TY - JOUR ID - 25747 TI - Effect of HER-2/neu Over-expression on Prognosis in Gastric Cancer: A Meta-analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2011 PY - 2011 VL - 12 IS - 6 SP - 1627 EP - 1633 KW - Gastric neoplasia KW - Her2/neu KW - Gene KW - Relative risk KW - Prognosis KW - Meta-analysis DO - N2 - Background: Her-2/neu is the most frequently studied molecular target in gastric cancer but its prognostic impact is still equivocal. We therefore conducted a meta-analysis to more precisely estimate its prognostic significance. Methods: Published studies that investigated between Her-2/neu status and survival were identified.Meta-analysis was performed by Dersimonian-Laird model. Pooled hazard ratio (HR) and its 95% confidence interval (95%CI) were calculated to evaluate the risk of disease. Results: A total of 19 studies were analyzed by meta-analysis method, cumulative 4342 cases were included. Pooled data of 15 studies using univariate analysis showed worse survival of patient with her-2/neu (+) (pooled HR=1.59, 95%CI: 1.20-2.12), which maintained in 7 studies of multivariate analysis (pooled HR=1.58, 95%CI: 1.18-2.12). The Q statistic test for 15 studies of univariate analysis and for 7 studies of multivariate analysis showed they had heterogeneity (Q=26.98, p=0.019,Q=17.76, p=0.007, respectively). Conclusion: HER-2/neu over-expression is related to poor prognosis of gastric cancer but has a modest effect on survival in gastric cancer as an independent prognosis factor. UR - https://journal.waocp.org/article_25747.html L1 - https://journal.waocp.org/article_25747_d5d81cf72250ff102d5f54398b33dc31.pdf ER -