TY - JOUR ID - 29076 TI - Inhibitory Effects of α-Pinene on Hepatoma Carcinoma Cell Proliferation JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 7 SP - 3293 EP - 3297 KW - α-pinene KW - hepatoma carcinoma KW - Proliferation KW - cell cycle proteins DO - N2 - Background: Pine needle oil from crude extract of pine needles has anti-tumor effects, but the effectivecomponent is not known. Methods: In the present study, compounds from a steam distillation extract of pineneedles were isolated and characterized. Alpha-pinene was identified as an active anti-proliferative compound onhepatoma carcinoma BEL-7402 cells using the MTT assay. Results: Further experiments showed that α-pineneinhibited BEL-7402 cells by arresting cell growth in the G2/M phase of the cell cycle, downregulating Cdc25CmRNA and protein expression, and reducing cycle dependence on kinase 1(CDK1) activity. Conclusion: Takentogether, these findings indicate that α-pinene may be useful as a potential anti-tumor drug. UR - https://journal.waocp.org/article_29076.html L1 - https://journal.waocp.org/article_29076_ea4d617486522c319a2b7c16cff7b317.pdf ER -