TY - JOUR ID - 25826 TI - Folate-functionalized Polymeric Micelles based on Biodegradable PEG-PDLLA as a Hepatic Carcinoma-targeting Delivery System JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2011 PY - 2011 VL - 12 IS - 8 SP - 1995 EP - 1999 KW - Folate targeting KW - Polymeric Micelles KW - hepatic carcinoma DO - N2 - Targeted delivery of anti-cancer drugs is a highly desirable strategy to improve therapeutic outcome because of the combination of enhanced efficacy and reduced toxicity. In this study, the anti-cancer drug doxorubicin (DOX) was accommodated in the cores of polymeric micelles self-assembled from amphiphilic block copolymers of poly(ethylene glycol)(PEGs) and poly(D,L-lactide) (PDLLA) with a targeting ligand (folate) attached to the distal ends of the PEG (Folate-PEG-PDLLA). In vitro tumor cell targeting efficacy was evaluated upon observing cellular uptake of these micelles by human hepatic carcinoma cells (Bel 7402 cells) overexpressing surface receptors for folate. In control release tests, DOX behavior of controlled release in folate receptor-mediated micellar folate-PEG-PDLLA-DOX-micelles was obvious, with pH sensitivity. Bel 7402 cells showed micelles to have low toxicity and suggested potential therapeustic application as a multifunctional platform for tumor management. UR - https://journal.waocp.org/article_25826.html L1 - https://journal.waocp.org/article_25826_0a17d0de747711988ea7104e528113da.pdf ER -