West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Circulating Tumor BRAF Mutation and Personalized Thyroid Cancer Treatment
293
294
EN
Fatemeh
Khatami
Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
f-khatami@farabi.tums.ac.ir
Bagher
Larijani
Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences
emrc@tums.ac.ir
Seyed
Mohammad
Tavangar
Department of Pathology, Doctor Shariati Hospital, Tehran University of Medical Sciences
tavangar@ams.ac.ir
10.22034/APJCP.2017.18.2.293
Circulating tumor DNA (ctDNA) is now being extensively studied as it is a noninvasive “real-time” biomarker that can provide diagnostic and prognostic information before, during treatment and at progression. These include DNA mutations, epigenetic alterations and other forms of tumor-specific abnormalities such as microsatellite instability (MSI) and loss of heterozygosity (LOH). ctDNA is of great value in the process of cancer treatment. However, up to date, there is no strict standard considering the exact biomarker because the development and progression of cancer is extremely complicated. Also, results of the studies evaluating ctDNA are not consistent due to the different detection methods and processing. The major challenge is still the exact position of ctDNA in cancer management and the exact place of it versus tissue biopsy. actually it is still under the debate that circulating tumor markers will take the place of standard tissue biopsy or will support it to guide us to the more effective interventions?
ctDNA,Thyroid cancer,Diagnosis,Personalized Medicine
https://journal.waocp.org/article_44521.html
https://journal.waocp.org/article_44521_b848252187a60cee4b3ea46b6975e4a7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences
295
314
EN
Mehdi
Nematbakhsh
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
nematbakhsh@med.mui.ac.ir
Zahra
Pezeshki
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh
Eshraghi Jazi
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Bahar
Mazaheri
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam
Moeini
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Tahereh
Safari
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Fariba
Azarkish
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh
Moslemi
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam
Maleki
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Alireza
Rezaei
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Shadan
Saberi
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Aghdas
Dehghani
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam
Malek
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Azam
Mansouri
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Marzieh
Ghasemi
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Farzaneh
Zeinali
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Zohreh
Zamani
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Mitra
Navidi
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Sima
Jilanchi
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Soheyla
Shirdavani
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Farzaneh
Ashrafi
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
10.22034/APJCP.2017.18.2.295
<br /> <span style="font-size: small;">Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements </span></span><span style="font-size: small;">have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded. </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">However, no definitive supplement has so far been proposed to prevent CDDP-induced nephrotoxicity; however, this condition is gender related and the sex hormone estrogen may protect the kidney against CDDP damage. In this review, the results of research related to the effect of different synthetic and herbal antioxidants supplements are presented and </span></span><span style="font-size: small;">discussed with suggestions included for future work. </span>
Cisplatin,Nephrotoxicity,Antioxidant,Herbal agents,Gender
https://journal.waocp.org/article_44110.html
https://journal.waocp.org/article_44110_c8fb0ac31caa82ef58592b6f39cf7968.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Potential Role of E4 Protein in Human Papillomavirus Screening: a Review
315
319
EN
Aidy Irman
Yajid
0000-0001-5058-2051
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
aidyirman84@gmail.com
Mohd Azali
Zakariah
Histopathology Unit, Pathology Department, Hospital Sultanah Aminah, Johor Bahru, Malaysia
azali0901@gmail.com
Anani Aila
Mat Zin
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
ailakb@usm.my
Nor Hayati
Othman
0000-0002-8640-5740
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
hayatikb@usm.my
10.22034/APJCP.2017.18.2.315
<br /> <span style="font-size: small;">In 2006, cervical cancer was reported as the second most common cancer in women of Malaysia. This type of cancer has been shown to correlate with persistent high risk human papillomavirus (HPV) infection. Although HPV is well known to induce cervical cancer, knowledge of pathways that link the latent stage of the viral replication cycle to precancerous and cancerous stages remains incomplete. However, it is interesting to note that the virus can be isolated from tissues ranging from normal to low-grade squamous intraepithelial lesions as well as high-grade intraepithelial lesions (HSILs), thus prompting scientists to develop HPV detection methods for screening. Detection of HPV using viral proteins such as L1 and E1 is proposed to be very useful in assisting the management of high risk infection and cervical cancer. These tests however can lead to false positive results, largely due to the exisstence of asymptomatic or transient HPV infections within any given individual. Somes observation indicate that use of HPV proteins such as E6 and E7 might lead to false positive results. However, one particular HPV protein, E4 shows potential as an accurate marker of the tissue state following HPV infection. E4 expression has been shown to correlate with the levels of HPV </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">DNA incorporation by the host. Thus, it is possible that E4 could serve as a useful marker to define stages of viral </span></span><span style="font-size: small;">carcinogenesis. </span>
HPV,E4,cervical cancer,Screening
https://journal.waocp.org/article_44507.html
https://journal.waocp.org/article_44507_b78cf936e8bdf2dc94cab0778019e452.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Patient-Linked Factors Associated with Delayed Reporting of Oral and Pharyngeal Carcinoma among Patients Attending National Cancer Institute, Maharagama, Sri Lanka
321
325
EN
Laurence Shreenikumari
Alahapperuma
Dental Surgeon, Oral Cancer Department, National Cancer Control Programme, Ministry of Health, Sri Lanka
shreeni2009@yahoo.com
Eshani Anoja
Fernando
Deputy Director, National Cancer Control Programme, Ministry of Health, Sri Lanka.
10.22034/APJCP.2017.18.2.321
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Diagnosis of cancer at an early stage improves prognosis following treatment. Unfortunately a large proportion of oral and pharyngeal cancer patients are diagnosed at late stages which require radical treatment with considerable morbidity and mortality. Many researchers have examined different types of delay that could occur between the onset of symptoms and diagnosis. The objective of this research was to identify patient-linked delays between the </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">time of first noticing symptoms and definitive diagnosis, and its association with the stage at diagnosis among oral </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">and pharyngeal carcinoma patients attending the National Cancer Institute, Maharagama, Sri Lanka. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">hospital-based descriptive cross-sectional study was carried out on 351 patients with histologically confirmed carcinoma </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">of oral cavity and pharynx. Data were collected using an interviewer- administered questionnaire and a data extraction sheet. If a patient had taken more than three months to visit a Health Care Practitioner, it was considered as ‘Patient Delay-1’. If a patient had taken more than two weeks following referral to reach for specialized cancer care, it was considered as ‘Patient Delay 2’. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Proportions of ‘Patient Delay-1’ and ‘Patient Delay-2’ were 19% (n=252) </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">and 16% (n=322) respectively. Mean time duration between noticing symptoms to definitive diagnosis was 14.1 </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">weeks (SD=10.3). The proportion of advanced-stage cancers at diagnosis was 59.8%. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Stage at diagnosis </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">was significantly associated with ‘Patient Delay -1’ (p = 0.001) but not with ‘Patient Delay-2’. ‘Patient Delay-1’ was significantly associated with level of education (p = 0.001) and the cost of travelling (p = 0.048). </span></span>
Early Detection of Cancer,Pharyngeal Neoplasms,Primary Health Care,Prognosis,Health Care Costs
https://journal.waocp.org/article_44508.html
https://journal.waocp.org/article_44508_f9e7571e940ea3cf88253e84b733818b.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Frequency of Epstein Barr Virus Type 1 Among Nasopharyngeal Carcinomas in Iranian Patients
327
331
EN
Toran
Shahani
Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
manoochehr
makvandi
0000-0003-2510-3033
Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
manoochehrmakvandi299@gmail.com
Alireza
Samarbafzadeh
Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Ali
Teimoori
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nastran
Ranjbar
Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nader
saki
Imam Khomeini Hospital, Department of Otolaryngology Head and Neck Surgery, Hearing
Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Soheila
Nikakhlagh
Imam Khomeini Hospital, Department of Otolaryngology Head and Neck Surgery, Hearing
Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Niloofar
Neisi
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Zeinab
Hosseini
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Samira
Pourrezaei
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abdolnabi
Shabani
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Hashem
Radmehr
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Hamide
Mehravaran
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Hadis
Kiani
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Azadeh
Haghi
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
10.22034/APJCP.2017.18.2.327
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Around 95% of the world’s population are infected with the Epstein-Barr virus (EBV), which can persist latent in B lymphocytes and epithelial cells life-long. EBV has been linked with lymphoid and epithelial cancers and persistence of EBV infection in lymphoid or epithelial cells may result in virus-associated B-cell tumors or nasopharyngeal carcinomas (NPC). This study was conducted to determine the frequency of EBV DNA in </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">nasopharyngeal carcinoma tissue of Iranian patients. </span></span><strong><span style="font-size: small;">Materials and methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 50 blocks of formalin-fixed paraffin-embedded tissue of NPCs from 38 (76 %) male and 12 (24%) female patients were collected from archives of Ahvaz hospitals. Sections were cut at 5 μm and DNA was extracted for detection of EBV DNA and EBV typing by mested PCR. DNA sequencing was performed to confirm PCR results. The distribution of EBV DNA was compared </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">among WHO histological subtypes of NPC. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Some 3 female and 11 (22%) male NPC samples showed positive </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">for EBV DNA type 1, 2/14(22.2%)WHO histological type II and 12/41(29.3%) WHO histological type III. </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The frequency of EBV DNA among NPCs in Iranian patients was found to be 28%, EBV type I predominating. Both WHO histological type II and III NPC subtypes demonstrated approximately the same detection prevalence. </span></span>
Epstein-Bar (EBV),Nasopharyngeal carcinoma(NCP),Nested PCR
https://journal.waocp.org/article_44486.html
https://journal.waocp.org/article_44486_7954009445a8f4ad8e1f258bb48b2065.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Esophageal Cancer and associated Factors among Uzbek-Turkmen and Other Ethnic Groups in the Northern Part of Afghanistan
333
337
EN
Mohammad Hassan
Hamrah
Curative Clinic, Andkhoy, Afghanistan
Mohammad Shoaib
Hamrah
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
mshoaibhamrah@gmail.com
Mitsuro
Kanda
Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
Junichi
Sakamoto
Tokai Central Hospital, Kakamigahara, Japan
Mohammad Hussain
Hamrah
Curative Clinic, Andkhoy, Afghanistan
Asif
Hami
Jahan Saht Endoscopic clinic in Shegerghan City, Jozjan province, Afghanistan
Ahmad Edris
Hamrah
Curative Clinic, Andkhoy, Afghanistan
Ahmad Elias
Dahi
Curative Clinic, Andkhoy, Afghanistan
Mohammad Hashem
Hamrah
Curative Clinic, Andkhoy, Afghanistan
hashem.sahab@gmail.com
10.22034/APJCP.2017.18.2.333
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A high incidence rate of esophageal cancer has been observed in the Northern part of Afghanistan, particularly among those of Uzbek-Turkmen ethnicity. However, there is a paucity of published data from which to compare the prevalence of environmental risk factors for esophageal cancer between Uzbek-Turkmen and other ethnic groups. Thus, we investigated the prevalence of environmental risk factors associated with esophageal cancer in the Northern part of Afghanistan, focusing on ethnicity differences. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This retrospective study covered 168 patients </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">diagnosed with esophageal cancer based on endoscopic findings when attending an outpatient clinic from October </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">2013 to April 2016. Demographic data and burden of relevant environmental risk factors were compared between Uzbek-Turkmen and other ethnic groups. Results: In the total of 168 patients (108 Uzbek-Turkmen and 60 other </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">ethnicities), males had significantly higher rates of opium use, chewing nass (a mixture of tobacco, ash and lime), and </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">smoking than female patients. The mean age of the Uzbek-Turkmen group was 62.9 years, while that of the other ethnic </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">group cases was 59.1. The prevalence of opium use, chewing nass and hot tea consumption was significantly higher in </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">the Uzbek-Turkmen group. </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This study showed that there were significant differences in prevalence of </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">opium, nass, and hot tea consumption between Uzbek-Turkmen and the other ethnic group patients with esophageal cancer in the northern part of Afghanistan. </span></span>
Esophageal Cancer,risks factors,ethnic,Andkhoy,Afghanistan
https://journal.waocp.org/article_44422.html
https://journal.waocp.org/article_44422_37c2b7d2813cce24c4ac164d42d32804.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression
339
345
EN
Nathalia
Soares
Programa de Pós-graduação em Ciência de Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
ncpsoares@gmail.com
Clara
Machado
Núcleo de Bioquímica Nutricional, Laboratório de Alimentos Funcionais e Biotecnologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
claramachado55@gmail.com
Bruno
Trindade
Núcleo de Bioquímica Nutricional, Laboratório de Alimentos Funcionais e Biotecnologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
bboquimpani@gmail.com
Ingridy
Lima
Fundação Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, Brazil
nathy.soares@gmail.com
Etel
Gimba
Programa de Biologia Celular, Coordenação de Pesquisa, Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro, Brazil
etelgimba@hotmail.com
Anderson
Teodoro
0000-0002-0949-9528
Núcleo de Bioquímica Nutricional, Laboratório de Alimentos Funcionais e Biotecnologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
atteodoro@gmail.com
Christina
Takiya
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
takiyacm@biof.ufrj.br
Radovan
Borojevic
Centro de Medicina Regenerativa, Faculdade de Medicina de Petrópolis - FASE, Rio de Janeiro, Brazil
rrborojevic@gmail.com
10.22034/APJCP.2017.18.2.339
<br /> <span style="font-size: small;">Carotenoids are the main tomato components, especially lycopene. Lycopene is more bioavailable in tomato processed products than in raw tomatos, since formation of lycopene cis-isomers during food processing and storage may increase </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">its biological activity. In the current study, we evaluated the influence of lycopene extracts (5 mg / mL) from different tomato-based food products (paste, sauce, extract and ketchup) on cell viability and apoptosis on primary human prostate cancer cells (PCa cels) for 96h. Using MTT assay, we observed a significant decrease on primary PCa cell viability upon treatment with lycopene extracted from either 4 tomato-based food products. Flow cytometeric analysis revealed that lycopene from tomato extract and tomato sauce promoted up to fifty-fold increase on the proportion of </span></span><span style="font-size: small;">apoptotic cells, when compared to the control group. Using real time PCR assay, we found that lycopene promoted an upregulation of </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">TP53 </span></span></em><span style="font-size: small;">and </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Bax </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">transcript expression and also downregulation of </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Bcl-2 </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">expression in PCa cells. In </span></span><span style="font-size: small;">conclusion, our data demostrate that </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">cis</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">-lycopene promoted a significant inhibition on primary PCa cell viability, as </span></span><span style="font-size: small;">well as an increase on their apoptotic rates, evidencing that </span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">cis</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">-lycopene contained in tomato sauce and extract cain </span></span><span style="font-size: small;">mainly modulate of primary human prostate cancer cell survival. </span>
