TY - JOUR ID - 26001 TI - Radiation-induced Sarcoma in the Head and Neck Region: a Clinicopathologic and Immunohistochemical Study of 13 Cases JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2011 PY - 2011 VL - 12 IS - 11 SP - 2995 EP - 2999 KW - Radiation-induced sarcoma KW - Ki-67 KW - Bcl-2 KW - Survivin KW - head and neck DO - N2 - Objectives: To study the clinical and histological features of radiation-induced sarcoma in the head and neck (RISHN). Methods: Medical records of 13 patients with RISHN treated at our institution between 1990 and 2011 were studied, and paraffin-embedded samples were analyzed by haematoxylin and eosin staining and immunohistochemistry to determine mitosis counts and assess expression of Ki-67, bcl-2, and survivin. Results: Positive bcl-2 was observed in 12 (100%) and survivin in 10 (76.9%) patients. The Ki-67 labeling index ranged from 1% to 90%, and it showed significant positive correlation with mitosis count in RISHN tissues, based on Spearman analysis. Percentage of distal metastasis with T2b was significantly higher than T1b stage (P=0.035). Conclusions: Stage T2b may be a useful indicator for predicting distant metastasis of RISHN. The MIB-1 score may be used as a histological grading system for RISHN. In addition, bcl-2 and survivin protein may play an important role in pathogenesis and progression of RISHN. UR - https://journal.waocp.org/article_26001.html L1 - https://journal.waocp.org/article_26001_4e6d50c0c1e837358bca89cc1fd169d2.pdf ER -