TY - JOUR ID - 26844 TI - Association Between TP53 Arg72Pro Polymorphism and Hepatocellular Carcinoma Risk: A Meta-analysis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2012 PY - 2012 VL - 13 IS - 9 SP - 4305 EP - 4309 KW - Hepatocellular carcinoma KW - TP53 Arg72Pro KW - Polymorphism KW - Meta-analysis KW - ethnicity DO - N2 - Background: Previous studies on the association between the TP53 Arg72Pro polymorphism and hepatocellularcarcinoma (HCC) risk obtained controversial findings. This study aimed to quantify the strength of theassociation by meta-analysis. Methods: We searched PubMed and Wangfang databases for published studieson the association between the TP53 Arg72Pro polymorphism and HCC risk, using the pooled odds ratio (OR)with its 95% confidence intervals (95% CI) for assessment. Results: 10 studies with a total of 2,026 cases and2,733 controls were finally included into this meta-analysis. Overall, the TP53 Arg72Pro polymorphism wasnot associated with HCC risk (all P values greaterth HCC risk in Caucasians in three genetic models (For Proversus Arg, OR = 1.20, 95%CI 1.03-1.41; For ProPro versus ArgArg, OR = 1.74, 95%CI 1.23-2.47; For ProProversus ArgPro/ArgArg, OR = 1.85, 95%CI 1.33-2.57). However, there was no significant association betweenthe TP53 Arg72Pro polymorphism and HCC risk in East Asians (all P values greater than 0.10). No evidenceof publication bias was observed. Conclusion: Meta-analyses of available data suggest an obvious associationbetween the TP53 Arg72Pro and HCC risk in Caucasians. However, the TP53 Arg72Pro polymorphism mayhave a race-specific effect on HCC risk and further studies are needed to elucidate this possible effect. UR - https://journal.waocp.org/article_26844.html L1 - https://journal.waocp.org/article_26844_51ccbe76308565874b6999c22b88273e.pdf ER -