tomato-based food products,lycopene,Prostate Cancer,Gene expression,Apoptosis
https://journal.waocp.org/article_44019.html
https://journal.waocp.org/article_44019_98d13cc4017ca22a4654bf3110a28bd8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Relationship of Lifetime Exposure to Tobacco, Alcohol and Second Hand Tobacco Smoke with Upper aero-digestive tract cancers in India: a Case-Control Study with a Life-Course Perspective
347
356
EN
Bhawna
Gupta
School of Dentistry and Oral Health, Griffith University, Gold Coast, Australia
bhawna.gupta@griffithuni.edu.au
Narinder
Kumar
Department of Orthopaedics, Military Hospital, Kirkee, Pune, India
kumarnarinder1969@gmail.com
Newell
Johnson
0000-0001-5866-262X
Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University
n.johnson@griffith.edu.au
10.22034/APJCP.2017.18.2.347
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Squamous cell carcinomas of the upper aero-digestive tract (UADTSCC) are a multifaceted public health problem. Effects of lifestyle risk factors, including tobacco (chewing and smoking), alcohol drinking and exposure to second hand tobacco smoke (SHS) at home and their association with UADT cancers was assessed in a case-control study with a life-course perspective. The study was conducted at two different hospitals in Pune, India. </span></span><strong><span style="font-size: small;">Material and methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The total sample size (N=480) included 240 histopathologically confirmed cases of UADT cancers and an equal number of controls frequency matched with cases by gender and age distribution (+5 years). All the patients were interviewed face-face using structured questionnaires. Self-reported information on socio-demographic and lifestyle risk factors from childhood to the date of diagnosis of disease/cancer was obtained. Frequency, duration and age of initiation of habits were also recorded to study dose-response relationships. Odds ratios and their 95% confidence intervals were calculated through unconditional logistic regression, adjusting for relevant potential confounders. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Chewing tobacco emerged as the strongest predictor for UADT cancers (OR=7.61; 95% CI 4.65-12.45) in comparison to smoking and drinking alcohol. Exposure to SHS during childhood (</span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Early exposure to various modifiable lifestyle risk factors has a strong positive association with UADT cancer incidence. Effective future public </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">health interventions with focus on vital time points in life targeting these risk factors could possibly be a major step in </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">primary prevention and control of this cancer at the population level. </span></span></span>
Upper aero-digestive tract cancer,Tobacco,drinking alcohol,second hand tobacco smoke,Case-control study
https://journal.waocp.org/article_43998.html
https://journal.waocp.org/article_43998_601ab385c3d103d58ad86f647f2c57ae.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Cervical Cancer Screening in Iranian Women: Healthcare Practitioner Perceptions and Views
357
363
EN
Mansoureh
Refaei
0000-0002-1114-7847
Department of Reproductive Health, Nursing and Midwifery School of Sciences, Tehran University of Medical Sciences, Tehran, Iran
mansourehrefaei@yahoo.com
Nahid
Dehghan Nayeri
Nursing and Midwifery Care Research Center, Nursing and Midwifery School of Sciences, Tehran University of Medical Sciences, Tehran, Iran
nahid.nayeri@gmail.com
Zohreh
Khakbazan
Department of Reproductive Health, Nursing and Midwifery School of Sciences, Tehran University of Medical Sciences, Tehran, Iran
khakbaza@sina.tums.ac.ir
minoo
pakgohar
Department of Gerontological Nursing,
Reproductive Health, Nursing and Midwifery school of sciences, Tehran University of Medical Sciences, Tehran, Iran
mpakgohar@razi.tums.ac.ir
10.22034/APJCP.2017.18.2.357
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Although regular screening for cervical cancer with the Papanicolaou test is an important element for reducing the incidence and mortality of cervical cancer, the actual screening program in Iranian women is not </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">sufficiently comprehensive at present. The purpose of this study was to explore healthcare provider perceptions of factors </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">affecting cervical cancer screening in Iranian women. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this qualitative study performed from September 2015 to August 2016 in Hamadan, Iran, we conducted semi-structured in depth interviews with 14 healthcare providers selected purposefully. All interviews were recorded, transcribed and analyzed according to a conventional thematic analysis approach. MAXQDA10 software was employed for data analysis. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Four themes were extracted from data: "Inefficient management of cervical cancer screening process, Personal and professional characteristics of health </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">care providers, Individual barriers and facilitators, Need for health system authorities to pay attention". </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Increased official attention to screening, and identifying challenges and providing strategies based on these challenges </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">will help in achieving a successful screening program. It is necessary to attend to professional features of medical science students and increase the skills of interaction with clients in addition to academic training. Efforts should be made to increase trust in healthcare providers regarding the Pap test and receptiveness of society to this screening modality through informing the public, with encouragement through the media. </span></span>
Papanicolaou Test,healthcare practitioners,Iran
https://journal.waocp.org/article_44520.html
https://journal.waocp.org/article_44520_1f6633b8e57c5521c9991ec14af3b77d.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Effects of Cisplatin-Loaded Niosomal Nanoparticleson BT-20 Human Breast Carcinoma Cells
365
368
EN
Leila
Kanaani
Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran
lk_rd@yahoo.com
Iraj
javadi
Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran
h.madadi92@gmail.com
Meysam
Ebrahimi-Far
Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran
ebrahimifar67@gmail.com
Hasan
Ebrahimi shahmabadi
Department
of Microbiology, Parasitology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan,
Kerman
Azim
Akbarzadeh Khiyavi
Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran
azimakbarzadehkhiyavi@yahoo.com
Torkan
Mehrdiba
Islamic Azad University,Ahar Branch,Ahar,Iran
mehrdiba_t@yahoo.com
10.22034/APJCP.2017.18.2.365
<br /> <span style="font-size: small;">Breast cancer is the fifth most common cause of death among women worldwide. Resistance to cisplatin is a main challenge in its treatment. Our present aim was to prepare nanoniosomated cisplatin and examine its efficacy in vitro </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">using the BT-20 cell line. Niosome nanoparticles containing cisplatin were prepared by reverse-phase evaporation and characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), spectrophotometry and MTT assay. The size and zeta potential of the nanodrug were estimated as 489.3 ± 23.66 nm and 23.4 ± 2.1 mV, respectively. </span></span><span style="font-size: small;">Drug encapsuies confirmed appropriate retention of particles. Nanoparticles also increased the cytotoxic effects of </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">cisplatin by 1.5 times compared to the standard drug. Findings of our study suggest that niosome nanoparticles are good carriers for cisplatin delivery to breast cancer cells. </span></span>
KEYWORDS: Breast cancer,Cisplatin,Niosome nanoparticles,MTT,Cytotoxicity
https://journal.waocp.org/article_44114.html
https://journal.waocp.org/article_44114_bff3b8e686e9c4f13af40387e5b71f6f.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Assessment of Anxiety and Depression Status in Turkish Cutaneous Melanoma Patients
369
373
EN
Faruk
Tas
Institute of Oncology, Istanbul University,
Capa, 34390, Istanbul, TURKEY
faruktas2002@yahoo.com
Senem
Karabulut
Institute of Oncology, Istanbul University,
Capa, 34390, Istanbul, TURKEY
drsenemkarabulut@gmail.com
Hulya
Guveli
Institute of Oncology, Istanbul University,
Capa, 34390, Istanbul, TURKEY
hulyaguveli@gmail.com
Sidika
Kurul
Institute of Oncology, Istanbul University,
Capa, 34390, Istanbul, TURKEY
skurul@istanbul.edu.tr
Kayhan
Erturk
Institute of Oncology, Istanbul University,
Capa, 34390, Istanbul, TURKEY
kayhanerturk@gmail.com
Murat
Guveli
Institute of Oncology, Istanbul University,
Capa, 34390, Istanbul, TURKEY
mguveli@gmail.com
Hasibe
Kinik
Institute of Oncology, Istanbul University,
Capa, 34390, Istanbul, TURKEY
hasibe_kinik@hotmail.com
10.22034/APJCP.2017.18.2.369
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Even though anxiety and depression are two mood disorders encountered commonly in cancer patients only few trials have been carried out so far in melanoma patients. The aim of the study was to determine the clinical prevalence of these disorders in Turkish cutaneous melanoma patients and to clarify possible clinicopathological factors </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">influencing them. </span></span><strong><span style="font-size: small;">Material and methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 100 consecutive outpatient melanoma patients were enrolled and asked to complete the Hospital Anxiety and Depression Scale (HADS) questionnaire immediately after scheduled visits. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 24 participants had clinical anxiety and 8 were diagnosed with borderline anxiety. Fifteen were diagnosed with clinical depression and 20 with borderline depression. Prior to melanoma diagnosis the majority of the patients, 93 and 86, were assessed as normal in terms of their anxiety and depression status, respectively (p<0.001). </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A statistically significant correlation was found between anxiety and depression scores (p<0.001). The patients with advanced disease were significantly more anxious and depressive than those with early stage disease. None of the other </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">socio-demographic parameters was found to be correlated with anxiety and depression status. </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Because a large group of Turkish melanoma patients, nearly one third of the cohort, was found to be suffering from relevant anxiety and depression, it is of uttermost importance that psychological support and pharmacological intervention for these patients be commenced as soon as possible. </span></span>
Anxiety,depression,Melanoma,Prevalence,Turkish
https://journal.waocp.org/article_43845.html
https://journal.waocp.org/article_43845_c7be97e41becb2ffa55766ddb06d4146.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study
375
379
EN
Sedigheh
Bakhtiari
Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
sbakhtiari2007@yahoo.com
Hamed
Mortazavi
Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
h.mortazavi@sbmu.ac.ir
Masoumeh
Mehdipour
Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
mehdipourf@gmail.com
Nahal
Jafarian
Dentist, Tehran, Iran
nahal_jafarian@yahoo.com
Nastaran
Ranjbari
Department
of Pathology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
ranjbari-n@ajums.ac.ir
Somayeh
Rahmani
Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
s.rahmani2011@yahoo.com
10.22034/APJCP.2017.18.2.375
<br /> <strong><span style="font-size: small;">Objective: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Squamous cell carcinoma (SCC) is a life threatening lesion but there has been only limited research about its frequency in Iran. The aim of this study was to evaluate the frequency of squamous cell carcinoma of the head and neck in the records of the pathology department of Imam Khomeini hospital in Ahvaz between 2005 and 2015. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The retrospective and cross-sectional study was conducted using 55,708 medical records of cancer throughout the body, accumulated in the pathology department of Imam Khomeini in Ahvaz in the designated period. Information about age, gender, site of involvement, histological characteristics, status of lymph node metastasis, smoking habit, family history, job and education level was extracted and data were analyzed with the Chi-square test with SPSS version 22. </span></span><strong><span style="font-size: small;">Result: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Of the total of 55,708 records, 582 patients (1.04%) had head and neck squamous cell carcinomas. The male to female ratio was 2.85. The frequencies in the head, mouth and neck were 28.7%, 22% and 49.3% respectively. Significant relationships between being male and location (neck) (p = 0.002), age (60 to 80 years old) and being a farmer (p = 0.001) was observed. The most important correlated risk factors were: smoking, sunlight exposure, rural residence, job and education level. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Head and neck squamous cell carcinomas were found to account for 1.04% of all cancers in Ahvaz, one of the southern provinces of Iran. </span></span>
Squamous Cell Carcinoma,Iran,Epidemiology
https://journal.waocp.org/article_44427.html
https://journal.waocp.org/article_44427_814623cec785bf883ebee596f5ad4ded.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
VEGFR-3 Expression in Oral Lichen Planus
381
384
EN
Zahra
Zolfaghari
Oral and Maxillofacial Pathology Department,Dental Faculty, Babol University of Medical Sciences, Babol, Iran
z_zolfaghari@yahoo.com
Maryam
Seyedmajidi
Dental Materials Research Center, Dental Faculty, Babol University of Medical Sciences, Babol, Iran
ms_majidi79@yahoo.com
Majid
Sharbatdaran
pathology department, Medical Faculty, Babol University of Medical Sciences, Babol, Iran
m.sharbatdaran@mubabol.ac.ir
Ali
Bijani
Non-Communicable pediatrics Diseases Research Center, Babol University of Medical Sciences, Babol, Iran
a.bijani@yahoo.com
Fatemeh
Mozaffari
Oral and Maxillofacial Pathology Department, Dental Faculty, Mazandaran University of Medical Sciences, Sari, Iran
fatemehmozaffari@yahoo.com
Pouyan
Aminishakib
Oral and Maxillofacial Pathology Department, Dental Faculty, Tehran University of Medical Sciences, Tehran, Iran
p_aminishakib@yahoo.com
10.22034/APJCP.2017.18.2.381
<br /> <strong><span style="font-size: small;">Background and objective: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Given the postulated the role of inflammation and possible contribution of lymphangiogenesis in oral lichen planus, this study aimed to assess any associated presence of VEGFR-3. </span></span><strong><span style="font-size: small;">Material and Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This cross-sectional study was performed on 52 formalin fixed and paraffin embedded blocks of oral lichen planus (pathological diagnosis based on Modified WHO criteria), comprising 25 of erosive and 27 of reticular type, along with 60 samples of normal mucosa (with minimal inflammation from clinical and histopathological aspects) obtained at crown lengthening surgery. Four micron sections were cut from paraffin blocks and stained with H and E for confirmation of diagnosis and by immunohistochemistry with primary antibodies against VEGFR-3. Negative controls were provided by omission of primary antibody and placenta was considered as a positive control. Data were analyzed by Chi-square, Mann-Whitney and Kruskal-wallis tests and P </span><strong><span style="font-size: small;">Findings: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">VEGFR-3 expression was apparent in 61.5% of lichen planus specimens and 5% of those from normal mucosa (p<0.001). Also, the average number of stained vessels was significantly higher in oral lichen planus than in normal mucosa (p<0.001). VEGFR-3 expression in oral lichen planus (p=0.262) and the average number of stained vessels (p=0.092) demonstrated no significant difference according to the type. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">It appears that VEGFR-3 expression might be involved in the pathogenesis of the oral lichen planus through increasing lymphatic vessels and lymphangiogenesis </span></span></span>
VEGFR-3,immunohistochemistry,Oral lichen planus
https://journal.waocp.org/article_44005.html
https://journal.waocp.org/article_44005_b93cfbf98e0c0e035dc4fac1fef95b2a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Quality of Life in Cervical Cancer Survivors and Healthy Women: Thai Urban Population Study
385
389
EN
Pichita
Prasongvej
Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang
delkaiser@gmail.com
Tongta
Nanthakomon
Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang
ntongta@gmail.com
Kankamol
Jaisin
Department of Psychiatry, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang, Pathum Thani, 10120, Thailand.
