TY - JOUR ID - 24996 TI - How to Estimate Cancer Stem Cell Frequency Correctly JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2009 PY - 2009 VL - 10 IS - 4 SP - 711 EP - 714 KW - Cancer stem cells KW - Tumorigenesis KW - Frequency KW - xenotransplantation KW - syngeneic transplantation DO - N2 - Cancer stem cell research is a focus for more and more cancer biologists and evidence of involvement incancer devleopment is becoming more abundant. Earlier studies indicated cancer stem cells to be rare asdetermined by the standard xenotransplantation assay using SCID mice in vivo. However, recent studies haveshown that syngeneic transplantation of mouse tumors or modifications to the xenotransplantation assay caneffectively improve the accuracy of detection, with stem cells being more abundant than hitherto thought.Furthermore, to estimate frequency correctly, it is necessary to considerate cancer stem cell subsets with differingcapacities for tumorigenesis. UR - https://journal.waocp.org/article_24996.html L1 - https://journal.waocp.org/article_24996_8eb290798215e4f3828bd33b10d161b5.pdf ER -