, including control group (n=319), TACE group (n=152), AVT group (n=335) and combined group (n=284). Multivariate Cox analysis showed that postoperative adjuvant AVT and TACE were the independent protective factors for OS and RFS. The median OS among the control group, TACE group, AVT group, and the combined group were 16.44, 18.36 months, 38.88 months, and 48.24 months respectively(p<0.01). The median RFS among 4 group were 4.68, 5.40 months, 8.64 months and 10.32 months respectively(p<0.01). Conclusions: Postoperative adjuvant TACE and AVT were the independent protective factors associated with mortality and tumor recurrence in HBV-related HCC with MVI after resection. This combined treatment strategy may provide useful clinical significance in the prevention of tumor recurrence in these patients.
Hepatocellular carcinoma,curative hepatectomy,long-term outcome,transarterial chemoembolization,antiviral therapy
https://journal.waocp.org/article_90240.html
https://journal.waocp.org/article_90240_a3b1ccc638c903bf745f00cf6230b7bf.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
HPV16-E6/E7 Oncogene Mutation and p53 Expression among Indonesian Women with Cervical Cancer
2705
2711
EN
I Nyoman Bayu
Mahendra
0000-0001-9336-8186
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Faculty of Medicine Udayana University/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.
bayu@unuc.ac.id
Pande
Kadek Aditya
Prayudi
0000-0002-1976-2043
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Faculty of Medicine Udayana University/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.
prayudipande@yahoo.com
Ida Bagus Nyoman Putra
Dwija
Department of Clinical Microbiology, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia.
putradwija@unud.ac.id
Ketut
Suwiyoga
0000-0002-3609-119X
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Faculty of Medicine Udayana University/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali, Indonesia.
ketutsuwiyoga@unud.ac.id
10.31557/APJCP.2022.23.8.2705
Objective: To characterize HPV16 E6/E7 mutation and its association with p53 expression among Indonesian women with cervical cancer. Methods: This is a cross-sectional study involving 31 Indonesian women with pathologically proven cervical cancer and HPV16 infection. Data about the clinical characteristics of the study population were obtained from the medical records. Biopsy specimen of the cervical cancer mass from each study participant was obtained for DNA isolation. The ORFs of E6 and E7 genes were amplified using specific primer designed according to K02718/HPV16R gene sequence obtained from GenBank. Sequencing was performed using software program MEGA10. HPV16 E6 and E7 prototype sequences for nucleotide alignment (HPv16. P, GenBank Access code: NC_001526) was selected from European variant. The sequence of nucleotide and amino acid was aligned using software program BioEdit. p53 expression was evaluated through immunohistochemistry and quantified using immunoreactivity score (IRS). Results: Twelve subjects (38.7%) present with E6 and E7 mutation. Median age, parity, stage and histologic type of the tumour did not associate with E6/E7 mutation. E6 and E7 mutation rate was 25.8% (8/31) and 12.9% (4/31), respectively. Seven single nucleotide changes were identified within the E6 and E7 oncogenes, including four non-synonymous and three synonymous mutations. E6 T27C was the most prevalent mutation (16.1%). Nonsynonymous mutations were more prevalent within E7 gene (9.6%) (N29T, N29S, and R77C). Median IRS did not differ between HPV16-E6/E7 variants and wildtype (p value = 0.990). There was no association between E6/E7 mutations and p53 expression in Indonesian women with cervical cancer (PR 1.4, 95% CI: 0.29-6.77, p value = 0.704). Conclusions: HPV16 E6 mutation was more prevalent than E7 mutation among Indonesian women. There was no association between E6/E7 mutation and p53 expression level.
HPV16,E6 oncogene,E7 oncogene,Mutation,Indonesian Women
https://journal.waocp.org/article_90249.html
https://journal.waocp.org/article_90249_b27b8d81447868a91030fc93c4a36cb0.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
The Optimal Cut-Off Point of the ADNEX Model for the Prediction of the Ovarian Cancer Risk
2713
2718
EN
Le
Lam Huong
0000-0003-2872-0344
Department of Obstetrics and Gynecology, University of Medicine & Pharmacy, Hue University, Vietnam.
lelamhuong@hueuni.edu.vn
Nguyen
Thi Phuong Dung
0000-0003-2514-0117
Department of Obstetrics and Gynecology, University of Medicine & Pharmacy, Hue University, Vietnam.
dungnguyen94711@gmail.com
Vo
Hoang Lam
0000-0002-8617-2887
Department of Obstetrics and Gynecology, University of Medicine & Pharmacy, Hue University, Vietnam.
hoanglam04031997@gmail.com
Nguyen
Tran Thao Nguyen
0000-0001-5627-5992
Department of Obstetrics and Gynecology, University of Medicine & Pharmacy, Hue University, Vietnam.
nguyen.ngtran@gmail.com
Le
Minh Tam
0000-0001-6225-3108
Department of Obstetrics and Gynecology, University of Medicine & Pharmacy, Hue University, Vietnam.
dr.lamhuong@gmail.com
Nguyen
Vu Quoc Huy
0000-0002-4744-7059
Department of Obstetrics and Gynecology, University of Medicine & Pharmacy, Hue University, Vietnam.
lelamhuong19@yahoo.com
10.31557/APJCP.2022.23.8.2713
Objective: This study aimed to assess the effectiveness and determine the optimal cut-off point of the ADNEX model in women presenting with a pelvic or adnexal tumor. Method: All women presented with adnexal mass and were scheduled for operation at Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital, Vietnam during June 2019 – May 2021 were included and categorized according to their histopathologic reports into ovarian cancer groups and benign ovarian tumor groups. Multivariable logistic regression was used to explore for potential predictors. The ADNEX model with and without CA125 was used to assess the risk of ovarian cancer preoperative. The goldden standard to evaluate the accuracy of ultrasonography using the ADNEX model was the pathological report. In addition, the accuracy as well as optimum cut-off point of the ADNEX model was estimated with and without CA125. Results: A total of 461 participants were included in analysis and predictive model development, 65 patients in ovarian cancer group and 361 in benign tumor group. The ADNEX model combined with CA125 proved to be a useful predictor with an area under ROC of 0.961 (0.940 – 0.977) with Youden’s index of 0.8395, p < 0.001. The ADNEX model without CA125 also had high predictive value between benign and malignant tumors, with an area under ROC of 0.956 (0.933 – 0.973) with Youden’s index of 0.8551, p < 0.001. Cut-off of the ADNEX with CA125 was 13.5 and without CA125 was 13.1 for sensitivities were 90.8 (81.0 – 96.5) and 93.9 (85.0 – 97.5), specificities 93.2 (90.2 – 95.5) and 91.67 (88.5 – 94.2). The difference in the predictive value of malignancy-risk between the ADNEX model with CA125, without CA125 was not statistically significant, p=0.4883. Conclusion: The ADNEX model, with or without the combining marker CA 125, provides a valuable predictive value for ovarian tumor malignancy preoperative.
