West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Educational Interventions for Cervical Cancer Screening Behavior of Women: A Systematic Review
875
884
EN
Marzieh
Saei Ghare Naz
Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
saeigarenaz@gmail.com
Nourossadat
Kariman
Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
noorakariman@gmail.com
Abbas
Ebadi
Behavioral Sciences Research Center,
Life style Institute, Faculty of Nursing, Baqiyatallah University of Medical Sciences, Tehran, Iran.
ebadi1347@yahoo.com
Giti
Ozgoli
Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
g.ozgoli@gmail.com
Vida
Ghasemi
Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
vidaghasemi89@gmail.com
Farzaneh
Rashidi Fakari
Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
rashidiff@yahoo.com
10.22034/APJCP.2018.19.4.875
Background: Cervical cancer is the second most common cancer in women worldwide; early detection can play<br />a key role in reducing the associated morbidity. The objective of this study was to systematically assess the effects of<br />educational interventions on cervical cancer screening (CCS) behavior of women. Methods: In this review the Cochrane<br />library, Web of Science, Science Direct, PubMed, Scopus and search engine of Google scholar were searched for all<br />interventional studies (trails, pre- and post-test or quasi-experimental) published in 2000-2017 for a systematic review,<br />The search was based on the following keywords: cervix cancer, uterine cervical neoplasms, screening, prevention and<br />control, Papanicolaou Test, pap test, pap smear, education, intervention, systematic review. Due to the heterogeneity<br />of the data, a qualitative analysis was performed. Results: Thirty seven articles with 15,658 female participants in<br />different parts of world were included in the review. About three quarters of the articles covered behavior change<br />interventions. About one fourth of the articles were based on health education methods. The heath belief model is<br />the most popular used framework for cervical cancer screening interventions. The results of our study showed that<br />different health education methods (such as calls, mailed postcards, mother/daughter education. consultation sessions,<br />picture books, videos, PowerPoint slides, small group discussions, educational brochures, radio broadcast education,<br />lecture presentations, tailored counseling and a fact sheet, Self-learning package, face-to- face interviews and etc) are<br />effective in modifying cervical cancer screening behavior of women. Conclusions: Our results showed that the different<br />interventions and health behavior change frameworks provide an effective base for cervical cancer prevention. Heath<br />providers can chose educational methods based on the particular client situations.
Cervical cancer,Screening,Systematic review,Prevention,Pap test
https://journal.waocp.org/article_59573.html
https://journal.waocp.org/article_59573_4c2e2a0ff4a4ea81d02ca43f14c75e8f.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Association of BRCA1 Promoter Methylation with Breast Cancer in Asia: A Meta- Analysis
885
889
EN
Ricvan Dana
Nindrea
0000-0002-1844-3323
Doctoral Program, Faculty of Medicine, Universitas Gadjah Mada, Indonesia.
ricvandana7@gmail.com
Wirsma Arif
Harahap
0000-0002-0356-5424
Surgical Oncology Divison, Faculty of Medicine Universitas Andalas/ Dr. M Djamil General Hospital Padang, West Sumatera Province, Indonesia.
wirsma@med.unand.ac.id
Teguh
Aryandono
0000-0002-1143-4125
Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta Province, Indonesia.
teguharyandono@yahoo.com
Lutfan
Lazuardi
Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta Province, Indonesia.
lutfan.lazuardi@gmail.com
10.22034/APJCP.2018.19.4.885
Objective: The aim of this study was to determine the degree of association of BRCA1 promoter methylation with<br />breast cancer in Asia. Methods: The study sample for the present meta-analysis was provided by published research<br />articles on associations of BRCA1 promoter methylation with breast cancer in Asia accessed through databases on<br />PubMed, ProQuest and EBSCO published between 1997 and November 2017. Pooled odds ratios (OR) were calculated<br />with fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3). Results: Of<br />a total of 475 articles, 11 studies were included in our systematic review with meta-analysis of relevant data. The<br />results showed a highly significant association between BRCA1 promoter methylation with breast cancer in Asia<br />(OR = 8.78 [95% CI 4.15-18.56, p < 0.00001]). Conclusion: This analysis confirmed association between BRCA1<br />promoter methylation and breast cancer in Asia. BRCA1 promoter assessment might be a predictive or diagnostic aid<br />for breast cancer prediction.
BRCA1,methylation,breast cancer,Asia
https://journal.waocp.org/article_57863.html
https://journal.waocp.org/article_57863_60e35e508d31e3b73cb7b8bb51abc1ac.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Patient Reported Weight Loss Predicts Recurrence Rate in Renal Cell Cancer Cases after Nephrectomy
891
895
EN
Priya
Tiwari
Department of Medical Oncology, New Delhi-29, India.
pluto_2k3@yahoo.co.in
Lalit
Kumar
Department of Medical Oncology, New Delhi-29, India.
lalitaiims@yahoo.com
Sanjay
Thulkar
DR. B.R.A. Institute Rotary Cancer Hospital, New Delhi-29, India.
sanjaythulkar@gmail.com
Geetika
Singh
All India Institute of Medical Sciences, New Delhi-29, India.
ggmed22@gmail.com
Prabhat
Malik
0000-0003-0205-8559
Department of Medical Oncology, New Delhi-29, India.
drprabhatsm@gmail.com
Amlesh
Seth
All India Institute of Medical Sciences, New Delhi-29, India.
amlesh.seth@gmail.com
10.22034/APJCP.2018.19.4.891
Background: Recurrence of renal cell cancer (RCC) affects approximately one-third of patients after curative<br />nephrectomy. However, studies from the Indian subcontinent have been scarce. We here ddetermine relapse rates<br />and patterns in an Indian cohort. Methods: This study included all patients with RCC who underwent nephrectomy<br />from 2004 to 2013 at our centre. Recurrence-free survival (RFS) was calculated from the date of surgery to date of<br />recurrence or death. The Cox regression model was applied to identify significant prognostic factors. Results: Overall<br />a total of 292 patients were included. Median age was 50 years (range 19-84 years), with a male:female ratio of 3:1.<br />Radical and partial nephrectomy were performed for 276 (94.5%) and 16 (5.5%) patients, respectively. Clear cell was<br />most common histological subtype (71.2%) and T1, T2, T3 and T4 stages accounted for 89 (30.5%), 86 (29.5%), 105<br />(36%) and 12 (4.1%) patients, respectively. One hundred and thirty-six patients (46.6%) demonstrated recurrence.<br />Eighty-six (63.2%) relapsed at distant sites, 14 (10.3%) and at locoregional sites whereas 36(26.5%) had both distant<br />and locoregional recurrence. Median time to recurrence was 18 months. Approximately 17.7% of cases had disease<br />reappearance after five years. Factors predicting shorter RFS on multivariate analysis were patient reported weight<br />loss (p=0.004), Fuhrman grade 3 or 4 (p<0.0001), presence of necrosis (p<0.0001) and higher tumour stage (p=0.005).<br />Conclusion: Compared to previous studies, our patients had higher rates of recurrence in general and locoregional<br />recurrence in particular. However, except for weight loss, other predictive factors remain similar. Finding weight loss<br />as the marker of recurrence emphasises the importance of the simple task of history taking.
Renal cell cancer,weight loss,Recurrence-free survival,Fuhrman grade
https://journal.waocp.org/article_60324.html
https://journal.waocp.org/article_60324_6db55708b19e0af9dadc1f62bdd9465e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
897
899
EN
Mitra
Modares Gilani
Department of Gynecology and obstetrics, Tehran University of Medical Sciences, Tehran, Iran.
modaresgilani@tums.ac.ir
Zohreh
Kazemi
Department of Gynecology and obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
zohrekazemi1122@yahoo.com
Narges
Zamani
Department of Gynecology and obstetrics, Tehran University of Medical Sciences, Tehran, Iran.
dr.narges,zamani@gmail.com
Hadis
Shahrami
Department of Gynecology and obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
hadisshahrami@yahoo.com
Akram
Ghahghaei-Nezamabadi
Department of Gynecology and obstetrics, Tehran University of Medical Sciences, Tehran, Iran.
aghaghaei@alumnus.tums.ac.ir
Soureh
Sheikham
Department of Gynecology and obstetrics, Tehran University of Medical Sciences, Tehran, Iran.
s.sheikham@gmail.com
10.22034/APJCP.2018.19.4.897
Background: Recently preoperative hematologic parameters have attracted attention for their capacity to predict<br />tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the<br />tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. Methods:<br />We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to<br />March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence.<br />Results: The majority of patients had tumors with the following characteristics: endometrioid histology (83.1%), low<br />grade (grade I-II, 71.7%) and stage I disease (68.1%). The mean ± SD monocyte, neutrophil and platelet counts were 8.23<br />x 109/L ± 3.56 x 109/L, 64.0 x 109/L ± 11.3 x 109/L and 261.6 x 109/L ± 74.6 x 109. Statistically significant associations<br />were noted with between preoperative monocyte count and tumor stage (p value=0.044), recurrence (p value<0.001) and<br />omentum involvement (p value< 0.001) but not with tumor grade (p value=0.897), depth of myometrium involvement<br />(p value=0.479), lymphovascular space invasion (p value=0.269) and lymph node involvement (p value=0.377).<br />Conclusion: An elevated preoperative monocyte count is related to more aggressive tumors and a higher recurrence<br />rate in patients with endometrial cancer.
Endometrial cancer,preoperative monocyte count,tumor characteristics,Recurrence,tumor-associated macrophage
https://journal.waocp.org/article_58428.html
https://journal.waocp.org/article_58428_993ce0817080e636cae73b6b70000d8a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Serum CXCL12, but not CXCR4, Is Associated with Head and Neck Squamous Cell Carcinomas
901
904
EN
Fatemeh
Lavaee
Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
lavaeef@sums.ac.ir
Sahar
Zareh
Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
saharezare@yahoo.com
Zahra
Mojtahedi
Shiraz Institute for Cancer
Research, Shiraz University of Medical Sciences, Shiraz, Iran.
mojtahediz@sums.ac.ir
Mahyar
Malekzadeh
0000-0003-1581-0471
Shiraz Institute for Cancer
Research, Shiraz University of Medical Sciences, Shiraz, Iran.
mahyar.malekzadeh@gmail.com
Bijan
Khademi
Department of Otolaryngology,
Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Abbas
Ghaderi
Shiraz Institute for Cancer
Research, Shiraz University of Medical Sciences, Shiraz, Iran.
ghaderia@sums.ac.ir
10.22034/APJCP.2018.19.4.901
Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region.<br />We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, with<br />HNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28<br />healthy individuals in the control group. Plasma levels of CXCL12 and CXCR4 were measured using ELISA kits.<br />Results: There was a significant difference in mean CXCL12, but not CXCR4, plasma levels between the patient and<br />control groups (P=0.0001). No significant associations were found between mean plasma levels of either CXCL12 or<br />CXCR4 with age, gender, tumor site, tumor size, lymph-node involvement or tumor stage. Conclusion: For the first<br />time, our findings demonstrate a significant association between serum CXCL12 but not CXCR4 levels and HNSCCs.
CXCL12,CXCR4, HNSCC, Serum
https://journal.waocp.org/article_59850.html
https://journal.waocp.org/article_59850_378cd5adef8bc2d147349f754a049fd8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Impact of Mesenchymal Stem Cells and Vitamin D on Transforming Growth Factor Beta Signaling Pathway in Hepatocellular Carcinoma in Rats
905
912
EN
Shimaa
Saad El-Din
Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
shimaasaadaldin@yahoo.com
Hanan
Fouad
Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
hanan.fouad@kasralainy.edu.eg
Laila Ahmed
Rashed
Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
lailaahmedrashed@gmail.com
Soheir
Mahfouz
Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
soheirmahfouz@yahoo.com
Rania Elsayed
Hussein
Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
rania.hussein@kasralainy.edu.eg
10.22034/APJCP.2018.19.4.905
Background: Transforming growth factor-beta (TGF-β) signaling is recognized as being critical for carcinogenesis.<br />Vitamin D has proved to exert numerous tumor suppressive effects. Effects of bone marrow derived mesenchymal stem<br />cells (BM-MSCs) on tumor progression are still controversial. The present study was conducted to evaluate the effects<br />of BM-MSCs and vitamin D on TGF-β signaling in an experimental hepatocellular carcinoma (HCC) model in rats.<br />Materials and Methods: The study was conducted on fifty female white albino rats divided equally into 5 groups:<br />controls, HCC induced by diethyl-nitrosamine (DENA) and carbon tetrachloride (CCl4), HCC plus MSCs, HCC plus<br />vitamin D and HCC plus both MSCs and vitamin D. The following parameters were assessed in rat liver tissues: TGF-β<br />and Smad2 protein levels by ELISA and western blotting, respectively, gene expression of Smad3, Smad7, Snail,<br />HNF4α and MMP-2 and histopathological lesions. Serum levels of alpha fetoprotein (AFP), ALT and albumin were<br />also assessed. Results: TGF-β protein levels and gene expression of its downstream effectors (Smad3 and Snail), in<br />addition to Smad2 protein levels were significantly higher in the HCC group than in the control group. On the other<br />hand, they were significantly down-regulated in all treated groups with most significant amelioration with both MSCs<br />and vitamin D. Also, the serum levels of AFP were significantly increased in the untreated HCC group, and this was<br />again reversed in all treated groups. Histopathological examination of liver tissue revealed that administration of<br />MSCs or vitamin D into HCC rat group improved the histopathological picture with residual tumor pathology, while<br />administration of both MSCs and vitamin D showed better restoration of liver parenchyma. These data suggest that<br />the TGF-β signaling pathway could be used as a therapeutic target in HCC.
