TY - JOUR ID - 26529 TI - MTHFR C667T Polymorphism Association with Lung Cancer Risk in Henan Province: A Case-control Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2012 PY - 2012 VL - 13 IS - 6 SP - 2491 EP - 2494 KW - MTHFR KW - mononucleotide polymorphism KW - Lung cancer KW - Susceptibility DO - N2 - The current study was performed to assess any association between the methylenetetrahydrofolate reductase(MTHFR) C677T polymorphism and risk of lung cancer in Henan province. This case-control study involved94patients with newly histological confirmed lung cancer and 78 healthy controls. Genotyping was achieved withperipheral blood lymphocytes DNA and association of the polymorphism with risk of lung cancer was estimatedby unconditional logistic regression analysis. The frequencies of the MTHFR 667TT genotype were 37.2% in casescompared with 23.1% in controls (χ2 = 4.008, P = 0.045). Individuals with the 667CC/CT genotype displayed asignificantly reduced risk of lung cancer compared with those with the TT genotypes [adjusted odds ratio (OR),0.506; 95% confidence interval (95% CI), 0.258 – 0.991]. The C667T polymorphism might have a significanteffect on the occurrence of lung cancer in Henan province. UR - https://journal.waocp.org/article_26529.html L1 - https://journal.waocp.org/article_26529_35bbccb63051c53a875170908048c589.pdf ER -