KEYWORDS: IOTA-ADNEX models,Ovarian Cancer,ovarian tumor
https://journal.waocp.org/article_90232.html
https://journal.waocp.org/article_90232_e59fb3945b7f5da4110845df602749b7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
University Students’ Knowledge about the Relation between Human Papillomavirus (HPV) and Head and Neck and Oral Cancers
2719
2726
EN
Valquiria
Kulig
Vieira
0000-0002-3718-8313
Graduate Program in Applied Health Sciences, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Brazil.
kuligvalquiria@gmail.com
Guilherme
Welter
Wendt
0000-0002-9014-6120
Center for Health Sciences, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Brazil.
guilhermewwendt@gmail.com
Lirane
Elize Defante
Ferreto
0000-0002-0757-3659
Graduate Program in Applied Health Sciences, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Brazil.
lferreto@gmail.com
Claudicéia
Risso
Pascotto
0000-0003-1265-2316
Graduate Program in Applied Health Sciences, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Brazil.
claudiceia_rp@hotmail.com
Léia
Carolina
Lucio
0000-0002-8094-4188
Graduate Program in Applied Health Sciences, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Brazil.
leiacarol@gmail.com
10.31557/APJCP.2022.23.8.2719
Introduction: Human papillomavirus (HPV) causes the most common sexually transmitted infection (STI) in the world. It affects people regardless of gender and age, causing genital warts and cancer. Objective: To evaluate university students’ knowledge of HPV and its relationship with head and neck and oral cancers. Methods: This is a cross-sectional study using an online questionnaire administered to undergraduate students at a public university (n=335). Results: In total, 69.3% of the participants were unaware of the relationship between HPV and head and neck cancers and 34.6% claimed that HPV may not cause oral cancer. The chances of knowing about the relationship of HPV with head and neck cancers were significant for participants who knew that HPV could be asymptomatic (OR = 9.9; p = 0.029), that might cause genital warts in men (OR = 4.0; p = 0.015), and those aged 24 years or older (OR = 1.9; p = 0.021). However, undergraduate students in the field of health and medicine (OR = 0.419; p = 0.002), who had sex at least twice a week (OR = 0.471; p = 0.017), and were unaware of the target public for the HPV vaccine (OR: 0.222, p<0.001) were less likely to know about the relationship. Students who knew of the relationship between HPV and female (OR = 3.6; p = 0.010) and male genital warts (OR = 3.0; p = 0.005) or were immunized (OR = 1.8; p = 0.020) were more likely to understand the viral interaction with oral cancer. Those who were unaware of the population eligible for HPV vaccine (OR = 0.493; p = 0.017) also showed gaps in their knowledge of this relationship. Conclusion: Our findings showed that there were limitations in the knowledge about HPV, its vaccine, and its relationship with head and neck and oral cancers.
Knowledge,head and neck neoplasms,Mouth Neoplasms,HPV,sexually transmitted diseases
https://journal.waocp.org/article_90233.html
https://journal.waocp.org/article_90233_1c936d84b30917a39bc5de843d8c4979.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Quality of life and Its Determinants among Cervical Cancer Patients in South India
2727
2733
EN
Shivaraj Nallur
Somanna
0000-0002-6006-0633
Department of Community Medicine, Ramaiah Medical College, Bengaluru, India.
shivarajns@gmail.com
Nandakumar
Bidare
Sastry
Department of Community Medicine, Ramaiah Medical College, Bengaluru, India.
bsnandakumar@gmail.com
Ramesh
Chaluvarayaswamy
Department of Epidemiology
and Biostatistics, Kidwai Memorial Institute of Oncology, Bengaluru, India.
ramesh_kidwai@yahoo.co.in
Nea
Malila
Finnish Cancer Registry, Finland.
nea.malila@cancer.fi
10.31557/APJCP.2022.23.8.2727
Introduction: Cervical Cancer is the leading cause of morbidity and mortality in India. It affects the patient’s, physical and psychological state which results in lower quality of life (QoL). Women with cervical cancer may require counselling and time to enable them to deal with the disease and its treatment. The present study aimed to determine the quality of life and its determinants among cervical cancer patients. Methods: A cross-sectional study was undertaken from April 2017 to September 2017 in a regional cancer centre in South India. Cervical cancer patients (N= 210) with histological confirmation were interviewed at the hospital. European Organization of Research and Treatment of Cancer (EORTC) questionnaire core module, QLQ-C30 Version 3.0, and recommended scoring algorithm were used to measure and analyse QoL. The Association of socio-economic determinants on quality of life was evaluated using multiple logistic regression. Results: Among 210 cervical cancer patients enrolled, the majority 106 (50.5%) of women were between the age group 46 to 59 years and most, i.e. 167(63.0%) were not literate. The median score in the global health status was 50.0[IQR 33.3 – 66.7], 66.7[IQR 60.0 – 80.0] in physical functioning, and 83.3[IQR 66.7 – 83.3] in pain symptoms respectively which were poor compared to reference score of EORTC for all normal females and those with any cancer. The factors which were significantly associated with the GHS QoL score were the advanced stage of disease (OR:2.1, 95%CI: 1.1 – 3.9) and the age of the patients ≥60 years compared with ≤ 45 years (OR:18.4, 95%CI: 6.8 – 50.1). Conclusion: Cervical cancer patients had poor global health status compared to the reference score for all females with any cancer and the normal females. Advanced stage of cancer and older age have a significant association with QoL.
Quality of Life,Cervical cancer,EORTC QLQ-C30
https://journal.waocp.org/article_90250.html
https://journal.waocp.org/article_90250_fda1bf14c1d6c18c8b81afcbad82dede.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Evaluation of miRNA 223/125a and COBLL1 Expressions and ROR-1 Levels as Reliable Markers in B- chronic Lymphocytic Leukemia
2735
2742
EN
Samia
Hussein
Medical Biochemistry& Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
samiahussein82@hotmail.com
Abdallah
S
Abdelazem
Medical Biochemistry Department, Faculty of Medicine, Suez University, Suez, Egypt.
dr_abdo.eldeeb@yahoo.com
Shimaa
Abdelmoneem
Hematologyl unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
shmohammed@zu.edu.eg
AL-Shabrawy
M
Abdelnabi
Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
alshabrawyabdelnabi201@yahoo.com
Tarek
Khamis
Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
khamistarek13@gmail.com
Ahmed
Ali
Obaya
Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
ahmedali161984@gmail.com
Huda
F
Ebian
Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
dodoebian2015@yahoo.com
10.31557/APJCP.2022.23.8.2735
Background: miRNA 223 /125a and Cordon-bleu Protein Like 1 (COBLL1) are novel biomarkers that can predict prognosis and guide treatment decisions in patients with chronic lymphocytic leukemia (CLL). Also, there is a growing interest in CLL monitoring based on flow cytometry of receptor tyrosine kinase-like orphan receptor-1 (ROR-1). Objective: This study aimed to evaluate the relationship between miRNA 223 /125a and COBLL1 expressions and ROR-1 expression in patients with CLL. Also, the study evaluated the relationship between the expression of these biomarkers with tumor staging and cancer progression. Methods: Our study included 40 patients newly diagnosed with B-CLL. In peripheral blood (PB), miRNA 223/125a and COBLL1 expressions were detected by real-time polymerase chain reaction (real-time PCR) and ROR-1 percentage was detected by flow cytometry before and after treatment. Results: High level of COBLL1 expression was statistically significantly associated with high ROR-1 percentage expression (P= 0.03). However, a high level of miRNA 223/125a expression was statistically significantly associated with low ROR-1 percentage expression (P=0.002). The sensitivity and specificity of ROR-1 as a predictor of high WBCs count after treatment were 96.6 and 81.1%, respectively. There was a statistically significant reduction of ROR-1 percentage after treatment compared to before treatment (P <0.001). Conclusion: ROR-1 percentage expression can be considered a possible prognostic predictor in CLL along with miRNA 223/125a and COBLL1 expressions. This can be explained by the significant correlation between ROR-1 and the studied molecular biomarkers; miRNA 223/125a and COBLL1. In addition, there was a significantly higher ROR-1 percentage in patients with higher WBC counts. Moreover, there was a significant reduction in ROR-1 percentage after treatment.
miRNA 223/125a,COBLL1,ROR-1,CLL
https://journal.waocp.org/article_90234.html
https://journal.waocp.org/article_90234_920d86f1ff606c0f0ed09b26cb8fc2dd.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Carcinogenic risk assessment and changes in Spirometric indices in casting and welding workers exposed to Metal fumes
2743
2748
EN
Somayeh
Rahimimoghadam
0000-0003-2330-2047
Department of Occupational Health Engineering, Neyshabur University of Medical Sciences, Neyshabur, Iran.
s.rahimimoghadam@gmail.com
Mohamad Nasser
Layegh Tizabi
Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran.
layegh_fa@yahoo.com
Narges
Khanjani
0000-0002-7235-9253
Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, Texas, USA.
