TY - JOUR ID - 27980 TI - Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2013 PY - 2013 VL - 14 IS - 8 SP - 4509 EP - 4513 KW - Hepatocellular carcinoma KW - Hepatitis B Virus KW - gene mutations DO - N2 - Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma(HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-relatedhepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate thathepatitis B virus mutations are associated with risk of HCC. These variations include, in particular, mutationsin ORF S,C,X gene regions. This mini-review summarizes results of clinical studies and molecular mechanismson the possible relations of HBV mutations with the development of hepatocellular carcinoma. UR - https://journal.waocp.org/article_27980.html L1 - https://journal.waocp.org/article_27980_1d580e75db69b84f3b47d9e6f4414c1a.pdf ER -