TY - JOUR ID - 29328 TI - Fotemustine, Teniposide and Dexamethasone in Treating Patients with CNS Lymphoma JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 11 SP - 4733 EP - 4738 KW - Central nervous system KW - Lymphoma KW - Chemotherapy DO - N2 - Purpose: We developed and evaluated a regimen including fotemustine, teniposide and dexamethasone (FTD)for treating patients with central nervous system (CNS) lymphoma based on pharmacokinetic properties ofindividual agents and in combination. Patients and Methods: In a comparison study, 8 patients with primaryCNS lymphoma (PCNSL) and 8 with secondary CNS lymphoma (SCNSL) were treated with FTD (comprisingfotemustine 100 mg/m2, 1h infusion, day 1; teniposide 60 mg/m2, >0.5 h infusion, on day 2, 3, 4; dexamethasone 40mg, 1h infusion, on day 1, 2, 3, 4 and 5; and methotrexate 12 mg, cytosine arabinoside 50 mg plus dexamethasone5 mg intrathecally, on day 2 and 7). Cycles were repeated every 3 weeks. After response assessment, patientsreceived whole brain radiotherapy. Results: Of the 8 PCNSL patients, 4 (50%) achieved CR and 3 (38%) PR, anoverall response rate of 88%. Four patients (50%) were in continuing remission at the end of this study after amedian follow-up of 30 months (range 10 to 56 months). Of the 8 SCNSL patients the overall response rate was63% (CR+PR: 38%+25%). All responses were achievable with predictable toxicity mainly reflecting reversiblemyelosuppression. Conclusion: This study suggests that FTD could be an effective treatment for CNS lymphoma,and is worthy of further evaluation. UR - https://journal.waocp.org/article_29328.html L1 - https://journal.waocp.org/article_29328_ea33a32708ea40d79f89092354de675f.pdf ER -