TY - JOUR ID - 16385 TI - DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Khoram-Abadi, Khadijeh Mirzaee AU - Mirzaee Khoram-Abadi, Khadijeh AU - Forat-Yazdi, Mohammad AU - Kheirandish, Shahnaz AU - Saeidi, Nasim AU - Zarezade, Zeinab AU - Mehrabi, Nahid AU - Neamatzadeh, Hossein AD - Department of Anatomy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran AD - Department of Anatomy,Shahid Sadoughi University of Medical Sciences, Yazd, Iran AD - Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran AD - Department of Biology, Science Faculty, University of Yazd, Iran AD - Department of Medical Genetics, Internationl Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Y1 - 2016 PY - 2016 VL - 17 IS - 6 SP - 3015 EP - 3020 KW - DNA methyltransferases KW - CRC KW - Gastric cancer KW - Polymorphism DO - APJCP.2016.17.6.3015 N2 - Background: Numerous studies have investigated associations of DNA methyltransferase (DNMT) -149 C>T and -579 G>T polymorphisms with gastric cancer (GC) and colorectal cancer (CRC) susceptibility; however, the findings are inconsistent prompting the present meta-analysis. Materials and Methods: Related studies were identified from PubMed, Google scholar, and SID until 10 October 2015. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. Results: Eleven studies were included based on the search criteria for CRC and GC related to the DNMT3B 149 C>T (3,353 cases and 4,936 controls) and DNMT3B 579 G>T (1,387 cases and 2,064 controls) polymorphisms. There was no significant association overall between DNMT3B -149 and 579 polymorphisms and the risk of cancer. In the stratified analysis by cancer type, DNMT3B 579G>T polymorphism was associated with the risk of CRC and GC. While the DNMT3B -149C/T polymorphism was related with a significantly increased risk of CRC in two tested models, dominant (GG+GT vs. TT: OR 0.51, 95 % CI 0.38-0.69; P = 0.00, Pheterogeneity=0.69, I2= 0 %) and heterozygote (GT vs. TT: OR 0.50, 95 % CI 0.37-0.69; P=0.00, Pheterogeneity=0.41, I2= 0 %), no evidence of any association with GC risk was observed as in the pooled analyses. Conclusions: More studies are needed to assess associations of DNMT3B -149C/T and DNMT3B 579G>T polymorphisms with cancer in different ethnicities with large population sizes to generate comprehensive conclusions UR - https://journal.waocp.org/article_16385.html L1 - https://journal.waocp.org/article_16385_d3d0c784e9ee716911290ee8e41167c1.pdf ER -