TY - JOUR ID - 25506 TI - The ECRG1 290Arg/Gln Polymorphism is Related to Risk of Esophageal Squamous Cell Carcinoma in Kashmir JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2011 PY - 2011 VL - 12 IS - 1 SP - 265 EP - 269 KW - ECRG1 KW - genetic risk KW - Esophageal SCC KW - RFLP KW - PCR DO - N2 - ECRG1 (esophageal cancer related gene 1) is a novel candidate member of the tumor suppressor gene familypreviously found to be down regulated in human esophageal cancer (ESCC). So far no evidence regarding therole of the ECRG1 gene in this cancer has been reported from the Kashmir valley, located on the border of thehigh risk ‘esophageal cancer belt’. A case control study was therefore carried out with genomic DNA from 165newly diagnosed ESCC patients (cases) and 200 control subjects. DNA was analyzed for ECRG1 polymorphismsby RFLP PCR, gel electrophoresis and direct sequencing. A statistically significantly increased risk of ESCCwas found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype occurrence compared to the Arg/Arg genotype (odds ratio (OR) 1.698, 95% confidence interval (CI) 1.112–2.593); P= 0.0138) was observed.Statistically significant results were also obtained between the ECRG1 polymorphism and histophathologicalgrade, smoking, dysphagia, low fruit/vegetable intake and salt tea consumption. UR - https://journal.waocp.org/article_25506.html L1 - https://journal.waocp.org/article_25506_b6098c42bdcbdc6b7effee1d897b36e9.pdf ER -