HCC,TGF-β signaling,MSCs,Vitamin D
https://journal.waocp.org/article_59870.html
https://journal.waocp.org/article_59870_0872c9bdb2c1c06f1e1fcb62ec44a39e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Sirt1 Gene Expression and Gastric Epithelial Cells Tumor Stage in Patients with Helicobacter pylori Infection
913
916
EN
Saman
Mohammadi Saravle
Liver and
Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
samanmohammadi888@gmail.com
Manouchehr
Ahmadi Hedayati
Liver and
Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
dr.ahmadi2000@gmail.com
Ebrahim
Mohammadi
Lung Diseases and Allergy Research Center,Kurdistan University of Medical Sciences, Sanandaj, Iran.
micrbiol2007@yahoo.com
Farshad
Sheikhesmaeili
Liver and
Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
microbiol2007@yahoo.com
Bahram
Nikkhoo
Department of Pathology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
dr.b.nikkhoo@gmail.com
10.22034/APJCP.2018.19.4.913
Introduction: The World Health Organization has categorized Helicobacter pylori as a carcinogen for gastric<br />cancer, which causes human mortality worldwide. A number of studies have shown that H. pylori affects cell signaling<br />in gastric epithelial cells and changes the expression of some proteins such as proinflammatory cytokines. Bacterial<br />infections may alter sirt1 and sirt2 genes expression in inflammatory tissues and cancer cells. In this study, sirt1 and<br />sirt2 genes expression in gastric cancers was surveyed with reference to H. pylori status. Methods: Stomach biopsies<br />were collected from 50 gastric cancer patients, 25 H. pylori-positive and 25 H. pylori-negative as determined by the<br />urea rapid test. Tumor grade was determined by a pathologist. After total RNA extraction from gastric cancer biopsy<br />samples and cDNA synthesis, sirt1 and sirt2 genes expression levels were determined by Real Time PCR and ΔΔCT<br />methods. Results: There was no statistically significant link between H. pylori infection and sirt1 (P<0.899) and sirt2<br />(P<0.169) genes expression in gastric epithelial cells. However, pathologic findings showed that there is a statistically<br />significant relationship between sirt1 gene expression and the tumor grade (P<0.024). Discussion: A statistically<br />significant association was found between sirt1 gene expression and tumor grade of gastric cancers that could be due<br />to effects on progression of cancer cells infected with H. pylori.
Helicobacter pylori,Gastric cancer,sirt1,sirt2,Tumor grade
https://journal.waocp.org/article_59836.html
https://journal.waocp.org/article_59836_e63c3ed5b995cdb371146b7d16a578c9.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Clausenidin Induces Caspase 8-Dependent Apoptosis and Suppresses Production of VEGF in Liver Cancer Cells
917
922
EN
Peter M
Waziri
MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
petermwaziri@gmail.com
Rasedee
Abdullah
Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Selangor, Malaysia.
rasedee@gmail.com
Rosita
Rosli
MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
rosita@upm.edu.my
Abdul Rahman
Omar
Laboratory of Vaccine and Therapeutics, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia
aro675@gmail.com
Ahmad Bustamam
Abdul
MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
zer2crystals@gmail.com
Nur Kartinee
Kassim
Department of Chemistry, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia.
kartinee@upm.edu.my
Ibrahim
Malami
MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
keepibinformed@yahoo.co.uk
Imaobong C
Etti
MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
ettiimaobong@gmail.com
Ja’afaru M
Sani
MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
biojafar@gmail.com
Mohd Azmi
Mohd Lila
Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
azmi@upm.edu.my
Jesse Faez Firdaus
Abdullah
Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
jesse@upm.edu.my
10.22034/APJCP.2018.19.4.917
Clausena excavata Burm f. is used by traditional healers to treat cancer patients in South East Asia. The use of the<br />plant and its compounds is based on Asian folklore with little or no scientific evidence supporting the therapeutic efficacy<br />The current study aimed to determine the effect of pure clausenidin isolated from C. excavata on caspase-8-induced cell<br />death as well as angiogenesis in the HepG2 hepatocellular carcinoma cell line. Caspase-8 and extrinsic death receptor<br />protein expression was determined using spectrophotometry and protein profile arrays, respectively. Ultrastructural<br />analysis of clausenidin-treated cells was conducted using transmission electron microscopy. In addition, anti-angiogenic<br />effects of clausenidin were investigated by Western blot analysis. Clausenidin significantly (p<0.05) increased the<br />activity of caspase-8 and expression of protein components of the death inducing signaling complex (DISC) in HepG2<br />cells. Ultrastructural analysis of the clausenidin-treated HepG2 cells revealed morphological abnormalities typical of<br />apoptosis. Furthermore, clausenidin significantly (p<0.05) decreased the expression of vascular endothelial growth<br />factor (VEGF). Therefore, clausenidin is a potential anti-angiogenic agent which may induce apoptosis of hepatocellular<br />carcinoma cells.
Clausenidin,caspase 8,death receptor,Apoptosis,Angiogenesis
https://journal.waocp.org/article_59717.html
https://journal.waocp.org/article_59717_ae99ad54c67cf0e827bcac9cbcd5ef94.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Detection of a 4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 Using Mismatch PCR-RFLP and Its Association with Susceptibility to Breast Cancer
923
926
EN
Mohammad
Hashemi
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
saeid.ghavami@gmail.com
Hiva
Danesh
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
daneshhiva@yahoo.com
Fatemeh
Bizhani
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
fatemebizhani9@yahoo.com
Hedieh
Sattarifard
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
hedieh.sattarifard@gmail.com
Seyed Mehdi
Hashemi
Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
mehdihashemi3107@gmail.com
Gholamreza
Bahari
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
saeid.ghavami@gmail.com
10.22034/APJCP.2018.19.4.923
It has been shown that a 4-bp insertion/deletion (ins/del) polymorphism of EGLN2 influences the risk of several<br />cancers. However, to date, no study has inspected the impact of the 4-bp ins/del polymorphism on breast cancer (BC)<br />risk. A case-control study, including 134 breast cancer patients and 154 healthy women, was here conducted to examine<br />the possible association between EGLN2 4-bp ins/del polymorphism and BC risk in a southeast Iranian population.<br />A mismatched polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was designed for<br />genotyping of the variant. Our findings did not support any association between the 4-bp ins/del polymorphism and<br />the risk of BC in the codominant, dominant, recessive and allele inheritance models tested. When links between<br />the EGLN2 4-bp ins/del polymorphism and clinicopathological characteristics of the patients were evaluate the variant<br />was only associated with HER2 status. More studies with larger sample sizes and diverse ethnicities are warranted to<br />verify our finding.
EGLN2,breast cancer,Polymorphism,deletion
https://journal.waocp.org/article_60587.html
https://journal.waocp.org/article_60587_a5816083f2a18cdaa9741271751321df.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Screening and Identification of Peptides Specifically Targeted to Gastric Cancer Cells from a Phage Display Peptide Library
927
932
EN
Deniz
Sahin
Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey.
sahinden@itu.edu.tr
Sevket Onur
Taflan
Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey.
taflan@itu.edu.tr
Gizem
Yartas
Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey.
yartasgizem@gmail.com
Hassan
Ashktorab
Department of Medicine and Cancer Center, Howard University, Washington, DC, United States of America.
hashktorab@howard.edu
Duane T
Smoot
Department of Internal Medicine, Meharry Medical College, Nashville, TN, United States of America.
dsmoot@mmc.edu
10.22034/APJCP.2018.19.4.927
Background: Gastric cancer is the second most common cancer among the malign cancer types. Inefficiency of<br />traditional techniques both in diagnosis and therapy of the disease makes the development of alternative and novel<br />techniques indispensable. As an alternative to traditional methods, tumor specific targeting small peptides can be used<br />to increase the efficiency of the treatment and reduce the side effects related to traditional techniques. The aim of this<br />study is screening and identification of individual peptides specifically targeted to human gastric cancer cells using<br />a phage-displayed peptide library and designing specific peptide sequences by using experimentally-eluted peptide<br />sequences. Methods: Here, MKN-45 human gastric cancer cells and HFE-145 human normal gastric epithelial cells<br />were used as the target and control cells, respectively. 5 rounds of biopannning with a phage display 12-peptide library<br />were applied following subtraction biopanning with HFE-145 control cells. The selected phage clones were established<br />by enzyme-linked immunosorbent assay and immunofluorescence detection. We first obtain random phage clones<br />after five biopanning rounds, determine the binding levels of each individual clone. Then, we analyze the frequencies<br />of each amino acid in best binding clones to determine positively overexpressed amino acids for designing novel<br />peptide sequences. Results: DE532 (VETSQYFRGTLS) phage clone was screened positive, showing specific binding<br />on MKN-45 gastric cancer cells. DE-Obs (HNDLFPSWYHNY) peptide, which was designed by using amino acid<br />frequencies of experimentally selected peptides in the 5th round of biopanning, showed specific binding in MKN-45<br />cells. Conclusion: Selection and characterization of individual clones may give us specifically binding peptides, but<br />more importantly, data extracted from eluted phage clones may be used to design theoretical peptides with better<br />binding properties than even experimentally selected ones. Both peptides, experimental and designed, may be potential<br />candidates to be developed as useful diagnostic or therapeutic ligand molecules in gastric cancer research.
Gastric cancer,phage display,targeted approach,subtraction biopanning
https://journal.waocp.org/article_58429.html
https://journal.waocp.org/article_58429_19b4625f614b24c1462931540e48253e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Comparative Cost-Effectiveness Analysis of Two Different Two-Dose Human Papillomavirus Vaccines in Malaysia
933
940
EN
Georges
Van Kriekinge
GSK, Avenue Fleming 20, 1300 Wavre, Belgium.
georges.m.van-kriekinge@gsk.com
Woo-Yun
Sohn
GSK, 23 Rochester Park, Singapore 139234, Singapore.
woo-yun.w.sohn@gsk.com
Syed Mohamed
Aljunid
International Centre
for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
saljunid@gmail.com
Ruey
Soon
Hospital Wanita
and Kanak-kanak Sabah, Kota Kinabalu, Sabah, Malaysia.
rueysoon@yahoo.com
Chee-Meng
Yong
Hospital Ampang, Ampang, Malaysia,
cmy2050@hotmail.com
Jing
Chen
GSK, 23 Rochester Park, Singapore 139234, Singapore.
jing.j.chen@gsk.com
I-Heng
Lee
GSK, 23 Rochester Park, Singapore 139234, Singapore.
ihelee.sg@gmail.com
10.22034/APJCP.2018.19.4.933
Purpose: To comparatively evaluate the results of a 2-dose human papillomavirus (HPV) vaccination programme<br />with the AS04-adjuvanted HPV16/18 vaccine (AS04-HPV-16/18v) or HPV-6/11/16/18 vaccine (4vHPVv), in addition<br />to cervical cancer (CC) screening, in Malaysia. Methods: A lifetime Markov model replicating the natural history of<br />HPV in 13-year-old girls was adapted to Malaysia to assess the impact of vaccination on pre-cancerous lesions, genital<br />warts and CC cases, CC deaths, quality-adjusted life years (QALYs), and costs from the perspective of the Malaysian<br />Ministry of Health. Vaccine effectiveness was based on efficacy and HPV type distribution. Both vaccines were assumed<br />to have equal efficacy against vaccine-type HPV but differed for protection against non-vaccine types. Vaccine price<br />parity was used and health and cost outcomes were discounted at 3%/annum. Sensitivity analyses tested the robustness<br />of the results. Results: The model predicted that AS04-HPV-16/18v would result in 361 fewer CC cases and 115 fewer<br />CC deaths than 4vHPVv, whereas 4vHPVv averted 4,241 cases of genital warts over the cohort’s lifetime. Discounted<br />total costs showed savings of 18.50 million Malaysian Ringgits and 246 QALYs in favour of AS04-HPV-16/18v. In<br />one-way sensitivity analyses, the discount rate was the most influential variable for costs and QALYs, but AS04-HPV-<br />16/18v remained dominant throughout. A two-way sensitivity analysis to assess the longevity of cross-protection for both<br />vaccines confirmed the base-case. Conclusions: In Malaysia, the use of AS04-HPV-16/18v, in addition to screening,<br />was modelled to be dominant over 4vHPVv, with greater estimated CC benefits and lower costs.
