TY - JOUR ID - 27078 TI - Correlation Between Auto-antibodies to Survivin and MUC1 Variable Number Tandem Repeats in Colorectal Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2012 PY - 2012 VL - 13 IS - 11 SP - 5557 EP - 5562 KW - Survivin KW - MUC1 VNTR KW - ELISA KW - colorectal cancer KW - auto-antibody DO - N2 - Aim: The aim of this study was to investigate the frequency and correlation between auto-antibodies tosurvivin and MUC1 variable number tandem repeats (VNTR) in colorectal cancer (CRC), which can providevaluable information for the design of immunotherapeutic vaccines for this disease. Methods: Enzyme-linkedimmunosorbent assays (ELISA) were used to examine the level of auto-antibodies against survivin and MUC1VNTR in the serum of 135 CRC patients and 95 healthy volunteers. Results: Using mean absorbance + 2 standarddeviations (SD) of the healthy samples as a cut-off value, the positive rates of survivin and MUC1 VNTR autoantibodiesin CRC were 31.1% and 18.5%, respectively. Altogether, the survivin and MUC1 VNTR positivesamples accounted for 36.3% of the CRC patients, and 7.4% were positive for both. Conclusion: A significantpositive correlation was found between levels of specific antibodies against survivin and MUC1 VNTR in theserum of CRC patients (r = 0.3652, P < 0.0001), suggesting that vaccines against both targets would elicit immuneresponses more effectively. UR - https://journal.waocp.org/article_27078.html L1 - https://journal.waocp.org/article_27078_a4fccfcca9a7407958f767d2cf3198c1.pdf ER -