kjaisin@gmail.com
Athita
Chanthasenanont
Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang
dr.athita@gmail.com
Supapen
Lertvutivivat
Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang
supapenl@gmail.com
Chamnan
Tanprasertkul
Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang
chamnandoctor@gmail.com
Kornkarn
Kornkarn Bhamarapravatana
Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang,
drkornkarn@gmail.com
Komsun
Suwannarurk
0000 0003 3019 9877
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Thailand. 95 Moo 8, Paholyotin Rd, Klongluang
k_suwannarurk@yahoo.com
10.22034/APJCP.2017.18.2.385
<br /> <strong><span style="font-size: small;">Background : </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">To determine a baseline quality of life (QoL) in cervical cancer survivors compared to that of healthy subjects in the tertiary Thammasat University Hospital, Thailand. </span></span><strong><span style="font-size: small;">Materials and Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The investigation was conducted at the outpatient gynecological department of Thammasat University Hospital between January and June 2016. A total of 192 women were entered into the study (97 cervical cancer survivors; 37 after radical hysterectomy (RH), 43 with concurrent chemoradiation (CRT), and 17 featuring both RH and CRT; and 95 control subjects from the same outpatient department with no history of malignancy). Participant QoL was assessed using a Thai version of the EORTC-QLQ-C30 (European Organization for Research Treatment of Cancer Quality-of-Life) and a general survey for the assessment of sociodemographic data was also conducted. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">There were significant differences in physical, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">role, emotional and social functions between cervical cancer survivor and control groups. Global health, fatigue, pain, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">appetite loss, and financial difficulties also demonstrated statistically significant variation. Cervical cancer survivors </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">treated by RH had higher scores for emotional and social function and global health than the control group. Moreover, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">they had less appetite loss, fatigue and financial difficulties. However, patients treated with CRT experienced more </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">pain than the control group. All cervical cancer survivors had lower physical function scores than the control group. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Quality of life in cervical cancer survivors is better than in healthy peers in some domains. Cervical cancer survivors treated with RH may have a better QoL than healthy peers. Early detection for early stage cervical cancer remains most important because treatment in early stages does not cause lowering of the QoL. </span></span>
cervical cancer,Quality of Life,Radical hysterectomy,Concurrent chemoradiation
https://journal.waocp.org/article_44462.html
https://journal.waocp.org/article_44462_e5133c73588fb01efba24b941df1a65f.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Meta-Analysis of Serum Gastrin-Releasing Peptide Precursor as a Biomarker for Diagnosis of Small Cell Lung Cancer
391
397
EN
Ping
Lv
Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, GuiZhou Province
lvshuipinglsp@163.com
Yi
Wang
Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, GuiZhou Province
403747910@qq.com
Lang
Huang
Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, GuiZhou Province
810199543@qq.com
Fei
Wang
Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, GuiZhou Province
861642896@qq.com
Guo
Jian
Zhou
Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, GuiZhou Province
435210693@qq.com
Hu
Ma
Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi, GuiZhou Province
mahuab@163.com
10.22034/APJCP.2017.18.2.391
<strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The serum level of gastrin-releasing peptide precursor (proGRP) is generally. elevated in patients with </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">small cell lung cancer (SCLC). However, the diagnostic sensitivity and specificity of serum proGRP in SCLC cases </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">remains controversial. The study aimed to assess the diagnostic value of this biomarker by meta-analysis. </span></span><strong><span style="font-size: small;">Materials and Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The Cochrane, Clinical trials, Pubmed, Web of Science and Embase databases were searched and diagnostic </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">values were calculated or extracted. Statistical analysis was accomplished with RevMan 5.3 and STATA 12.0 software. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 27 studies with 7268 participants were included. The pooled sensitivity, specificity, PLR, NLR </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">and DOR were 0.754 (95% CI: 0.700-0.802), 0.945 (95% CI: 0.916-0.965), 13.804 (95% CI: 9.096-20.948), 0.260 (95% CI: 0.213-0.317) and 53.101 (95% CI: 34.327-82.145) respectively. The AUC was 0.910 (95% CI: 0.880-0.930). </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Significant publication bias was not found (</span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">=0.622). </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The meta-analysis indicated that serum proGRP </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">is indeed a useful biomarker with good sensitivity and high specificity for diagnosis of SCLC. Therefore proGRP can be expected to be widely applied in the clinic for identification of lung cancer patients. </span></span>
proGRP,Diagnosis,SCLC,Meta-analysis
https://journal.waocp.org/article_44104.html
https://journal.waocp.org/article_44104_d1277ea5826bbaae917d70e0ffca3d04.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Antioxidant and Antiproliferative Activities of an Ethylacetate Fraction of Picria Fel-Terrae Lour. Herbs
399
403
EN
Denny
Satria
0000-0003-4724-3256
Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara
dennysatria@usu.ac.id
Jansen
Silalahi
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara
jansen@usu.ac.ic
Ginda
Haro
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara
gindaharo@yahoo.com
Syafruddin
Ilyas
Department of Biology, Faculty of Mathematics and Natural Sciences, University of Sumatera Utara
syafruddinilyas2013@gmail.com
Poppy
Anjelisa Zaitun
Hasibuan
Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara
poppyanjelisa@usu.ac.id
10.22034/APJCP.2017.18.2.399
<br /> <span style="font-size: small;">Background: Excessive production of oxygen free radicals and imbalance in the mechanisms responsible for antioxidant protection may result in the onset of many diseases including breast cancer. Objective: To evaluate antiproliferative and antioxidant activity of an ethylacetate fraction (EAF) of Picria fel-terrae Lour. Herbs in the T47D </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">cell line. Methods: Phenolic and total flavonoid contents in EAF were determined. EAF was tested for cytotoxicity and </span></span><span style="font-size: small;">effects on the cell cycle and apoptosis, as well as antioxidant activity. Results: EAF was found to contain high levels of </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">phenolic agents (92.88 ± 0.50 mg GAE/g), total flavonoid (84.39 ± 0.07 mg QE/g). The EAF of Picria fel-terrae Lour. </span></span><span style="font-size: small;">herbs was found to have an IC50 of 62.98μg/mL, caused accumulation in G0-G1 and S phase and increased early and late apoptosis. Antioxidant activity in DPPH assays gave an IC50 of 166.90 ± 0.10 μg/mL. Conclusions: The results reveal that EAF of Picria fel-terrae Lour. herbs has antiproliferative activity and strong antioxidant potential. Further studies are now needed to isolate the responsible antiproliferative and antioxidant components. </span>
Antiproliferative,Antioxidant,Picria fel-terrae Lour,ethylacetate fraction
https://journal.waocp.org/article_44105.html
https://journal.waocp.org/article_44105_271adce8918bb3634f442cb8eae28b16.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
The Optimal Cut-Off Level of The Fecal Immunochemical Test For Colorectal Cancer Screening in a Country with Limited Colonoscopy Resources: A Multi-Center Study from Thailand
405
412
EN
Satimai
Aniwan
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
satimai@gmail.com
Thawee
Ratanachu-Ek
Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
thawee1958@gmail.com
Supot
Pongprasobchai
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
supotpong@gmail.com
Julajak
Limsrivilai
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
alimsrivilai@gmail.com
Ong-Ard
Praisontarangkul
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
ongardpr@gmail.com
Pises
Pisespongsa
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
pises70@gmail.com
Pisaln
Mairiang
0000-0001-8127-9952
Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
pisaln_m@hotmail.com
Apichat
Sangchan
Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
apichaz@yahoo.com
Jaksin
Sottisuporn
NKC Institute of Gastroenterology and Hepatology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, Thailand
pondjaksin@hotmail.com
Naruemon
Wisedopas
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
wnaruemon@gmail.com
Pinit
Kullavanijaya
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
pinitkul@hotmail.com
Rungsun
Rerknimitr
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand
ercp@live.com
10.22034/APJCP.2017.18.2.405
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Selecting the cut-off point for the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening programs is of prime importance. The balance between the test performance for detecting advanced neoplasia and the available colonoscopy resources should be considered. We aimed to identify the optimal cut-off of FIT for advanced neoplasia in order to minimize colonoscopy burden. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">We conducted a multi-center study in 6 hospitals from diverse regions of Thailand. Asymptomatic participants, aged 50-75 years, were tested with one-time quantitative FIT (OC-SENSOR, Eiken Chemical Co.,Ltd., Tokyo, Japan) and all participants underwent colonoscopy. We assessed test performance in detecting advanced neoplasia (advanced adenoma and CRC) and measured the burden of colonoscopy with different cut-offs [25 (FIT25), 50 (FIT50), 100 (FIT100), 150 (FIT150), and 200 (FIT200)ng/ml]. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Among 1,479 participants, advanced neoplasia and CRC were found in 137 (9.3%) and 14 (0.9%), respectively. From FIT25 to FIT200, the positivity rate decreased from 18% to 4.9%. For advanced neoplasia, an increased cut-off </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">decreased sensitivity from 42.3% to 16.8% but increased specificity from 84.2% to 96.3%. The increased cut-off </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">increased the positive predictive value (PPV) from 21.5% to 31.5%. However, all cut-off points provided a high negative predictive value (NPV) (>90%). For CRC, the miss rate for FIT25 to FIT 150 was the same (n=3, 21%), whereas that with FIT200 increased to 35% (n=5). </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In a country with limited-colonoscopy resources, using FIT150 may be preferred because it offers both high PPV and NPV for advanced neoplasia detection. It could also decrease colonoscopy workload, while maintaining a CRC miss rate similar to those with lower cut-offs. </span></span>
Fecal Occult Blood Test,Colorectal cancer screening,colonoscopy,colorectal cancer
https://journal.waocp.org/article_44420.html
https://journal.waocp.org/article_44420_aac901ecac61c9bf254aac68eb41960c.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Mutation Analysis of Isocitrate Dehydrogenase (IDH1/2) and DNA Methyltransferase 3A (DNMT3A) in Thai Patients with Newly Diagnosed Acute Myeloid Leukemia
413
420
EN
Tanasan
Sirirat
Doctoral Program in Clinical Pathology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
tansno@hotmail.com
Suporn
Chuncharunee
Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
supornch@gmail.com
Pimjai
Nipaluk
Division of Hematology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
niparuckblue@gmail.com
Teerapong
Siriboonpiputtana
Human Genetic Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
teerapong.sir@mahidol.ac.th
Takol
Chareonsirisuthigul
0000-0003-3524-0349
Human Genetic Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
takol.cha@mahidol.ac.th
Nittaya
Limsuwannachot
Human Genetic Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
lae_ha@yahoo.com
Budsaba
Rerkamnuaychoke
Human Genetic Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
budsaba.rer@mahidol.ac.th
10.22034/APJCP.2017.18.2.413
<br /> <span style="font-size: small;">Acute myeloid leukemia (AML) is a clonal hematopoietic stem/progenitor cell disorder which features several </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">genetic mutations. Recurrent genetic alterations identified in AML are recognized as causes of the disease, finding application as diagnostic, prognostic and monitoring markers, with potential use as targets for cancer therapy. Here, we performed a pyrosequencing technique to investigate common mutations of IDH1, IDH2 and DNMT3A in 81 newly diagnosed AML patients. The prevalences of IDH1, IDH2 and DNMT3A mutations were 6.2%, 18.5%, and 7.4%, respectively. In addition, exclusive mutations in IDH1 codon 132 (R132H, R132C, R132G and R132S) were identified in all IDH1-mutated cases indicating that these are strongly associated with AML. Interestingly, higher median blast cell counts were significantly associated with IDH1/2 and DNMT3A mutations. In summary, we could establish a routine robust pyrosequencing method to detect common mutations in IDH1/2 and DNMT3A and demonstrate the frequency </span></span><span style="font-size: small;">of those mutations in adult Thai AML patients. </span>
acute myeloid leukemia,Isocitrate dehydrogenase,DNA methyltransferase,Pyrosequencing
https://journal.waocp.org/article_43436.html
https://journal.waocp.org/article_43436_40554f5ac47f842bf25edaeb3bafe023.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Epidemiological Characteristics of Retinoblastoma in Children Attending Almouassat University Hospital, Damascus, Syria, 2012-2016
421
424
EN
Ahmad
Al Hasan
Department of Ophthalmology, Damascus University, Al Mouassat University Hospital, Damascus, Syria
ophth.ahmadalhasan@gmail.com
Rashad
Murad
Faculty of Pharmacy, University of Damascus, Damascus, Syria
dr.murad.r@gmail.com
Khaldoun
Zaid
Department of Ophthalmology, Damascus University, Al Mouassat University Hospital, Damascus, Syria
khaldounzaid91@gmail.com
Jourjous
A Daoud
Department of Ophthalmology, Damascus University, Al Mouassat University Hospital, Damascus, Syria
jourjous.aldaoud@gmail.com
Khaled
Zaid
0000-0003-1034-4061
Department of Oral Histology and Pathology, Faculty of Dentistry , Damascus University
dr.khaled.zaid@gmail.com
10.22034/APJCP.2017.18.2.421
<br /> <span style="font-size: small;">Retinoblastoma (Rb) is a malignant tumor that originates from the developing retina. Diagnosis is based on clinical </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">signs and symptoms and usually children under the age of five years are affected. Early diagnosis and treatment of Rb </span></span><span style="font-size: small;">and non-ocular tumors can reduce morbidity and increase longevity. Treatment in the early stages may allow a good prognosis and salvage of visual function.The aim of this study is to present descriptive epidemiological aspects of retinoblastomas in children seen at Almouassat University Hospital (AUH) in Damascus, Syria from 1 January 2012 to 31 October 2016In this retrospective, observational hospital survey, medical records of 37 retinoblastoma cases were reviewed. The male/female (M/F) ratio was 1.6. The most frequent presenting sign was leukocoria (56.7%) and 81% of cases were diagnosed between the ages of 4 months and 3 years. More than 73% of cases were diagnosed early at stages I and II. </span>
retinoblastoma,Epidemiology,children
https://journal.waocp.org/article_44494.html
https://journal.waocp.org/article_44494_3af1e9d7f49081d5cf6e07446cb3a519.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Comparison of Hypersensitivity Reactions to Carboplatin Retreatment in Gynecologic Cancer Patients between One and Two Hour Infusions: a Randomized Trial Study
425
430
EN
Weerawich
Pornwattanakrilert
