TY - JOUR ID - 28897 TI - A Systemic Analysis of S-1 Regimens for Treatment of Patients with Colon Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 5 SP - 2191 EP - 2194 KW - Systemic analysis KW - S-1 KW - Colon cancer DO - N2 - Background: Fluorouracil-based regimens have been widely accepted and recommended in the guidelinesfor treating patients with early or advanced staged colon cancer, although results are controversial. Here weperformed a systemic analysis to evaluate the impact of S-1 based regimens on response and survival of patientswith colon cancer. Methods: Clinical studies evaluating the impact of S-1 based regimens on response andsurvival of patients with colon cancer were identified using a predefined search strategy. Summary responserates (RRs) to treatment were calculated. Results: Six clinical studies which including 227 patients with advancedcolorectal cancer were considered eligible for inclusion. Two studies were conducted using combination of S-1and Oxaliplatin, and four studies featured S-1 and irinotecan. Systemic analysis showed that, in all patients,pooled RRs was 43.17%. Major adverse effects were hematological toxicities, gastrointestinal disturbance,neurosensory toxicity. No treatment related death occurred. Conclusion: This systemic analysis suggests thatS-1 based regimens, both with oxaliplatin or irinotean are associated with acceptable response and toxicity inpatients with colon cancer. UR - https://journal.waocp.org/article_28897.html L1 - https://journal.waocp.org/article_28897_3c6937cad3532932f96f7a41447cb316.pdf ER -