TY - JOUR ID - 27960 TI - Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2013 PY - 2013 VL - 14 IS - 7 SP - 4369 EP - 4371 KW - Lung cancer KW - CEA KW - CA199 KW - NSE KW - CYFRA21-1 DO - N2 - Objective: To evaluate the association of a diagnosis of lung cancer and combined detection of serumcarcinoembryonic antigen (CEA), carbohydrateantigen 19-9 (CA19-9), neuron specific enolase (NSE) as well asthe cytokeratin 19 fragment (CYFRA21-1). Methods: Serum CEA, CA19-9, NSE and CYFRA21-1 were assessedin 150 patients with lung cancer, 100 patients with benign lung disease and 100 normal control subjects, anddifferences of expression were compared in each group, and joint effects of these tumor markers in the diagnosisof lung cancer were analyzed. Results: Serum CEA, CA19-9, NSE and CYFRA21-1 in patients with lung cancerwere significantly higher than those with benign lung disease and normal controls (p<0.01). It is suggested thatthese four tumor markers combined together could produce a positive detection rate of 90.2%, significantlyhigher than that of any single test. Conclusion: Combination detection of CEA, CA19-9, NSE and CYFRA21-1could significantly improve the sensitivity and specificity in diagnosis of lung cancer, and could be important inearly detection. UR - https://journal.waocp.org/article_27960.html L1 - https://journal.waocp.org/article_27960_016bfe99d3148cc0705d07b6c16e626b.pdf ER -