n_khanjani@kmu.ac.ir
Mojtaba
Emkani
0000-0001-5175-6447
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
mojtabaemkani@gmail.com
Ali
Ganjali
Student Research Committee, Neyshabur University of Medical Sciences, Iran.
aliganjali7088@gmail.com
10.31557/APJCP.2022.23.8.2743
Introduction: The aim of this study was to investigate exposure to dust, and metal fumes, changes in pulmonary function indices among industrial workers to estimate the carcinogenic and non-carcinogenic risk of exposure to occupational metal fume.<br /><br />Methods: This cross-sectional study was performed on 98 workers exposed to metal fumes. Air sampling was performed according to the NIOSH 0500 method and was analyzed by gravimetry and metal levels were analyzed by atomic absorption spectrometry. Spirometric results for 2010-2016 were collected. Carcinogenic and non-carcinogenic risk assessments were performed according to the US Environmental Protection Agency guidelines. Data were analyzed by SPSS 20 software. Results: The mean occupational exposure of the subjects to workplace dust and iron fumes was 15.95 ± 6.65 mg/m3 and 13.18 ± 3.06 mg/m3 respectively. During these 6 years, the FVC (P=0.04), PEFR (P=0.04), and FEV1 (P=0.03) indices decreased significantly among welders, but there was no significant difference between FEV1/ FVC indexes. Also, the mean of FEV1 and PEFR decreased significantly amongst casting workers, but FVC and FEV1/ FVC had no significant difference. Multivariate regression showed that in both jobs, BMI and work history were related to pulmonary function indices. The mean total excess ifetime carcinogenic risk (ELCR) of hexavalent chromium in the study population was 0.708 per 1000 people and the mean non-carcinogenic risk of hexavalent chromium was HQ = 19.62. Conclusions: The results showed that exposure to metal fumes in casting and welding jobs reduces pulmonary function indices. Although the average occupational exposure to hexavalent chromium is lower than the recommended limit and the risk of carcinogenesis is within an acceptable range, the risk of non-carcinogenic effects among workers is significant Therefore, it is important to prevent this problem, by adequate ventilation and using respiratory masks.
Metal Fumes,Pulmonary Function Indices,OCCUPATIONAL EXPOSURE,risk assessments,carcinogenic
https://journal.waocp.org/article_90260.html
https://journal.waocp.org/article_90260_b073b39bd9e923d5a524f8d9b7f44f69.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers
2749
2754
EN
Irianiwati
Widodo
0000-0002-0346-0550
Department of Anatomic Pathology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Indonesia.
irianiwati@ugm.ac.id
Ahmad
Ghozali
0000-0003-3220-7519
Department of Anatomic Pathology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Indonesia.
ahmadghozali.ugm@gmail.com
Ibnu
Purwanto
0000-0002-2246-4813
Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Indonesia.
ibnupurwanto@ugm.ac.id
Paranita
Ferronika
0000-0001-7881-7924
Department of Anatomic Pathology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Indonesia.
paranita.ferronika@ugm.ac.id
10.31557/APJCP.2022.23.8.2749
Objective: This study aimed to investigate the association of sTILs with clinicopathological parameters and overall survival (OS) in patients with triple negative breast cancer (TNBC). Methods: One hundred and twenty-five paraffin embedded tissue of patients with TNBC, collected from Dr. Sardjito General Hospital Yogyakarta, Indonesia, between 2008-2017, were used in this study. Stromal TILs were examined from hematoxylin and eosin (H&E)-stained samples, and classified as either low or high score using 20% cut-off. Analysis of the association of sTILs with clinicopathological parameters, relative risk (RR) and OS used 95% confidence interval (CI) with significance set as p<0.05. Results: The higher proportion of TNBC patients in this study were ≥40 years old (83.3%), high tumor grade (68%), tumor stage >IIIa (56%), alive (50.4%), and with low sTILs (54.4%). The results showed significant association between sTILs and a higher grade or a lower stage of tumor (B = 0.259, 95%CI = 0.090-0.468, p = 0.004 and B = -0.255, 95%CI = -0.433 - -0.080, p = 0.005, respectively ). Meanwhile sTILs were not associated with age at diagnosis (B = 0.027, 95%CI = -0.193 – 0.264 p = 0.758 nor 3-year OS of patients (HR = 0.342, 95%CI = 0.41 - 1.43 p = 0.402). Conclusion: The results indicate that sTILs may serve as an additional pathological parameter for TNBC.
TNBC,TIL,neoplasm grading,neoplasm staging,survival
https://journal.waocp.org/article_90244.html
https://journal.waocp.org/article_90244_65c7fd40939fe0d1b63f98b760f808a8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Comparative Study of Helicobacter Pylori Resistance to Clarithromycin and Metronidazole and Its Association with Epidemiological Factors in A Moroccan Population
2755
2761
EN
Imane
Essaidi
Laboratory of Helicobacter pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
essaidiimane1981@gmail.com
Ghizlane
Bounder
Laboratory of Helicobacter pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
bounder.ghizlane2012@gmail.com
Reda
Mohamed
Jouimyi
Laboratory of Helicobacter pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
reda.jouimyi@gmail.com
Hasna
Boura
Laboratory of Helicobacter pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
hasna.boura@pasteur.ma
Ilhame
Elyounsi
Faculty of Medicine,
University of Tours, France.
elyounsiilhame02@gmail.com
Fatima-Zahra
Kheir
Laboratory of Helicobacter pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
fatimazahrakheir@gmail.com
Hakima
Benomar
Laboratory of Histo-Cytopathology, Pasteur Institute of Morocco, Casablanca 20360, Morocco.
hakima.benomar@gmail.com
Wafaa
Badre
Gastroenterology Department, Ibn Rochd University Hospital Center, Casablanca 20360, Morocco.
wafaa6badre6dr@gmail.com
Khalid
Zerouali
Faculty of
Medicine of Casablanca, IbnRochd University Hospital Center, Hassan II University, Casablanca, Morocco.
khalid.zerouali2000@gmail.com
Fatima
Maachi
Laboratory of Helicobacter pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
fatima.maachi@pasteur.ma
10.31557/APJCP.2022.23.8.2755
Objective: Knowledge of local antibiotic resistance is crucial to the adaption of the effective empirical first-line treatment for Helicobacter Pylori (H. pylori) infection. This study aimed to evaluate the prevalence of H. pylori resistance to clarithromycin and compare it with that of metronidazole, and highlight the impact of epidemiological factors and gastric lesions severity on H. pylori resistance. Methods: The susceptibility to clarithromycin of 96 isolates was determined by PCR-RFLP and the susceptibility to metronidazole of 185 isolates was determined by classic PCR. Result: Our results showed that the prevalence of H. pylori resistance to clarithromycin (14.6%) was low compared to that recorded with metronidazole (62.7%). Moreover, we remarked that 7.3% of isolates were co-resistant to both antibiotics. The assessment of epidemiological factors’ impact on the resistance to studied antibiotics has revealed no association. Besides, our results had demonstrated that the metronidazole and clarithromycin resistance was not related to the severity of gastric lesions. Conclusion: In our population, clarithromycin seems to be an effective antibiotic as long as the resistance rate of H. pylori is low. In contrast to metronidazole, it appears that this antibiotic will lose its efficacy, due to the high rate of resistance among our population. Therefore, each population must conduct their epidemiologic studies separately to survey the resistance profile of strains and choose the appropriate antibiotic, in order to avoid the failure of H. pylori eradication and the development of severe gastric diseases.