Cost-Effectiveness,human papillomavirus,Malaysia,Two-dose schedule
https://journal.waocp.org/article_58370.html
https://journal.waocp.org/article_58370_60f936a7ede4833dc2d33a3837826815.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Contrast-Enhanced Perfusion MR Imaging to Differentiate Between Recurrent/Residual Brain Neoplasms and Radiation Necrosis
941
948
EN
Noha Ahmed Kamal
Metaweh
0000-0003-4187-6415
Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
nohametawe3@gmail.com
Amr Osama
Azab
Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
amrsraafat@gmail.com
Ayman Abd El Hameed
EL Basmy
Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
rouma_81@hotmail.com
Karim Nabil
Mashhour
0000-0001-9980-6474
Kasr El-Ainy Center of Clinical Oncology, Cairo
University, Cairo, Egypt.
karim.mashhour.81@gmail.com
Wael Mokhtar
EL Mahdy
Department of Neurosurgery, Faculty of Medicine, Cairo
University, Cairo, Egypt.
weedo_82@hotmail.com
10.22034/APJCP.2018.19.4.941
Purpose: To determine the value of dynamic susceptibility contrast enhanced (DSC) MRI (magnetic resonance imaging)<br />perfusion in the characterization of newly developed/enlarging lesions within irradiated regions after treatment of brain<br />tumors. Methods: This prospective cross-sectional study covered 23 patients, 12 females and 11 males. All cases<br />initially presented with histologically proven malignant brain tumors and underwent surgical intervention followed by<br />radiotherapy (+/- chemotherapy). On follow up imaging, they presented with newly developed/progressively enhancing<br />mass lesions at the sites of the primary tumors. All patients then underwent conventional MRI, DSC MRI perfusion<br />and MR spectroscopy. Results: In our study, we found DSC MR perfusion to be a useful non-invasive method for<br />differentiating recurrent brain tumors from radiation necrosis. This approach allows hemodynamic measurements to<br />be obtained within the brain as the relative cerebral blood volume (rCBV) to complement the anatomic information<br />obtained with conventional contrast enhanced MR imaging. The sensitivity and specificity of DSC MR perfusion<br />for differentiation were found to be 77.8% and 80.0%, respectively. Conclusion: DSC MR perfusion is a promising<br />technique in differentiating recurrent brain tumors from radiation necrosis as it has acceptable spatial resolution and<br />can be routinely performed in the same settings after conventional MRI.
Dynamic susceptibility contrast enhanced MR Perfusion,Recurrent brain tumors,Radiation necrosis
https://journal.waocp.org/article_58431.html
https://journal.waocp.org/article_58431_dc6696b942f58c9c13830061d2746f7d.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Effecst of Patho- Biological Factors on the Survival of Recurrent Breast Cancer Cases
949
953
EN
Mohammad Esmail
Akbari
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
info@crc.ir
Marzieh
Rohani- Rasaf
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
rohani_marzieh@yahoo.com
Nahid
Nafissi
Department of surgery, Iran University of Medical Sciences, Tehran, Iran.
nahid.nafissi@gmai.com
Atieh
Akbari
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
atieh.akbari@yahoo.com
leyla
Shojaee
Department of Surgery, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
shojaeeleyla11@gmail.com
10.22034/APJCP.2018.19.4.949
Background: Recurrence of breast cancer after treatment is generally due to loco-regional invasion or distant<br />metastasis. Although patients with metastasis are considered incurable, existing treatments might prolong a patient’s life<br />while also improving its quality. Choice of approach for individual patients requires identification of relevant survival<br />factors. This study concerns factors influencing survival after recurrence in Iranian breast cancer patients. Methods: This<br />study was performed on 442 recurrent breast cancer patients referred to the Cancer Research Center of Shahid Beheshti<br />University between 1985 and 2015. After confirming recurrence as a distant metastasis or loco-regional invasion, the<br />effects of demographic, clinic-pathologic, biological, type of surgery and type of adjuvant treatment on survival were<br />evaluated using univariate and multivariate stratified Cox models. Results: The mean survival after recurrence was<br />18 months (5 days to 13 years), 219 patients (70.42%) survived two years, 75 patients (24.12%) survived from 2 to 5<br />years, and 17 patients (5.47%) survived more than 5 years. In this study, it was found through univariate analysis that the<br />factors of age, lymph node status, DFI, place of recurrence and nodal ratio demonstrated greatest influence on survival<br />after recurrence. On multivariate analysis, the most important factors influencing survival were the place of recurrence<br />and the lymph node status. Conclusion: The results of this study enhance our knowledge of effects of different factors<br />on survival of patients after breast cancer recurrence. Thus, they may be used to inform treatment choice.
Recurrent breast cancer,survival,Prognosis
https://journal.waocp.org/article_59589.html
https://journal.waocp.org/article_59589_6231d037bc92e27c48388b9bdecc80e3.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Proliferative Index (Ki67) for Prediction in Breast Duct Carcinomas
955
959
EN
Shatha Th
Ahmed
0000-0002-8990-4211
MBChB, Msc, PhD mol. Pathology/UK, College of Medicine,Ninevah University, Iraq.
shatha_1961@yahoo.com
Azad M
Ahmed
MD, FIBMS Pathology, University of Duhok, College of Dentistry, Iraq.
dr_azad_mustafa@hotmail.com
Dildar H
Musa
MD, MBChB, FIBMS, General Surgeon, College of Medicine, University of Duhok, Iraq.
dildar@uod.ac
Farhad K
Sulayvani
MD, CABS. FRCS, College of Medicine, University of Duhok, Iraq.
Muzahm
Al-Khyatt
FRCP, FRCS, Professor of General and Laparoscopic Surgery,
Ninevah University, Iraq.
president@uoninevah.edu.iq
Intisar S
Pity
MD, FIBMS, Pathology, College of Medicine, University of Duhok, Iraq.
intisarsimpity@gmail.com
10.22034/APJCP.2018.19.4.955
Background and objectives: To date, many tumor markers have been used to predict prognosis and therapeutic<br />response in patients with breast cancer. The well established and routinely applied tumor markers are the estrogen-receptor,<br />progesterone-receptor and Her2/neu-receptor. In the current study, we aimed to highlight any association of the<br />proliferation index (Ki67) in breast infiltrative duct carcinoma with the tumor grade, tumor size and nodal status in<br />addition to hormone receptor status. Tissue sections were stained immunohistochemically for Ki67 nuclear antigen,<br />estrogen, progesterone and Her2/neu receptors using an automated Dako machine (Dako Denmark. There was a<br />significant inverse relationship of Ki67 levels with ER and PR, while values were directly proportional to the tumor<br />grade and Her2/neu status. No significant association was found between Ki67 and size of tumor or nodal status. Ki67<br />immunoexpression may offer an independent predictive tumor marker and for routine application in cases of breast cancer.
KEYWORDS: Breast cancer,Ki67,immunohistochemistry
https://journal.waocp.org/article_59558.html
https://journal.waocp.org/article_59558_c5035a478615d4580854e5099a688846.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Metagenomics of Microbial Communities in Gallbladder Bile from Patients with Gallbladder Cancer or Cholelithiasis
961
967
EN
Yasuo
Tsuchiya
Division of Preventive Medicine, Niigata University Graduate School of Medical and
Dental Sciences, Niigata, Japan.
troof441@gmail.com
Ernest
Loza
Instituto de Gastroenterologia Boliviano-Japones, La Paz, Bolivia.
ernestoantonioloza@gmail.com
Guido
Villa-Gomez
Instituto de Gastroenterologia Boliviano-Japones, La Paz, Bolivia.
villagomezroig@gmail.com
Carlos C
Trujillo
Instituto de Gastroenterologia Boliviano-Japones, La Paz, Bolivia.
drtrujillo-patologo@hotmail.com
Sergio
Baez
Sotero del Rio Hospital, Santiago, Chile.
sbaez@ssmso.cl
Takao
Asai
0000-0002-3536-5072
Division of Preventive Medicine, Niigata University Graduate School of Medical and
Dental Sciences, Niigata, Japan.
asai@nuhw.ac.jp
Toshikazu
Ikoma
Division of Preventive Medicine, Niigata University Graduate School of Medical and
Dental Sciences, Niigata, Japan.
toikoma28@gmail.com
Kazuo
Endoh
Faculty of Health Sciences, Niigata University of Health and Welfare, Niigata, Japan.
endo@nuhw.ac.jp
Kazutoshi
Nakamura
Division of Preventive Medicine, Niigata University Graduate School of Medical and
Dental Sciences, Niigata, Japan.
kazun@med.niigata-u.ac.jp
10.22034/APJCP.2018.19.4.961
Salmonella typhi and Helicobacter infections have been shown to increase risk of gallbladder cancer (GBC), but<br />findings have been inconsistent. Other bacterial infections may also be associated with GBC. However, information on<br />microbial pathogens in gallbladder bile of GBC patients is scarce. We aimed to investigate the microbial communities in<br />gallbladder bile of patients with GBC and cholelithiasis (CL). Seven GBC patients and 30 CL patients were enrolled in<br />this study. Genomic DNA was extracted from bile and the V3-V4 region of 16S rRNA was amplified. The sequencing<br />results were compared with the 16S database, and the bacteria were identified by homology searches and phylogenetic<br />analysis. DNA was detected in the bile of three GBC (42.9%; Bolivia, 1; Chile, 2) and four CL patients (13.3%; Bolivia,<br />1; Chile, 3). Of the 37 patients, 30 (81.1%) were negative and unable to analyze. Salmonella typhi and Helicobacter sp.<br />were not detected in bile from any GBC patients. As the predominant species, Fusobacterium nucleatum, Escherichia<br />coli, and Enetrobacter sp. were detected in bile from GBC patients. Those in bile from CL patients were Escherichia<br />coli, Salmonella sp., and Enerococcus gallinarum. Escherichia coli was detected in bile samples from both GBC and<br />CL patients. Whether the bacteria detected in bile from GBC patients would associated with the development of GBC<br />warrant further investigation.
gallbladder bile,next generation sequencing,16S rRNA,V3-V4 region,gallbladder cancer
https://journal.waocp.org/article_59593.html
https://journal.waocp.org/article_59593_1937103ddda3a56e2b33699617694db7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Identification of Key Candidate Genes and Pathways in Endometrial Cancer by Integrated Bioinformatical Analysis
969
975
EN
Lihong
Liu
0000-0001-7643-4583
Department of Gynecological Ward, The Third Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China.
liulihong024@163.com
Fangxu
Chen
Department of Gynecological Ward, The First Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China.
Aihui
Xiu
Department of Gynecological Ward, The First Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China.
Bo
Du
Department of Gynecological Ward, The Third Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China.
Hao
Ai
Liaoning Provincial Key Laboratory of Follicle Development and Reproductive Health (Office of Science and Technology)
, Jinzhou, China.
Wei
Xie
Department of Gynecological Ward,Dongzhimen Hospital of Traditional Chinese Medicine,Beijing University of Chinese Medicine ,Beijing,China.
10.22034/APJCP.2018.19.4.969
Endometrial Cancer is the most common female genital tract malignancy, its pathogenesis is complex, not yet<br />fully described. To identify key genes of Endometrial Cancer we downloaded the gene chip GSE17025 from the Gene<br />Expression Omnibus database. Differentially expressed genes (DEGs) were identified through the GEO2R analysis<br />tool. Functional and pathway enrichment analysis were performed for DEGs using DAVID database. The network of<br />protein–protein-interaction (PPI) was established by STRING website and visualized by Cytoscape. Then, functional<br />and pathway enrichment analysis of DEGS were performed by DAVID database. A total of 1000 significant differences<br />genes were obtained, contain 362 up-regulated genes and 638 down-regulated genes. PCDH10, SLC6A2, OGN,<br />SFRP4, TRH, ANGPTL, FOSB are down-regulated genes. The gene of IGH, CCL20, ELF5, LTF, ASPM expression<br />level in tumor patients are up-regulated. Biological function of enrichment include metabolism of xenobiotics by<br />cytochrome P450, MAPK signaling pathway, Serotonergic synapse, Protein digestion and absorption, IL-17 signaling<br />pathway, Chemokine signaling pathway, HIF-1 signaling pathway, p53 signaling pathway. All in all, the current study<br />to determine endometrial differentially expressed genes and biological function, comprehensive analysis of intrauterine<br />membrane carcinoma pathogenesis mechanism, and might be used as molecular targets and diagnostic biomarkers for<br />the treatment of endometrial cancer.