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Faculty of Medicine, Chiang Mai University, Chiang
Mai 50200, Thailand
weerawich.medic32@gmail.com
Prapaporn
Suprasert
0000-0002-0205-2280
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Faculty of Medicine, Chiang Mai University, Chiang
Mai 50200, Thailand
psuprase@gmail.com
10.22034/APJCP.2017.18.2.425
<br /> <strong><span style="font-size: small;">Objective: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">To compare the incidence rate of carboplatin hypersensitivity reactions (HSRs) in gynecologic cancer patients receiving one-hour or two-hour carboplatin retreatment infusions. </span></span><strong><span style="font-size: small;">Setting: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A Prospective Randomized Controlled Trial. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Recurrent gynecologic cancer patients 25 to 80-years of age who were scheduled to receive carboplatin retreatment after previously receiving at least six cycles of carboplatin without a history of platinum allergy were invited to enroll. They were randomized to receive either a one-hour or two-hour carboplatin infusion in each cycle. The nurses recorded any occurrence of HSR. Patients who developed carboplatin HSR were discontinued from the study. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Forty-five patients were enrolled and randomized to receive either a one-hour carboplatin infusion </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">arm in 69 cycles or a two-hour infusion arm in 67 cycles. Both groups were well balanced regarding median age, body mass index, type of cancer, history of drug allergy, median platinum free interval time, median total number of previous carboplatin cycles, premedication type, regimen and median total dose of carboplatin. Five (3.67%) of the 136 cycles resulted in carboplatin HSR, all of which were Grade 1. Of these, four cycles developed HSR during the one-hour infusion and only one cycle with a two-hour infusion (P=0.37). The onset of carboplatin HSR occurred within 30-105 minutes after infusion start. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Extending the carboplatin infusion time to two hours from one hour did not </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">significantly decrease carboplatin HSR. </span></span>
Carboplatin,hypersensitivity reaction,gynecologic cancer,extended infusion time
https://journal.waocp.org/article_44021.html
https://journal.waocp.org/article_44021_81a750a09a20b7523eea7522f39cd07a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Value of Sentinel Lymph Node (SLN) Mapping and Biopsy using Combined Intracervical Radiotracers and Blue Dye Injections for Endometrial Cancer
431
435
EN
Farah
Farzaneh
0000-0002-5062-4386
Preventative Gynecology Research Center, Shahid Beheshti university of Medical Sciences, Tehran, Iran.
farahzaneh@yahoo.com
Atefeh
Moridi
0000-0002-7791-4439
Preventative Gynecology Research Center, Shahid Beheshti university of Medical Sciences, Tehran, Iran.
moridi59@gmail.com
Zahra
Azizmohammadi
Nuclear Medicine Department, Imam Hossein Hospital, Shahid Beheshti university of Medical Sciences, Tehran, Iran
azizmohammadi@gmail.com
Mojtaba
Ansari J
Nuclear Medicine Department, Imam Hossein Hospital, Shahid Beheshti university of Medical Sciences, Tehran, Iran
ansari_j@gmail.com
Maryam Sadat
Hosseini
Preventative Gynecology Research Center, Shahid Beheshti university of Medical Sciences, Tehran, Iran.
milmedjournal@gmail.com
Maliheh
Arab
0000-0002-2244-3529
Preventative Gynecology Research Center, Shahid Beheshti university of Medical Sciences, Tehran, Iran.
drmarab@yahoo.com
Tahereh
Ashrafganjoei
Preventative Gynecology Research Center, Shahid Beheshti university of Medical Sciences, Tehran, Iran.
seyedo2@yahoo.com
Mina
Mazaheri
Radiology Technologist, Nuclear Medicine Department, Shahid Beheshti university of Medical Sciences, Tehran, Iran.
seyedbmsu@gmail.com
10.22034/APJCP.2017.18.2.431
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Lymphadenectomy, as part of the initial surgical staging of patients with endometrial carcinoma, remains a controversial topic in gynecologic oncology. Sentinel lymph node (SLN) mapping has become a well-accepted procedure for melanomas and breast cancer; a number of investigators have begun to explore the utility and accuracy of this technique with regard to endometrial cancer. </span></span><strong><span style="font-size: small;">Aim: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This study was conducted to evaluate SLN mapping of early stage endometrial cancer with blue dye in conjunction with a radioactive tracer. </span></span><strong><span style="font-size: small;">Subjects and methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this prospective cross-sectional study, patients with stage I and II endometrial cancer who were candidates for systemic lymph node dissection during surgery were enrolled, some underwent lymph node mapping and SLN biopsy using combined intra cervical radiotracer and blue dye injections and some applying only an intra cervical radiotracer. SLNs </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">and other lymph nodes were sent for pathological assessment. Sensitivity, specificity, the positive predictive value, and </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">the negative predictive value were calculated as predictive values for the radiotracer and blue dye. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Pre-operative lymph node mapping showed SLN in 29 out of 30 patients. Intra operations in 29/30 patients, SLNs were harvested by gamma probe; in 13 out of 19 patients SLNs were detected by blue dye. The median number of SLNs per patient was 3 and the total number of SLNs detected was 81. Four patients had positive pelvic lymph nodes. All of the positive nodes were SLNs. Using this technique (radiotracer and blue dye) an overall detection rate of 96.7%, an NPV of 100%, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">a sensitivity of 100% and a specificity of 3.85% were achieved. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Results of SLN research for endometrial </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">cancer are promising and make feasible the possibility of avoiding unnecessary aggressive surgical procedures in near </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">future by advances in SLN mapping. </span></span>
Sentinel Lymph Node,radiotracer,blue dye,cervical injection,Endometrial cancer
https://journal.waocp.org/article_44109.html
https://journal.waocp.org/article_44109_7787e35dededf054029162caeea4c6e3.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Polycyclic Aromatic Hydrocarbons In Edible Mushrooms from Niger Delta, Nigeria: Carcinogenic and Non-Carcinogenic Health Risk Assessment
437
447
EN
sorbari
igbiri
Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port-Harcourt, Rivers State, Nigeria
sorbariigbiri@gmail.com
Nnaemeka
Udowelle
Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port-Harcourt, Rivers State, Nigeria
emekaudowelle@gmail.com
Osazuwa
Ekhator
Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port-Harcourt, Rivers State, Nigeria
osaclinsungyung@gmail.com
Rose
Ngozi
Asomugha
Department of Chemistry, Faculty of Science, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
roseasomugha2006@yahoo.com
Zelinjo
Nkeiruka
Igweze
Faculty of Pharmacy, Madonna University Elele, Port Harcourt, Rivers State, Nigeria
zeligweze@yahoo.co.uk
orish
orisakwe
Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port-Harcourt, Rivers State, Nigeria
orishebere@gmail.com
10.22034/APJCP.2017.18.2.437
<br /> <span style="font-size: small;">In the oil-rich Niger Delta, hydrocarbon pollution and oil spillages, gas flaring and sundry anthropogenic activities </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">constitute sources of polycyclic aromatic hydrocarbons (PAHs), with food contamination playing a major role in human exposure. In this study we assessed PAH levels in wild and cultivated edible mushroom species consumed by the general population from the oil producing Niger Delta, Nigeria. The concentrations of USEPA-16 PAHs were determined by gas chromatography and carcinogenic and non-carcinogenic health risks were calculated. The concentrations of USEPA-16 PAHs ranged from 0.02 mg/kg – 3.37 mg/kg. The dietary intake of carcinogenic and non-carcinogenic USEPA-16 PAHs (Naphthalene, Acenaphthylene, Acenaphthene, Anthracene, Phenanthrene, Flourene, Flouranthene, Pyrene, Benzo[a]Anthracene, Chrysene, Benzo[a]Pyrene, Benzo[b]Flouranthene, Benzo[K]Flouranthene, Benzo[g,h,i] Perylene, Dibenz[a,h]Anthracene and Ideno[1,2,3-cd]Pyrene) for adults, adolescents and seniors ranged from 0.00 – 0.05 mg/kg/day, 0.00 – 0.06 mg/kg/day and 0.00 – 0.07 mg/kg/day. The BaPeq ranged from 0.02 – 2.76 with margin of exposure MOE values of BaP ranging from 3,500,000 to 700,000, 3,500,000 and 3,500,000 to 7,000,000 for adults, </span></span><span style="font-size: small;">adolescents and seniors indicating very insignificant health risk. The incremental lifetime cancer risk was within the </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">safe range of 1.56x10-8 – 1.73x10-6 with the highest calculated risk found for wild </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Pleurotus ostreatus </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">mushroom species from the study area. </span></span>
superfoods,farm produce,Organic pollutants,risk assessments,public health
https://journal.waocp.org/article_44448.html
https://journal.waocp.org/article_44448_d7490ba738f9bddb0464fedf1f9a742f.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Effects of a Self-Encouragement Program on Stress of Mothers of Children with Cancer Referred to Imam Ali Hospital, Zahedan, In 2015
449
453
EN
Mahdieh
Saljughi
Faculty of Nursing, Islamic Azad University, Khorasgan Branch, Isfahan, Iran
mahdie.saljooghi@gmail.com
Narges
Sadeghi
Faculty of Nursing, Islamic Azad University, Khorasgan Branch, Isfahan, Iran
n45sadeghi@yahoo.com
10.22034/APJCP.2017.18.2.449
<br /> <strong><span style="font-size: small;">Introduction: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In addition to the physical problems for the patients themselves, cancer can cause several social and psychological problems to the family, especially the mother in pediatric cases. This study aimed to investigate the effects of a self-encouragement program on stress of mothers of children with cancer referred to Imam Ali Hospital of Zahedan in 2015. </span></span><strong><span style="font-size: small;">Materials and Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This case-control study was performed on 44 mothers with children suffering from cancer, referred to the hospital during October and November of 2015. Convenience sampling was used, and the mothers were randomly allocated into two 22-member groups. The Impact of Event Scale – Revised (IES-R) </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">was the data collection instrument. Educational classes were held in the hospital. Confidentiality and mutual respect </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">were observed by each and every member of the group. Data obtained before and after the intervention were analyzed </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">using the independent t-test, paired t-test and ANOVA. The significance level was set at 0.05. </span></span><strong><span style="font-size: small;">Findings: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The most frequent diseases were acute lymphoblastic leukemia (47%) and brain tumors (16%). The results indicated that the </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">mean score of stress in the control group did not significantly between the two time points (P=0.106). In the intervention group, however, there was a significant difference in stress mean scores before (54.3±2.0) and after (37.1±1.8) the intervention (P<0.001). </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Self-encouragement can help mothers dealing with a diseased child to feel less stressed. Therefore, they may be able to act more effectively when faced with problems. </span></span>
Stress,Self-encouragement,cancer,children,Mothers
https://journal.waocp.org/article_43624.html
https://journal.waocp.org/article_43624_e8d90c36b6bcda2deef4418f3ce991a7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
High Fluoroquinolone Resistant Strains of Helicobacter Pylori in the Golden Triangle
455
458
EN
Ratha-korn
Vilaichone
0000-0003-4298-9331
Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathumthani, Bangkok, Thailand
vilaichone@hotmail.co.th
Thawee
Ratanachu-ek
Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
thawee1958@gmail.com
Pornpen
Gamnarai
Department of Biochemistry, Thammasat University Hospital, Pathumthani, Thailand
noi_gch@yahoo.com
Phawinee
Subsomwong
0000-0002-9961-9350
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Hasama-machi, Yufu-City, Oita, Japan
pha_203@hotmail.com
Tomahisa
Uchida
Department of Molecular Pathology, Oita University Faculty of Medicine, Japan
tomou2002@gmail.com
Yoshio
Yamaoka
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Hasama-machi, Yufu-City, Oita, Japan
yyamaoka@bcm.edu
Varocha
Mahachai
GI and Liver center, Bangkok Medical Center (BMC), Bngkok, Thailand
vmahachai88@gmail.com
10.22034/APJCP.2017.18.2.455
<br /> <strong><span style="font-size: small;">Background and aims: </span></strong><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Helicobacter pylori (H. pylori) </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">infections, associated with fatal GI diseases such as gastric cancer and MALT lymphoma, remain a major health problem in ASEAN countries. The Golden triangle has long been known as one of Asia’s main opium-producing areas. There have been no prior studies of </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">infection in this area. The major objectives of this project were therefore to establish prevalence, antibiotic resistance patterns and associated predictive in the Golden triangle. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">We recruited dyspeptic patients in Chiang khong and Chiang saen districts, Chiangrai province of Thailand. All subjects underwent gastroscopy, and 3 antral gastric biopsies were collected for rapid urease tests and </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">culture. E-tests were used to evaluate the MICs for metronidazole (MNZ), levofloxacin (LVX), ciprofloxacin (CIP), amoxicillin(AMX), tetracycline (TET) and clarithromycin (CLR). </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Total of 148 patients was included. </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">infection was present in 36.3%(37/102) of Chiang khong and 34.8 % (16/46) of Chiang saen subjects and the overall </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">infection rate was 35.8% (53/148). Antibiotic resistance was demonstrated in </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">44%, including 2% for CLR and 26% for MNZ, whereas fluoroquinolone resistance was demonstrated to be as high </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">as 25% in Chiang khong. Multi-drug resistant </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">was detected in 4%. There was no AMX and TET resistance </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">in this study. The prevalence of CLR resistance on a background of gastritis was significantly higher than peptic ulcer disease in the golden triangle area (100%vs 0%: P= 0.04). </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">remains a common infection in the </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Golden triangle. MNZ resistance appears to be high, whereas fluoroquinolone resistance is prevalent and is becoming a significant problem in this area. Diagnosis of gastritis might be a predictor of CLR resistance in the Golden triangle. </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">eradication with an appropriate regimen by using the local antibiotic resistant pattern is a key important tool to reduce </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">H. pylori </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">associated GI diseases in this particular part of the world. </span></span>
Helicobacter pylori,Antibiotic Resistance,Golden triangle
https://journal.waocp.org/article_44106.html
https://journal.waocp.org/article_44106_23fea6983b834458e63c089b891bb96e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Histopathologic Evolution of Urothelial Carcinoma Recurrence in Transurethral Resection of the Urinary Bladder:35 Consecutive Cases And Literature Review
459
463
EN
Ali
Koyuncuer
Department of Pathology, Antakya State Hospital, Hatay, Turkey.