Helicobacter pylori,Resistance,Metronidazole,Clarithromycin,Eradication.&lrm
https://journal.waocp.org/article_90256.html
https://journal.waocp.org/article_90256_206d44041643c3b15508bab9668059b0.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Stromal Tumor Infiltrating Lymphocytes (sTIL) as an Independent Predictor of Pathologic Response to Neadjuvant Chemotherapy in Breast Cancer in Indonesia: A Hospital-based Study
2763
2769
EN
Devi
Felicia
0000000341330498
Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia (FMUI), Cipto Mangunkusumo Hospital (CMH),
Jakarta, Indonesia.
devi.felicia81@ui.ac.id
Tantri
Hellyanti
0000-0001-9277-5628
Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia (FMUI), Cipto Mangunkusumo Hospital (CMH),
Jakarta, Indonesia.
tantri.hellyanti@gmail.com
10.31557/APJCP.2022.23.8.2763
Objective: We aim to describe the sTIL profiles of Indonesian breast cancer patient and its role in predicting neoadjuvant chemotherapy response. Method: This retrospective cohort study used secondary data from the archive of Anatomic Pathology Department FMUI/CMH. We did total sampling of 62 cases of locally advanced breast cancer cases that were biopsied, had neoadjuvant chemotherapy, and operated on from 2015 to 2020. We collected the clinicopathological data of each sample, measured the sTIL intensity in the biopsy specimen and evaluated the chemotherapy response from the mastectomy specimen using residual cancer burden (RCB) scoring method. Multivariate linear regression determined the independent predictors of RCB score. Result: There were 62 female patients, 45.2% were Luminal-HER2-, 43.5% were HER2+, and 11.3% were triple negative (TN). Most sTIL intensity (59.7%) were low (median 10%; 1%-60%). Moderate-high sTIL intensity was associated with HER2+ type, while low sTIL was with luminal-HER2- (p=0.038). Only 8.1% patients achieved pCR. Statistically different median sTIL intensity in minimal, moderate, and extensive burden group were 28%, 20%, and 8%, respectively (p=0.002). sTIL was an independent predictor for better response (lower RCB score), which were 0.07 (95% CI 0.04-0.09) lower for every 1% increase in sTIL intensity.Conclusion: sTIL intensity was mostly low in Indonesian breast cancer patient. However, it can predict neoadjuvant chemotherapy response, with 0.07 lower RCB score for every 1% increase of sTIL intensity.
Breast,cancer,sTIL,neoadjuvant chemotherapy response
https://journal.waocp.org/article_90243.html
https://journal.waocp.org/article_90243_b9f1b753ccf0c57d2bcc1d894a7fe546.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Prevalence and Predictors of Cervical Cancer Screening among Reproductive Age Group Women: Evidence from Cross-Sectional Study in Rohtak and Delhi
2771
2777
EN
Shobhit
Srivastava
0000-0002-7138-4916
MAMTA Health Institute for Mother and Child, B-5, Greater Kailash Enclave II, New Delhi, India.
shobhitsrivastava889@gmail.com
Kauma
Kurian
0000-0003-1287-1404
MAMTA Health Institute for Mother and Child, B-5, Greater Kailash Enclave II, New Delhi, India.
kurian.kauma@gmail.com
Priyanka
Rani
Garg
0000-0002-9752-8762
MAMTA Health Institute for Mother and Child, B-5, Greater Kailash Enclave II, New Delhi, India.
kittu.dec2007@gmail.com
Ataur
Rehman
MAMTA Health Institute for Mother and Child, B-5, Greater Kailash Enclave II, New Delhi, India.
arehman@mamtahimc.in
Rishi
Garg
MAMTA Health Institute for Mother and Child, B-5, Greater Kailash Enclave II, New Delhi, India.
rishi@mamtahimc.in
Suresh Kumar
Rathi
0000-0002-8480-1627
MAMTA Health Institute for Mother and Child, B-5, Greater Kailash Enclave II, New Delhi, India.
rathisj07@gmail.com
Sunil
Mehra
0000-0001-7414-7054
MAMTA Health Institute for Mother and Child, B-5, Greater Kailash Enclave II, New Delhi, India.
dr_mehra@mamtahimc.in
10.31557/APJCP.2022.23.8.2771
Background: The present study aims to estimate the prevalence and determine the factors for cervical cancer screening among women in the reproductive age group in Delhi and Rohtak, India. Methods: The data were utilized from a survey conducted as part of a larger study to increase the access to cervical cancer screening and care by MAMTA-Health Institute for Mother and Child in collaboration with the Health Departments of Palam, New Delhi, and Rohtak, Haryana between 2015 and 2017. Data pertaining to the socio-economic and demographic information along with the information related to cervical cancer screening were utilized for the present study. The sample size was 1020 women in reproductive age group. Descriptive statistics (percentage and frequency distribution), bivariate analysis along with multivariable analysis were done to represent the results. The Fisher exact test was used to test the level of significance during bivariate analysis. Results: About 35.2% [Delhi: 44.9% and Rohtak: 23.8%] of the respondents had heard about cervical cancer screening. Further about 3.9% [Delhi-2.9% and Haryana-5.1%] had screened for cervical cancer. Women who had heard about cervical cancer were five times more likely to go for screening [aOR: 5.27; CI: 2.53,10.96]. It was found that women over 30 years of age had 12.04 significantly higher odds of going for cervical cancer screening in reference to women aged 30 years and less [aOR: 12.04; CI: 3.01,53.20]. Women from households with a monthly income of more than 15000 had 2.98 significantly higher odds of going for cervical cancer screening in reference to women from households with an income of 5000 and less [aOR : 2.98; CI: 1.12,9.09]. Conclusion: Findings suggest that awareness about cervical cancer screening test along with its thorough knowledge about its benefits would be an effective intervention to increase the uptake of cervical cancer screening.
cervical cancer screening,human papillomavirus,Women,India
https://journal.waocp.org/article_90252.html
https://journal.waocp.org/article_90252_6073b418792ba023b65a44472f710f07.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Diagnostic Value of Claudin-4 and EZH2 Immunohistochemistry in Effusion Cytology
2779
2785
EN
Aliaa
Elhosainy
Department of Pathology, Faculty of Medicine, Assiut University, Asyut, Egypt.
aliaa.elhosainy88@yahoo.com
Momen
M A
Hafez
Department of Pathology, Faculty of Medicine, Assiut University, Asyut, Egypt.
moemenhafez60@yahoo.com
Etemad
H
Yassin
Department of Pathology, Faculty of Medicine, Assiut University, Asyut, Egypt.
etemad_yassin@yahoo.com
Mohamed
Adam
Department of Chest Diseases, Faculty of
Medicine, Assiut University, Asyut, Egypt.
mohamedadam200010@yahoo.com
Maha
S
Elnaggar
Department of Clinical Oncology, Faculty of Medicine, Assiut University, Asyut, Egypt.
maha_elnaggar@yahoo.com
Noha
A
Aboulhagag
Department of Pathology, Faculty of Medicine, Assiut University, Asyut, Egypt.
nohah74@yahoo.com
10.31557/APJCP.2022.23.8.2779
Background: Metastatic adenocarcinoma (MAC) accounts for most cases of malignant effusions. Sometimes, it can be difficult to distinguish MAC from reactive mesothelial cells (RMC) in cytologic specimens. Our aim was to assess the diagnostic performance of a novel immunohistochemical panel composed of claudin-4 and EZH2 in differentiating MAC from RMC in effusion cytology. Methods: A total of 80 cases of serous effusions (48 MAC and 32 RMC) were included. Immunohistochemistry using claudin-4 and EZH2 was performed on cell block sections of these cases. Assessment of staining patterns, intensity and percentage of target cells stained was done. Results: Claudin-4 showed membranous staining in 46/48 of MAC and 1/32 of RMC. High EZH2 (≥ 50% of target cells) was detected in 42/48 MAC and 2/32 RMC. For the discrimination between MAC and RMC, claudin-4 exhibited 95.8% sensitivity and 96.9% specificity, high-EZH2 exhibited 87.5% sensitivity and 93.8% specificity, while the combination of both claudin-4 and high EZH2 showed 100% sensitivity and 90.6% specificity. Conclusion: Claudin-4 shows high sensitivity and specificity in differentiation between MAC and RMC in effusion cytology, and might be useful as a solitary marker for MAC. Adding EZH2 to claudin-4 increases the sensitivity to 100%. However, the interpretation of EZH2 results can be challenging due to its focal expression in RMC and inflammatory cells.