Endometrial cancer,bioinformatical analysis,differentially expressed genes,functional enrichment analysis . protein–protein interaction
https://journal.waocp.org/article_59575.html
https://journal.waocp.org/article_59575_3450d0036d9de8c98bed7543df9d72c5.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression
977
982
EN
Sara
Rasooli
Department of Genetics, Faculty of Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
sararasouli@gmail.com
Nosratollah
Zarghami
Department of Medical Biotechnology,
Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
zarghami@tbzmed.ac.ir
10.22034/APJCP.2018.19.4.977
Objective: To explore the possibility of a novel chemopreventive strategy for improving breast cancer treatment,<br />the anticancer effects of a combination two natural compounds, Chrysin and Metformin, against T47D breast cancer<br />cells were investigated. Materials and Methods: After treatment of T47D cells with Metformin, Chrysin and the two<br />drugs in combination, toxicity to cancer cells was evaluated by MTT assay. Real time PCR was then used to determine<br />the expression levels of hTERT and cyclin D1 genes. Results: The MTT test findings showed that the combination of<br />metformin and chrysin had high synergistic effects in killing cancer cells. In addition PCR demonstrated a significant<br />decrease in cyclin D1 and hTERT gene expression in the T47D breast cancer cell line. Conclusion: The conmbination<br />of metformin and chrysin suppressing hTERT and cyclin D1 gene expression might offer an appropriate approach for<br />breast cancer therapy.
breast cancer,Cyclin D1,hTERT,Metformin,silibinin
https://journal.waocp.org/article_58018.html
https://journal.waocp.org/article_58018_84338d012ec11e848ac9e5a36b0e6c10.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
The Impact of Perceived Barriers on Self-Efficacy for HPV Preventive Behavior
983
988
EN
Kyeonghee
Bossard
College of Nursing, Chungnam National University, Daejeon, Republic of Korea.
bossardkh@hotmail.com
Youngshin
Song
College of Nursing, Chungnam National University, Daejeon, Republic of Korea.
yssong87@cnu.ac.kr
10.22034/APJCP.2018.19.4.983
Background: Cervical cancer is one of the most common cancers found among women. Many studies have focused<br />on factors associated with human papilloma virus (HPV) preventive behavior and early detection using models such as<br />the health belief model (HBM). Despite a growing body of knowledge regarding HPV preventive behavior, few studies<br />have examined how self-efficacy affects this behavior in foreign women living in South Korea. This study identified<br />factors affecting the self-efficacy of foreign women living in South Korea and the impact on HPV preventive behavior.<br />Methods: A total of 171 participants consisting of international school parents who voluntarily participated in HPV<br />preventive behavior were selected. A multivariate regression analysis included key variables such as demographics,<br />cervical cancer knowledge, perceived susceptibility, and perceived barriers. Results: Self-efficacy for HPV preventive<br />behavior was significantly associated with perceived barriers. That is, women with lower perceived barriers were likely<br />to have higher self-efficacy scores. However, demographics, cervical cancer knowledge, and perceived susceptibility<br />did not show any association with self-efficacy. The final model was significant and accounted for 14.4% of the<br />variance in self-efficacy. Conclusion: This study showed the importance of considering perceived barriers of HPV<br />preventive behavior related to self-efficacy. However, different from HBM, modifying factors, such as knowledge,<br />perceived susceptibility, and individual demographics were not related to self-efficacy. Based on these findings, future<br />research should investigate self-efficacy and HPV preventive behavior among individuals who do not participate in<br />HPV preventive behavior.
Cervical cancer,self-efficacy,barrier,Susceptibility,Immigrant
https://journal.waocp.org/article_59599.html
https://journal.waocp.org/article_59599_0ae9b27751240b0b69cc879029d65ab7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Psychometric Properties of the Farsi Version of “Spiritual Needs Questionnaire” for Cancer Patients in Iran: A Methodological Study
989
995
EN
Khadijeh
Hatamipour
0000-0002-2152-5952
School of Nursing, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran.
kh_hatamipour@yahoo.com
Maryam
Rassouli
Pediatric Nursing Department, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
rassouli.m@gmail.com
Farideh
Yaghmaei
Department of
Nursing, Islamic Azad University, Zanjan Branch, Zanjan, Iran.
farideh_y200@yahoo.com
Kazem
Zendedel
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
kzendeh@sina.tums.ac.ir
10.22034/APJCP.2018.19.4.989
Background and objectives: Spiritual needs are very important requirements to cancer patients. A valid and<br />reliable instrument is needed for evaluation. This study was conducted to psychometrically evaluate a Spiritual Needs<br />Questionnaire (SpNQ) for cancer patients in Iran. Methods: In this study, the methodology and psychometric properties<br />of the Farsi version of the SpNQ (Büssing et al., (2010)) were evaluated, based on the model proposed by Wilde et al.,<br />(2005). The study population included cancer patients referred to the largest referral center in Iran. Some 400 subjects<br />were selected. Then, the content, face and construct validity, as well as the internal consistency and reliability of the<br />Farsi version were assessed. Findings: In the confirmatory factor analysis, the original four-factor version with 19<br />phrases was not confirmed. Subsequently, an exploratory factor analysis (EFA) was carried out in which phrases were<br />included in three dimensions (peace and active giving, religion, and existence) that explained 48.1% of the variance.<br />Later, a confirmatory factor analysis (CFA) was conducted, which showed a good fit of the model (CFI=0.94, GFI=0.94,<br />RMSEA=0.071, and AGFI=0.96). Cronbach’s alpha was α=0.91 for the whole SpNQ. Cronbach’s alpha values ranged<br />from 0.76 to 0.86 for the three factors. The intra-class correlation coefficient was ICC=0.82 between two tests performed<br />with a two-week interval. Conclusion: The modified Farsi version of the SpNQ shows good psychometric properties<br />for patients and can be used to investigate the spiritual needs of Iranian cancer patients.
Spiritual Needs,Psychometric,Questionnaire,Validity,Reliability
https://journal.waocp.org/article_59615.html
https://journal.waocp.org/article_59615_a9d1f1fa48a4844dea25753d9b58f596.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Determinants of Breast Cancer Screening by Mammography in Women Referred to Health Centers of Urmia, Iran
997
1003
EN
Fatemeh
Moghaddam Tabrizi
Reproductive Health Research Center,Urmia University of Medical Sciences, Urmia, Iran.
Sakineh
Vahdati
Midwifery Consultation Masters' Degree Student, Student Research Center affiliated to Urmia University of Medical Sciences, Urmia, Iran.
Shahriar
Khanahmadi
Medical Student, Faculty of Medicine, Student Research Center affiliated to Urmia University of Medical Sciences, Urmia, Iran.
Samira
Barjasteh
Department of Economics and Management
Sciences for Health, 5Nursing and Midwifery School, Tehran University of Medical Sciences, Tehran, Iran.
samira_barjaste_70@yahoo.com
10.22034/APJCP.2018.19.4.997
Background: In women, breast cancer accounts for 30 percent of all cancers and it is the second leading cause of<br />mortality. Mammography is considered an effective procedure to detect early breast cancer recommended by World<br />Health Organization. This study was aimed to evaluate breast cancer screening determinants in women referred to<br />health centers of Urmia for mammography in 2017. Materials and Methods: In this descriptive-analytic cross-sectional<br />study, 348 women referred to health centers of Urmia were selected using multistage sampling. Data were collected<br />using a standard questionnaire for mammography screening determinants, with a checklist including demographic<br />characteristics, family, social and economic factors and midwifery background. Analysis was with SPSS software<br />version 20for descriptive and inferential statistic tests, Pperforming mammography was 12%. Significant relationships were noted with income, menopause status, a history of<br />breast cancer in close relatives, beliefs, inaccessibility, knowledge, cues to action, emotions, self-care, and life priorities<br />(P<0.05). There were no significant links with age at marriage, first age of delivery, number of children, duration of<br />breastfeeding, status of residency, education, marital status, occupation, history of breastfeeding, and previous breast<br />problems (P>0.05). Conclusions: The findings of this study showed that the status of breast cancer screening in<br />participating women was not satisfactory. Therefore, promotion of screening methods by health policy makers in Iran<br />is necessary and given that reliance solely on education is not sufficient, it is essential to pay attention to barriers and<br />eliminate them.
Screening Tests,breast cancer,mammography
https://journal.waocp.org/article_59556.html
https://journal.waocp.org/article_59556_74c2c51a014324e9189208c71fb6bf82.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Quality of Life of Nepalese Women Post Mastectomy
1005
1012
EN
Muna
Maharjan
0000-0001-8601-8620
HOPE School of Nursing, Zhongnan Hospital of Wuhan University, Wuhan, China.
munni_ma13@hotmail.com
Niresh
Thapa
0000-0003-3641-5622
Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
niresht@hotmail.com
Raj
Adhikari
Nursing Campus Maharajgunj, Institute of Medicine, Tribhuwan University, Kathmandu, Nepal.
rajdevi_adhikari@yahoo.com
Marcia A
Petrini
0000-0003-3494-0415
Chiang Mai University, Faculty of Nursing, Chiang Mai, Thailand.
petrinima2012@gmail.com
Kapendra Shekhar
Amatya
Nepal Cancer Hospital and Research
Centre, Department of Surgical Oncology, Lalitpur, Nepal.
ksa712@yahoo.com
10.22034/APJCP.2018.19.4.1005
Introduction: Worldwide breast cancer is the common invasive cancer among the females. The quality of life of<br />women after treatment, which is often a mastectomy, is frequently decreased. Objective: To determine the life quality<br />of Nepalese women post mastectomy. Materials and Methods: One hundred seven women after a mastectomy were<br />selected and interviewed by using the European Organization for Research and Treatment of Cancer-Quality of Life<br />Questionnaire and its Breast Specific Module to assess women’s quality of life. Result: The study findings revealed a<br />good score on global health status/quality of life. The respondents performed well on functional and symptom scales.<br />In the Breast Specific Module, all respondents performed poor regarding sexual function and sexual enjoyment. Global<br />Health Status was found useful among the women involved in service/business/agriculture and the survivors using<br />breast prosthesis. In Breast Specific Module, systemic therapy side effects showed strong statistical associations with<br />age, marital status, occupation, education, use of breast prosthesis and co-morbidity. Body image was highly significant<br />with age, occupation, education, use of breast prosthesis and co-morbidity. Conclusion: Based on the study findings,<br />counseling, and a structured educational programme is recommended to improve the QOL of women after a mastectomy.
breast cancer,EORTC,Quality of Life,mastectomy,Nursing
https://journal.waocp.org/article_59745.html
https://journal.waocp.org/article_59745_50c7fe1006d5080763248c58c6845234.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Expression of CDK6 in Oral Squamous Cell Carcinomas
1013
1016
EN
Azadeh
Andisheh-Tadbir
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
andisheh@sums.ac.ir
Mohamad Javad
Ashraf
Department of
Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
ashrafm@sums.ac.ir
Naghmeh
Jeiroodi
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
jeiroodi@yahoo.com
10.22034/APJCP.2018.19.4.1013
Background: CDK6 is the key factor in regulation of the cell cycle and essential for passage into the G1 phase. It<br />also plays an important role in the development of various tumors. In this cross-sectional study expression of the CDK6<br />protein in oral squamous cell carcinoma (OSCC) and healthy oral mucosa of controls was assessed to determine relations<br />with malignant transformation and clinicopathologic factors. Method: A total of 60 samples, 45 from OSCCs and 15<br />from healthy tissue, underwent immunohistochemistry for CDK6. Nuclear and cytoplasmic staining of keratinocytes<br />was considered as positive and the percentages of positive cells were calculated. Results: Expression of CDK6 was<br />detected in 55.6% of OSCC samples (25 cases) and 13.3% of controls (2 cases), the difference being significant. Mean<br />percentage of CDK6 stained cells was 24.2±29.3 in the OSCC cases and 4.33±2.1 in the control group, again statistically<br />significant. No relationship was detected between CDK6 expression and clinicopathologic factors. Conclusion:<br />Overexpression of CDK6 observed in OSCC points to a role for this protein in oral carcinogenesis.
