TY - JOUR ID - 29195 TI - Diagnostic and Prognostic Value of miR-205 in Colorectal Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 9 SP - 4033 EP - 4037 KW - MicroRNA KW - MiR-205 KW - colorectal cancer KW - Metastasis KW - Biomarker DO - N2 - Emerging evidence has shown associations of microRNA-205 (miR-205) with crucial cell processes such as theepithelial-mesenchymal transition (EMT) and aberrant expression with tumorigenesis in many types of humanmalignancy. This prospective study characterized the contribution of miR-205 to the colorectal cancer (CRC)tumorigenesis. The real-time reverse transcription–polymerase chain reaction was used to examine miR-205levels prospectively in 36 pairs of samples of CRC tissue and adjacent noncancerous tissue (>2 cm from cancertissue). In addition, the relationship between miR-205 levels and clinicopathological features was explored. Thecapability of miR-205 to function as a tumor marker was also examined. miR-205 expression levels did not showsignificant changes overall. However, miR-205 was significantly downregulated in a group of CRC samplescompared with matched noncancerous tissue samples. Moreover, decreased miR-205 correlated significantlywith lymphatic metastasis. A receiver operating characteristic (ROC) curve also showed an optimum cut offpoint of 1.4×10-3 to distinguish lymphatic metastatic CRCs from non-metastatic CRCs. Interestingly we foundlymphatic metastasis in almost 80% of the depressed samples. This study suggested that miR-205 could bereduced in the majority of metastatic CRCs and the risk of CRC metastasis may be predicted by monitoringmiR-205 in patient samples collected at the time of the initial diagnosis. Therefore, targeting miR-205 and itspotential environmental activators might be a promising therapeutic option to prevent malignant progressiontoward metastasis. UR - https://journal.waocp.org/article_29195.html L1 - https://journal.waocp.org/article_29195_d9ecdbbaca69416f7b202b0699d0a233.pdf ER -