claudin-4,EZH2,immunohistochemistry,effusion cytology,adenocarcinoma
https://journal.waocp.org/article_90225.html
https://journal.waocp.org/article_90225_aedf8461e12b6b99405407d3894e7eda.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
The Trend and Prediction of Cervical Cancer Incidence in Delhi, India: An Age-Period-Cohort Analysis
2787
2795
EN
Rajeev
Kumar
Malhotra
0000-0002-2249-7754
Delhi Cancer Registry Dr BRA IRCH, All India Institute of Medcial Sciences New Delhi, India.
rajeev.kumar.malhotra@gmail.com
N
Manoharan
Delhi Cancer Registry Dr BRA IRCH, All India Institute of Medcial Sciences New Delhi, India.
nmano67@yahoo.com
SV
Suryanarayana
Deo
Department of Surgical Oncology, Institute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
svsdeo@yahoo.co.in
10.31557/APJCP.2022.23.8.2787
Objective: The objective of the study is to assess the trend of age-standardised incidence rate (ASIRs) of cervical cancer, standardised median age at diagnosis, and projection of cervical cancer incidence rate and the number of new cases up to 2030. The projections help in making strategies for resource allocation to circumvent the future burden. Methods: The data were extracted from the Delhi population-based cancer registry from 1990 to 2014. Joinpoint regression analysis was applied to ASIRs to assess the trend. The natural cubic splines age-period-cohort (APC) model was fitted to project the incidence rate and incidence cases. The trend of standardised median age at diagnosis and percentage of cervical cancer to total women cancer was also assessed using regression analysis. Projections of new cases are decomposed into three components aging, the structure of the population, and age-specific incidence rate. Results: The age-standardised incidence rate of cervical cancer decreased with an annual decline at a rate of 2.98% (95% CI -3.48 to -2.47) from 1990 to 2014. The standardised median age at diagnosis showed an upward trend with an average annual increase of 0.167 per year and the median age increased by 4.18 years during 25-years period, this change was due to the shifting of the peak from 40-44 in 1990 to 60-64 in 2014. The APC model revealed ASIRs would decline by 43.8% in 2030 compared to average ASIRs 2010-2014, albeit a net 12% increase in the incidence cases. An increase in incidence cases is primarily attributed to the aging of the population and population growth by 38.87% and 33.84% respectively. The trend analysis of cervical cancer ASIRs in pre (< 50 years) and post menopause (≥ 50 years) showed a decreasing trend. However, the ratio of cervical to total women increased over time from 1:1 in 1990 to 2:3 in 2014. Conclusion: The declining trend in ASIRs was observed in Delhi and will continue to decrease up to 2030. The burden of the number of new cases of cervical cancer showed an upward trend primarily due to the aging of the population and shifting of population structure. To counter this big challenge a cost-effective vaccination for vulnerable populations, community-based screening programs, and awareness about cervical cancer prevention might help in eliminating this preventable cancer.
age-period-cohort model,Cervical cancer,Projection,cubic splines
https://journal.waocp.org/article_90236.html
https://journal.waocp.org/article_90236_246c863e0658f6bd2f5d79d8a574aa2b.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Analysis of Metabolic Regulators PGC1-α and PGC1-β in Oral Squamous Cell Carcinoma with and without Hyperglycemia
2797
2803
EN
Tamizh Paavai
Thamizhanambi
0000-0003-3598-2422
Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram Campus, SRM Institute of Science and
Technology, Chennai, Tamil Nadu, India.
paavaitamizh@gmail.com
Annasamy
Rameshkumar
Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram Campus, SRM Institute of Science and
Technology, Chennai, Tamil Nadu, India.
arkjayamdj@gmail.com
Ramadoss
Ramya
0000-0001-9408-3158
Department of Oral Biology, Saveetha Dental College and Hospital, Chennai, Tamil
Nadu, India.
drramya268@gmail.com
Rajkumar
Krishnan
0000-0002-6875-0663
Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram Campus, SRM Institute of Science and
Technology, Chennai, Tamil Nadu, India.
drrajkumar22163@gmail.com
Thayalan
Dineshkumar
0000-0001-8138-9916
Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram Campus, SRM Institute of Science and
Technology, Chennai, Tamil Nadu, India.
drtdineshkumar@gmail.com
Gunasekaran
Nandhini
0000-0002-7694-4046
Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram Campus, SRM Institute of Science and
Technology, Chennai, Tamil Nadu, India.
drnandhuguna@gmail.com
10.31557/APJCP.2022.23.8.2797
Aim: To assess the expression of PGC1-α and PGC1-β in Oral squamous cell carcinoma in the presence and absence of hyperglycemia. Materials and Methods: Fresh tissue samples were collected from 14 well differentiated OSCC patients with hyperglycemia, 14 OSCC patients without hyperglycemia and 14 healthy controls and subjected to quantitative real-time PCR to assess expression of PGC1-α and PGC1-β. The relative gene expression of PGC1-α and PGC1-β was calculated using the double delta Ct method. A two-fold difference was defined as over or under- expression. To further evaluate clinicopathological association, Independent t-test was employed. Results: The expression of both PGC1-α and PGC1-β were increased in OSCC patients when compared to healthy controls and similar findings were observed on calculating the fold change healthy controls and OSCC study groups. On assessing the expression of target genes within study groups, they did not present with significant fold change and the hyperglycemic status of the individual did not contribute to the expression of the target genes as P value obtained for PGC1-α and PGC1-β were >0.05. Conclusion: The hyperglycemic status of the individual does not influence the expression of PGC1-α and PGC1-β in OSCC tissues and the cause for over-expression of the study targets in OSCC tissues must be further evaluated to assess their potential as possible candidates for targeted therapy in OSCC patients.
Diabetes Mellitus,Hyperglycemia,oral cancer,PGC1-α,PGC1-&beta
https://journal.waocp.org/article_90241.html
https://journal.waocp.org/article_90241_669c1f4e03a8a923c4c60c51b330c471.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Inferior Clinical Outcomes of Pediatric Rhabdomyosarcoma in Thailand: A 16-Year Experience in a Single Tertiary Institution
2805
2811
EN
Ploypailin
Preechawetchakul
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
ploypailin79@yahoo.com
Pornpun
Sripornsawan
0000-0001-5130-0714
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
spornpun@medicine.psu.ac.th
Songyos
Rajborirug
Epidemiology
Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
s.rajborirug@gmail.com
Surasak
Sangkhathat
Tumor Biology Research Unit,
Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
s.sangkhathat@gmail.com
Pasuree
Sangsupavanich
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
pasurees@gmail.com
Thirachit
Chotsampancharoen
0000-0002-0111-6318
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
cthirachit@yahoo.com
10.31557/APJCP.2022.23.8.2805
Introduction: There is limited data available on the treatment outcomes of pediatric rhabdomyosarcoma (RMS) in Asian populations. Therefore, we aimed to review the baseline characteristics, clinical outcomes, and prognostic factors in children with RMS from Thailand. Methods: The data of children under 15 years of age diagnosed with RMS between 2003 and 2019 from a large tertiary hospital in Southern Thailand were retrospectively reviewed. Descriptive statistics were utilized to describe the clinical characteristics. The Kaplan–Meier method was utilized to estimate survival. Cox proportional hazards regression analysis was utilized to determine prognostic factors that affect survival. Results: A total of 42 children RMS were included in this study. The median age at diagnosis was 6.4 years (IQR, 2.4–10.2). Among these patients, 11 (26%) were older than 10 years, and 13 (31%) presented with metastatic disease at diagnosis. The 5-year overall survival (OS) rate was 39% for all children. Age greater than 10 years (hazard ratio (HR): 3.3, 95% CI: 1.2–9.2) and metastatic disease at diagnosis (hazard ratio (HR): 2.8, 95% CI: 1.1–7.5) were independently associated with poorer survival. The 3-year OS for children with metastatic disease (stage IV) was 15% (95% CI: 4.3–55). Conclusion: The percentage of metastatic disease in our cohort was higher than that in previous reports and may have contributed to a poorer outcome. Age greater than 10 years and metastatic disease at diagnosis were noted as adverse prognostic factors.