CDK6,Squamous Cell Carcinoma,immunohistochemistry
https://journal.waocp.org/article_57602.html
https://journal.waocp.org/article_57602_14ba43c4ef6a3d6a08d0d75e5b7e33d8.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Assessing Breast Cancer Risk with an Artificial Neural Network
1017
1019
EN
Mojtaba
Sepandi
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
msepandi@gmail.com
Maryam
Taghdir
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
mtaghdir@gmail.com
Abbas
Rezaianzadeh
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
rezaiana@gmail.com
Salar
Rahimikazerooni
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz,
Iran.
rahimi@gmail.com
10.22034/APJCP.2018.19.4.1017
Objectives: Radiologists face uncertainty in making decisions based on their judgment of breast cancer risk.<br />Artificial intelligence and machine learning techniques have been widely applied in detection/recognition of cancer.<br />This study aimed to establish a model to aid radiologists in breast cancer risk estimation. This incorporated imaging<br />methods and fine needle aspiration biopsy (FNAB) for cyto-pathological diagnosis. Methods: An artificial neural<br />network (ANN) technique was used on a retrospectively collected dataset including mammographic results, risk<br />factors, and clinical findings to accurately predict the probability of breast cancer in individual patients. Area under<br />the receiver-operating characteristic curve (AUC), accuracy, sensitivity, specificity, and positive and negative predictive<br />values were used to evaluate discriminative performance. Result: The network incorporating the selected features<br />performed best (AUC = 0.955). Sensitivity and specificity of the ANN were respectively calculated as 0.82 and 0.90.<br />In addition, negative and positive predictive values were respectively computed as 0.90 and 0.80. Conclusion: ANN<br />has potential applications as a decision-support tool to help underperforming practitioners to improve the positive<br />predictive value of biopsy recommendations.
breast cancer,Artificial Neural Network,Risk Assessment
https://journal.waocp.org/article_57859.html
https://journal.waocp.org/article_57859_38a35ab9ea6a97db2efc9a184e7c5d34.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Evaluation of Osteopontin as a Biomarker in Hepatocellular Carcinomas in Egyptian Patients with Chronic HCV Cirrhosis
1021
1027
EN
Samah Mamdouh
Abdel-Hafiz
0000-0001-5979-3189
Theodore Bilharz Research Institute (TBRI), Cairo University,Giza, Egypt.
samah_mmdh@yahoo.com
Hussam EM
Hamdy
Theodore Bilharz Research Institute (TBRI), Cairo University,Giza, Egypt.
hamdy.hussam@gmail.com
Fatma M
Khorshed
0000-0003-0642-1239
Theodore Bilharz Research Institute (TBRI), Cairo University,Giza, Egypt.
fatmakhorshed@gmail.com
Tarek S
Aboushousha
0000-0002-6686-2442
Theodore Bilharz Research Institute (TBRI), Cairo University,Giza, Egypt.
taboushousha@gmail.com
Gehan
Safwat
Faculty of Biotechnology, October University of Modern Sciences and Arts, Egypt.
gehan.safwat@hotmail.co.uk
mohamed A
Saber
Theodore Bilharz Research Institute El-Warrak, Embaba Giza, Egypt.
maasaber@yahoo.com
Mohamed
Seleem
4National Hepatology and Tropical Medicine Institute (NHTMRI), Egypt.
saleem_1961@hotmail.com
Amira H
Soliman
National Cancer Institute, Cairo University, Cairo, Egypt.
amirasoliman777@hotmail.com
10.22034/APJCP.2018.19.4.1021
Background: Hepatocellular carcinoma (HCC) is a high incidence disease in Egypt with a poor prognosis and<br />survival. Biomarkers are important for diagnosis of HCC at an early stage. Osteopontin (OPN), a glycoprotein secreted by<br />macrophages, osteoblasts, and T cells, is also highly expressed in a variety of tumors, such as examples in the breast, colon,<br />and stomach. The present study aimed to correlate the serum level of OPN in HCV-positive hepatocellular carcinoma<br />patients, with OPN expression in tumor and non-tumor liver tissues in order to identify its efficacy as a biomarker<br />for diagnosis. Material and Methods: Out of total of 146 patients, 80 were selected for inclusion in the study. Blood<br />samples as well as specimens of tumor and non-tumor liver tissue were collected. In addition, blood samples from 20<br />healthy volunteers were obtained as controls. Serum OPN and alpha-fetoprotein (AFP) were evaluated by ELISA for<br />HCC and control groups. OPN and AFP gene expression were examined by real-time PCR, after homogenization and<br />DNA extraction from serum samples and liver tissues. Results: It was found that serum OPN levels were significantly<br />higher in the HCC group compared to normal group (P=0.009), with a strong positive correlation with AFP expression.<br />However, there was no significant difference between OPN expression in tumor and non-tumor liver tissue. Conclusion:<br />Serum OPN is highly suggested to be a professional candidate for HCC early diagnosis, with a diagnostic ability and<br />accuracy equal or higher than for AFP.
Osteopontin,Alpha-fetoprotein,Hepatocellular carcinoma,Real-Time PCR
https://journal.waocp.org/article_59746.html
https://journal.waocp.org/article_59746_c023a6d546c7c7a17632fcd6807bec9d.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Diagnostic Yield of Transbronchial Biopsy in Comparison to High Resolution Computerized Tomography in Sarcoidosis Cases
1029
1033
EN
H Serpil
Akten
Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey.
hserpilyeni@yahoo.com.tr
Hatice
Kilic
Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
drhaticeb@yahoo.com
Bulent
Celik
Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey.
bucelik@gazi.edu.tr
Gonca
Erbas
Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey.
gerbas@yahoo.com
Zeynep
Isikdogan
Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey.
zeynepisikdogan@gmail.com
Haluk
Turktas
Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey.
haluktur@superonline.com
Nurdan
Kokturk
Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey.
kokturk.nurdan@gmail.com
10.22034/APJCP.2018.19.4.1029
This study aimed to evaluate the diagnostic yield of fiberoptic bronchoscopic (FOB) transbronchial biopsy and<br />its relation with quantitative findings of high resolution computerized tomography (HRCT). A total of 83 patients,<br />19 males and 64 females with a mean age of 45.1 years diagnosed with sarcoidosis with complete records of high<br />resolution computerized tomography were retrospectively recruited during the time period from Feb 2005 to Jan 2015.<br />High resolution computerized tomography scans were retrospectively assessed in random order by an experienced<br />observer without knowledge of the bronchoscopic results or lung function tests. According to the radiological staging<br />with HRCT, 2.4% of the patients (n=2) were stage 0, 19.3% (n=16) were stage 1, 72.3% (n=60) were stage 2 and 6.0%<br />(n=5) were stage 3. This study showed that transbronchial lung biopsy showed positive results in 39.7% of the stage I<br />or II sarcoidosis patients who were diagnosed by bronchoscopy. Different high resolution computerized tomography<br />patterns and different scores of involvement did make a difference in the diagnostic accuracy of transbronchial biopsy<br />(p=0.007).
Transbronchial Biopsy,High Resolution Computerized Tomography,sarcoidosis,Total lob scores
https://journal.waocp.org/article_59838.html
https://journal.waocp.org/article_59838_c0e085043e2d091a6ac7d97149ce2092.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Association between Helicobacter pylori Infection and Cardiovascular Risk Factors among Patients in the Northern Part of Afghanistan: a Cross-Sectional Study in Andkhoy City
1035
1039
EN
Mohammad Shoaib
Hamrah
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
mshoaibhamrah@gmail.com
Mohammad Hassan
Hamrah
Curative Clinic, Andkhoy, Afghanistan.
Hideki
Ishii
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Susumu
Suzuki
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Mohammad Hussain
Hamrah
Curative Clinic, Andkhoy, Afghanistan.
Ahmad Edris
Hamrah
Curative Clinic, Andkhoy, Afghanistan.
Ahmad Elias
Dahi
Curative Clinic, Andkhoy, Afghanistan.
Kyosuke
Takeshita
Department of Clinical Laboratory, Nagoya University Hospital, Nagoya University
Graduate School of Medicine, Nagoya, japan.
Mohammad Hashem
Hamrah
Curative Clinic, Andkhoy, Afghanistan.
Akbar
Fotouhi
Department of Epidemiology and Biostatistics, School of Public Health, Tehran.
Junichi
Sakamoto
Tokai Central Hospital, Kakamigahara, Japan.
Toyoaki
Murohara
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
10.22034/APJCP.2018.19.4.1035
Background: The association between Helicobacter pylori infection and cardiovascular risk factors remains<br />controversial. The high prevalence of H. pylori infection among Afghan patients warranted the investigation of this<br />association. The aim of the present study was to determine the association between H. pylori infection and cardiovascular<br />risk factors among patients visiting an outpatient clinic in Andkhoy, Afghanistan. Methods: We performed a<br />cross-sectional study of 271 consecutive patients in an outpatient clinic in Andkhoy, Afghanistan from April 2017 to<br />June 2017. The diagnosis of H. pylori infection was achieved using an enzyme-linked immunosorbent assay test. The<br />patients were divided into H. pylori positive (n=189) and H. pylori negative (n=82) groups. The association between H.<br />pylori infection and cardiovascular risk factors was analyzed. Results: Of the total 271 study participants, 102 (37.6%)<br />were male and 169 (62.4%) female. The mean age ± standard deviation of the patients who were H. pylori-positive<br />and H. pylori-negative was 51.0 ± 17.6 years and 51.6 ± 17.6 years, respectively. In multivariate logistic regression<br />analyses, H. pylori infection was significantly associated with diabetes mellitus (DM) (odds ratio [OR] 3.16, 95%<br />confidence interval [CI] 1.31-7.62, P = 0.011), and body mass index (BMI) levels (OR 1.17, 95% CI 108-1.26, P <<br />0.001). Conclusions: Our study indicated that H. pylori infection was significantly associated with DM and elevated<br />BMI levels in patients from an outpatient clinic in Andkhoy, Afghanistan. More aggressive measures, including DM,<br />obesity control, and H. pylori eradication are needed.
H. pylori,cardiovascular risk factors,Andkhoy,Afghanistan
https://journal.waocp.org/article_59576.html
https://journal.waocp.org/article_59576_f66bd281e4de3b27e76e332e0e1b9f2b.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Prevalence, Cognitive and Socio-Demographic Determinants of Prostate Cancer Screening
1041
1046
EN
Mehdi
Mirzaei-Alavijeh
Department of Public Health, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
mehdimirzaeia@yahoo.com
Touraj
Ahmadi-Jouybari
Clinical Research Development Center, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
dr.ahmadi_jouybari@yahoo.com
Masoumeh
Vaezi
Faculty of Medicine, Kateb University, Kabul, Afghanistan.
masumeh.vaezi@yahoo.com
Farzad
Jalilian
Department of Public Health, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
f_jalilian@yahoo.com
10.22034/APJCP.2018.19.4.1041
Screening may be effective for reducing deaths due to prostate cancer. The aim of this study was determine the prevalence<br />and determinants influencing prostate cancer early detection behaviors based on the theory planned behavior (TPB).<br />In this cross-sectional study, conducted in the west of Iran, a total of 250 men aged 50 to 70 years old were randomly<br />selected to participate. Of these, 200 (80%) signed the consent form and voluntarily agreed to take part. A structured<br />questionnaire based on TPB constructs was applied for collecting data by interview. Analyses were conducted with<br />SPSS version 16 using bivariate correlations, and logistic and linear regression. Some 26.5% of the participants<br />demonstrated prostate cancer early detection behavior. Age higher than 60 (OR: 5.969), academic education (OR: 2.904),<br />number of family members more than four (OR: 3.144), and knowledge about prostate cancer (OR: 3.693) were the<br />most influential predictive factors for early detection behavior. Furthermore, among the TPB constructs, attitude<br />(OR=1.090) and subjective norms (OR=1.280) were the most influential predictors. Attitude, subjective norms, and<br />perceived behavioral control accounted for 43% of the variation in the outcome measure of the intention to screen<br />for prostate cancer (adjusted R squared= 0.43, F= 49.270 and P < 0.001). Designing and implementation programs to<br />increase positive attitudes and encourage subjective norms towards prostate cancer screening behavior may be useful<br />for promotion of early detection.
