TY - JOUR ID - 26862 TI - Estimation of Superoxide Dismutase and Glutathione Peroxidase in Oral Submucous Fibrosis, Oral Leukoplakia and Oral Cancer - A Comparative Study JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2012 PY - 2012 VL - 13 IS - 9 SP - 4409 EP - 4412 KW - Oral submucous fibrosis KW - Oral leukoplakia KW - oral cancer KW - Superoxide dismutase KW - Glutathione peroxidase DO - N2 - Present study was undertaken to estimate and compare erythrocyte superoxide dismutase (E-SOD) andGlutathione peroxidase (GPx) levels in oral submucous fibrosis, oral leukoplakia and oral cancer patients andage/sex matched healthy subjects, 25 in each group. Statistically significant (P<0.001) decrease in E-SOD andGPx levels were observed in OSF, oral leukoplakia and oral cancer groups as compared to the control group.Oral leukoplakia group showed lower levels in comparison with OSF (P>0.05). Oral cancer group had the lowestlevels amongst the study groups. Imbalance in antioxidant enzyme status may be considered as one of the factorsresponsible for the pathogenesis of cancer and may serve as a potential biomarker and therapeutic target toreduce the malignant transformation in oral premalignant lesions/conditions. UR - https://journal.waocp.org/article_26862.html L1 - https://journal.waocp.org/article_26862_02eed077dd9d90e81e65bf087e4f010e.pdf ER -