Childhood cancer,Rhabdomyosarcoma,survival outcome,Prognostic factors,Asians
https://journal.waocp.org/article_90257.html
https://journal.waocp.org/article_90257_18d6a936bb10c5d4883eb7c7fa86b05b.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Prevalence of Anxiety Symptoms in Women Newly Diagnosed with Breast Cancer in Kazakhstan and Its Associated Factors
2813
2819
EN
Indira
Karibayeva
0000-0003-1796-2604
Department of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
indira.karibayeva@gmail.com
Botagoz
Turdaliyeva
0000-0001-9884-0777
Department of
Epidemiology, Evidence-Based Medicine and Biostatistics, Kazakhstan’s Medical University “KSPH,” Almaty, Kazakhstan.
777fun@mail.ru
Nor Zuraida
Zainal
0000-0002-3519-711X
Department of Psychological Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
zuraida@ummc.edu.my
Fatima
Bagiyarova
0000-0003-0000-1321
Department of
Communicative Skills, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
bagiyarova.f@kaznmu.kz
Dinara
Kussainova
0000-0002-7123-8927
Department of Psycho-Social
Help, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan.
dinara_k2011@mail.ru
10.31557/APJCP.2022.23.8.2813
Introduction: Diagnosis of breast cancer is associated with high psychological distress. There is a lack of studies examining the prevalence of anxiety among newly diagnosed breast cancer patients in Kazakhstan. Objective: This study aims to assess the mean prevalence and associated sociodemographic and clinical factors of anxiety symptoms in women newly diagnosed with breast cancer. It also aims to determine independent predictors of anxiety risk. Methods: An analysis of 162 newly diagnosed breast cancer patients at the oncology institute in Almaty was performed. Data were collected using a structured questionnaire on social, demographic, and clinical information, as well as the Beck Anxiety Inventory. In addition, multiple regression analysis was used to model the relationship between anxiety risk and independent predictors. Results: The average age of the patients was 54.41 years (SD=8.1; min.-max: 32-75). The majority of the patients were married (52%), employed or self-employed (51%), had children (91%), had a bachelor’s or a graduate degree (50%), lived in an urban area (54%), did not drink (41%), did not smoke (67%), did not engage in physical activity (54%), and had social support (91%). A total of 48% of patients had symptoms of moderate anxiety, and 33% had symptoms of severe anxiety. Based on the multivariate analysis, factors associated with a lower risk of anxiety symptoms included higher household income (OR -2.21 (95 CI: -1.35, -3.07)) and having reliable social support (OR -2.93 (95% CI: -2.25, -3.61)). Conclusion: The prevalence of anxiety symptoms is very high among newly diagnosed breast cancer patients. Anxiety is more likely to develop in patients from low-income households and those without reliable social support.
Psychological distress,cancer patients,Social Support,income
https://journal.waocp.org/article_90227.html
https://journal.waocp.org/article_90227_b7aa092ef4cb26ff59ba0ade60981848.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
The Relationship between Unmet Need, Physical Symptoms, Psychological Well-Being and Health-Related Quality of Life in Cholangiocarcinoma Survivors
2821
2828
EN
Monthida
Sangruangake
0000-0001-6893-0317
Faculty of Nursing, Khon Kaen University, Khon Kaen, Thailand.
montsa@kku.ac.th
Ueamporn
Summart
0000-0001-9557-2199
Faculty of Nursing, Western University, (Buriram Campus),
Buriram, Thailand.
yogiueamporn@gmail.com
Metha
Songthamwat
0000-0002-5694-8138
Department of Obstetrics and Gynecology, Ang Thong Hospital, Ang Thong, Thailand.
udonhome@yahoo.com
Bumphenchit
Sangchart
Faculty of Nursing, Khon Kaen University, Khon Kaen, Thailand.
bamphenc@kku.ac.th
10.31557/APJCP.2022.23.8.2821
Background: Cholangiocarcinoma (CCA) survivors continue to face challenges that affect their health-related quality of life (HRQOL) along the survivorship trajectory. Objective: This study intends to investigate the association and to create a model for explaining the link between unmet needs, physical symptoms, psychological well-being, and HRQOL in CCA survivors. Method: This cross-sectional study consecutively recruited 231CCA survivors from an oncology unit of a university hospital in Khon Kaen, Thailand. Cancer-related unmet need, physical symptoms, psychological well-being and HRQOL were all assessed using the questionnaire, and medical records were used to acquire demographic and clinical data. We use a path analysis to create a hypothesized model in which symptoms, unmet need, anxiety, and depression, support care need predicting HRQOL. Results: The mean total of HRQOL score was 75.59±6.24 (95%CI: 74.78-76.39) indicated that the subjects had a low level of HRQOL as a whole. The hypothesis model was found to fit the actual data and explained 39.8% of the variance of HRQOL. Symptoms and anxiety had a significant negative effect on HRQOL (β = -0.62, p< 0.001) and (β=-0.18, p<0.001), respectively. However, the relationship between HRQOL and other mediators was not found significant association. Conclusion: According to our findings, the research model can be used to investigate how symptoms affect HRQOL. It also means that cancer care providers should be aware of these factors while caring for CCA survivors in order to enhance their HRQOL.
Cholangiocarcinoma survivors,Health-related quality of life,Unmet needs,physical symptoms,Psychological Well-Being
https://journal.waocp.org/article_90226.html
https://journal.waocp.org/article_90226_7ba824b33df1c1fe80ce4340f927126f.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
An Evaluation of the Prognosticative Value of Hyalinization in the Biological Behaviour of Oral Lesions Using Image Analysis
2829
2834
EN
S
Samyukta
Department of Oral and Maxillofacial Pathology, Chettinad Dental Collage and Research Institute, Chennai, India.
samyu26797@gmail.com
Harini
Priya
A H R
Department of Oral and Maxillofacial Pathology, Chettinad Dental Collage and Research Institute, Chennai, India.
drharinicdcri@gmail.com
Sathish
Muthu
Kumar
Department of Oral and Maxillofacial Pathology, Chettinad Dental Collage and Research Institute, Chennai, India.
smkop@gmail.com
Premika Sri
V L
Department of Oral and Maxillofacial Pathology, Chettinad Dental Collage and Research Institute, Chennai, India.
premilaksh@gmail.com
10.31557/APJCP.2022.23.8.2829
Objective: To evaluate the efficacy of artificial intelligence-based analysis of polychromatic staining in oral premalignant and malignant lesions and to predict their biological behavior. The study also aims to evaluate the prognostic value of collagen in these oral lesions. Methods: In this study, a total of 45 histopathologically diagnosed normal (15), Premalignant lesions (n-15), and oral squamous cell carcinoma (n=15) were included. The tissue sections were subjected to routine Hematoxylin and Eosin (H and E) staining and a differential staining technique- Herovici’s stain. The stained slides were viewed under 10x magnification in the microscope and images of these sections were captured. The images were labelled, transferred and stored in the computer for image analysis. The collagen content in the photomicrographs were analysed using Image J software. The results were tabulated and subjected to Kruskal- Wallis test using the SPSS software. Results: A significant increase in the amount of type III (blue stained) collagen fibers, compared to type I collagen fibers, was seen as the lesion progressed from premalignant disorders to oral squamous cell carcinoma. Normal mucosa showed predominantly type I (red stained) collagen fibers. The difference in the ratio of type I and III collagen fibers between the three groups was found to be statistically significant (P= 0.00). Conclusion: The study concluded that a significant change in stromal collagen composition exists, with an increase in the amount of type III collagen, that can be correlated to the lesion’s progression from premalignant to oral squamous cell carcinoma. Differential staining is an inexpensive and highly reproducible method of evaluating the composition of the stroma and using Image analysis to carry out this analysis makes the process more objective and renders it bias free.
