TY - JOUR ID - 24558 TI - Efficacy of Cisplatin in Early Stage Cervical Cancer with a Long Waiting Period for Surgery JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2007 PY - 2007 VL - 8 IS - 1 SP - 51 EP - 54 KW - cervical cancer KW - early stage KW - Cisplatin KW - pre-operation DO - N2 - This study was undertaken as a prospective trial to evaluate the efficacy and safety of pre-operative cisplatinfor controlling the tumor volume of stage IB-IIA cervical cancer patients whose schedule for radical surgerywas longer than 3 weeks. Between June 2004 and July 2005, 42 patients were recruited to enter the study.Seventy-five mg/m2 of cisplatin was administered for 1-2 courses. Cervical tumor volume was measured 1 daybefore chemotherapy and 1 day before the operation by using 3-dimensional ultrasound. Reduction of cervicaltumor volume was noted in 76.2%of cases. The clinical stage, gross appearance of the tumor, histology andnumber of chemotherapy courses did not significantly affect chemo-responsiveness. The incidence of lymphnode metastases was 16.3%. One patient experienced severe vomiting which could be controlled by ondansetronantiemetic. No severe hematologic or other non-hematologic toxicities were identified. In conclusion cisplatin iseffective and safe for administration in a pre-operative setting for early stage cervical cancer patients whosesurgical schedule is delayed more than 3 weeks. UR - https://journal.waocp.org/article_24558.html L1 - https://journal.waocp.org/article_24558_78842b16ab6647d7b71a867a0debf308.pdf ER -