TY - JOUR ID - 28901 TI - Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 5 SP - 2211 EP - 2215 KW - cervical cancer KW - positive vaginal margin KW - Radical hysterectomy KW - vaginal involvement KW - vaginal metastasis DO - N2 - Background: To examine the incidence of positive vaginal surgical margins and determine the predictingfactors following radical hysterectomy for stage IB1 carcinoma of the cervix. Materials and Methods: The clinicaland histological data of 656 FIGO stage IB1 cervical cancer patients who had radical hysterectomy with bilateralpelvic lymphadenectomy (RHPL) from January 2003 to December 2012 were retrospectively reviewed andwere analyzed for their association with a positive vaginal surgical margin. A p-value of < 0.05 was consideredsignificant. Results: Thirty-five patients (5.3%) had positive vaginal surgical margins following RHPL; 24(3.7%) for intraepithelial lesions and 11 (1.7%) for carcinoma. On multivariate analysis, microscopic vaginalinvolvement by high-grade squamous intraepithelial lesion and/or carcinoma (adjusted odd ratio (OR) 186.8;95% confidence interval (CI) 48.5-718.5) and squamous histology (OR 8.7; 95% CI 1.7-44.0), were significantlyassociated with positive vaginal surgical margin. Conclusions: Microscopic vaginal involvement by HSIL and/or carcinoma are strong predictors for positive vaginal surgical margins for stage IB1 cervical cancer patientsundergoing radical hysterectomy. Preoperative ‘mapping’ colposcopy or other strategies should be consideredto ensure optimal vaginal resection. UR - https://journal.waocp.org/article_28901.html L1 - https://journal.waocp.org/article_28901_16638bb600fef060ad6f7bbead507f3c.pdf ER -