alikoyuncuer@hotmail.com
10.22034/APJCP.2017.18.2.459
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Urothelial carcinoma (UC) is the malignancy most frequently encountered in the urinary bladder.The primary aim of this study was to make a reappraisal of histopathologic features, recurrence and progression. </span></span><strong><span style="font-size: small;">Materials and Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The records of cases consecutively diagnosed with UC in the state hospital pathology laboratory were </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">collected. Cases were classified according to age, gender, histologic grade, pathologic staging [primary Tumor (pT)] ,tumor configuration, primary or recurrent status, and progression. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 35 (29 male and 6 female) cases were examined. The mean age was 68.9 years with a male-to-female incidence ratio of 4.8:1. Low-grade UCs accounted </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">for 20 (57.1%) and high-grade for 15 (42.9%). A papillary pattern was observed in 80% of the UCs, classified into the </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">following pathological stages: 11 (31.4%) pTa, 22 (62.9%) pT1, and 2 (5.9%) pT2 cases. Eleven patients progressed to a higher stage (pT1 to pT2), and three cases from low to higher grade. We analyzed results for 26 (74.3%) cases aged 65 years or older. </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">UCs have a great tendency for recurrence but potentially may be amenable to effective local or systemic treatments. </span></span>
Bladder,Carcinoma,Grade,stage,Recurrence,Urothelial
https://journal.waocp.org/article_43627.html
https://journal.waocp.org/article_43627_c1c33810e3376bd0c4000893d9b762df.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Anxiety Disorders in Family Caregivers of Breast Cancer Patients Receiving Oncologic Treatment in Malaysia
465
471
EN
Siti Hazrah
Selamat Din
Department of Psychiatry and Mental Health, Hospital Tuanku Jaafar, Seremban, Negeri Sembilan, Malaysia
mamafarha@yahoo.com
Nik Ruzyanei
Nik Jaafar
Department of Psychiatry,
Faculty of Medicine, Hospital Tuanku Canselor Tuanku Mukhriz, University Kebangsaan Malaysia, Cheras, Malaysia
ziana_0185@yahoo.com.my
Hazli
Zakaria
Department of Psychiatry,
Faculty of Medicine, Hospital Tuanku Canselor Tuanku Mukhriz, University Kebangsaan Malaysia, Cheras, Malaysia
chermzak@yahoo.com
Suriati
Mohamed Saini
Department of Psychiatry,
Faculty of Medicine, Hospital Tuanku Canselor Tuanku Mukhriz, University Kebangsaan Malaysia, Cheras, Malaysia
suriati.saini@yahoo.com.my
Siti Nor Aizah
Ahmad
Department of
Psychiatry, Hospital Kuala Lumpur, Jalan Pahang, Kuala Lumpur, Malaysia
sitinoraizah.ahmad@gmail.com
Marhani
Midin
Department of Psychiatry,
Faculty of Medicine, Hospital Tuanku Canselor Tuanku Mukhriz, University Kebangsaan Malaysia, Cheras, Malaysia
marhanimidin@yahoo.com
10.22034/APJCP.2017.18.2.465
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Anxiety is recognized as a normal psychological reaction of those caring for cancer patients. However, anxiety disorders in caregivers may interfere with their care-giving role and require further clinical attention. </span></span><strong><span style="font-size: small;">Objectives: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">To determine the prevalence and associated factors of anxiety disorders among caregivers of breast cancer patients receiving oncologic treatment in Kuala Lumpur Hospital. </span></span><strong><span style="font-size: small;">Methodology: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A cross-sectional study was conducted on 130 caregiver-patient dyads, recruited by non-random sampling at Kuala Lumpur Hospital. Data were collected in 2 stages: 1) the caregivers were screened for psychological distress using the Depression, Anxiety, Stress, Scale (DASS-21) while </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">other related factors for the patients and their caregivers were obtained; 2) the identified distressed caregivers (n=64) </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">were then administered the Mini International Neuropsychiatric Interview (MINI) to diagnose anxiety disorders. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 11.5% (n=15) of the caregivers reported suffering from anxiety disorders. Bivariate analysis found duration of caregiving (OR=3.31; CI=2.21-11.93), shared caregiving (OR=4.07; CI=1.34-12.36), and patients’ treatment type (OR=3.42; CI=1.92-12.76) were significantly associated with anxiety disorders (p value <0.05), with shared caregiving and patient’s treatment type remaining significant using logistic regression (p value < 0.05, R2 = 0.255). </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Every one in ten of the caregivers in this study had a diagnosable anxiety disorder, associated with certain care-giving </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">factors and patients’ treatment. This should alert clinicians to such risk and indicates psychological support needs for </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">family caregivers. </span></span>
family caregivers,anxiety disorders,psycho oncology,cancer
https://journal.waocp.org/article_44496.html
https://journal.waocp.org/article_44496_e0d396c2e317b951f9a447e4aec428e6.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Metformin Inhibits Migration and Invasion of Cholangiocarcinoma Cells
473
477
EN
Son
Trinh
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
trinhxuansonbvnthoa@gmail.com
Huyen
Thi Bich
Nguyen
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
nguyenbichhuyentg@gmail.com
Kween
Saimuang
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
kween.sai@gmail.com
Virapong
Prachayasittikul
Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
drvirapong@gmail.com
Waraporn
Chan-on
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
waraporn.cho@mahidol.ac.th
10.22034/APJCP.2017.18.2.473
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Metformin is an oral anti-diabetic agent that has been widely prescribed for treatment of type II diabetes. Anti-cancer properties of metformin have been revealed for numerous human malignancies including cholangiocarcinoma (CCA) with anti-proliferative effects </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">in vitro</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">. However, effects on CCA cell migration and invasion have not been fully investigated. The present study aimed to explore the inhibitory effects of metformin on motility, migration and invasion of the CCA cell line HuCCT1, and examine molecular mechanisms underlying metformin effects. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">HuCCT1 cells were exposed to increasing doses of metformin. Viability and growth of HuCCT1 cells were assessed by MTS and colony formation assays, respectively. Motility, migration and invasion of metformin-treated HuCCT1 cells were determined </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">in vitro </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">using wound healing, transwell migration and matrigel invasion assays. Expression of signaling molecules and epithelial-mesenchymal transition (EMT) markers was assessed by Western blotting. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">It was observed that metformin significantly decreased HuCCT1 cell viability and colony formation. The agent also </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">markedly reduced wound closure, migration and invasion of HuCCT1 cells. Furthermore, metformin exposure resulted in decreased STAT3 activation and down-regulation of anti-apoptotic protein Bcl-2 and Mcl-1 expression. In addition, it upregulated the expression of E-cadherin, while downregulating that of N-cadherin, Snail, and MMP-2. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">These results demonstrated inhibitory effects of metformin on CCA cell migration and invasion, possibly involving the STAT3 pathway and reversal of EMT markers expression. They further suggest that metformin may be useful for CCA management. </span></span>
cholangiocarcinoma,Metformin,migration,Invasion,EMT
https://journal.waocp.org/article_44421.html
https://journal.waocp.org/article_44421_320d80d9b5cf5f7740f9e9a2ae4490fe.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Efficacy and Toxicity of Low-Dose versus Conventional-Dose Chemotherapy for Malignant Tumors: a Meta-Analysis of 6 Randomized Controlled Trials
479
484
EN
Xianhe
Xie
Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China
xiexianhe@yahoo.com
Yupeng
Wu
Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China
329108428@qq.com
Shuimei
Luo
Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China
shuimeiluo@sina.com
Haitao
Yang
Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China
454849946@qq.com
Lina
Li
Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China
linalifjmu@sina.com
Sijing
Zhou
Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China
511863579@qq.com
Ruifen
Shen
Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China
1406838170@qq.com
Heng
Lin
Department of Oncology, Fuzhou Pulmonary Hospital, Fuzhou, Fujian 350008, China
linheng5168@163.com
10.22034/APJCP.2017.18.2.479
<br /> <span style="font-size: small;">Low-dose chemotherapy has emerged as a new strategy for control of cancer. However, there is a controversy as to whether low-dose chemotherapy is an effective way to manage many human malignancies. To shed light on this controversy, we performed a meta-analysis of relative merits between low-dose and conventional-dose chemotherapy in different carcinomas. Studies published before February 29, 2016 were reviewed for the meta-analysis and selected according to </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">defined criteria. The effect levels of low-dose chemotherapy regarding overall survival (OS), progression-free survival (PFS) and severe adverse events (SAEs) (Grade≥3) were calculated as risk ratios (ORs) or adjusted hazard ratios (HRs). Six randomized controlled studies (RCTs) have provided data for low-dose chemotherapy versus conventional-dose chemotherapy for 838 cases and 833 cases, respectively. Interestingly, low-dose chemotherapy achieved the same desired potency as conventional-dose chemotherapy, with no differences in pooled ORR (RR=1.00, 95%CI [0.89, 1.13]; (</span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.97), OS (HR=1.07, 95%CI [0.90, 1.26]; </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.44) and PFS (HR=1.02, 95%CI [0.84, 1.23]; </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.87) values. </span></span><span style="font-size: small;">Furthermore, pooled data for common SAEs showed that, compared with conventional-dose chemotherapy regimen, </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">low-dose chemotherapy regimen resulted in significant less mucositis (</span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-size: small;"><0.0001), thrombocytopenia (</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-size: small;"><0.00001), anemia (</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.0001) and febrile neutropenia (</span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.004). At the same time, no statistically significant differences were </span></span><span style="font-size: small;">observed with regard to treatment-related death (</span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.36), diarrhea (</span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.49), leucopenia (</span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.11), neutropenia (</span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">P</span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN"><span style="font-family: Times New Roman,Times New Roman; font-size: small;" lang="ZH-CN">=0.74) and nausea/vomiting (ʺʺ0.21). Publication bias was assessed by Egger?s test and the funnel plot. In conclusion, the </span></span><span style="font-size: small;">meta-analysis seems to support the idea that low-dose chemotherapy may play an important role in achieving the same desired potency as conventional-dose chemotherapy in managing malignant tumors. Moreover, low-dose regimen seems to possess positive advantages of lower toxicity which is a particular concern for most patients. </span>
low-dose,conventional-dose,Chemotherapy,malignant tumors,RCT
https://journal.waocp.org/article_44107.html
https://journal.waocp.org/article_44107_edd4b101d4d89cf49fda3d7545aaa174.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Hyperuricemia at The Time Of Diagnosis is a Factor for Poor Prognosis in Patients With Stage II and III Colorectal Cancer (Uric Acid and Colorectal Cancer)
485
490
EN
Ahmet Ozan
Cetin
Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Mugla
aozancetin@hotmail.com
Muhyettin
Omar
Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Mugla
classomar@hotmail.com
Serkan
Calp
Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Mugla
serkancalp@gmail.com
Hasan
Tunca
Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Mugla
dr.hasan.tunca@gmail.com
Nevin
Yilmaz
Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Division of Gastroentero-hepatology, Mugla
nevinyilmaz@mu.edu.tr
Burak
Ozseker
Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Division of Gastroentero-hepatology, Mugla
burakozseker@gmail.com
Ozgur
Tanriverdi
Mugla Sitki Kocman University Faculty of Medicine, Department of Oncology
dr.ozgur.tanriverdi@gmail.com
10.22034/APJCP.2017.18.2.485
<br /> <strong><span style="font-size: small;">Purpose: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this pilot study we investigated whether serum levels of uric acid, the final breakdown product of purine metabolism, might influence cancer-related events in stage II and III colorectal cancer patients. </span></span><strong><span style="font-size: small;">Material and methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this cross-sectional retrospective study, a total of 150 stage II and III colorectal adenocarcinoma patients with no exclusion criteria were included. Serum uric acid levels of the patients measured at diagnosis and demographic, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">clinical, laboratory analyses were performed and histologically features recorded. Patients were stratified into quartiles </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">according to serum uric acid level with different cut-off values. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The mean serum uric acid level of all patients was determined o be 6.97±2.87 md/dL (range, 3.1-12.4). Median follow-up time was 98 (range 9-98) months and the proportion of patients who did not relapse was 22%. It was determined that majority of the patients who had serum uric acid levels over 8.37 mg/dL had stage IIIB lesions, were smokers, were among those who lost weight, with metastasis </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">to the liver and with significantly leukocyte and platelet counts. </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Serum uric acid levels measured at the time of diagnosis may be associated with cancer-related events so we can conclude a prognostic value of increase in colorectal cancer patients. </span></span>
