TY - JOUR ID - 25378 TI - Chemoprevention by Prunella vulgaris L. Extract of Non-Small Cell Lung Cancer Via Promoting Apoptosis and Regulating the Cell Cycle JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2010 PY - 2010 VL - 11 IS - 5 SP - 1355 EP - 1358 KW - Prunella vulgaris L.- in vivo chemoprevention KW - NSCLC KW - Apoptosis KW - Cell cycle KW - SPC-A-1 cells DO - N2 - Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lungcancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunellavulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction oflung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the abilityto regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as alung cancer chemopreventive agent. UR - https://journal.waocp.org/article_25378.html L1 - https://journal.waocp.org/article_25378_18dd6c56e9f81511903a7937ef7d1873.pdf ER -