dysplasia,Image analysis,collagen,Differential stain
https://journal.waocp.org/article_90259.html
https://journal.waocp.org/article_90259_f9e4328ad7ef2bba9f3d72ce93226fb6.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Adopting Lean Management in Quality of Services, Cost Containment, and Time Management
2835
2842
EN
Omar
Ayaad
0000-0003-1521-117X
Sultan Qaboos Comprehensive Cancer Care and Research Center, Oman.
omarayyad86@yahoo.com
Ronza
Al-Dewiri
King Hussein Cancer Center, Jordan.
rdewiri@khcc.jo
Lara
Kasht
Traning Office/GME Office, Jordan.
lara-kasht@gmail.com
Bayan
Qaddumi
KHCC, Jordan.
bayanomarayyad@gmail.com
Malik
Ayyad
Mutah University, Jordan.
mkhadoor@yahoo.com
10.31557/APJCP.2022.23.8.2835
Objectives: This study aims to identify the role of adopting lean management in the quality of service, cost containment, and time management and to identify factors affecting lean management adoption, quality of service, cost containment, and time management in oncology settings. Methods: A cross-sectional design was adopted in this study at the King Hussein Cancer Center (KHCC), a private institution in Amman, Jordan. A convenience sampling technique was used to select 360 participants. A self-administered questionnaire (58 items) was used to collect the data. Results: The mean value for the quality of services was 3.84±0.56. These values for adoption of lean, time management, and cost containment were 3.82±0.74, 3.73±0.75, and 3.40±0.76 respectively. The results showed that the impacts of lean management adoption on the quality of service, cost containment, and time management were significant (p-value<0.001). The results showed substantial effects of all factors (organizational, departmental, and individual factors) on lean adoption, quality of service, cost containment, and time management (p value<.001). Conclusion: Lean management adoption had a significant impact on quality of service, cost containment, and time management in oncology settings.
Lean,Cost Containment,Quality of Service,Oncology setting,Adoption of lean
https://journal.waocp.org/article_90235.html
https://journal.waocp.org/article_90235_70fada6ea22864da6afa9da9fbbb5d6e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma
2843
2850
EN
Shivani
Priya
Cancer & Radiation Countermeasures Unit, Department of Biochemistry, North-Eastern Hill University, Shillong-793022, India.
priya.shivani1988@gmail.com
Lakhon
Kma
Cancer & Radiation Countermeasures Unit, Department of Biochemistry, North-Eastern Hill University, Shillong-793022, India.
lakhonkma@gmail.com
10.31557/APJCP.2022.23.8.2843
Background: Hepatocellular carcinoma (HCC) is one of the leading drivers of cancer-related mortality in the world. As a result, researchers are constantly looking for ways to optimize the screening and diagnosis of the said malignancy. Objective: To establish the mice model of hepatocellular carcinoma with the administration of a suitable dose of diethylnitrosamine (DEN) and examine the utility of EphA7 and pEphA7 as ideal diagnostic markers in HCC. Methods: Swiss Albino (BALB/c) mice of around 10-12 weeks old were exposed to a known hepatocarcinogen-diethylnitrosamine at a dose of 20 mg/kg body weight at weekly intervals for a period of 4, 8, 12, & 16 weeks. Blood was collected from mice of different experimental groups, and age-matched control and serum were separated from whole blood samples. The liver homogenate was prepared after completion of treatment, and the resulting supernatant was used for enzyme assays. A range of liver biomarker enzyme assays such as Gamma-glutamyl transpeptidase (GGT), Acetylcholine esterase (AChE), GPx activity and GSH level, Heme oxygenase-1 (HO-1), GPC3 and alpha-fetoprotein (AFP) level along with the expression of Caspase-3, EphA7 and pEphA7 were evaluated. Results: An elevation in body weight and relative liver weight across the treatment period (4, 8, 12, 16 weeks) was observed in DEN-treated mice. Significant differences in GGT levels between control and DEN treated mice were noted in the present study (P < 0.005). In the 16th week of the treatment period, a significant difference in AchE level was noted between the treated and control group (P < 0.001). However, there was no statistically significant difference in the levels of SGOT and SGPT levels between the control and DEN treated groups (P > 0.001). Lower GSH and GPx levels were demonstrated in the treated mice as compared to control over all the treatment period. Loss of Caspase-3 expression and significant differences in expression of HO-1 activity in treated vs. non-treated group of mice were observed. Significant differences in EphA7 and pEphA7 protein expression levels were noted in the DEN-treated vs. control groups across all the treatment periods (4 weeks: P < 0.05; 8 weeks: P < 0.05; 12 weeks: P < 0.005; 16 weeks: P < 0.05). Conclusion: The present study indicated that EphA7 and phosphoEphA7 over-expression might contribute to the malignancy transition, invasion development, and metastasis of HCC. As a result, along with the known markers such as AFP and others, EphA7 and pEphA7 could be a very putative biomarkers of HCC, particularly at a very early stage of cancer development.
Hepatocellular carcinoma,Biomarker,diethylnitrosamine,EphA7
https://journal.waocp.org/article_90228.html
https://journal.waocp.org/article_90228_c571d5e894d52aff5c03660be18e5b0e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Simultaneous Increase in Serum Levels of IL-37 and IL-18 Binding Protein In Low-Grade and High-Grade Brain Tumors
2851
2856
EN
Mohammad Reza
Haghshenas
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
haghshenasmr@sums.ac.ir
Arash
Saffarian
Department of Neurosurgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
saffarrian@yahoo.com
Aida
Khademolhosseini
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
khademaida@sums.ac.ir
Amirreza
Dehghanian
Molecular Pathology and Cytogenetics Division, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
adehghan@sums.ac.ir
Abbas
Ghaderi
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
ghaderia@sums.ac.ir
Abdolreza
Sotoodeh Jahromi
0000-0002-2131-2113
Research Center for Non-Communicable Diseases, Jahrom
University of Medical Sciences, Jahrom, Iran.
sotoodehj2002@yahoo.com
10.31557/APJCP.2022.23.8.2851
Background: IL-18binding protein (IL-18BP) might play a role in tumor escape from immune surveillance through interacting with IL-37. Such interactions modulate the antitumor activity of IL-18 and affect regulatory T cell (Treg) function. However, the biological roles of IL-37 and IL-18BP have not yet been explored in brain tumors. This study aimed to investigate serum levels of IL-37 and IL-18BP in high-grade and low-grade brain tumors and determine their associations with pathological characteristics of the patients. Subjects and methods: This case-control study consisted of 60 patients with brain tumors (40 low-grade and 20 high-grade) and 30 healthy controls. Enzyme-linked immunosorbent assay (ELISA) kits were used to measure the levels of IL-37 and IL-18BP in serum. Results: Our results indicated that serum levels of IL-37 and IL-18BP were significantly higher in patients with brain tumors (109.02, 426.37 pg/mL), high-grade (104.44, 428.87 pg/mL), and low-grade (113.88, 426.37 pg/mL) tumors in compared to healthy controls (35.03, 362.00 pg/mL), (P<0.05). Interestingly, our results revealed a significant positive correlation between IL-37 and IL-18BP serum levels in brain tumors (n=60, R=0.42, P=0.001). Our study also showed that serum levels of IL-37 and IL-18BP in glioblastoma grade IV were approximately similar to those in astrocytoma grade II, meningioma type I, and pituitary adenoma. Furthermore, no significant differences were found in serum levels of IL-37 and IL-18BP between patients with low-grade and high-grade tumors (P=0.24 and P=0.61, respectively). Conclusion: The simultaneous increase in IL-37 and IL-18BP serum levels and their positive correlation may facilitate disease progression in low-grade and high-grade brain tumors by inhibiting antitumor immune responses.
