TY - JOUR ID - 24660 TI - Immunoglobulin Heavy and Light Chain Isotypes in Multiple Myeloma Patients JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2007 PY - 2007 VL - 8 IS - 4 SP - 593 EP - 596 KW - plasma cells KW - multiple myeloma KW - M-proteins KW - biclonal gammopathy KW - Biomarkers DO - N2 - The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myelomaproteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patientssamples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniquesin this study. We found that majority of the myeloma proteins (58%) were of the IgG isotype followed by IgA(24%) and biclonal gammopathy associated with IgG and IgA (5%). Both kappa and lambda light chains wereassociated with the heavy chain isotypes. We recommend the triangular combination for detection of M-proteinsand biclonal gammopathy of cancerous plasma cells as biomarkers for diagnosis of myeloma. UR - https://journal.waocp.org/article_24660.html L1 - https://journal.waocp.org/article_24660_5d035e587fb012a8d58364ece596f130.pdf ER -