Early Detection of Cancer,Life style,Health Education
https://journal.waocp.org/article_59595.html
https://journal.waocp.org/article_59595_e6413dfeed301a4c4a49c3ad3eaaa161.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Symptoms in Advanced Cancer Patients in a Greek Hospital:a Descriptive Study
1047
1052
EN
Maria
Lavdaniti
Research Laboratory “Care in Adult Cancer Patients”, Department of Nursing, Alexander Technological Educational Institute,
Thessaloniki, Sparta, Greece.
maria_lavdaniti@yahoo.gr
Evangelos C
Fradelos
Nursing Research and Practice Laboratory, Department of Nursing, University of Peloponnese, Sparta, Greece.
evagelosfradelos@hotmail.com
Konstantina
Troxoutsou
Research Laboratory “Care in Adult Cancer Patients”, Department of Nursing, Alexander Technological Educational Institute,
Thessaloniki, Sparta, Greece.
troix.konw@yahoo.gr
Efrosini
Zioga
Research Laboratory “Care in Adult Cancer Patients”, Department of Nursing, Alexander Technological Educational Institute,
Thessaloniki, Sparta, Greece.
efr.zioga@gmail.com
Dimitroula
Mitsi
Research Laboratory “Care in Adult Cancer Patients”, Department of Nursing, Alexander Technological Educational Institute,
Thessaloniki, Sparta, Greece.
mdimitra21@yahoo.gr
Victoria
Alikari
Nursing Research and Practice Laboratory, Department of Nursing, University of Peloponnese, Sparta, Greece.
vicalikari@gmail.com
Sofia
Zyga
Nursing Research and Practice Laboratory, Department of Nursing, University of Peloponnese, Sparta, Greece.
zygas@spa.forthnet.gr
10.22034/APJCP.2018.19.4.1047
Background: Advanced cancer patients experience several physical or psychological symptoms which require<br />palliative care for alleviation. Purpose: To assess the prevalence and intensity of symptoms among cancer patients<br />receiving palliative care in a Greek hospital and to examine the association between reported symptoms and social<br />clinical and demographic characteristics. Material-methods: This descriptive research was conducted during a sixmonth<br />period using a convenient sample of 123 advanced cancer patients. All participants were assessed for their<br />symptoms using the Edmonton Symptom Assessment System (ESAS) with a questionnaire covering demographic<br />and clinical characteristics. Results: The mean age was 63.8± 10.8 years, with lung and breast (58.5% and 11.4%,<br />respectively) as the most common primary cancer types. The most severe symptoms were fatigue, sleep disturbance,<br />dyspnea, depression and anxiety. Negative correlations were revealed between age and the following symptoms: pain<br />(r = -0.354, p = 0.001), fatigue (r = -0.280, p = 0.002), nausea (r = -0.178, p = 0.049), anorexia (r = -0.188, p = 0.038),<br />dyspnea (r = -0.251, p = 0.005), and depression (r = -0.223, p = 0.013). Advanced breast cancer patients scored higher<br />in pain, fatigue and dyspnea compared to those with other cancers. Conclusions: Hospitalized cancer patients in Greece<br />experience several symptoms during the last months of their life. These are influenced by demographic characteristics.<br />Appropriate interventions are strongly advised with appropriate recognition and evaluation of symptoms by health<br />professionals.
End stage cancer symptoms,palliative care,symptoms management,cancer patients
https://journal.waocp.org/article_60588.html
https://journal.waocp.org/article_60588_1e5a62da4e5dc8a63f6c5c8b14af39cf.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Circulating MicroRNA-21 Expression as a Novel Serum Biomarker for Oral Sub-Mucous Fibrosis and Oral Squamous Cell Carcinoma
1053
1058
EN
Pooja
Singh
SINGHPOOJAPS
Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow.
poojaa.singh1989@gmail.com
Anand Narain
Srivastava
Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow.
Rolee
Sharma
Department of Biosciences, Integral University, Lucknow.
Saboor
Mateen
Department of Medicine, Era’s Lucknow Medical College and Hospital, Lucknow.
Bharat
Shukla
Oral and Maxillofacial Department, Sardar Patel Post Graduate Institute of
Dental and Medical Sciences, Lucknow.
Alok
Singh
Department of Pathology, Era’s Lucknow Medical College and Hospital, Lucknow.
Siddhartha
Chandel
Department of Dentistry,Era's Lucknow Medical College and Hospital, Lucknow.
siddhartha.chandel@gmail.com
10.22034/APJCP.2018.19.4.1053
Background: Circulating miRNAs (miRs) in the biofluids such as serum and plasma act as potential biomarkers<br />for early diagnosis, treatment and prognosis. In the present study, an attempt made to see the expression of miR-21<br />in serum of 20 cases of Oral sub-mucous fibrosis (OSMF), 20 cases of Oral squamous cell carcinoma and 40 healthy<br />volunteers. The expression of miR-21 was evaluated in relation to different demographical and clinicopathological<br />features such as sex, tobacco, pan-masala, alcohol, smoking and clinical staging respectively with an aim to identify<br />correlation with oral pre-cancer and cancer stages. Materials and Methods: The relative expression level of miR-21<br />was determined by quantitative real-time RT-PCR (qRT-PCR) in the sera of 20 OSCC, 20 OSMF patients and 40<br />healthy subjects as a control. Association between expression of miR-21 and OSCC clinical stages and demographical<br />parameters such as sex, pan-masala, tobacco, smoking, alcohol have also been analyzed in detail. Results: The results<br />obtained by t-test revealed significant increase in the expression level of miR-21 in OSCC as compared to OSMF. The<br />study also revealed the positive correlation between higher miR-21 expression and pan-masala chewers as shown by<br />t-test. The statistical test, ANOVA has also indicated a positive correlation between up-regulation of miR-21 in the<br />clinical stages of the OSCC. Conclusion: The results of present study indicated up-regulation of circulating miR-21 in<br />serum of OSCC as compared to OSMF (p=0.001), this study also elucidated the positive correlation between miR-21<br />expression in OSCC/OSMF patients, only one demographical parameter (Pan-masala) and negative correlation for<br />other parameters such as sex, tobacco, smoking, alcohol etc. Other findings suggested a significant increase (p=0.000)<br />in the expression of miR-21 in clinical staging (I-IV) of oral cancer. More studies are needed to validate it as potential<br />diagnostic and prognostic biomarker for OSMF and OSCC for better management.
Circulating miRNA,Non-invassive biomarker,miR21
https://journal.waocp.org/article_60073.html
https://journal.waocp.org/article_60073_890b3b8957d1d1b9515847a271771957.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish Population
1059
1062
EN
Meral
Yilmaz
Department of Gastronomy and Culinary Arts Cumhuriyet University of Tourism Faculty, Sivas, Turkey.
meralylmz@cumhuriyet.edu.tr
Ayca
Tas
Department of Diet and Nutrition, Cumhuriyet University, Faculty of Health Sciences, Sivas, Turkey.
aycatas@cumhuriyet.edu.tr
Gonca
Donmez
Department of Medical Biology and Genetics, Ömer Halis Demir University, of Medicine Faculty, Niğde, Turkey.
gdonmez@ohu.edu.tr
Turgut
Kacan
Department of Oncology, Afyonkarahisar State Hospital, Afyonkarahisar, Turkey.
kacanturgut@gmail.com
Yavuz
Silig
0000-0002-0562-7457
Department of Biochemistry, Cumhuriyet University of Medicine Faculty, Sivas, Turkey.
ysilig@cumhuriyet.edu.tr
10.22034/APJCP.2018.19.4.1059
Background: Breast cancer is a leading cause of death in women worldwide. Genetic polymorphisms have been<br />reported to be important etiological factors. Murine double minute 2 (MDM2) T309G interacts with p53 and mutations<br />in p53 are present in approximately 50% of all cancers. However, it has been reported that effect of the polymorphism<br />on breast cancer risk may vary in different populations. Here, we therefore investigated whether there is an association<br />between MDM2 T309G (rs2279744) polymorphism and breast cancer in a Turkish population. Materials and Methods:<br />We analysed 110 patients with breast cancer and 138 matched? controls. For genotyping, polymerase chain reaction<br />and restriction length fragment polymorphism methods were used. Results: A significant difference was observed<br />between case and control groups with regard to the distribution of the MDM2 T309G polymorphism (p<0.05). There<br />was a significantly higher frequency of the TT genotype in the control group (p=0.028; OR, 2.42; 95% CI, 1.09-5.37).<br />However, we did not find any relationships among tumor grade and metastasis status and this polymorphism. Conclusion:<br />This study indicates that the MDM2 T309G polymorphism GG genotype and the TG+GG combination may be risk<br />factors for breast cancer in our Turkish population.
breast cancer,Murine double minute 2,MDM2 T309G,Polymorphism
https://journal.waocp.org/article_59594.html
https://journal.waocp.org/article_59594_33fa66939e690a4c37fa761d19b9a6ad.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Psychological Limbo as a Barrier to Spiritual Care for Parents of Children with Cancer: A Qualitative Study
1063
1068
EN
Neda
Sheikhzakaryaee
0000-0002-2349-0503
Student Research Committee, Department of Nursing Management, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
n.zakaryaie@gmail.com
Foroozan
Atashzadeh-Shoorideh
0000-0002-6144-6001
Center for the Study of Religion and Health, Department of Nursing Management, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
f_atashzadeh@sbmu.ac.ir
Fazlollah
Ahmadi
Nursing Department, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
ahmadi_fazl@hotmail.com
Mahdi
Fani
Center for the Study of Religion and Health, Department of Islamic Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
fanimahdi@chmail.ir
10.22034/APJCP.2018.19.4.1063
Background: Pediatric cancer causes reduced life quality and psychological problems for parents. It is necessary<br />to pay attention to spirituality, which plays a significant role in increasing the life quality of these parents and their<br />patient children and managing the conditions associated with the disease. This study was performed to determine<br />factors predisposing to spiritual care in parents of children suffering from cancer. Methods: This qualitative study was<br />conducted by conventional content analysis. Fifteen parents of children with cancer hospitalized in the oncology and<br />hematology wards of governmental hospitals in Iran were selected using a purposive sampling method and underwent<br />semi-structured deep interviews from 2015.1.10 until 2017.3.10. Results: On data analysis, 12 subcategories emerged<br />leading to extraction of three : “projection”, “mental concern”, and “psychological pains”. The final result was a focus<br />on the theme “psychological limbo”. Conclusion: Our findings showed that cancer induces psychological problems<br />in parents, which may serve as factors that drive them towards spiritual affairs. Hence, attention should be paid to<br />predisposing factors of spiritual care to facilitate tranquility and an ability to adapt to their circumstances in affected<br />parents.
Spiritual care,cancer,Nursing,Qualitative study
https://journal.waocp.org/article_57790.html
https://journal.waocp.org/article_57790_d557dfc57cb771ef7091c2fd7418d04a.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Inverse Association between Glucose‒6‒Phosphate Dehydrogenase Deficiency and Hepatocellular Carcinoma
1069
1073
EN
Maria Pina
Dore
Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari 07100, Italy.
mpdore@uniss.it
Gianpaolo
Vidili
Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari 07100, Italy.
gianpaolovidili@uniss.it
Giuseppina
Marras
Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari 07100, Italy.
specialgastro2013@gmail.com
Silas
Assy
Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari 07100, Italy.
silas_assy@yahoo.com
Giovanni Mario
Pes
0000-0003-3265-2823
Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Sassari 07100, Italy.
gmpes@uniss.it
10.22034/APJCP.2018.19.4.1069
Background: Studies in experimental models and humans suggest that glucose‒6‒phosphate dehydrogenase<br />(G6PD) deficiency, an inherited condition, may be inversely related to hepatocellular carcinoma (HCC). We tested<br />this hypothesis in a large cohort of Sardinian patients. Methods: A case-control study was performed using data<br />from 11,143 records of patients who underwent upper endoscopy between 2002 and 2017. Gender, age, G6PD status<br />and information regarding the presence of HCC, were recorded. Cases (HCC positive) and controls (HCC negative)<br />were compared for the presence of G6PD deficiency adjusting for major HCC risk factors using logistic regression.<br />Results: Overall, 114 HCC cases and 11,029 controls were identified. G6PD deficiency was detected in 11.5% of<br />study participants, and was associated with a reduced risk of HCC [odds ratio (OR); 0.451; 95% confidence interval<br />(CI), 0.207−0.982] after adjusting for all covariates. Factors significantly associated with HCC were cirrhosis (OR,<br />23.30; 95% CI, 11.48−47.25), diabetes (OR, 2.396; 95% CI, 1.449−3.963), among infection hepatitis HBV with an<br />OR of 2.326, age ≥65 years (OR, 1.941; 95% CI, 1.234−2.581) and male gender (OR, 1.611; 95% CI, 1.006−3.081).<br />Conclusions: Our study revealed a significant inverse association between G6PD deficiency and risk of HCC. These<br />findings need to be confirmed in further studies.
