TY - JOUR ID - 26120 TI - Chronic Heavy Metal Exposure and Gallbladder Cancer Risk in India, a Comparative Study with Japan JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2012 PY - 2012 VL - 13 IS - 1 SP - 187 EP - 190 KW - gallbladder cancer KW - heavy metals KW - chemical carcinogenesis KW - India KW - Japan DO - N2 - Background: High incidence of gallbladder cancer (GBC) is reported from North India, with elevatedconcentrations of heavy metals in water and soil. This Indo-Japan collaborative study compared presence ofheavy metals in gallbladder tissues. Methods: Heavy metal concentrations were estimated in Indian GBC andcholecystitis tissues and compared with Japanese GBC and cholecystitis tissues. Spectrophotometry was donefor 13 Indian gallbladder tissues (8 GBC, 5 cholecystitis) and 9 Japanese (5 GBC, 4 cholecystitis). Transmissionelectron microscopy (TEM) thin foil element analysis was done in 10 Indian samples (6 GBC, 4 cholecystitis).Results: Chromium, lead, arsenic and zinc were significantly high in Indian GBC compared with Japanese GBC.Chromium, lead and arsenic were significantly high in the Indian cholecystitis tissues compared to the Japanese.TEM of Indian tissues demonstrated electron dense deposits in GBC. Conclusion: Heavy metals- chromium,lead, arsenic and zinc are potential carcinogens in Indian GBC from endemic areas. This preliminary studylinks presence of heavy metals in gallbladder cancer tissues in endemic areas. UR - https://journal.waocp.org/article_26120.html L1 - https://journal.waocp.org/article_26120_fda0a7210a194a1de85df52eda0f3ab1.pdf ER -