TY - JOUR ID - 27015 TI - Association Between the XRCC3 T241M Polymorphism and Head and Neck Cancer Susceptibility: a Meta-analysis of Case-control Studies JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2012 PY - 2012 VL - 13 IS - 10 SP - 5201 EP - 5205 KW - Meta-analysis KW - head and neck cancer KW - XRCC3 DO - N2 - Background: To evaluate the role of the X-ray repair cross complementing group 3 (XRCC3) T241Mpolymorphism in head and neck cancer susceptibility. Materials and Methods: We performed a meta-analysis ofall available studies, which included 3,191 cases and 5,090 controls. Results: Overall, a significant risk effect of theT241M polymorphism was not found under homologous contrast (MM vs TT: OR=1.293, 95% CI=0.926-1.805;TM vs TT: OR=1.148 95% CI=0.930-1.418) and recessive models (MM vs TT+TM): OR=1.170, 95% CI=0.905-1.512, but a significantly increased risk was observed under a dominant model (MM+TM vs TT): OR=1.243,95% CI=1.001-1.544. In stratified analyses, there were no significant associations for Asians or Caucasians.Conclusion: Our meta-analysis suggested the XRCC3 241M allele (MM+TM) might act as a head and neckcancer risk factor among all subjects, and the effect of T241M polymorphism on head and neck susceptibilityshould be studied with a larger, stratified population. UR - https://journal.waocp.org/article_27015.html L1 - https://journal.waocp.org/article_27015_770c3521d9ebbc330197fc679d347c0d.pdf ER -