TY - JOUR ID - 28529 TI - Immunoregulatory Function of HLA-G in Gastric Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2013 PY - 2013 VL - 14 IS - 12 SP - 7681 EP - 7684 KW - HLA-G KW - Gastric cancer KW - CD8 T lymphocytes KW - Treg cells DO - N2 - Background: Human leukocyte antigen (HLA)-G-positive gastric cancers are associated with poorsurvival, but links with tumor escape mechanisms remain to be determined. Materials and Methods: We usedimmunohistochemistry to investigate HLA-G expression, tumor infiltrating CD8+ T lymphocytes, and Tregcells in 52 gastric cancer patients. Results: There were 29 cancer-related deaths during the follow-up period.Kaplan-Meier analysis indicated that patients with HLA-G-positive (n=16) primary tumors had a significantlypoorer prognosis than patients with HLA-G-negative tumors (n=36, p=0.008). The median survival time was14 months and 47 months, respectively. Patients with high numbers of Tregs and low numbers of CD8+Tlymphocytes in the primary tumor had a poorer prognosis than those with low numbers of Tregs and highnumbers of CD8+T lymphocytes (p=0.034, p=0.043). Multivariate Cox proportional hazard regression analysisshowed that HLA-G expression (hazard ratio: 2.662; 95% confidence interval: 1.242-5.723; p=0.012) and stage(hazard ratio: 2.012;95% confidence interval: 1.112-3.715; p=0.041) were independent unfavorable factors forpatient survival. Conclusions: We found a significant positive correlation between HLA-G expression and thenumber of tumor infiltrating Tregs (p=0.01) and a negative correlation with the number of CD8+T lymphocytes(p=0.041). HLA-G may protect gastric cancer cells from cytolysis by inducing Foxp3+Treg lymphocytes andsuppressing CD8+T lymphocytes. UR - https://journal.waocp.org/article_28529.html L1 - https://journal.waocp.org/article_28529_a608d2a24ab3bd6492eaf1b7711d3ba2.pdf ER -