Hepatocellular carcinoma,glucose‒6‒phosphate dehydrogenase,liver disease,risk stratification
https://journal.waocp.org/article_59739.html
https://journal.waocp.org/article_59739_762ac36e69f8cae5f2440751974517ea.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
1075
1080
EN
Krishna Singh
Arora
Department of Oral Pathology and Microbiology, Desh Bhagat Dental College and Hospital, Mandigobindgarh, Punjab, India.
babanank133.ksa@gmail.com
Amit
Nayyar
Department of Oral Pathology and Microbiology,
Swami Devi Dyal Hospital and Dental College, Barwala, Haryana, India.
coolkdsa@gmail.com
Prabhpreet
Kaur
Department of
Oral Pathology and Microbiology, BJS Dental College Hospital and Research Institute, Ludhiana, Ludhiana, Punjab, India.
drpp_oberoi@yahoo.com
Karandeep Singh
Arora
0000-0003-1753-2305
Department of Oral Medicine and Radiology, Bhojia Dental College and Hospital, Bhud,
Baddi, Himachal Pradesh, India.
drkaranarora@yahoo.com
Ankur
Goel
Department of Oral Pathology and Microbiology, BRS Dental College and
General Hospital, Barwala, Haryana, India.
coolkdsa@yahoo.com
Simarjeev
Singh
Department of Oral Medicine
and Radiology, Sri Sukhmani Dental College and Hospital, Derabassi, Punjab, India.
coolkdsa@hotmail.com
10.22034/APJCP.2018.19.4.1075
Objectives: Picrosirius red and MMP are capable of degrading extracellular matrix proteins, expressed in lesions such<br />as squamous cell carcinomas. The present study was undertaken with an aim to analyze and compare changes in collagen<br />using Picrosirius red staining under polarizing microscopy and immunohistochemical staining using anti MMP-13 in<br />samples of oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. Materials and Methods:<br />A total of 70 slides were prepared and divided into 3 groups. Group I comprised 10 slides of normal gingival tissue,<br />Group II 40 slides of potentially malignant disorders and Group III 20 slides of well differentiated oral squamous cell<br />carcinoma. Half the slides for each group were stained with Picrosirius red stain and the remainder with antibodies to<br />MMP-13. Rerults: In Group II, MMP-13 connective tissue expression was greater in OSMF as compared to leukoplakia.<br />Group III showed elevated expression among 70% of cases. Picrosirius red staining in Group II cases, showed higher<br />staining Yellow-Orange andGreen-Yellow mature fibers in OSMF than leukoplakia cases while in Group III, 50%<br />OSCC cases showed Green-yellow stained immature thin fibers. Conclusion: In future, therapeutic measures targeted<br />against MMP-13 may inhibit collagenolysis to some extent and delay spread of tumors. An easy and reliable method<br />to determine the state of the stroma in such cases may be Picrosirius red staining with polarizing microscopy.
immunohistochemistry,MMP-13,picrosirius red stain,polarizing microscopy,oral squamous cell carcinoma
https://journal.waocp.org/article_58014.html
https://journal.waocp.org/article_58014_d185f48e2c84666ce99abbcedae23a22.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Tobacco Cessation Scenarios Among Healthcare Profession Students: A Multidisciplinary Study
1081
1088
EN
Almas
Binnal
0000-0001-6995-8741
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, India.
dr_almas123@yahoo.co.in
Rajesh
Gururaghavendran
0000-0001-8476-6393
Department of Public Health Dentistry, Manipal College of Dental Sciences, Mangalore,
Manipal Academy of Higher Education, India.
drrajeshgrao@gmail.com
Ceena
Denny
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, India.
ceen226@yahoo.com
Junaid
Ahmed
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, India.
drjunna2004@yahoo.co.in
Arjun Kumar
Tallada
Sree Narayana Dental Clinic,
Maripeda, Telangana, India.
arjunkumar446@gmail.com
10.22034/APJCP.2018.19.4.1081
Background: It is acknowledged that the most effective means to contain the tobacco epidemic is to involve<br />healthcare providers across various disciplines. The present study was undertaken to gain a comprehensive insight<br />into various factors that determine the efficacy of multidisciplinary approaches in tobacco control. Methods: A cross<br />sectional study design using a structured, pretested and self-administered questionnaire was employed in the present study,<br />conducted among medical and dental interns and final year nursing students. Respondent demographics, knowledge,<br />attitude, behaviour, perceived effectiveness and barriers, and willingness to participate in tobacco cessation were assessed.<br />Results: A total of 268 subjects participated, with mean knowledge, attitude, behaviour, perceived effectiveness and<br />barrier scores of 69. 7%, 89.0%, 72.0%, 80.6% and 88.6% respectively. There were significant differences among the<br />mean scores of the study domains across the 3 disciplines. The majority (92.91%) of the respondents were willing to<br />participate in tobacco cessation activities, but only 14.2% had previously received relevant training. Regression analysis<br />revealed that the significant predictors of behaviour scores were gender, course, attitude and perceived effectiveness;<br />those for willingness to undertake tobacco cessation activities were course, attitude, behaviour and perceived barriers.<br />Conclusions: The study highlighted the willingness but low previous training among the participants and also identified<br />factors that determine t behaviour and willingness to undertake tobacco cessation activities. The study emphasizes the<br />need for modification in the policies pertaining to curricula of medical, dental and nursing training programs.
Smoking & Tobacco Use,Training Health Professionals,Workforce Development,Tobacco Control & Policy,Multidisciplinary approach
https://journal.waocp.org/article_59581.html
https://journal.waocp.org/article_59581_37670329ce4e9da4c2dea2e2c5deb3a7.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Early Detection of Breast Cancer and Barrier to Screening Programmes amongst Thai Migrant Women in Australia: A Qualitative Study
1089
1097
EN
Dusanee
Suwankhong
Department of Public Health, Faculty of Health and Sports Science, Thaksin University, Phatthalung, Thailand.
dsuwankhong@yahoo.com
Pranee
Liamputtong
School of Science
and Health, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia.
p.liamputtong@westernsydney.edu.au
10.22034/APJCP.2018.19.4.1089
Background: Breast cancer screening programme is seen as the best practice to detect breast cancer early. However,<br />there are circumstances that can prevent immigrant women from attending screening programmes. Little is known<br />about Thai migrants and the barriers to their seeking breast cancer screening when living in a new homeland. This paper<br />aimed to discuss the barriers to attending screening services among Thai migrant women living in Australia. Methods:<br />This study adopted qualitative approach. Semi-structured in-depth interviewing and drawing methods were employed<br />as data collection technique with 25 Thai migrant women who had not experienced breast cancer and were living in<br />Metropolitan Melbourne, Australia. Thematic analysis method was employed to analyse the data. Results: Basing on<br />the Health Belief Model, most Thai migrant women did not perceive that they were at risk of breast cancer. Despite<br />seeing a breast cancer screening programme as important, the women rarely paid attention to breast cancer screening<br />and used the mammography services provided by the Australian health care system. The barriers included the location<br />of the services, unfamiliar patterns of health care provision, and language difficulties. Conclusions: There are many<br />barriers that that they encountered in Australia that prevent Thai migrant women living in Melbourne Australia to pay<br />attention to mammographic screening service provided by Australia health system. Our findings suggest that health<br />services and interventions need to be designed more sensitive to the needs and socio-cultural context of migrant women<br />in general and Thai migrant women in particular.
breast cancer,early detection,mammography service,Barriers,Thai migrant women
https://journal.waocp.org/article_59744.html
https://journal.waocp.org/article_59744_56a3fc3ab5e12d89aca9bd7a6cfbbda5.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Exploring Spatial Patterns of Colorectal Cancer in Tehran City, Iran
1099
1104
EN
Kamyar
Mansori
Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
kamyarmansori@yahoo.com
Alireza
Mosavi-Jarrahi
0000-0001-8043-9221
Department of Health and Community Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
journal@waocp.org
Ali
Ganbary Motlagh
Department of Radiotherapy, Shahid Baheshti University of Medical Sciences, Tehran Iran.
aliuo@yahoo.com
Masoud
Solaymani-Dodaran
Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
masoud@yahoo.com
Masoud
Salehi
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
masoud@gmail.com
Alireza
Delavari
Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
alireza56@gmai.com
Ali
Sanjari Moghaddam
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohsen
Asadi-Lari
0000-0001-6778-8750
Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
mohsen.asadi@yahoo.com
10.22034/APJCP.2018.19.4.1099
Objectives: Colorectal cancer (CRC) may now be the second most common cancer in the world. The aim of this<br />study was to determine whether clusters of high and low risk of CRC might exist at the neighborhood level in Tehran<br />city. Methods: In this study, new cases of CRC provided from Cancer Registry Data of the Management Center of<br />Ministry of Health and Medical Education of Iran in the period from March 2008 to March 2011 were analyzed. Raw<br />standardized incidence rates (SIRs) were calculated for CRC in each neighborhood, along with ratios of observed to<br />expected cases. The York and Mollie (BYM) spatial model was used for smoothing of the estimated raw SIRs. To<br />discover clusters of high and low CRC incidence a purely spatial scan statistic was applied. Results: A total of 2,815<br />new cases of CRC were identified and after removal of duplicate cases, 2,491 were geocoded to neighborhoods. The<br />locations with higher than expected incidence of CRC were northern and central districts of Tehran city. An observed<br />to expected ratio of 2.57 (p<0.001) was found for districts of 2, 6 and 11, whereas, the lowest ratio of 0.23 (p<0.001)<br />was apparent for northeast and south areas of the city, including district 4. Conclusions: This study showed that there<br />is a significant spatial variation in patterns of incidence of CRC at the neighborhood level in Tehran city. Identification<br />of such spatial patterns and assessment of underlying risk factors can provide valuable information for policymakers<br />responsible for equitable distribution of healthcare resources.
colorectal cancer,spatial analysis,Neighborhood,York and Mollie (BYM) spatial model,Tehran
https://journal.waocp.org/article_57328.html
https://journal.waocp.org/article_57328_ef31d6f2326ed7ea8a2971c2d24f602e.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Knowledge, Perception, and Acceptance of HPV Vaccination and Screening for Cervical Cancer among Women in Yogyakarta Province, Indonesia
1105
1111
EN
Dwi
Endarti
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
endarti_apt@ugm.ac.id
-
Satibi
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
satibi@ugm.ac.id
Susi Ari
Kristina
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
susiarikristina@gmail.com
Muhaya Almira
Farida
BPJS Kesehatan Health Insurance, Indonesia.
muhayaafarida@gmail.com
Yuni
Rahmawanti
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
rahmawantiyuni@yahoo.co.id
Tika
Andriani
Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
tika.andriani@yahoo.com
10.22034/APJCP.2018.19.4.1105
Objective: To determine knowledge, perception, and acceptance related to cervical cancer, HPV vaccination and<br />screening for cervical cancer among Indonesian women, particularly in Yogyakarta province. Methods: A convenience<br />sample of 392 women consists of 192 young women, 100 mothers of girls aged 12 – 15 years, and 100 adult women<br />in Yogyakarta province, Indonesia was participated in this study. A self-administered paper-based questionnaire was<br />used to determine demographics characteristics of respondents, as well as their knowledge – perception – acceptance<br />related to cervical cancer, HPV vaccination, and screening for cervical cancer. Data collection were conducted during<br />December 2013 to March 2014. Descriptive statistics was used to analyze description of demographics characteristics,<br />knowledge, perception, and acceptance; while crosstab analysis using Chi-Square was used to analyze the relationship<br />between demographics characteristics versus knowledge, perception, and acceptance. Results: This study found that<br />knowledge and perception regarding cervical cancer, HPV vaccination, and screening for cervical cancer among women<br />in Indonesia, particularly in Yogyakarta Province were still insufficient, however the acceptance was good. Among female<br />young women, 64% had good knowledge, 62% had positive perception of cervical cancer and HPV vaccination, and<br />92% tended to accept HPV vaccination. Among mothers of girls aged 12 – 15 years, 44% had good knowledge, 46%<br />had positive perception of cervical cancer and HPV vaccination, and 91% tended to accept HPV vaccination for their<br />daughters. Among adult women, 68% had good knowledge, 57% had positive perception of cervical cancer and screening<br />for cervical cancer, and 90% tended to accept cervical cancer screening. In general, demographics characteristics of<br />having experience and exposure to information had significant relationship with knowledge, perception, and acceptance<br />of HPV vaccination and screening for cervical cancer. Conclusions: Either knowledge or perception of cervical cancer<br />and strategies toward it among Indonesian women particularly in Yogyakarta province were still unsatisfied. Efforts<br />should be improved for supporting cervical cancer prevention and control in Indonesia through such as education on<br />cervical cancer disease and strategies toward it.
knowledge,Perception,acceptance,HPV vaccination, screening of cervical cancer
https://journal.waocp.org/article_58028.html
https://journal.waocp.org/article_58028_73d0d30e0f223980b1f8f025103487df.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Prognostic Factors for Hormone Sensitive Metastatic Prostate Cancer: Impact of Disease Volume
1113
1118
EN
Alshimaa Mahmoud
Alhanafy
0000-0002-5452-5967
Department of Clinical Oncology and Nuclear Medicine,Faculty of Medicine, Menoufia University, Egypt.
alshimaa_alhanafy@yahoo.com
Fouad
Zanaty
Department of Urology,Faculty of Medicine, Menoufia University, Egypt.
