TY - JOUR ID - 27340 TI - Low-Dose Docetaxel/Cisplatin - Leucovorin and 46 Hour Infusional Fluorouracil in Metastatic Gastric Carcinoma JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2013 PY - 2013 VL - 14 IS - 1 SP - 423 EP - 427 KW - Cisplatin KW - Docetaxel KW - fluorouracil KW - Gastric cancer KW - Turkey DO - N2 - Background: Phase II and III trials of docetaxel, cisplatin and fluorouracil (DCF) have shown superiorefficacy versus cisplatin and fluorouracil alone but with high rates of hematologic toxicity in metastatic gastriccancer cases. To reduce toxicity while maintaining the efficacy of DCF, we investigated low dose docetaxel (D),cispatin (C) - leucovorin and fluorouracil (De Gramont regimen). Patient and methods: Chemotherapy-naïvepatients with metastatic gastric cancer (MGC) received D 60 mg/m2 on day 1 and cisplatin 30 mg/m2 on day 1-2and the De Gramont regimen (Folinic acid 400 mg/m2 on day 1 and 5-FU 2400 mg/m2/46h continuous infusion)every 3 weeks. The primary endpoint was response rate. Results: One hundred twenty patients with a medianage of 52.5 years (range, 32-78) received a median of 6 cycles (range, 2-12 cycles). Of the 120 evaluable patients,4 showed complete remission and 36 achieved a partial response. The overall response rate was 56.6%. Twentyeight patients (23.3%) showed stable disease and 52 (43.3%) progression. The median time to progression was7 months (95%CI 6-7.9). The median overall survival was 15 months (95%CI 13.7-16.2). The most frequenthematological toxicity was leucopenia, which occurred at grade ¾ intensity in 24 patients (20%). Conclusions:Low-dose DC- De Gramont regimen is active in MGC with a tolerable toxicity profile. UR - https://journal.waocp.org/article_27340.html L1 - https://journal.waocp.org/article_27340_bcf892c991795adfc5049a0d64492177.pdf ER -