Uric Acid,colorectal cancer,Prognosis
https://journal.waocp.org/article_44113.html
https://journal.waocp.org/article_44113_16a1e1576f441b4322a5de89d161f8c0.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Evolution of the Histo-Epidemiological Profile of Urological Cancers in Togo
491
494
EN
Tchin
Darre
Department of Pathology, the University Teaching Hospital of Lomé, Togo
paolodarre@yahoo.fr
Kue
Folligan
Department of Histology-Embryology, the University Teaching Hospital of Lomé, Togo
bfolligan@yahoo.fr
Tchilabalo Matchonna
Kpatcha
Department of Urology, the University Teaching Hospital of Lomé, Togo
fakpatcha@yahoo.fr
Kokou
Kanassouwa
Department of Surgery, the University Teaching Hospital of Lomé, Togo
kokou.kanassouwa@yahoo.fr
Edoe
Sewa
Department of Urology, the University Teaching Hospital of Lomé, Togo
viyomedoe35@yahoo.fr
Sassil
Dare
Department of Surgery, the University Teaching Hospital of Lomé, Togo
dare.sassil@yahoo.fr
Kodjo
Tengue
Department of Urology, the University Teaching Hospital of Lomé, Togo
drtenguekodjo@yahoo.fr
Koffi
Amegbor
Department of Pathology, the University Teaching Hospital of Lomé, Togo
fkamegbor@yahoo.fr
Gado
Napo-Koura
Department of Pathology, the University Teaching Hospital of Lomé, Togo
fgnapo@yahoo.fr
10.22034/APJCP.2017.18.2.491
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Urological cancers are an important public health issue and pose problems with diagnosis and adequate management in developing countries. Our aim was to determine and report epidemiological and histological features of urological cancers in Togo. </span></span><strong><span style="font-size: small;">Materials and methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A retrospective descriptive study was conducted of cases of urological cancers observed in the laboratory of pathological anatomy of the CHU Tokoin over the last 4 years (2012-2016). The parameters studied were frequency, age, sex, sites of development and histological type. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Epidemiological data were collected for 182 cases, representing 16.4% of all cancers (1108 cases). The annual frequency was 45.5±1.1 cases on average. The male:female sex ratio was 8.6 with a mean age of 60.2 years. Regarding location, in decreasing order of frequency, the tumors were found in the prostate (n=121 cases; 66.5%), bladder (n=28; 15.4%), kidney (n=19; 10.4%), testis (n=10; 5%), penis (n=3; 1.7%) and scrotum (n=1; 0.5%). Histologically, prostate cancers were predominantly adenocarcinomas (n=116 cases; 95.8%) with a Gleason score of 6 (n=46; 39.7%) predominant. Bladder cancers were mainly squamous cell carcinomas (n=11; 39.3%) followed by transitional carcinomas (n=9 cases; 32.1%) and adenocarcinomas (n=7; 25%). Kidney cancers were predominantly nephroblastomas (n=10, 52.6%) in children and clear cell carcinomas (n=8 cases; 42.1%) in adults. Testicular cancers were Burkitt lymphomas in 5 cases. The cases of penis and scrotum cancers were all squamous cell carcinomas. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Urological cancers are experiencing an upsurge in frequency in Togo, dominated by prostate cancer, with a high frequency of squamous cell carcinoma of the bladder due to endemic bilharziasis. </span></span>
Key words: Cancer,urology,Epidemiology,histology,Togo
https://journal.waocp.org/article_44485.html
https://journal.waocp.org/article_44485_4918c020d95afa2d8806f7f41478fb87.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Assessing the Effect of Waterpipe Smoking on Cancer Outcome - a Systematic Review of Current Evidence
495
502
EN
Kamran Habib
Awan
0000-0002-3831-7455
College of Dental Medicine, Roseman University of Health Sciences, South Jordan, Utah 84095, United States
kamranhabibawan@gmail.com
Kamran
Siddiqi
Clinical Senior Lecturer in Epidemiology and Public Health
Department of Health Sciences/Hull York Medical School
Room 105a, First floor, ARRC Building
University of York
Heslighton, York YO10 5DD
kamran.siddiqi@york.ac.uk
Shankargouda
Patil
0000-0001-7246-5497
Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia
dr.ravipatil@gmail.com
Quratul Ann
Hussain
Department of Oral Medicine & Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia
dr_qurat@hotmail.com
10.22034/APJCP.2017.18.2.495
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Waterpipe smoking (WPS) is widely believed to be a safe and hazard-free tobacco habit. However, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">a number of studies have indicated that exposure to several toxicants and carcinogens through WPS is strongly related </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">to serious health hazards. The current paper presents a narrative review on the effects of WPS on cancer outcome. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The addressed focused question was "Is there an association between waterpipe smoking and cancer outcome?" PubMed, Medline, EMBASE, ISI Web of Science and the Cochrane databases were searched until June 2015 using the key words "Waterpipe", "Hookah", "Narghileh", "Shisha", "Hubbly Bubbly" "cancer" in various combinations. Letters to the Editor, review articles, case-reports and unpublished articles were excluded. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 16 studies were included: six on lung cancer, three on oesophageal cancer, two on gastric cancer, two on bladder cancer, and one each on nasopharyngeal, pancreatic and prostate cancers. Our search did not yield any study that evaluated the risk of oral </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">cancer in WPS users. The available evidence showed a significant association of WPS with lung cancer (UOR 6.0, 95% CI 1.78–20.26); however, no association was observed with bladder, nasopharyngeal, pancreatic and prostate cancers. Gastric (OR 3.4, 95% CI 1.7-7.1) and oesophageal cancers (OR 1.85, 95% CI 1.41-2.44) were observed to have weak </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">associations with WPS. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Regardless of the limitations, there is sufficient evidence to suggest associations </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">of WPS with cancer, particularly in the lung. Future well-designed studies are required to identify and quantify with </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">confidence all the health effects of this form of smoking. </span></span>
Waterpipe smoking,Shisha,Tobacco,cancer,Systematic review
https://journal.waocp.org/article_44108.html
https://journal.waocp.org/article_44108_7e4c5da4bdddfe04baf85aff2117773e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Association of the Asp1312Gly Thyroglobulin Gene Polymorphism with Susceptibility to Differentiated Thyroid Cancer in an Iranian Population
503
506
EN
Maryam
Abidi
Department of Genetics, Science and Research branch, Islamic Azad University, Tehran, Iran
maryam_abidi89@yahoo.com
Shima
Fayaz
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran
shimafayaz@pasteur.ac.ir
Pezhman
Fard-Esfahani
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran
fard-esfahani@pasteur.ac.ir
10.22034/APJCP.2017.18.2.503
<strong><span style="font-size: small;">Background and aim: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">While the causes of thyroid cancer in most patients remain largely unknown, it has recently been reported that there may be links to particular chromosome regions. In particular, polymorphisms (SNPs) in the </span></span><em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">thyroglobulin (TG) </span></span></em><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">gene could be susceptibility factors. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this case-control study, any association of the Asp1312Gly single nucleotide polymorphism (SNP) in the TG gene (rs2069556) with susceptibility to differentiated thyroid cancer (DTC) was investigated among 103 Iranian patients and 100 controls who had no history of any type of cancer. Genomic DNA was extracted from the whole blood by salting out procedure. High Resolution Melting (HRM) technique was used to detect this SNP. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Data were analyzed with SPSS software and the results showed that the recessive GG genotype was associated with an increased risk of differentiated thyroid carcinoma when compared to the AA+AG genotypes (OR: 2.06; CI: 1.09-3.89; P-value: 0.025). </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Although our study demonstrated that </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">differentiated thyroid cancer is significantly associated with this polymorphism, further studies with larger populations are required to confirm our findings. </span></span>
High resolution melting (HRM) analysis,thyroid carcinoma,Single nucleotide polymorphism
https://journal.waocp.org/article_43620.html
https://journal.waocp.org/article_43620_2830f83538a6179b9335a9dce98e54f3.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
ERCC1 Expression in Metastatic Triple Negative Breast Cancer Patients Treated with Platinum-Based Chemotherapy
507
513
EN
Mohamed Ali
El Baiomy
0000-0001-8702-7633
Medical Oncology Unit, Oncology Center, Faculty of medicine, Mansoura University, Egypt
malibasha1@mans.edu.eg
Wagdi F
El Kashef
Pathology Department, Oncology Center, Faculty of medicine, Mansoura University, Egypt
wagdi.elkashef@gmail.com
10.22034/APJCP.2017.18.2.507
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Possible targeted therapies for metastatic triple negative breast cancer (TNBC) include cytotoxic chemotherapy that causes interstrand breaks (platinum-based drugs). The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway, removing platinum-induced DNA adducts and contributing to cisplatin resistance. Detecting ERCC1 overexpression is important in considering treatment options for metastatic TNBC, including individualized approaches to therapy, and may facilitate improved responses or reduction of unnecessary toxicity. We hypothesized that assigning cisplatin based on pretreatment ERCC1 expression would improve response and survival. This study was conducted to assess the impact of ERCC1 expression on PFS, OS and response rates in metastatic triple negative breast cancer patients treated with platinum-based chemotherapy. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">From June 2012 to November 2013, 52 metastatic triple negative breast cancer patients were enrolled. ERCC1 protein expression was detected from pretreatment biopsies by Immunohistochemistry. All patients received cisplatin plus paclitaxel. The primary end point was the impact of ERCC1 expression on PFS and OS. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">34 patients (65.4%) showed positive ERCC1 expression while 18 (34.6%) proved negative. Positive ERCC1 expression was associated with short PFS (median, 5 months vs. 7 months; P = 0.043), short OS (median, 9 months vs. 11 months; P = 0.033) and poor response to cisplatin based chemotherapy (P = 0.046). </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This prospective study further validated ERCC1 as a reliable biomarker for customized chemotherapy in metastatic triple negative breast cancer </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">patients. High expression of ERCC1 was thereby fond to be significantly associated with poor outcome in patients </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">treated with platinum based chemotherapy. </span></span>
ERCC1,Triple negative,Metastatic,Breast
https://journal.waocp.org/article_44510.html
https://journal.waocp.org/article_44510_46efe8bdef8d1ebdbace827e66a971fd.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Validation of an Indonesian Version of the Breast Cancer Awareness Scale (BCAS-I)
515
522
EN
Solikhah
0000-0001-6895-6840
Doctor of Public Health Program, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand
solikhah@ikm.uad.ac.id
Supannee
Promthet
0000-0001-5787-1948
Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand
supannee@kku.ac.th
Nitchamon
Rakkapao
Faculty of Public Health,
Thammasat University,
Thailand
nitchamonbt@fph.tu.ac.th
Cameron
Paul
Hurst
Biostatistics center of excellence
Faculty of Medicine
Chulalongkorn University
cphurst@gmail.com
10.22034/APJCP.2017.18.2.515
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Raising breast cancer awareness is a key strategy to reduce associated mortality. While a paucity of adequately validated instruments for breast cancer awareness is applicable across cultures, even outside the health care setting such instruments have been developed. </span></span><strong><span style="font-size: small;">Objective: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This study investigated the validity and psychometric properties of a breast cancer awareness scale in Indonesia (BCAS-I). </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This cross-sectional study was carried out among Indonesian women conveniently selected within three provinces (Yogyakarta, South of Sumatera and East Nusa Tenggara) located in rural-urban areas using stratified random sampling. First, we translated all questionnaires from English to the local language and then back-translated. The third step was to perform psychometric testing of the adapted instrument by establishing internal consistency (Cronbach’s alpha score 0.79) and construct validity by confirmatory factor analysis (CFA). </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In the 856 participants who responded (responded rate = 98.28%), the age ranged from 18 to 80 years old (mean = 30, SD = 11). The BCAS-I was shown to have good internal consistency, and CFA demonstrated the model fit data adequately (χ2 = 922.267, df = 515, p <0.001, comparative fit index = 0.965, Tucker-Lewis Index = 0.96, goodness-of-fit index = 0.97, adjusted goodness-of-fit index = 0.97, root-mean-square error of approximation = 0.03 95% confidence interval: 0.027, 0.034). The final version of BCAS-I consists of 33 items across 5 domains that cover most key aspects of breast cancer awareness for this population. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">BCAS-I demonstrated good psychometric properties and was found to be valid to provide a measurement of breast cancer awareness in Asian women in general and Indonesian women in particular. </span></span>
