TY - JOUR ID - 24824 TI - Ethanolic Rhizome Extract from Kaempferia parviflora Wall. ex. Baker Induces Apoptosis in HL-60 Cells JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2008 PY - 2008 VL - 9 IS - 4 SP - 595 EP - 600 KW - K. parviflora Wall.ex.Baker KW - Apoptosis KW - HL-60 cells KW - caspase-3 KW - Akt KW - mitochondria DO - N2 - Kaempferia parviflora Wall. ex. Baker is a Thai herb containing many flavonoids that have anti-inflammatory,anti-allergic and antioxidant activities. The objective of this study was to demonstrate apoptotic effects ofKaempferia parviflora Wall. ex. Baker rhizome ethanolic extract on HL-60 cells in vitro. The extract suppressedHL-60 cell growth and decreased cell viability in a dose- and time-dependent manner. Apoptotic cell death wasdemonstrated by changes in cell morphology, externalization of phosphatidylserine on the cell surface, loss inmitochondrial transmembrane potential and activation of caspase 3. Apoptosis induced by K. parviflora Wall.ex. Baker rhizome ethanolic extract was enhanced by treatment with paclitaxel or doxorubicin, and inhibitorsof Akt, PI3-K and MEK. UR - https://journal.waocp.org/article_24824.html L1 - https://journal.waocp.org/article_24824_8c895c17733c10ea30e5b35e5349a036.pdf ER -