Reda
Ibrahem
Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Egypt.
Suzan
Omar
Department of Radiodiagnosis, Faculty of Medicine, Menoufia University, Egypt.
10.22034/APJCP.2018.19.4.1113
Background and Aim: The optimal management of metastatic hormone-sensitive prostate cancer has been<br />controversial in recent years with introduction of upfront chemohormonal treatment based on results of several Western<br />studies. This changing landscape has renewed interest in the concept “disease volume”, the focus of the present study<br />is the Egyptian patients. Methods: Patients with hormone sensitive metastatic prostate cancer presenting at Menoufia<br />University Hospital, Egypt, during the period from June 2013 to May 2016, were enrolled. All received hormonal<br />treatment. Radiologic images were evaluated and patients were stratified according to their disease volume into high or<br />low, other clinical and pathological data that could affect survival also being collected and analyzed. Results: A total<br />of 128 patients were included, with a median age of 70 years (53.9% ≥70). About 46% had co-morbidities, 62% having<br />high volume disease. During the median follow up period of 28 months about half of the patients progressed and one<br />third received chemotherapy. On univariate analysis, disease volume, performance status (PS), prostate specific antigen<br />level (PSA) and presence of pain at presentation were identified as factors influencing overall survival. Multivariate<br />analysis revealed the independent predictor factors for survival to be PS, PSA and disease volume. The median overall<br />survival with 27 months was high volume versus 49 with low volume disease (hazard ratio 2.1; 95% CI 1.2 - 4.4;<br />P=0.02). Median progression free survival was 19 months in the high volume, as compared with 48 months in the low<br />volume disease patients (hazard ratio, 2.44; 95% CI, 1.42 – 7.4; P=0.009). Conclusions: Disease volume is a reliable<br />predictor of survival which should be incorporated with other important factors as; patient performance status and<br />comorbidities in treatment decision-making.
Disease volume,Metastatic prostate cancer,survival
https://journal.waocp.org/article_59851.html
https://journal.waocp.org/article_59851_8f664414bedc3a971ae633773f69b701.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor Types
1119
1125
EN
Munazza
Khan
Department of Physiology, Institute of Medical Sciences, Kohat, Pakistan.
Zafaruddin
Khan
Department of Urology and Transplantation, Shaikh Zayed Hospital, Lahore, Pakistan.
Yaser
Uddin
Department of Neurosurgery unit II, Lahore General Hospital, Lahore, Pakistan.
Sadaf
Mustafa
Department of Internal Medicine, MedStar Good Samaritan Hospital, Baltimore, MD, 21239, USA.
Irfan
Shaukat
Department of Internal Medicine, MedStar Good Samaritan Hospital, Baltimore, MD, 21239, USA.
Jianbo
Pan
Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Naseruddin
Höti
Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
nhoti1@jhmi.edu
10.22034/APJCP.2018.19.4.1119
The miRNAs nuclear export protein XPO5 has been previously studied in several individual malignancies. In our<br />recent study we have demonstrated that excess levels of XPO5 enhanced the proliferation of prostate cancer cells.<br />Similarly, there are studies to support the inhibitory role of XPO5 in cancers. In order to evaluate discrepancies in the<br />expression levels of XPO5 in differential tumor types, we quantified the expression of XPO5 using gene expression<br />RNA-seq data for several tumor types which were independently confirmed by immunohistochemistry in multiple<br />organs cancer tissue microarray (TMAs) experiment. We found that while some tumors (Breast, Bladder, Lymph-node,<br />Lung, Esophagus and Ovary) showed higher differences between normal and malignant tumors in XPO5 expression,<br />there were tissues (Kidney and Brain) that have a significantly lower XPO5 expression in malignant tumors. We further<br />studies these observations of overexpression and down-regulation of XPO5 in breast and kidney cancer cell lines and<br />found that XPO5 might have a dual role in promoting or inhibiting tumor growth in different cancer tissue types.
miRNA,TMA,XPO5,Tumors,IHC
https://journal.waocp.org/article_59852.html
https://journal.waocp.org/article_59852_bdf658105e5dfdae593897e0fee3c954.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Inhibitory Effects of Arsenic Trioxide and Thalidomide on Angiogenesis and Vascular Endothelial Growth Factor Expression in Leukemia Cells
1127
1134
EN
Mahnaz
Mohammadi Kian
Hematology Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
mahnazmohammadikian@gmail.com
Saeed
Mohammadi
Hematology Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
saeedm_58@yahoo.com
Mahmoud
Tavallaei
Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
tavallaei@gmail.com
Bahram
Chahardouli
Hematology Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
b-chahardouli@sina.tums.ac.ir
Saharbano
Rostami
Hematology Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mahdi
Zahedpanah
Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
zhdpnh@yahoo.com
Ardeshir
Ghavamzadeh
Hematology Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
ghavamza@sina.tums.ac.ir
Mohsen
Nikbakht
0000-0001-6621-5424
Hematology Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
m-nikbakht@sina.tums.ac.ir
10.22034/APJCP.2018.19.4.1127
Acute myeloid leukemia (AML) is a blood disorder characterized by uncontrolled proliferation of myeloid<br />progenitors and decrease in the apoptosis rate. The vascular endothelial growth factor (VEGF) promotes blood vessel<br />regeneration which might play important roles in development and progression of neoplasia. Our previous studies<br />focused on cytotoxicity and anticancer effects of arsenic trioxide (ATO) and thalidomide (THAL) as an anti-VEGF<br />compound in the AML cell model. ATO also affects regulatory genes involved in cell proliferation and apoptosis. The<br />aim of present study was to examine the effects of ATO and THAL alone and in combination on U937 and KG-1 cells<br />, with attention to mRNA expression for VEGF isoforms. Growth inhibitory effects was assessed by MTT assay and<br />apoptosis induction was determined by Annexin/PI staining. mRNA expression levels were evaluated by real-time<br />PCR. Our data indicated that ATO (1.618μM and 1μM in KG-1 and U937 cell lines respectively), THAL (80μM and<br />60μM) and their combination inhibited proliferation and induced apoptosis in our cell lines. mRNA expression of<br />VEGF (A, B) decreased while C and D isoforms did not show any significant changes. Taken together, according to<br />the obtained results, the VEGF autocrine loop could be a target as a therapeutic strategy for cases of AML.
Arsenic trioxide,Thalidomide,Vascular Endothelial Growth Factor (VEGF),acute myeloid leukemia
https://journal.waocp.org/article_60589.html
https://journal.waocp.org/article_60589_b07e3adab92be52eac7f83356c7d8f9d.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Potential Impact of Vascular Endothelial Growth Factor Gene Variation (-2578C>A) on Breast Cancer Susceptibility in Saudi Arabia: a Case-Control Study
1135
1143
EN
Ibrahim Abdullah
Al Balawi
0000-0002-2952-9501
Department of Surgical Oncology, Faculty of Medicine, University of Tabuk, Kingdom of Saudi Arabia.
drbalawi@yahoo.com
Rashid
Mir
Prince Fahd Bin Sultan Research Chair, Department of Medical
Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Kingdom of Saudi Arabia.
rashidmirtabuk@gmail.com
F M
Abu-Duhier
Prince Fahd Bin Sultan Research Chair, Department of Medical
Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Kingdom of Saudi Arabia.
fabu-duhier@ut.edu.sa
10.22034/APJCP.2018.19.4.1135
Aim: VEGF gene polymorphisms can induce either increase or inhibition of VEGF secretion, with altered promoter<br />activity. The VEGF rs699947 SNP is located in the promoter region and is associated with susceptibility to breast<br />carcinoma development. Here, we investigated the association of the -2578C>A polymorphism in the VEGF gene with<br />breast cancer risk in Saudi women. Methodology: Genotyping of the VEGF-gene variation (-2578A>C) was performed<br />using the amplification refractory mutation system PCR. We investigated the association of VEGF gene variants with<br />different clinicopathological features of breast cancer patients. Results: A significant difference was observed in<br />genotype distribution among the breast cancer cases and sex matched healthy controls (p=0.03). The frequencies of the<br />three genotypes CC, CA, AA found in the patient samples were 37%, 45% and 18% and in the healthy controls were<br />54%,37% ,and 09% respectively. An increased risk of developing breast cancer in Saudi women was associated with<br />the VEGF −2578 AA genotype (OR = 2.91, 95 % CI, 1.18-7.20; p = 0.01; RR 1.78 (1.01-3.11 p=0.01), the VEGF −2578<br />A allele (OR = 1.79, 95 % CI, 1.17-2.73; p = 0.004: RR 1.35 1.07-1.71) and the VEGFR-(CA+ AA) (OR 1.99 1.13-3.51;<br />RR 1.401.0-1.85). Thus the A allele increased the risk of BC when compared with C allele. When we stratified groups<br />of patients according to the status of tumor markers, stage, age and metastasis, statistically significant associations<br />with −2578 C/A SNP were revealed. Conclusion: Our data showed a significant association of the VEGF -2578C>A<br />polymorphism with BC susceptibility in Saudi women. The VEGF -2578AA homozygote significantly increases the<br />risk and can be useful as a predisposing genetic marker. Further studies with larger sample sizes are necessary to<br />confirm our findings.
VEGF-Vascular endothelial growth factor,SNP- Single-nucleotide polymorphism,UTR-Untranslated region,ARMS-Amplification refractory mutation system,OR-Odds ratio
https://journal.waocp.org/article_60270.html
https://journal.waocp.org/article_60270_0a1caba441e9c1f613463a44eb763aad.pdf
West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.
Asian Pacific Journal of Cancer Prevention
1513-7368
2476-762X
19
4
2018
04
01
Digital Cervicography by Simply Portable Device as an Alternative Test for Cervical Cancer Screening in Rural Area of Thailand
1145
1149
EN
Nissana
Singhakum
0000-0002-0710-7789
Obstetrician-Gynecologist, Bangmunnak Hospital, Phichit province, Thailand.
anissa-gyn@hotmail.com
Somsak
Laiwejpithaya
0000-0002-4704-4196
Obstetrics-Gynecology Department, Faculty of Medicine
Siriraj Hospital, Mahidol University, Bangkok, Thailand.
sislj@yahoo.com
Pattama
Chaopotong
0000-0001-7118-3340
Obstetrics-Gynecology Department, Faculty of Medicine
Siriraj Hospital, Mahidol University, Bangkok, Thailand.
chaopotong@gmail.com
10.22034/APJCP.2018.19.4.1145
Objective: Various screening methods for cervical cancer are proved to be effective in reducing such type of cancer.<br />We aims to introduce a new portable device as an alternative method for cervical cancer screening. The performance<br />of device was tested on the assessment of cervical lesions using cervicograph score with the cervical cytology.<br />Methods: 325 non-pregnant women were tested from March 2013 to August 2015. The cervical and vaginal cells<br />from the sample were collected for cytology, then all of them received the digital cervicography conducted with our<br />new device and scored using cervicograph score. Small pieces of cervical tissues were also collected for histologic<br />examination. SPSS software version 18.0 was used for the statistical analysis. Results: We grouped cytology results<br />and cervicograph scores to 2 subgroups, ≤ ASC-US and ≥ LSIL, and 0-3 points and 4-6 points, respectively. The data<br />then correlated with histology results which sub-grouped to ≤ CIN 1 and ≥ CIN 2. The accuracy, sensitivity, specificity,<br />and positive predictive value (PPV) of cervicograph scores 4-6 points to detect CIN 2+ were 92%, 72.41%, 97%, and<br />84%, respectively which were not inferior to Pap smear did. Conclusion: The digital cervicography device provides<br />similar accuracy to Pap cytology screening and is suitable to use in the area that lacks cytoscreeners. Large scale use<br />and generalization are required for this new device.
Alternative Test,Cervical cancer,Screening,Cervicography,Rural area
https://journal.waocp.org/article_59600.html
https://journal.waocp.org/article_59600_65aadcb7505107f5c1a315d2a17b4e7f.pdf