breast cancer,Breast cancer awareness,Instrument Validation,Indonesian Women
https://journal.waocp.org/article_44428.html
https://journal.waocp.org/article_44428_8be86975af1e5002f6c433650b530ee2.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Correlation between Epstein-Barr Virus Infection and Disease Activity of Systemic Lupus Erythematosus: a Cross-Sectional Study
523
527
EN
Ahmad
Piroozmand
Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
piroozmand-a@gmail.com
Hamed
Haddad Kashani
Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
hamedir2010@gmail.com
Batool
Zamani
Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
batol_zamani2007@yahoo.com
10.22034/APJCP.2017.18.2.523
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Systemic lupus erythematosus (SLE) is an autoimmune disease for whose pathogenesis viral infections are important. The Epstein-Barr virus (EBV) is the main infectious etiological agent. This study aimed to quantitative evaluation of EBV in SLE patients. </span></span><strong><span style="font-size: small;">Materials and Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this cross-sectional study, 40 patients with SLE diagnosed </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">based on American College of Rheumatology criteria were selected using purposive sampling. All were included in the </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">study after obtaining informed consent for participation. Whole blood samples were taken and buffy coat preparations </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">were isolated to determine viral load using the real-time polymerase chain reaction method and assessment with the SLE disease activity index (SLE-DAI). </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">From a total of 40 patients, 37 cases (92.5%) were women. The EBV test was positive in 67.5% and mean viral load was 5396 ± 1891.9 copy/ml. Twenty of forty patients had active and 50% inactive disease, mean EBV viral loads being 6798 and 28.25 copy/ml, respectively (P-value = 0.003). In terms of the severity of disease activity, 17.5 % of female patients had mild to moderate activity, whilst 32.5% of them had severe activity, with respective viral loads of 5,803.3 and 29.73 copy/ml (P-value = 0.003). </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The Epstein-Barr </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">viral load in SLE patients with active disease was found to be markedly higher than in inactive cases. Thus, EBV may have an important role in the pathogenesis and activity of SLE. </span></span>
Epstein-Barr Virus,Viral load,Systemic lupus erythematosus,Real-Time PCR,Infection
https://journal.waocp.org/article_44449.html
https://journal.waocp.org/article_44449_9ce3cce9084099f9140c13435ed34eb5.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Carcinogenic Liver Fluke and Others Contaminated in Pickled Fish of Northeastern Thailand
529
533
EN
Ratchadawan
Aukkanimart
Department of Thai Traditional Medicine, Faculty of Natural Resources, Rajamangala University of Technology Isan Sakonnakhon Campus, Sakon Nakhon 47160, Thailand
ratchadawan_aukkanimart@yahoo.com
Thidarut
Boonmars
Neglected, Zoonosis and Vector-Borne Disease Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
bthida@kku.ac.th
Pranee
Sriraj
Department of Thai Traditional Medicine, Faculty of Natural Resources, Rajamangala University of Technology Isan Sakonnakhon Campus, Sakon Nakhon 47160, Thailand
plarty_1@hotmail.com
Panupan
Sripan
Neglected, Zoonosis and Vector-Borne Disease Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
sokun44120@hotmail.co.th
Jiraporn
Songsri
Neglected, Zoonosis and Vector-Borne Disease Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
benzll_jpcnas@hotmail.com
Panaratana
Ratanasuwan
Department of Anesthesiology, , Faculty of Medicine, Khon Kaen University, Khon Kaen 40002 Thailand
rpanar@gmail.com
Porntip
Laummaunwai
Neglected, Zoonosis and Vector-Borne Disease Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
porlau@kku.ac.th
Apiporn
Suwannatrai
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002 Thailand
apiporn@kku.ac.th
Surasit
Aunpromma
Faculty of Veternary Medicine, KhonKaen University, Khon Kaen 40002 Thailand
asuras@kku.ac.th
Sukhonthip
Khueangchaingkhwang
Neglected, Zoonosis and Vector-Borne Disease Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
emmykku41@gmail.com
Benjamabhorn
Pumhirunroj
Neglected, Zoonosis and Vector-Borne Disease Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
benjamabhorn.pumhirunroj@gmail.com
Atchara
Artchayasawat
Neglected, Zoonosis and Vector-Borne Disease Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
spiderman_puy@hotmail.com
Narong
Khuntikeo
Liver Fluke and Cholangiocarcinoma Research Center, Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen 40002, Thailand
narong@gmail.com
Watcharin
Loilome
Liver Fluke and Cholangiocarcinoma Research Center, Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen 40002, Thailand
watclo@kku.ac.th
Nisana
Namwat
Liver Fluke and Cholangiocarcinoma Research Center, Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen 40002, Thailand
nnamwat@gmail.com
Puangrat
Yongvanit
Liver Fluke and Cholangiocarcinoma Research Center, Cholangiocarcinoma Screening and Care Program (CASCAP), Khon Kaen University, Khon Kaen 40002, Thailand
puangrat@kku.ac.th
Sirintip
Boonjaraspinyo
Department of Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002 Thailand
boonjaraspinyo@gmail.com
10.22034/APJCP.2017.18.2.529
<br /> <span style="font-size: small;">Twenty provinces in northeastern Thailand were investigated for fluke metacercariae contamination in pickled fish, or pla-som, during January –June 2016. A total of 129 pickled fish shops were randomly chosen. Samples were digested </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">with acid-pepsin and those found to be infected with metacercariae were fed to hamsters to test for metacercariae </span></span><span style="font-size: small;">infectivity. The results demonstrated that only 20.2% of the pla-som samples were infected with fluke metacercariae (mc), at various levels (1 to 268 mc/kg). All recovered fluke metacercariae were inactive, degenerated and could not develop to adults in the animal model. In conclusion, the fluke mc infection status in pla-som was correlated with the prevalence of fluke infection in this region known for high O.viverrini and cholangiocarcinoma development. Clearly, systematic control of the fluke life cycle is needed. Whether pickling is an effective preventive measure needs further </span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">assessment. </span></span>
Fluke,Pickled fish,cholangiocarcioama,Survey,Metacercariae
https://journal.waocp.org/article_44495.html
https://journal.waocp.org/article_44495_57d4457bc404c289ac884276aeee91a4.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Bone Mineral Density in Survivors of Childhood Acute Lymphoblastic Leukemia
535
540
EN
Farzaneh
Rohani
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Science, Tehran ,Iran
j.tartibi60@gmail.com
Khadijeh
Arjmandi Rafsanjani
Department of Pediatrics, Ali-Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran.
khadijeharjmandir@yahoo.com
Gholamreza
Bahoush
Pediatric and Growth Development Research Center, Ali-Asghar Children’s Hospital, Department of Pediatrics, Iran University of Medical Sciences, Tehran, Iran.
gholamrezabahoush@yahoo.com
Mansoureh
Sabzehparvar
General Physician, Iran University of Medical Sciences, Tehran, Iran.
mansourehsabzehparvar@yahoo.com
Mohammad
Ahmadi
General Physician, Iran University of Medical Sciences, Tehran, Iran.
mohammadahmadi@gmail.com
10.22034/APJCP.2017.18.2.535
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The objective of this study was to evaluate bone mineral density (BMD) after completion of treatment for childhood acute lymphoblastic leukemia (ALL). </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this cross-sectional study, 103 survivors of ALL aged 13.5 ± 0.45 who completed their treatment at least one year earlier were enrolled. Among these, 49.5% and 51.5% received chemotherapy alone and chemotherapy plus cranial radiotherapy, respectively. Bone mineral content, BMD, and bone mineral apparent density in the lumbar spine (LS), femoral neck (FN) and forearm were assessed </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">using dual-energy X-ray absorptiometry (DEXA). BMD Z-scores were classified according to International Society </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">for Clinical Densitometry (ISCD) criteria. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The mean BMD Z-scores ± SD forLS, FN and forearm were -1.60 </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">± 0.12, -1.21 ± 0.9 and -2.43 ± 0.14 respectively with significant differences (P<0.001). Considering the lowest BMD Z-score in LS and FN areas (at any site) and according to the ISCD classification, 62.1%, 33% and 4.9% of the patients </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">had normal BMD, low BMD and osteoporosis, respectively. Also, 8.7% of patients had developed fractures after </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">completion of the treatment period, 4.9% having BMD Z-Scores </span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">ALL patients are at risk for low BMD and fracture. Therefore, applying DEXA scanning is recommended after completion of therapy for prevention of BMD reduction and osteoporosis. </span></span></span>
Acute Lymphoblastic Leukemia,treatment,Bone,Chemotherapy,fracture
https://journal.waocp.org/article_43241.html
https://journal.waocp.org/article_43241_244ee4e35a05a75b60598d5c67c454f6.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Diagnostic Value of Fine-Needle Aspiration Biopsies and Pathologic Methods for Benign and Malignant Breast Masses and Axillary Node Assessment
541
548
EN
Mojtaba
Ahmadinejad
Department of Surgery, Alborz University of Medical Sciences, Karaj, Iran
mojtabaahmadinejad@yahoo.com
Leila
Hajimaghsoudi
Department of Surgery, Alborz University of Medical Sciences, Karaj, Iran
leilahajimaghsoudi@gmail.com
Seyyed Mohsen
Pouryaghobi
Department of Anesthesiology, Alborz University of Medical Sciences, Karaj, Iran
smpouryaghobi@yahoo.com
Izadmehr
Ahmadinejad
Allameh Helli No.3 High School NODET (National Organization for Development of Exceptional Talents), Tehran, Iran
izadmehrahmadinejad@gmail.com
Koorosh
Ahmadi
Department of Emergency Medicine, Alborz University of Medical Sciences, Karaj, Iran
kooroshahmadi@hotmail.com
10.22034/APJCP.2017.18.2.541
<br /> <strong><span style="font-size: small;">Bacground: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The goal of this study was to evaluate the fine needle aspiration (FNA) preoperatively together with </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Touch Print, Crush Print, frozen section and pathologic methods to reach a diagnosis for patients with breast and axillary masses. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">This study was conducted on 107 patients, and included 111 samples of breast and 43 of axillary masses taken at surgery. Data on epidemiological and clinical features of the patients were collected using a questionnaire. The results of the methods of FNA, Touch Print, and Crush Print were compared with the results of pathology after operations. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Comparison between the diagnosis values of FNA with pathology for breast cancer showed sensitivity, sensitivity, positive predictive values, negative predictive values, positive mendacious percentages, and negative mendacious percentages of 80.4%, 98%, 97.3%, 87.6%, 2%, and 19.6% , respectively, and for metastatic axillary lymph nodes, 80%, 95.6%, 94.1%, 84.6%, 4.4%, and 20%. Comparison of diagnosis values of FNA with Touch Print and Crush Print for breast cancer gave values of 82.2%, 89%, 97.3%, 89%, 1.6%, and 17.8%, respectively, and for metastatic axillary lymph nodes 84.2%, 95.8%, 94.1%, 88.4%, 14.2%, and 15.8%. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Use of these methods, compared with pathology, can decrease cost, time, and a need for a second surgery and related complications. </span></span>
Breast,Axillary,Mass,Fine-Needle Aspiration,Pathology
https://journal.waocp.org/article_43629.html
https://journal.waocp.org/article_43629_19bdb66cfcd99ca2b7372eb5b2c1424d.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Association between the DNA Repair Gene XRCC3 rs861539 Polymorphism and Risk of Osteosarcoma: a Systematic Review and Meta-Analysis
549
555
EN
Mohammad Reza
Sobhan
Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
mrsobhanardakani@gmail.com
Mohammad
Forat-Yazdi
Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
mohammad.foratyazdi@gmail.com
Mahta
Mazaheri
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
mazaheri54@yahoo.com
Masoud
Zare-Shehneh
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
masoud.zare.sheneh@gmail.com
Hossein
Neamatzadeh
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
neamatzadehh@gmail.com
10.22034/APJCP.2017.18.2.549
<br /> <strong><span style="font-size: small;">Objective: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Although there are a few studies investigating the relation between X-Ray Repair Cross Complementing 3 (XRCC3) gene rs861539 polymorphism and osteosarcoma (OSA), the results are inconsistent. Therefore, we performed this systematic review and meta-analysis to clarify the associations between XRCC3 rs861539 polymorphism and OSA risk. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">We have retrieved published literature from PubMed, Google scholar, and ISI Web of Knowledge up to </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">25 January 2017. Odds ratios were pooled using either fixed-effects or random effects models. Overall and subgroup </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">analyses were performed. Statistical analysis was performed running comprehensive meta-analysis (CMA) 2.0 software. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of four studies with 515 cases and 1,109 controls were identified in order to investigate the association </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">between XRCC3 rs861539 polymorphism and OSA risk. The results showed that XRCC3 rs861539 polymorphism was associated with OSA in allelic (T vs. C: OR= 1.563, 95% CI: 1.244-1.963, p= <0.001), homozygote (TT vs. CC: OR= 2.574, 95% CI: 1.573-4.212, p= <0.001), dominant (TT+TC vs. CC: OR= 1.255, 95% CI: 1.011-1.558, p= 0.039), and recessive (TT vs. TC+CC: OR= 2.224, 95% CI: 1.393-3.552, p= 0.001), but not with heterozygote (TC vs. CC: OR= 1.361, 95% CI: 0.982-1.885, p= 0.064). The XRCC3 rs861539 polymorphism conferred susceptibility to OSA in Asians, but not in Caucasians. Additionally, we observed no evidence of publication bias. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">To the best of </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">our knowledge, this is the first meta-analysis investigating the association between XRCC3 rs861539 polymorphism and OSA risk. Our results revealed a significant association between the XRCC3 rs861539 polymorphism and risk of </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">OSA, especially in Asian populations. Future more comprehensive and well-designed case control studies with larger </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">sample size are needed to warrant these findings. </span></span>
