TY - JOUR ID - 29256 TI - Endpoint of Cancer Treatment: Targeted Therapies JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 11 SP - 4395 EP - 4403 KW - cancer KW - cytotoxic chemotherapy KW - targeted therapy DO - N2 - Nowadays there are several limitations in cancer treatment. One of these is the use of conventional medicineswhich not only target cancer cells and thus also cause high toxicity precluding effective treatment. Recentelucidation of mechanisms that cause cancer has led to discovery of novel key molecules and pathways whichhave have become successful targets for the treatments that eliminate only cancer cells. These so-called targetedtherapies offer new hope for millions of cancer patients, as briefly reveiwed here focusing on different types ofagents, like PARP, CDK, tyrosine kinase, farnysyl transferase and proteasome inhibitors, monoclonal antibodiesand antiangiogenic agents. UR - https://journal.waocp.org/article_29256.html L1 - https://journal.waocp.org/article_29256_be57e5fda930c266153b0431557975bc.pdf ER -