TY - JOUR ID - 25869 TI - Anticancer Effects of Huaier are Associated with Down-Regulation of P53 JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2011 PY - 2011 VL - 12 IS - 9 SP - 2251 EP - 2254 KW - Huaier KW - Hepatocellular carcinoma KW - anticancer effect KW - animal model DO - N2 - This study was designed to explore the mechanism of Huaier anticancer effects on experimental hepatocellular cancer (HCC) development. Seventy five rats were divided into 5 groups, administered N-nitrosodiethylamine (groups B, C, D and E) or natural saline (group A). Rats in group C and E were also given Huaier. At the 15 week sacrifice point, the HCC incidence of group C was lower than group correlating with serum AFP. The serum ALT concentration (98.9% greater) and P53 mRNA levels (23.2% ) were higher in Group B than group C. Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53. UR - https://journal.waocp.org/article_25869.html L1 - https://journal.waocp.org/article_25869_c4d3cd57ec1d207e3f1af99b7fbcfe6d.pdf ER -