IL-37,IL-18BP,Brain tumors
https://journal.waocp.org/article_90246.html
https://journal.waocp.org/article_90246_d4875d220ed46f499d6fb62354d697d8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Efficacy of Glucose Starvation of Cancer Cells in the Progress of Oral Squamous Cell Carcinoma Induced in Hamster
2857
2862
EN
Safa
Zakaraia
Department of Oral Histology and Pathology. University of Damascus, Damascus, Syria.
dr.safa.zakarea@gmail.com
Amer
Takkem
Department of Oral Histology and Pathology. University of Damascus, Damascus, Syria.
dr.amer.takkem@gmail.com
Hazem
Redwan
Department of Oral & Maxillofacial
Surgery. University of Damascus, Damascus, Syria.
redwanhazem@gmail.com
Charif
Barakat
Department of Oral Pathology, Faculty of Dentistry, Damascus University,
Damascus, Syria
dr.sharifbarakat@gmail.com
10.31557/APJCP.2022.23.8.2857
Background and aim of the study: Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer, showing poor prognosis and high mortality. Meanwhile, cancer metabolism is an essential contributor to its progression and response to treatment. This research aims to investigating the effect of a glucose-rich and glucose-free diet on the progress of oral squamous cell carcinoma induced in hamsters. Materials and Methods: forty Syrian Hamsters were incubated in two groups. The first one consisted of twenty hamsters, in which the carcinogenic material (DMBA) was applied in the buccal pouch of the hamster three days per week with a glucose-rich diet). The second one was composed of twenty hamsters, in which the carcinogenic material (DMBA) was applied in the buccal pouch three days per week with a glucose-free diet). Hamsters in both groups were sacrificed in groups of five hamsters at a time and at intervals (two weeks, six weeks, ten weeks, and Fourteen weeks). A histological study was performed after conventional staining with hematoxylin and eosin was done. Results: After two weeks of the experiment hyperplasia, mild dysplasia, and moderate dysplasia were recorded in hamster buccal pockets with a glucose-rich diet, and after six weeks moderate dysplasia, severe dysplasia, and carcinomas in situ were recorded, after ten weeks severe dysplasia, carcinomas in situ, and OSCC, after fourteen weeks OSCC were recorded. While with a glucose-free diet Hyperkeratosis, hyperplasia, and mild dysplasia were observed after a two-week the experiment, after six weeks, mild dysplasia, moderate dysplasia, and severe dysplasia were recorded, after ten weeks, moderate dysplasia, severe dysplasia, and carcinoma in situ, after fourteen weeks Severe dysplasia, carcinoma in situ, and OSCC were reported. Conclusion: our results showed that a glucose-free diet slightly prevents oral squamous cell carcinoma, It may be a supportive treatment in addition to conventional cancer treatment.
oral squamous cell carcinoma,cancer metabolism,glucose diet
https://journal.waocp.org/article_90261.html
https://journal.waocp.org/article_90261_f476d8e20883e956737f6feddd97d4c8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Modulation of POPDC1 Expression by Phenothiazine and Trifluoperazine Suppress Colon Cancer Growth and Migration
2863
2871
EN
Fiona
Macniesia
Thomas
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu
88400, Sabah, Malaysia.
fionamac11@yahoo.com
Suhaini
Sudi
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu
88400, Sabah, Malaysia.
suhainisudi@gmail.com
Falah Abas
Muhamad Salih
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu
88400, Sabah, Malaysia.
muhamad_salih@ums.edu.my
Praneetha
Palasuberniam
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu
88400, Sabah, Malaysia.
praneetha@ums.edu.my
Latifah
Suali
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu
88400, Sabah, Malaysia.
latifah_suali@yahoo.com
Mohd Hijaz
Mohd Sani
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu
88400, Sabah, Malaysia.
hijazsani@ums.edu.my
Caroline
Sunggip
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu
88400, Sabah, Malaysia.
carolsun@ums.edu.my
10.31557/APJCP.2022.23.8.2863
Objective: The aim of this study was to investigate the effects of CaM antagonist, PTZ, and TFP on cell proliferation and migration of colon cancer cells and its impact on POPDC protein expression. Methods: The 50% inhibitory concentration (IC50) of PTZ and TFP in SW1116, SW480, HCT-15, and COLO205 colon cancer cell lines are measured using MTT. Western blot and immunocytochemistry were used to determine the expression of PCNA, cyclin D1 (CD1), and POPDC proteins. Cell migration was observed using a scratch wound-healing assay. Results: Treatment with PTZ and TFP inhibited colon cancer cells growth in a dose-dependent manner. PTZ and TFP significantly inhibited the activation of proliferation markers, PCNA and CD1, and the migration of colon cancer cells. Furthermore, POPDC protein was significantly suppressed in all cell types of colon cancer, particularly in SW480. Finally, the CaM antagonist upregulates the POPDC1 expression in colon cancer cells. Conclusion: These findings suggest that CaM antagonists suppress colon cancer cells proliferation via downregulation of CD1 and PCNA. In addition, POPDC protein could be used as a biomarker in colon cancer, and CaM antagonist could be used to regulate POPDC1 expression. This study suggests that targeting POPDC1 with CaM inhibition could be a potential therapeutic strategy for colon cancer treatment. <br />
POPDC,Colon cancer,calmodulin antagonist
https://journal.waocp.org/article_90242.html
https://journal.waocp.org/article_90242_a938dabf54d9ec31d75362e66fa529ec.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
23
8
2022
08
01
Evaluation of Complications of Short-term and Long-term Drainage Following Mastectomy with Removal of Axillary Lymph Nodes: A Randomized Clinical Trial
2873
2878
EN
Jamal
Jafari Nedooshan
Department of Surgery, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
jamalnedooshan@yahoo.com
Mohammad Hossein
Dashti Rahmatabadi
Department of Surgery, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
dashti.mh@gmail.com
Saeed
Kargar
Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
saeedkargar@yahoo.com
Mohammad Hasan
lotfi
Research center for the prevention of non-communicable diseases and epidemiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
mhlotfi56359@gmail.com
10.31557/APJCP.2022.23.8.2873
Background: Breast cancer is one of the most common cancers in Iran and round the globe. Seroma formation is the most common primary complication after mastectomy (partial/radical). Nowadays, drainage is used as a routine method to reduce seroma formation after mastectomy, although there is no consensus about the appropriate time to perform drainage after this surgery. This study evaluated the effects of short-term and long-term drainage after mastectomy along with removal of axillary lymph nodes. Methods: This randomized clinical trial was performed on 88 women who underwent mastectomy with ALND in hospitals in Yazd (were randomly divided into two groups). Suction drains were inserted for all patients at completion of surgery. The data collection tool was a researcher-made form based on variables. In the first group, the drain was removed 24 hours after surgery and the patients were discharged, but the second group was discharged with the drain in place after 24 hours and the drain was removed 5 days after surgery. Data were analyzed with SPSS18 using T-Test, Chi square, and Mann-Whitney U test. Results: The results showed that 28 (31.8%) participants had formed seroma, of whom 22 (50%) were in the 1-day drainage group and 6 (13.6%) were in the 5-day drainage group. There was a statistically significant correlation among seroma frequency, mean aspiration volume, mean number of aspirations, mean seroma volume in sonography one week after surgery, and mean seroma volume in sonography between the two groups three weeks after surgery (P<0.05). Conclusion: Based on the results, it can be concluded that long-term drainage reduces the risk of seroma formation after mastectomy with removal of axillary lymph nodes compared to short-term drainage. Complementary study be performed by considering other underlying factors such as comorbidities to obtain the best drain removal time in breast cancer patients.
Drainage,Breast,cancer,Sonography
https://journal.waocp.org/article_90262.html
https://journal.waocp.org/article_90262_ebffddbdbaa7b797cde463a14944de58.pdf