TY - JOUR ID - 26913 TI - Transforming Growth Factor Beta-1 C-509T Polymorphism and Cancer Risk: A Meta-analysis of 55 Case-control Studies JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2012 PY - 2012 VL - 13 IS - 9 SP - 4683 EP - 4688 KW - TGF-β1 KW - Polymorphism KW - cancer risk- meta-analysis DO - N2 - Aim: To investigate the association of transforming growth factor-beta 1 (TGF-β1) C-509T polymorphismand susceptibility to cancer by means of meta-analysis. Methods: An extensive search was performed to identifyeligible case-control studies investigating such a link. The strength of the association between TGF-β1 C-509Tpolymorphism and cancer risk was assessed by pooled odds ratios (ORs) and 95%confidence intervals (95%CIs)in fixed or random effects models. Results: 55 published case-control studies with a total number of 21,639 casesand 28,460 controls were included. Overall, there was no association between TGF-β1 C-509T and cancer risk inall genetic comparison models (TT vs. CC: OR=1.01, 95%CI=0.89-1.15; T vs. C: OR=1.01, 95%CI=0.94-1.07).However, a stratified analysis by cancer type indicated -509 T allele was significantly associated with decreasedrisk of colorectal cancer (CRC) (TT vs. CT/CC: OR=0.85, 95%CI=0.76-0.95), especially for Caucasians (TT vs.CT/CC: OR=0.83, 95%CI=0.71-0.98) and for population-based studies (TT vs. CT/CC: OR=0.78, 95%CI=0.68-0.89). Conclusion: This meta-analysis suggested that TGF-β1 C-509T polymorphism might contribute to adecreased risk on colorectal cancer susceptibility, especially for Caucasians. UR - https://journal.waocp.org/article_26913.html L1 - https://journal.waocp.org/article_26913_56b7868ff2fe48c8d446400cc81fc18f.pdf ER -