TY - JOUR ID - 25402 TI - Clinicopathological Features Including Hormonal Receptor Expression and Survival in Young Endometrial Cancer Patients: A Case Control Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2010 PY - 2010 VL - 11 IS - 6 SP - 1487 EP - 1492 KW - Young endometrial cancer KW - clinicopathological features KW - hormonal receptor expression KW - survival DO - N2 - Objective: To compare clinicopathological features, including hormonal receptor expression and survival,in young Thai endometrial carcinoma (EMC) patients with older patients. Methods: Young EMC patientsaged ≤45 years, treated in the institution from 1992 to 2008, were identified as cases. Controls included EMCpatients aged >45 years who had an operation on the nearest dates to the cases. Clinicopathological data andsurvival of the cases and controls were compared. Results: Mean ages of 41 cases and 123 controls were 40.4 ±3.7 years and 58.4 ± 8.3 years, respectively. Cases were significantly different from controls in terms of havingmore nulliparity (58% vs 25%), less medical illness (57% vs 79%), more low-grade tumors (49% vs 14%),more positive estrogen (78% vs 56%) and progesterone (97% vs 61%) receptors expression, and fewer nodalmetastases (3% vs 21%). Adjuvant therapy was administered in 29% of the cases and 46% of the controls. Froma median follow up of 51 months, cases had significantly fewer progression events and recurrence (5% vs 19%),cancer-related deaths (2% vs 16%), and all deaths (5% vs 23%), with significantly longer 5-year disease-free(97.2% vs 79.6%, p=0.023), cancer-specific (97.1% vs 83.2%, p=0.020), and overall survival (93.1% vs 78.8%p=0.005) than controls as determined by univariate analysis. Survival of cases and controls were not significantlydifferent after adjusting for other prognostic factors. Conclusion: Young Thai EMC patients had more favorableclinicopathological features with significantly longer survival than older patients as determined by univariateanalysis. UR - https://journal.waocp.org/article_25402.html L1 - https://journal.waocp.org/article_25402_46c488dfd90a7b7abb7c0115d2755818.pdf ER -