osteosarcoma,XRCC3,rs861539 polymorphism,Meta-analysis
https://journal.waocp.org/article_43333.html
https://journal.waocp.org/article_43333_21e512daac369c9d1c7279c9339e1736.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
The Pre-Treatment Neutrophil-Lymphocyte Ratio: a Useful Tool in Predicting Non-Sentinel Lymph Node Metastasis in Breast Cancer Cases
557
562
EN
Suphawat
Laohawiriyakamol
0000-0002-4055-8784
Division of General Surgery, Department of Surgery,
Faculty of Medicine,
Prince of Songkla University
lsuphawa@medicine.psu.ac.th
Somrit
Mahattanobon
0000-0002-8997-9678
Division of General Surgery, Department of Surgery,
Faculty of Medicine,
Prince of Songkla University
msomrit@medicine.psu.ac.th
Supparerk
Laohawiriyakamol
Division of General Surgery, Department of Surgery,
Faculty of Medicine,
Prince of Songkla University
lsuppare@medicine.psu.ac.th
Puttisak
Puttawibul
0000000198530015
Division of General Surgery, Department of Surgery,
Faculty of Medicine,
Prince of Songkla University
putpnu@hotmail.com
10.22034/APJCP.2017.18.2.557
<br /> <strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The sentinel lymph node (SLN) biopsy is a highly accurate predictor of overall axillary nodal status </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">in early breast cancer patients. There is however, still a debate on which patients with a positive SLN can benefit from </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">axillary lymph node dissection (ALND). Numerous studies have been designed to identify variables that are predictive of non-SLN metastasis to avoid a complete ALND. The aim of this study was to determine whether the pre-treatment neutrophil-lymphocyte ratio (NLR) can be a predictive factor of non-SLN metastasis in early breast cancer patients. </span></span><strong><span style="font-size: small;">Materials and Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">The records of 214 consecutive patients with cT1-3N0 invasive breast cancer who had undergone intraoperative SLN evaluation at Songklanagarind Hospital between the 1stof March 2011 and the 30thof May 2016 were examined. Data on patient demographics, tumor variables and NLR were collected and factors for </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">non-SLN metastasis were analyzed using multivariate logistic regression. The power of the NLR was quantified with </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">receiver operating characteristics (ROC) curves as measured by the areas under curves (AUC). </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Multivariate analysis established presence of lymphovascular invasion (OR 8.4, 95%CI 2.3-31.3, p=0.002), macrometastasis (OR 6.6, 95%CI 1.8-24.7, p=0.005), and NLR (OR 2.3, 95%CI 1.1-4.8, p=0.033) as predictive factors of non-SLN </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">metastasis with statistical significance. The AUC for NLR was 0.7 (95%CI 0.6-0.8) with an optimal cut-off of 2.6 giving a sensitivity of 62%, a specificity of 83.8%, a positive predictive value of 77.3% and a negative predictive value </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">of 70.5%. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Pre-treatment NLR is a useful diagnostic aid for predicting additional non-SLN metastasis. </span></span>
Neutrophil-Lymphocyte ratio,NLR,breast cancer,non sentinel lymph node
https://journal.waocp.org/article_44503.html
https://journal.waocp.org/article_44503_9667639f88e37bc2da8d456b885599ab.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Compliance with Tobacco Promotion and Sale Laws in School Neighbourhoods in India
563
570
EN
aswini
balappanavar
Department of Public Health Dentistry,
Maulana Azad Institute of Dental Sciences, New Delhi, India
aswinicomm@gmail.com
Vikrant
Ranjan
Mohanty
Department of Public Health Dentistry, Maulana Azad Institute of Dental Sciences, New Delhi, India
vikrantmohanty@gmail.com
Abrar
Hussain
24th year BDS student, Maulana Azad Institute of Dental Sciences, New Delhi, India
10.22034/APJCP.2017.18.2.563
<br /> <strong><span style="font-size: small;">Objective: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Regulation of sale of tobacco has given sufficient attention in India and little information exists about </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">the impact of bans near schools. Our study aim was to check the levels of tobacco promotion, advertising and sales in school neighborhoods’ of Central Delhi. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Using multistage random sampling 15 schools were selected in Central Delhi. Areas 100 meters around each were mapped using a map tool and screened using a self designed questionnaire consisting of 26 questions, both closed and open ended, to determine the details of outlets, sales of tobacco and tobacco products, advertising, promotions, school roles, and children seeking tobacco. The data were subjected to statistical analysis. </span></span><strong><span style="font-size: small;">Results: T</span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">he response rate was 65%. Outlet licenses were present in only 6 (3.47%). The point sale of tobacco was most frequently in tea stalls and a total of 173 (41.2%) outlets had some form of tobacco sale. The brands of smokeless tobacco sold more were shikar (50%) and classic citrus (30%). Advertisement or promotion of sales was mainly in the form of signs and displays (53%). Major schools did not have any no tobacco boards displayed. </span></span><strong><span style="font-size: small;">Conclusion: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Sale of tobacco continues in central Delhi with a lack of compliance with the rules of COPTA. The </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">implications of this non compliance in the Capital region is of major significance for the rest of the country. </span></span>
COPTA,Tobacco,Tobacco sale and advertisement,Tobacco outlets,Tobacco free schools
https://journal.waocp.org/article_44504.html
https://journal.waocp.org/article_44504_8600f486b3f8bb420e0ccd4dffa2718b.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Five-Year Survival is Not a Useful Measure for Cancer Control in the Population: an Analysis Based on UK Data
571
576
EN
Siqi
Li
Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, RenminNanlu 3-17, Chengdu 610041, China
pxt1228@163.com
Xiongfei
Pan
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College,Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430032, China
441651301@qq.com
Michael
Kashaf
Johns Hopkins University School of Medicine, 733 North Broadway Street, Baltimore, MD, 21205, USA
mskashaf@jhmi.edu
Qingping
Xue
Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, RenminNanlu 3-17, Chengdu 610041, China
1205558553@qq.com
Huijing
Luo
Department of Clinical Laboratory, Tianjin Medical University General Hospital, NO.154, Anshan Road, Heping Strict, Tianjin 300052, China
374288165@qq.com
Yanyan
Wang
Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China
469435974@qq.com
Ying
Wen
Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, RenminNanlu 3-17, Chengdu 610041, China
39044508@qq.com
Chunxia
Yang
Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, RenminNanlu 3-17, Chengdu 610041, China
chunxia815@aliyun.com
10.22034/APJCP.2017.18.2.571
<strong><span style="font-size: small;">Background: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Five-year survival is an important metric for progress in cancer control broadly used both in the cancer literature and by the public. In order to assess its validity and relation to other common metrics, we analyzed the relationship between 5-year survival, incidence and mortality using publicly available cancer registry data from England and Wales. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Five-year survival, incidence and mortality data were obtained from the online database </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">of a registered charity, Cancer Research UK. We extracted sex-specific age-standardized mortality, incidence, and </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">5-year survivalfor16 types of cancer over the period from 1976 to 1995. The relationships between 5-year survival, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">incidence and mortality were estimated using both Pearson and Spearman correlation coefficients. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">All 16cancer types showed an increase in 5-year survival for both genders from 1976 to 1995, ranging from 0.2% (pancreas and lung cancer) to 16.6% (prostate cancer) for males and 0.2% (pancreas cancer) to 16.6% (leukemia) for females. From </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">1976 to 1995, there was no significant correlation between changes in 5-year survival and cancer mortality for either </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">sex (males, Pearson r=0.16, Spearman r=-0.06; females, Pearson r=-0.33, Spearman r=-0.43). A positive relationship between 5-year survival and incidence was noted among males, but not among females (males, Pearson r=0.61, Spearman r=0.53; females, Pearson r=0.03, Spearman r=0.11). However, after excluding breast and prostate cancer, </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">the positive association became weaker and became statistically non-significant for males (Pearson r=0.47; Spearman </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">r=0.41). </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Our findings suggest that there are no reliable relationships between changes in 5-year survival </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">and cancer incidence or mortality. Increases in 5-year survival might therefore represent poor indicators of progress in cancer control at the population level. In the absence of over-diagnosis, 5-year survival might only indicate improved diagnosis and treatment in clinical practice. </span></span>
Cancer control,Surveillance,Incidence,mortality,5-Year Survival
https://journal.waocp.org/article_44522.html
https://journal.waocp.org/article_44522_bf526d296c1a6571dcb9fab003c937eb.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
18
2
2017
02
01
Expression of Cytokines Interleukin-2, Interleukin-4, Interleukin-10 and Transforming Growth Factor β in Gastric Adenocarcinoma Biopsies Obtained from Mexican Patients
577
582
EN
Maria Alicia
Diaz Orea
Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
diazorea@yahoo.com.mx
Veronica Muñoz
Perez
Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
vemupe@hotmail.com
Eduardo
Gómez Conde
Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
gom_conde@yahoo.com
Victor Omar
Castellanos Sánchez
Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
victoromarcs@yahoo.com.mx
Rogelio
Gonzalez Lopez
Departamento de Patología, Hospital de Especialidades, Centro Médico Nacional General de División “Manuel Ávila Camacho”, Instituto Mexicano del Seguro Social, Unidad Médica de Alta Especialidad, Puebla. Mexico
gonzalezloroge@gmail.com
Juan Carlos
Flores Alonso
Centro de Investigacion Biomedica, Instituto Mexicano del Seguro Social, Puebla, Mexico
flores_alonso_jc@hotmail.com
M Elena
Cárdenas
Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
marielcardenasperea@yahoo.com.mx
A Luisa
Galicia
Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
algz_99@hotmail.com
Aurelio
Mendoza
Departamento de Patología, Hospital de Especialidades, Centro Médico Nacional General de División “Manuel Ávila Camacho”, Instituto Mexicano del Seguro Social, Unidad Médica de Alta Especialidad, Puebla. Mexico
aurelio.medoza@imss.gob.mx
10.22034/APJCP.2017.18.2.577
<br /> <strong><span style="font-size: small;">Objective: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">In this study, expression of Interleukin-2, Interleukin-4, Interleukin-10 and transforming growth factor beta in diffuse and intestinal type gastric cancers from Mexican patients was assessed for use as markers of malignancy. </span></span><strong><span style="font-size: small;">Methods: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">A total of 30 biopsies from gastric adenocarcinomas, 60% diffuse, 20% intestinal and 20% mixed in type, were studied by immunohistochemistry. </span></span><strong><span style="font-size: small;">Results: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">Regarding expression of cytokines, 23% were positive for IL-2, 26.7% for </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">IL-4, 16.6% for IL-10 and none for TGF-β. There were found Significant statistically stage differences were noted.For </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">example, for stages I-II 100% were IL-2 positive (p = 0.009), 87.5% were IL-4 positive (p = 0.005) and 100.0% IL-10 positive (p = 0.009). Young women were more likely to suffer gastric adenocarcinoma. In biopsies of male patients with gastric cancer, there was an increased expression of IL-2 and in biopsies from female patients in IL4. There was </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">significantly greater detection of IL-4 and IL-10 expression in stages I and II than in stages III and IV. It was also found </span></span><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">that IL-4, IL-10 had a higher positive expression in patients biopsies with low-level differentiations than patients with well differentiated gastric cancer in which cases were undetected. </span></span><strong><span style="font-size: small;">Conclusions: </span></strong><span style="font-family: Times New Roman,Times New Roman; font-size: small;"><span style="font-family: Times New Roman,Times New Roman; font-size: small;">These results suggest that positive expression of IL-4 and IL-10 may be useful as a molecular marker to distinguish stage I and II diffuse gastric cancers which can be more readily controlled. </span></span>
Gastric adenocarcinoma,Cytokines,IL2,IL4,IL10
https://journal.waocp.org/article_44560.html
https://journal.waocp.org/article_44560_8c6757efda7fa7cde9a25b3a4cae62ea.pdf