TY - JOUR ID - 24655 TI - Do TNFA -308 G/A and IL6 -174 G/C Gene Polymorphisms Modulate Risk of Gallbladder Cancer in North Indian Population? JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2007 PY - 2007 VL - 8 IS - 4 SP - 567 EP - 572 KW - TNFA KW - IL6 KW - gallbladder carcinoma KW - Genetic susceptibility KW - gallstones KW - Inflammation KW - Polymorphism DO - N2 - Objectives: Gallbladder carcinoma (GBC) is highly aggressive neoplasm which arises in the background ofgall stones and inflammation. GBC affects women 2-3 times more frequently than men. Pro-inflammatory TNFAand IL6 gene polymorphism has been associated with various inflammatory diseases. The aim of this study wasto investigate whether TNFA -308 (G/A) and IL6 -174 G/C polymorphisms within flanking region of the genesare associated with GBC susceptibility. Methods: The promoter polymorphisms were genotyped using PCRRFLPin 200 healthy subjects and 124 GBC patients. Results: Frequency distribution of TNFA -308 (G/A) andIL6 -174 G/C were not significantly different in GBC patients in comparison to healthy controls. However,frequency of TNFA -308 (G/A) polymorphism in female GBC patients without gallstone were significantly different(p-value= 0.006) when compared to healthy female subjects (OR=3.054; 95% CI=1.39-6.72). Conclusion: Theseresults suggest that TNFA -308 (G/A) polymorphism may influence the susceptibility of female gender gallbladdercancer in absence of gallstones while IL6 -174 G/C polymorphism does not seem to be playing significant role inthe susceptibility to gallbladder cancer. UR - https://journal.waocp.org/article_24655.html L1 - https://journal.waocp.org/article_24655_16adf90505a29a1781312f6f3a6140f5.pdf ER -