TY - JOUR ID - 26065 TI - Glutathione S-transferase Polymorphisms and Bone Tumor Risk in China JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2011 PY - 2011 VL - 12 IS - 12 SP - 3357 EP - 3360 KW - GSTM1 KW - GSTT1 KW - polymorphisms KW - osteosarcoma DO - N2 - Aim: We aimed to study the potential role of GSTM1 and GSTT1 in the risk of osteosarcoma in Chinese population. Methods: We collected 110 osteosarcomas by pathologic examination and 226 controls from the First Affiliated Hospital of Harbin Medical University during December 2008 to December 2010. Genotyping was based upon duplex polymerase-chain-reaction with the PCR-CTPP method. Results: Individuals carrying null GSTM1 and GSTT1 had 1.50 and 2.07 fold risks of osteosarcoma when compared with non-null genotypes, respectively. The increased risk associated with the GSTT1 polymorphism seemed more evident among males (Null GSTT1 genotype vs. non-null genotype, adjusted OR= 2.43, 95% CI: 1.29-3.30) than females (adjusted OR =1.66, 95% CI: 1.02-2.78). The increased risk was also more evident among individuals aged 15 years or less (adjusted OR for null GSTT1 genotype vs. non-null genotype = 2.24, 95% CI: 1.20-3.24) than those aged more than 15 years (adjusted OR = 1.82, 95% CI: 1.07-2.95). Conclusion: Our study of the association between polymorphisms in GSTM1 and GSTTI and the risk of osteosarcoma in a Chinese population provided evidence that null GSTTI might be a useful marker of susceptibility to osteosarcoma development, especially for male sand young age individuals. UR - https://journal.waocp.org/article_26065.html L1 - https://journal.waocp.org/article_26065_12270900e5f696d5ce0ff0ed468e6d29.pdf ER -